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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for PPARD
Z-value: 0.42
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Transcription factors associated with PPARD
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PPARD | hg19_v2_chr6_+_35310312_35310359 | -0.22 | 1.2e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_10687948 Show fit | 5.41 |
ENST00000592285.1
|
adaptor-related protein complex 1, mu 2 subunit |
|
| chr2_+_120125245 Show fit | 4.80 |
ENST00000393103.2
|
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) |
|
| chr1_+_165864821 Show fit | 4.68 |
ENST00000470820.1
|
uridine-cytidine kinase 2 |
|
| chr12_-_53320245 Show fit | 4.60 |
ENST00000552150.1
|
keratin 8 |
|
| chr2_+_219283815 Show fit | 4.55 |
ENST00000248444.5
ENST00000454069.1 ENST00000392114.2 |
villin 1 |
|
| chr1_+_165864800 Show fit | 4.54 |
ENST00000469256.2
|
uridine-cytidine kinase 2 |
|
| chr6_+_32006159 Show fit | 4.46 |
ENST00000478281.1
ENST00000471671.1 ENST00000435122.2 |
cytochrome P450, family 21, subfamily A, polypeptide 2 |
|
| chr6_+_32006042 Show fit | 4.34 |
ENST00000418967.2
|
cytochrome P450, family 21, subfamily A, polypeptide 2 |
|
| chr4_+_140586922 Show fit | 3.89 |
ENST00000265498.1
ENST00000506797.1 |
microsomal glutathione S-transferase 2 |
|
| chr8_-_80942061 Show fit | 3.86 |
ENST00000519386.1
|
mitochondrial ribosomal protein S28 |
Network of associatons between targets according to the STRING database.
First level regulatory network of PPARD
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.4 | GO:0050690 | regulation of defense response to virus by virus(GO:0050690) |
| 0.1 | 10.9 | GO:0070125 | mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126) |
| 2.3 | 9.2 | GO:0006238 | CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035) |
| 0.5 | 8.8 | GO:0006705 | mineralocorticoid biosynthetic process(GO:0006705) mineralocorticoid metabolic process(GO:0008212) |
| 0.6 | 8.5 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) |
| 0.3 | 7.0 | GO:0015879 | carnitine transport(GO:0015879) |
| 0.3 | 4.8 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.3 | 4.6 | GO:0051599 | response to hydrostatic pressure(GO:0051599) |
| 0.9 | 4.5 | GO:1902896 | terminal web assembly(GO:1902896) |
| 0.2 | 3.7 | GO:0034063 | stress granule assembly(GO:0034063) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.4 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.4 | 10.9 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.0 | 9.7 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 2.1 | 8.5 | GO:0001405 | presequence translocase-associated import motor(GO:0001405) |
| 0.0 | 7.0 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 4.6 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.2 | 4.5 | GO:0032433 | filopodium tip(GO:0032433) |
| 0.1 | 3.7 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.3 | 3.6 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.4 | 3.4 | GO:0005683 | U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 9.6 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
| 1.3 | 9.2 | GO:0004849 | uridine kinase activity(GO:0004849) |
| 1.3 | 6.6 | GO:0004095 | carnitine O-palmitoyltransferase activity(GO:0004095) |
| 0.5 | 4.8 | GO:0036042 | long-chain fatty acyl-CoA binding(GO:0036042) |
| 0.6 | 4.5 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) |
| 1.3 | 3.9 | GO:0004464 | leukotriene-C4 synthase activity(GO:0004464) |
| 0.3 | 3.8 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.0 | 3.7 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.2 | 3.6 | GO:0051400 | BH domain binding(GO:0051400) |
| 0.0 | 3.3 | GO:0051087 | chaperone binding(GO:0051087) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.9 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 4.6 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 3.7 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.1 | 3.6 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 2.7 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 2.5 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 2.1 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.4 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.0 | 0.4 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.0 | 0.3 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 11.4 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.3 | 9.2 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.4 | 8.8 | REACTOME ENDOGENOUS STEROLS | Genes involved in Endogenous sterols |
| 0.1 | 8.5 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.1 | 7.6 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.2 | 5.0 | REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 0.1 | 4.4 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.1 | 3.9 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 3.7 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.0 | 3.7 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |