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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for PRDM14

Z-value: 0.04

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Transcription factors associated with PRDM14

Gene Symbol Gene ID Gene Info
PRDM14
ENSG00000147596.3 PR/SET domain 14

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PRDM14hg19_v2_chr8_-_70983506_70983562-0.036.9e-01Click!

Activity profile of PRDM14 motif

Sorted Z-values of PRDM14 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_21492251 10.03 ENST00000554398.1
NDRG2
NDRG family member 2
chr14_-_21492113 9.58 ENST00000554094.1
NDRG2
NDRG family member 2
chr11_-_62474803 6.50 ENST00000533982.1
ENST00000360796.5
BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr11_+_62475130 6.05 ENST00000294117.5
GNG3
guanine nucleotide binding protein (G protein), gamma 3
chr12_-_49351303 5.31 ENST00000256682.4
ARF3
ADP-ribosylation factor 3
chr20_-_3154162 5.04 ENST00000360342.3
LZTS3
Homo sapiens leucine zipper, putative tumor suppressor family member 3 (LZTS3), mRNA.
chr12_-_49351228 5.02 ENST00000541959.1
ENST00000447318.2
ARF3
ADP-ribosylation factor 3
chr17_-_19651654 4.54 ENST00000395555.3
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr1_+_36621529 4.14 ENST00000316156.4
MAP7D1
MAP7 domain containing 1
chr1_+_50571949 4.11 ENST00000357083.4
ELAVL4
ELAV like neuron-specific RNA binding protein 4
chr17_-_19651668 4.00 ENST00000494157.2
ENST00000225740.6
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chrX_+_51636629 3.56 ENST00000375722.1
ENST00000326587.7
ENST00000375695.2
MAGED1
melanoma antigen family D, 1
chr7_-_124405681 3.43 ENST00000303921.2
GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr5_-_16936340 2.88 ENST00000507288.1
ENST00000513610.1
MYO10
myosin X
chr22_+_23241661 2.85 ENST00000390322.2
IGLJ2
immunoglobulin lambda joining 2
chr11_-_65624415 2.57 ENST00000524553.1
ENST00000527344.1
CFL1
cofilin 1 (non-muscle)
chr12_-_49351148 2.28 ENST00000398092.4
ENST00000539611.1
RP11-302B13.5
ARF3
ADP-ribosylation factor 3
ADP-ribosylation factor 3
chr1_+_39796810 1.98 ENST00000289893.4
MACF1
microtubule-actin crosslinking factor 1
chr3_-_47517302 1.66 ENST00000441517.2
ENST00000545718.1
SCAP
SREBF chaperone
chr8_-_102216925 1.56 ENST00000517844.1
ZNF706
zinc finger protein 706
chr19_+_39109735 1.55 ENST00000593149.1
ENST00000248342.4
ENST00000538434.1
ENST00000588934.1
ENST00000545173.2
ENST00000589307.1
ENST00000586513.1
ENST00000591409.1
ENST00000592558.1
EIF3K
eukaryotic translation initiation factor 3, subunit K
chr17_-_17485731 1.37 ENST00000395783.1
PEMT
phosphatidylethanolamine N-methyltransferase
chr11_+_64879317 1.36 ENST00000526809.1
ENST00000279263.7
ENST00000524986.1
ENST00000534371.1
ENST00000540748.1
ENST00000525385.1
ENST00000345348.5
ENST00000531321.1
ENST00000529414.1
ENST00000526085.1
ENST00000530750.1
TM7SF2
transmembrane 7 superfamily member 2
chr1_+_65730385 1.32 ENST00000263441.7
ENST00000395325.3
DNAJC6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr9_+_132597722 1.25 ENST00000372429.3
ENST00000315480.4
ENST00000358355.1
USP20
ubiquitin specific peptidase 20
chr12_-_52967600 1.15 ENST00000549343.1
ENST00000305620.2
KRT74
keratin 74
chr12_+_121647962 1.04 ENST00000542067.1
P2RX4
purinergic receptor P2X, ligand-gated ion channel, 4
chr7_-_140714739 1.03 ENST00000467334.1
ENST00000324787.5
MRPS33
mitochondrial ribosomal protein S33
chr10_+_12171636 1.03 ENST00000379051.1
ENST00000379033.3
ENST00000441368.1
ENST00000298428.9
ENST00000304267.8
SEC61A2
Sec61 alpha 2 subunit (S. cerevisiae)
chr10_+_12171721 0.99 ENST00000379020.4
ENST00000379017.3
SEC61A2
Sec61 alpha 2 subunit (S. cerevisiae)
chr3_+_10289707 0.96 ENST00000287652.4
TATDN2
TatD DNase domain containing 2
chr5_-_24645078 0.94 ENST00000264463.4
CDH10
cadherin 10, type 2 (T2-cadherin)
chr6_-_46048116 0.87 ENST00000185206.6
CLIC5
chloride intracellular channel 5
chr12_+_121647868 0.73 ENST00000359949.7
ENST00000541532.1
ENST00000543171.1
ENST00000538701.1
P2RX4
purinergic receptor P2X, ligand-gated ion channel, 4
chr9_+_87283430 0.69 ENST00000376214.1
ENST00000376213.1
NTRK2
neurotrophic tyrosine kinase, receptor, type 2
chr1_-_31845914 0.69 ENST00000373713.2
FABP3
fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
chr7_-_140714430 0.66 ENST00000393008.3
MRPS33
mitochondrial ribosomal protein S33
chr12_+_3600356 0.60 ENST00000382622.3
PRMT8
protein arginine methyltransferase 8
chr3_+_155838337 0.58 ENST00000490337.1
ENST00000389636.5
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr2_-_228244013 0.57 ENST00000304568.3
TM4SF20
transmembrane 4 L six family member 20
chr16_-_55866997 0.53 ENST00000360526.3
ENST00000361503.4
CES1
carboxylesterase 1
chr11_-_46615498 0.45 ENST00000533727.1
ENST00000534300.1
ENST00000528950.1
ENST00000526606.1
AMBRA1
autophagy/beclin-1 regulator 1
chr3_-_155394152 0.39 ENST00000494598.1
PLCH1
phospholipase C, eta 1
chr19_+_49838653 0.31 ENST00000598095.1
ENST00000426897.2
ENST00000323906.4
ENST00000535669.2
ENST00000597602.1
ENST00000595660.1
CD37
CD37 molecule
chr11_+_85956182 0.29 ENST00000327320.4
ENST00000351625.6
ENST00000534595.1
EED
embryonic ectoderm development
chr17_+_75450075 0.29 ENST00000592951.1
SEPT9
septin 9
chr1_-_27216729 0.27 ENST00000431781.2
ENST00000374135.4
GPN2
GPN-loop GTPase 2
chr14_+_22993296 0.27 ENST00000390517.1
TRAJ20
T cell receptor alpha joining 20
chr2_-_69098566 0.21 ENST00000295379.1
BMP10
bone morphogenetic protein 10
chr12_-_76742183 0.19 ENST00000393262.3
BBS10
Bardet-Biedl syndrome 10
chr6_+_72926145 0.18 ENST00000425662.2
ENST00000453976.2
RIMS1
regulating synaptic membrane exocytosis 1
chr20_-_48770174 0.18 ENST00000341698.2
TMEM189-UBE2V1
TMEM189-UBE2V1 readthrough
chr7_+_39989611 0.13 ENST00000181839.4
CDK13
cyclin-dependent kinase 13
chr19_-_49314269 0.12 ENST00000545387.2
ENST00000316273.6
ENST00000402551.1
ENST00000598162.1
ENST00000599246.1
BCAT2
branched chain amino-acid transaminase 2, mitochondrial
chr3_-_155394099 0.03 ENST00000414191.1
PLCH1
phospholipase C, eta 1
chr19_-_53757941 0.03 ENST00000594517.1
ENST00000601413.1
ENST00000594681.1
ZNF677
zinc finger protein 677

Network of associatons between targets according to the STRING database.

First level regulatory network of PRDM14

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 19.6 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.5 2.6 GO:0051510 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) regulation of barbed-end actin filament capping(GO:2000812) positive regulation of barbed-end actin filament capping(GO:2000814)
0.3 3.4 GO:0045915 positive regulation of catecholamine metabolic process(GO:0045915) positive regulation of dopamine metabolic process(GO:0045964)
0.3 1.7 GO:0045541 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.3 6.5 GO:0034389 lipid particle organization(GO:0034389)
0.2 0.7 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.2 1.4 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.2 1.6 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
0.1 1.3 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.1 1.8 GO:0042118 endothelial cell activation(GO:0042118)
0.1 3.6 GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.1 0.7 GO:0099540 synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551)
0.1 12.6 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.1 6.0 GO:0071377 cellular response to glucagon stimulus(GO:0071377)
0.1 0.9 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.1 8.5 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.1 0.3 GO:1990022 RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
0.1 0.6 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.1 2.0 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.1 0.5 GO:0051791 medium-chain fatty acid metabolic process(GO:0051791)
0.1 0.2 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.0 1.2 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.6 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.0 2.9 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.0 0.3 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.0 1.1 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.0 1.7 GO:0070126 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.0 1.4 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.0 1.0 GO:0006308 DNA catabolic process(GO:0006308)
0.0 0.4 GO:0098780 response to mitochondrial depolarisation(GO:0098780)
0.0 0.2 GO:0098828 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.0 0.3 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.9 GO:0032433 filopodium tip(GO:0032433)
0.1 6.0 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 22.2 GO:0030426 growth cone(GO:0030426)
0.1 1.8 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.1 0.6 GO:1990635 proximal dendrite(GO:1990635)
0.1 1.7 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 7.9 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.1 GO:0002945 cyclin K-CDK13 complex(GO:0002945)
0.0 0.7 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.3 GO:0001739 sex chromatin(GO:0001739)
0.0 1.7 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 1.1 GO:0045095 keratin filament(GO:0045095)
0.0 6.9 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 1.2 GO:0031526 brush border membrane(GO:0031526)
0.0 14.6 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 1.4 GO:0032587 ruffle membrane(GO:0032587)
0.0 4.1 GO:0005819 spindle(GO:0005819)
0.0 3.4 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 0.9 GO:0034707 chloride channel complex(GO:0034707)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 8.5 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.5 1.4 GO:0000773 phosphatidyl-N-methylethanolamine N-methyltransferase activity(GO:0000773) phosphatidylethanolamine N-methyltransferase activity(GO:0004608) phosphatidyl-N-dimethylethanolamine N-methyltransferase activity(GO:0080101)
0.5 1.4 GO:0050613 delta14-sterol reductase activity(GO:0050613)
0.3 6.0 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.3 2.9 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.2 0.7 GO:0070538 oleic acid binding(GO:0070538)
0.2 0.6 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.2 1.1 GO:1990254 keratin filament binding(GO:1990254)
0.2 1.8 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 0.4 GO:0050429 calcium-dependent phospholipase C activity(GO:0050429)
0.1 0.7 GO:0060175 brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
0.1 4.1 GO:0017091 AU-rich element binding(GO:0017091)
0.1 1.0 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.1 0.5 GO:0004771 sterol esterase activity(GO:0004771) methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.1 3.6 GO:0043022 ribosome binding(GO:0043022)
0.1 3.4 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 12.4 GO:0003924 GTPase activity(GO:0003924)
0.0 0.3 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0 1.7 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.6 GO:0070402 NADPH binding(GO:0070402)
0.0 2.6 GO:1902936 phosphatidylinositol bisphosphate binding(GO:1902936)
0.0 0.2 GO:0031433 telethonin binding(GO:0031433)
0.0 0.9 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 1.2 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 1.3 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 15.2 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 19.6 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 1.7 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 2.9 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 4.3 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.5 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 12.6 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.3 6.0 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.3 3.6 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 2.6 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.1 1.4 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 2.9 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 1.4 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.3 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.9 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 2.0 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
0.0 0.2 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.2 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.6 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels