Project
GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for PPARG
Z-value: 0.70
Motif logo
Transcription factors associated with PPARG
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PPARG | hg19_v2_chr3_+_12392971_12392983, hg19_v2_chr3_+_12329397_12329433, hg19_v2_chr3_+_12329358_12329393, hg19_v2_chr3_+_12330560_12330579 | -0.01 | 9.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr22_+_23241661 Show fit | 22.73 |
ENST00000390322.2
|
immunoglobulin lambda joining 2 |
|
| chr22_+_23264766 Show fit | 22.61 |
ENST00000390331.2
|
immunoglobulin lambda constant 7 |
|
| chr19_+_50016411 Show fit | 20.91 |
ENST00000426395.3
ENST00000600273.1 ENST00000599988.1 |
Fc fragment of IgG, receptor, transporter, alpha |
|
| chr7_-_150498426 Show fit | 20.41 |
ENST00000447204.2
|
transmembrane protein 176B |
|
| chr22_+_23229960 Show fit | 18.76 |
ENST00000526893.1
ENST00000532223.2 ENST00000531372.1 |
immunoglobulin lambda-like polypeptide 5 |
|
| chr19_+_50016610 Show fit | 15.59 |
ENST00000596975.1
|
Fc fragment of IgG, receptor, transporter, alpha |
|
| chr7_+_150498610 Show fit | 15.27 |
ENST00000461345.1
|
transmembrane protein 176A |
|
| chr11_-_5255696 Show fit | 14.61 |
ENST00000292901.3
ENST00000417377.1 |
hemoglobin, delta |
|
| chr14_-_106642049 Show fit | 14.36 |
ENST00000390605.2
|
immunoglobulin heavy variable 1-18 |
|
| chr19_-_10445399 Show fit | 14.28 |
ENST00000592945.1
|
intercellular adhesion molecule 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of PPARG
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 71.7 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 3.5 | 49.5 | GO:2001199 | negative regulation of dendritic cell differentiation(GO:2001199) |
| 5.2 | 36.5 | GO:0002414 | immunoglobulin transcytosis in epithelial cells(GO:0002414) |
| 0.2 | 27.0 | GO:0002223 | stimulatory C-type lectin receptor signaling pathway(GO:0002223) |
| 1.7 | 24.9 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.1 | 21.1 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 3.5 | 17.5 | GO:0060741 | prostate gland stromal morphogenesis(GO:0060741) |
| 4.0 | 16.1 | GO:1903781 | positive regulation of cardiac conduction(GO:1903781) positive regulation of atrial cardiac muscle cell action potential(GO:1903949) positive regulation of regulation of vascular smooth muscle cell membrane depolarization(GO:1904199) regulation of vascular smooth muscle cell membrane depolarization(GO:1990736) |
| 3.6 | 14.5 | GO:0070434 | positive regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070426) positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070434) |
| 0.9 | 14.3 | GO:0060213 | regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 88.3 | GO:0016021 | integral component of membrane(GO:0016021) |
| 1.4 | 69.8 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 54.2 | GO:0005615 | extracellular space(GO:0005615) |
| 0.2 | 32.5 | GO:0072562 | blood microparticle(GO:0072562) |
| 1.8 | 24.9 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.1 | 22.3 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.1 | 21.2 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.9 | 19.7 | GO:0001931 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
| 0.2 | 18.0 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.6 | 16.1 | GO:0034706 | sodium channel complex(GO:0034706) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 69.8 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 9.1 | 36.5 | GO:0019770 | IgG receptor activity(GO:0019770) |
| 0.2 | 29.6 | GO:0005178 | integrin binding(GO:0005178) |
| 1.9 | 24.9 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.1 | 22.8 | GO:0003823 | antigen binding(GO:0003823) |
| 0.1 | 19.8 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.0 | 17.5 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.4 | 16.1 | GO:0005227 | calcium activated cation channel activity(GO:0005227) |
| 1.3 | 14.5 | GO:0055131 | C3HC4-type RING finger domain binding(GO:0055131) |
| 3.5 | 14.1 | GO:0015254 | glycerol channel activity(GO:0015254) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 27.8 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.1 | 27.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 26.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 12.1 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 11.8 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.2 | 11.1 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.2 | 10.9 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.2 | 10.2 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.2 | 9.1 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.2 | 8.2 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 58.2 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 17.8 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 1.6 | 16.2 | REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS | Genes involved in Membrane binding and targetting of GAG proteins |
| 0.2 | 15.8 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 1.0 | 14.1 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.5 | 14.1 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.6 | 12.6 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.2 | 11.5 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.3 | 10.7 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.7 | 9.9 | REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR | Genes involved in Trafficking and processing of endosomal TLR |