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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for PRDM14
Z-value: 0.04
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Transcription factors associated with PRDM14
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PRDM14 | hg19_v2_chr8_-_70983506_70983562 | -0.03 | 6.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_21492251 Show fit | 10.03 |
ENST00000554398.1
|
NDRG family member 2 |
|
| chr14_-_21492113 Show fit | 9.58 |
ENST00000554094.1
|
NDRG family member 2 |
|
| chr11_-_62474803 Show fit | 6.50 |
ENST00000533982.1
ENST00000360796.5 |
Berardinelli-Seip congenital lipodystrophy 2 (seipin) |
|
| chr11_+_62475130 Show fit | 6.05 |
ENST00000294117.5
|
guanine nucleotide binding protein (G protein), gamma 3 |
|
| chr12_-_49351303 Show fit | 5.31 |
ENST00000256682.4
|
ADP-ribosylation factor 3 |
|
| chr20_-_3154162 Show fit | 5.04 |
ENST00000360342.3
|
Homo sapiens leucine zipper, putative tumor suppressor family member 3 (LZTS3), mRNA. |
|
| chr12_-_49351228 Show fit | 5.02 |
ENST00000541959.1
ENST00000447318.2 |
ADP-ribosylation factor 3 |
|
| chr17_-_19651654 Show fit | 4.54 |
ENST00000395555.3
|
aldehyde dehydrogenase 3 family, member A1 |
|
| chr1_+_36621529 Show fit | 4.14 |
ENST00000316156.4
|
MAP7 domain containing 1 |
|
| chr1_+_50571949 Show fit | 4.11 |
ENST00000357083.4
|
ELAV like neuron-specific RNA binding protein 4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of PRDM14
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 19.6 | GO:0090360 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 0.1 | 12.6 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.1 | 8.5 | GO:0006081 | cellular aldehyde metabolic process(GO:0006081) |
| 0.3 | 6.5 | GO:0034389 | lipid particle organization(GO:0034389) |
| 0.1 | 6.0 | GO:0071377 | cellular response to glucagon stimulus(GO:0071377) |
| 0.1 | 3.6 | GO:0090190 | positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190) |
| 0.3 | 3.4 | GO:0045915 | positive regulation of catecholamine metabolic process(GO:0045915) positive regulation of dopamine metabolic process(GO:0045964) |
| 0.0 | 2.9 | GO:0051489 | regulation of filopodium assembly(GO:0051489) |
| 0.5 | 2.6 | GO:0051510 | regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) regulation of barbed-end actin filament capping(GO:2000812) positive regulation of barbed-end actin filament capping(GO:2000814) |
| 0.1 | 2.0 | GO:0043001 | Golgi to plasma membrane protein transport(GO:0043001) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 22.2 | GO:0030426 | growth cone(GO:0030426) |
| 0.0 | 14.6 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.1 | 7.9 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 6.9 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.1 | 6.0 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 4.1 | GO:0005819 | spindle(GO:0005819) |
| 0.0 | 3.4 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 0.1 | 2.9 | GO:0032433 | filopodium tip(GO:0032433) |
| 0.1 | 1.8 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453) |
| 0.1 | 1.7 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.4 | GO:0003924 | GTPase activity(GO:0003924) |
| 1.7 | 8.5 | GO:0018479 | benzaldehyde dehydrogenase (NAD+) activity(GO:0018479) |
| 0.3 | 6.0 | GO:0031702 | type 1 angiotensin receptor binding(GO:0031702) |
| 0.1 | 4.1 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.1 | 3.6 | GO:0043022 | ribosome binding(GO:0043022) |
| 0.1 | 3.4 | GO:0030544 | Hsp70 protein binding(GO:0030544) |
| 0.3 | 2.9 | GO:0060002 | plus-end directed microfilament motor activity(GO:0060002) |
| 0.0 | 2.6 | GO:1902936 | phosphatidylinositol bisphosphate binding(GO:1902936) |
| 0.2 | 1.8 | GO:0035381 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 0.0 | 1.7 | GO:0015485 | cholesterol binding(GO:0015485) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.6 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.5 | 15.2 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.0 | 4.3 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 2.9 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.1 | 1.7 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 0.5 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 12.6 | REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 0.3 | 6.0 | REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 0.3 | 3.6 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.0 | 2.9 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.1 | 2.6 | REACTOME SEMA3A PAK DEPENDENT AXON REPULSION | Genes involved in Sema3A PAK dependent Axon repulsion |
| 0.0 | 2.0 | REACTOME ER PHAGOSOME PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.1 | 1.4 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.0 | 1.4 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 1.3 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.0 | 0.9 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |