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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for PPARD

Z-value: 0.42

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Transcription factors associated with PPARD

Gene Symbol Gene ID Gene Info
PPARD
ENSG00000112033.9 peroxisome proliferator activated receptor delta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PPARDhg19_v2_chr6_+_35310312_35310359-0.221.2e-03Click!

Activity profile of PPARD motif

Sorted Z-values of PPARD motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_10687948 5.41 ENST00000592285.1
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr2_+_120125245 4.80 ENST00000393103.2
DBI
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
chr1_+_165864821 4.68 ENST00000470820.1
UCK2
uridine-cytidine kinase 2
chr12_-_53320245 4.60 ENST00000552150.1
KRT8
keratin 8
chr2_+_219283815 4.55 ENST00000248444.5
ENST00000454069.1
ENST00000392114.2
VIL1
villin 1
chr1_+_165864800 4.54 ENST00000469256.2
UCK2
uridine-cytidine kinase 2
chr6_+_32006159 4.46 ENST00000478281.1
ENST00000471671.1
ENST00000435122.2
CYP21A2
cytochrome P450, family 21, subfamily A, polypeptide 2
chr6_+_32006042 4.34 ENST00000418967.2
CYP21A2
cytochrome P450, family 21, subfamily A, polypeptide 2
chr4_+_140586922 3.89 ENST00000265498.1
ENST00000506797.1
MGST2
microsomal glutathione S-transferase 2
chr8_-_80942061 3.86 ENST00000519386.1
MRPS28
mitochondrial ribosomal protein S28
chr4_-_7069760 3.76 ENST00000264954.4
GRPEL1
GrpE-like 1, mitochondrial (E. coli)
chr8_-_80942139 3.69 ENST00000521434.1
ENST00000519120.1
ENST00000520946.1
MRPS28
mitochondrial ribosomal protein S28
chr11_+_66624527 3.68 ENST00000393952.3
LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr17_+_37894179 3.66 ENST00000577695.1
ENST00000309156.4
ENST00000309185.3
GRB7
growth factor receptor-bound protein 7
chr2_+_198365122 3.59 ENST00000604458.1
HSPE1-MOB4
HSPE1-MOB4 readthrough
chr19_-_10687907 3.54 ENST00000589348.1
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr19_-_10687983 3.48 ENST00000587069.1
AP1M2
adaptor-related protein complex 1, mu 2 subunit
chr12_+_96252706 3.44 ENST00000266735.5
ENST00000553192.1
ENST00000552085.1
SNRPF
small nuclear ribonucleoprotein polypeptide F
chr8_-_80942467 3.32 ENST00000518271.1
ENST00000276585.4
ENST00000521605.1
MRPS28
mitochondrial ribosomal protein S28
chr22_-_51016846 3.31 ENST00000312108.7
ENST00000395650.2
CPT1B
carnitine palmitoyltransferase 1B (muscle)
chr2_+_198365095 3.29 ENST00000409468.1
HSPE1
heat shock 10kDa protein 1
chr22_-_51017084 3.25 ENST00000360719.2
ENST00000457250.1
ENST00000440709.1
CPT1B
carnitine palmitoyltransferase 1B (muscle)
chr4_+_174089904 3.16 ENST00000265000.4
GALNT7
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)
chr2_+_178257372 3.12 ENST00000264167.4
ENST00000409888.1
AGPS
alkylglycerone phosphate synthase
chr10_+_94050913 3.09 ENST00000358935.2
MARCH5
membrane-associated ring finger (C3HC4) 5
chr22_+_30163340 2.99 ENST00000330029.6
ENST00000401406.3
UQCR10
ubiquinol-cytochrome c reductase, complex III subunit X
chr1_-_43855444 2.97 ENST00000372455.4
MED8
mediator complex subunit 8
chr16_-_4401258 2.93 ENST00000577031.1
PAM16
presequence translocase-associated motor 16 homolog (S. cerevisiae)
chr7_-_87342564 2.74 ENST00000265724.3
ENST00000416177.1
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr1_-_109968973 2.66 ENST00000271308.4
ENST00000538610.1
PSMA5
proteasome (prosome, macropain) subunit, alpha type, 5
chr2_-_207024134 2.58 ENST00000457011.1
ENST00000440274.1
ENST00000432169.1
NDUFS1
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr1_-_120311517 2.51 ENST00000369406.3
ENST00000544913.2
HMGCS2
3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
chr2_-_28113217 2.46 ENST00000444339.2
RBKS
ribokinase
chr15_-_82555000 2.43 ENST00000557844.1
ENST00000359445.3
ENST00000268206.7
EFTUD1
elongation factor Tu GTP binding domain containing 1
chr17_+_7483761 2.35 ENST00000584180.1
CD68
CD68 molecule
chr17_+_7123125 2.29 ENST00000356839.5
ENST00000583312.1
ENST00000350303.5
ACADVL
acyl-CoA dehydrogenase, very long chain
chr1_-_161193349 2.21 ENST00000469730.2
ENST00000463273.1
ENST00000464492.1
ENST00000367990.3
ENST00000470459.2
ENST00000468465.1
ENST00000463812.1
APOA2
apolipoprotein A-II
chr19_+_17420340 2.14 ENST00000359866.4
DDA1
DET1 and DDB1 associated 1
chr1_+_145727681 1.94 ENST00000417171.1
ENST00000451928.2
PDZK1
PDZ domain containing 1
chr15_+_43885252 1.94 ENST00000453782.1
ENST00000300283.6
ENST00000437924.1
ENST00000450086.2
CKMT1B
creatine kinase, mitochondrial 1B
chr6_-_33547975 1.87 ENST00000442998.2
ENST00000360661.5
BAK1
BCL2-antagonist/killer 1
chr16_-_4401284 1.86 ENST00000318059.3
PAM16
presequence translocase-associated motor 16 homolog (S. cerevisiae)
chr5_+_34757309 1.80 ENST00000397449.1
RAI14
retinoic acid induced 14
chr6_-_33548006 1.73 ENST00000374467.3
BAK1
BCL2-antagonist/killer 1
chr19_-_51869592 1.69 ENST00000596253.1
ENST00000309244.4
ETFB
electron-transfer-flavoprotein, beta polypeptide
chr11_+_64073699 1.63 ENST00000405666.1
ENST00000468670.1
ESRRA
estrogen-related receptor alpha
chr9_-_33402506 1.55 ENST00000377425.4
ENST00000537089.1
ENST00000297988.1
ENST00000539936.1
ENST00000541274.1
AQP7
aquaporin 7
chr1_+_55107449 1.55 ENST00000421030.2
ENST00000545244.1
ENST00000339553.5
ENST00000409996.1
ENST00000454855.2
MROH7
maestro heat-like repeat family member 7
chr15_+_43985084 1.52 ENST00000434505.1
ENST00000411750.1
CKMT1A
creatine kinase, mitochondrial 1A
chr6_+_33172407 1.50 ENST00000374662.3
HSD17B8
hydroxysteroid (17-beta) dehydrogenase 8
chr5_-_143550241 1.41 ENST00000522203.1
YIPF5
Yip1 domain family, member 5
chrX_-_108868390 1.38 ENST00000372101.2
KCNE1L
KCNE1-like
chr5_-_143550159 1.36 ENST00000448443.2
ENST00000513112.1
ENST00000519064.1
ENST00000274496.5
YIPF5
Yip1 domain family, member 5
chr19_+_49867181 1.33 ENST00000597546.1
DKKL1
dickkopf-like 1
chr17_-_39728303 1.30 ENST00000588431.1
ENST00000246662.4
KRT9
keratin 9
chrX_+_2746850 1.27 ENST00000381163.3
ENST00000338623.5
ENST00000542787.1
GYG2
glycogenin 2
chr17_-_34270668 1.26 ENST00000293274.4
LYZL6
lysozyme-like 6
chr17_-_34270697 1.25 ENST00000585556.1
LYZL6
lysozyme-like 6
chr7_+_7222233 1.20 ENST00000436587.2
C1GALT1
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
chr6_+_43266063 1.13 ENST00000372574.3
SLC22A7
solute carrier family 22 (organic anion transporter), member 7
chrX_+_2746818 1.12 ENST00000398806.3
GYG2
glycogenin 2
chr6_+_88299833 1.11 ENST00000392844.3
ENST00000257789.4
ENST00000546266.1
ENST00000417380.2
ORC3
origin recognition complex, subunit 3
chr19_+_10196981 0.95 ENST00000591813.1
C19orf66
chromosome 19 open reading frame 66
chr9_+_115142217 0.88 ENST00000398805.3
ENST00000398803.1
ENST00000262542.7
ENST00000539114.1
HSDL2
hydroxysteroid dehydrogenase like 2
chr17_-_34344991 0.85 ENST00000591423.1
CCL23
chemokine (C-C motif) ligand 23
chr22_-_42526802 0.85 ENST00000359033.4
ENST00000389970.3
ENST00000360608.5
CYP2D6
cytochrome P450, family 2, subfamily D, polypeptide 6
chr1_-_161102367 0.84 ENST00000464113.1
DEDD
death effector domain containing
chr21_-_27107198 0.81 ENST00000400094.1
ATP5J
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
chr6_+_43265992 0.78 ENST00000449231.1
ENST00000372589.3
ENST00000372585.5
SLC22A7
solute carrier family 22 (organic anion transporter), member 7
chr21_-_27107344 0.75 ENST00000457143.2
ATP5J
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
chr15_+_75494214 0.73 ENST00000394987.4
C15orf39
chromosome 15 open reading frame 39
chr21_-_27107283 0.72 ENST00000284971.3
ENST00000400099.1
ATP5J
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
chr6_+_143999072 0.72 ENST00000440869.2
ENST00000367582.3
ENST00000451827.2
PHACTR2
phosphatase and actin regulator 2
chr1_-_11863171 0.70 ENST00000376592.1
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr20_+_42187608 0.69 ENST00000373100.1
SGK2
serum/glucocorticoid regulated kinase 2
chr20_+_42187682 0.62 ENST00000373092.3
ENST00000373077.1
SGK2
serum/glucocorticoid regulated kinase 2
chr3_+_186383741 0.61 ENST00000232003.4
HRG
histidine-rich glycoprotein
chr13_+_113760098 0.59 ENST00000346342.3
ENST00000541084.1
ENST00000375581.3
F7
coagulation factor VII (serum prothrombin conversion accelerator)
chr21_-_27107881 0.58 ENST00000400090.3
ENST00000400087.3
ENST00000400093.3
ATP5J
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
chr18_-_47340297 0.58 ENST00000586485.1
ENST00000587994.1
ENST00000586100.1
ENST00000285093.10
ACAA2
acetyl-CoA acyltransferase 2
chr15_+_78441663 0.57 ENST00000299518.2
ENST00000558554.1
ENST00000557826.1
ENST00000561279.1
ENST00000559186.1
ENST00000560770.1
ENST00000559881.1
ENST00000559205.1
ENST00000441490.2
IDH3A
isocitrate dehydrogenase 3 (NAD+) alpha
chr2_-_178257401 0.53 ENST00000464747.1
NFE2L2
nuclear factor, erythroid 2-like 2
chr17_-_34345002 0.52 ENST00000293280.2
CCL23
chemokine (C-C motif) ligand 23
chr1_-_161102421 0.51 ENST00000490843.2
ENST00000368006.3
ENST00000392188.1
ENST00000545495.1
DEDD
death effector domain containing
chr1_+_62417957 0.46 ENST00000307297.7
ENST00000543708.1
INADL
InaD-like (Drosophila)
chr2_+_28113583 0.41 ENST00000344773.2
ENST00000379624.1
ENST00000342045.2
ENST00000379632.2
ENST00000361704.2
BRE
brain and reproductive organ-expressed (TNFRSF1A modulator)
chr3_-_187009798 0.41 ENST00000337774.5
MASP1
mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
chr11_-_119599794 0.30 ENST00000264025.3
PVRL1
poliovirus receptor-related 1 (herpesvirus entry mediator C)
chr1_-_160832642 0.30 ENST00000368034.4
CD244
CD244 molecule, natural killer cell receptor 2B4
chr12_-_21757774 0.28 ENST00000261195.2
GYS2
glycogen synthase 2 (liver)
chr20_+_46130601 0.28 ENST00000341724.6
NCOA3
nuclear receptor coactivator 3
chr1_-_11107280 0.27 ENST00000400897.3
ENST00000400898.3
MASP2
mannan-binding lectin serine peptidase 2
chr9_+_34458771 0.26 ENST00000437363.1
ENST00000242317.4
DNAI1
dynein, axonemal, intermediate chain 1
chr14_+_32546274 0.26 ENST00000396582.2
ARHGAP5
Rho GTPase activating protein 5
chr1_-_43855479 0.26 ENST00000290663.6
ENST00000372457.4
MED8
mediator complex subunit 8
chr2_+_206547215 0.26 ENST00000360409.3
ENST00000540178.1
ENST00000540841.1
ENST00000355117.4
ENST00000450507.1
ENST00000417189.1
NRP2
neuropilin 2
chr1_-_197036364 0.25 ENST00000367412.1
F13B
coagulation factor XIII, B polypeptide
chr16_+_2255841 0.23 ENST00000301725.7
MLST8
MTOR associated protein, LST8 homolog (S. cerevisiae)
chrX_+_38211777 0.23 ENST00000039007.4
OTC
ornithine carbamoyltransferase
chr16_+_2255710 0.21 ENST00000397124.1
ENST00000565250.1
MLST8
MTOR associated protein, LST8 homolog (S. cerevisiae)
chr11_-_47470591 0.14 ENST00000524487.1
RAPSN
receptor-associated protein of the synapse
chr17_+_73997419 0.13 ENST00000425876.2
CDK3
cyclin-dependent kinase 3
chr2_+_73441350 0.09 ENST00000389501.4
SMYD5
SMYD family member 5
chr6_+_72922590 0.09 ENST00000523963.1
RIMS1
regulating synaptic membrane exocytosis 1
chr21_+_27107672 0.09 ENST00000400075.3
GABPA
GA binding protein transcription factor, alpha subunit 60kDa
chr12_-_95467267 0.08 ENST00000330677.7
NR2C1
nuclear receptor subfamily 2, group C, member 1
chr6_+_72922505 0.08 ENST00000401910.3
RIMS1
regulating synaptic membrane exocytosis 1
chr12_+_121163538 0.05 ENST00000242592.4
ACADS
acyl-CoA dehydrogenase, C-2 to C-3 short chain
chr3_-_125094093 0.04 ENST00000484491.1
ENST00000492394.1
ENST00000471196.1
ENST00000468369.1
ENST00000544464.1
ENST00000485866.1
ENST00000360647.4
ZNF148
zinc finger protein 148
chr11_-_47470703 0.04 ENST00000298854.2
RAPSN
receptor-associated protein of the synapse
chr14_-_25045446 0.01 ENST00000216336.2
CTSG
cathepsin G
chr11_-_47470682 0.00 ENST00000529341.1
ENST00000352508.3
RAPSN
receptor-associated protein of the synapse

Network of associatons between targets according to the STRING database.

First level regulatory network of PPARD

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 9.2 GO:0006238 CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035)
1.2 3.6 GO:0048597 B cell negative selection(GO:0002352) post-embryonic camera-type eye morphogenesis(GO:0048597)
1.0 3.1 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.9 4.5 GO:1902896 terminal web assembly(GO:1902896)
0.8 2.5 GO:0006014 D-ribose metabolic process(GO:0006014)
0.7 2.2 GO:0060620 regulation of cholesterol import(GO:0060620) negative regulation of cholesterol import(GO:0060621) regulation of sterol import(GO:2000909) negative regulation of sterol import(GO:2000910)
0.6 8.5 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.5 8.8 GO:0006705 mineralocorticoid biosynthetic process(GO:0006705) mineralocorticoid metabolic process(GO:0008212)
0.5 2.5 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.4 2.7 GO:1901529 positive regulation of anion channel activity(GO:1901529)
0.4 3.0 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.4 1.1 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.3 4.6 GO:0051599 response to hydrostatic pressure(GO:0051599)
0.3 7.0 GO:0015879 carnitine transport(GO:0015879)
0.3 4.8 GO:0018345 protein palmitoylation(GO:0018345)
0.3 0.6 GO:0097068 response to thyroxine(GO:0097068) response to L-phenylalanine derivative(GO:1904386)
0.3 2.3 GO:0046322 negative regulation of fatty acid oxidation(GO:0046322)
0.2 11.4 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.2 1.6 GO:0015793 glycerol transport(GO:0015793)
0.2 3.7 GO:0034063 stress granule assembly(GO:0034063)
0.2 0.8 GO:0033076 alkaloid catabolic process(GO:0009822) isoquinoline alkaloid metabolic process(GO:0033076) cellular organohalogen metabolic process(GO:0090345) cellular organofluorine metabolic process(GO:0090346)
0.2 2.5 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.2 2.8 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.2 3.1 GO:0090344 negative regulation of cell aging(GO:0090344)
0.2 3.3 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.2 3.4 GO:0019184 glutathione biosynthetic process(GO:0006750) nonribosomal peptide biosynthetic process(GO:0019184)
0.2 0.6 GO:2001027 negative regulation of endothelial cell chemotaxis(GO:2001027)
0.1 10.9 GO:0070125 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.1 0.7 GO:0070829 response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)
0.1 1.5 GO:0006600 creatine metabolic process(GO:0006600)
0.1 3.4 GO:0008334 histone mRNA metabolic process(GO:0008334)
0.1 0.3 GO:2000566 positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566)
0.1 0.6 GO:1902109 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029) negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
0.1 2.9 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.1 1.2 GO:0060576 intestinal epithelial cell development(GO:0060576)
0.1 0.2 GO:0070781 arginine biosynthetic process via ornithine(GO:0042450) response to biotin(GO:0070781)
0.1 2.4 GO:0005980 glycogen catabolic process(GO:0005980)
0.1 0.2 GO:1900073 regulation of neuromuscular synaptic transmission(GO:1900073) positive regulation of neuromuscular synaptic transmission(GO:1900075)
0.1 3.2 GO:0016266 O-glycan processing(GO:0016266)
0.1 1.3 GO:0045109 intermediate filament organization(GO:0045109)
0.0 1.5 GO:0051290 protein heterotetramerization(GO:0051290)
0.0 0.6 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 1.9 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.3 GO:0035624 receptor transactivation(GO:0035624)
0.0 2.6 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 1.6 GO:1900078 positive regulation of cellular response to insulin stimulus(GO:1900078)
0.0 0.3 GO:0097491 sympathetic neuron projection extension(GO:0097490) sympathetic neuron projection guidance(GO:0097491)
0.0 2.7 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.0 1.4 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.0 0.3 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 1.3 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.0 0.6 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.1 GO:0045023 G0 to G1 transition(GO:0045023)
0.0 0.1 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.0 0.4 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.0 1.3 GO:0032411 positive regulation of transporter activity(GO:0032411)
0.0 3.3 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 2.1 GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032434)
0.0 1.4 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 8.5 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.5 2.6 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
0.4 3.4 GO:0005683 U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715)
0.4 10.9 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.4 1.1 GO:0005656 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.3 3.6 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.3 3.0 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.2 11.4 GO:0030131 clathrin adaptor complex(GO:0030131)
0.2 4.5 GO:0032433 filopodium tip(GO:0032433)
0.2 2.7 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.2 2.5 GO:0097524 sperm plasma membrane(GO:0097524)
0.2 2.9 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 4.6 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 2.2 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.1 2.8 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 3.2 GO:0016592 mediator complex(GO:0016592)
0.1 1.9 GO:0031528 microvillus membrane(GO:0031528)
0.1 0.4 GO:0031931 TORC1 complex(GO:0031931)
0.1 3.7 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 2.3 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 9.7 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 2.1 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.6 GO:0036019 endolysosome(GO:0036019)
0.0 0.3 GO:0036157 outer dynein arm(GO:0036157)
0.0 2.3 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 1.6 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.7 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.3 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 1.9 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 7.0 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 2.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.8 GO:0001650 fibrillar center(GO:0001650)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 9.2 GO:0004849 uridine kinase activity(GO:0004849)
1.3 6.6 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095)
1.3 3.9 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.6 2.4 GO:0008466 glycogenin glucosyltransferase activity(GO:0008466)
0.6 2.3 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.6 4.5 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.6 2.2 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.5 2.7 GO:0090554 phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.5 2.5 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.5 1.9 GO:0005124 scavenger receptor binding(GO:0005124)
0.5 4.8 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.4 3.0 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.4 2.5 GO:0003796 lysozyme activity(GO:0003796)
0.4 1.6 GO:0015254 glycerol channel activity(GO:0015254)
0.3 3.8 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.3 1.5 GO:0070404 NADH binding(GO:0070404)
0.3 9.6 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.2 3.2 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.2 1.4 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.2 1.5 GO:0004111 creatine kinase activity(GO:0004111)
0.2 3.6 GO:0051400 BH domain binding(GO:0051400)
0.1 0.6 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.1 0.7 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.1 2.6 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.1 3.1 GO:0071949 FAD binding(GO:0071949)
0.1 2.7 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 1.2 GO:0048531 beta-1,3-galactosyltransferase activity(GO:0048531)
0.1 2.5 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.1 0.3 GO:0001855 complement component C4b binding(GO:0001855)
0.1 1.1 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 0.6 GO:0003988 acetyl-CoA C-acyltransferase activity(GO:0003988)
0.1 1.9 GO:0015301 anion:anion antiporter activity(GO:0015301)
0.1 1.3 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 0.3 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.0 2.7 GO:0097110 scaffold protein binding(GO:0097110)
0.0 3.3 GO:0051087 chaperone binding(GO:0051087)
0.0 3.7 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.6 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 3.2 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.0 2.9 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 0.3 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.2 GO:0042301 phosphate ion binding(GO:0042301)
0.0 1.6 GO:0098531 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 0.7 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.5 GO:0001221 transcription cofactor binding(GO:0001221)
0.0 0.3 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.3 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.4 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.2 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.0 0.3 GO:0042288 MHC class I protein binding(GO:0042288)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.6 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 8.9 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 4.6 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 3.7 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 2.1 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 2.7 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 2.5 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.3 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 1.4 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.0 0.4 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.3 PID NECTIN PATHWAY Nectin adhesion pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 11.4 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.4 8.8 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.3 9.2 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.2 3.4 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.2 2.7 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.2 2.9 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.2 5.0 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.1 8.5 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 2.3 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 1.9 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.1 3.9 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 1.6 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 3.7 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.1 4.4 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.1 2.2 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 1.1 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.1 2.4 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 3.6 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.1 2.1 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 7.6 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 0.6 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.8 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 0.6 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 2.7 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.6 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.3 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.4 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 3.7 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.3 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.5 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.9 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.7 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors