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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for PRDM4

Z-value: 0.10

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Transcription factors associated with PRDM4

Gene Symbol Gene ID Gene Info
PRDM4
ENSG00000110851.7 PR/SET domain 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PRDM4hg19_v2_chr12_-_108154925_108154945-0.018.9e-01Click!

Activity profile of PRDM4 motif

Sorted Z-values of PRDM4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_105953246 11.28 ENST00000392531.3
CRIP1
cysteine-rich protein 1 (intestinal)
chr14_+_105953204 11.17 ENST00000409393.2
CRIP1
cysteine-rich protein 1 (intestinal)
chr12_-_58240470 11.01 ENST00000548823.1
ENST00000398073.2
CTDSP2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
chr19_+_42724423 9.90 ENST00000301215.3
ENST00000597945.1
ZNF526
zinc finger protein 526
chr2_+_219264466 5.31 ENST00000273062.2
CTDSP1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr7_+_143079000 4.95 ENST00000392910.2
ZYX
zyxin
chr22_-_39636914 4.81 ENST00000381551.4
PDGFB
platelet-derived growth factor beta polypeptide
chr19_+_41117770 4.65 ENST00000601032.1
LTBP4
latent transforming growth factor beta binding protein 4
chr6_-_24721054 4.27 ENST00000378119.4
C6orf62
chromosome 6 open reading frame 62
chr2_+_234296792 3.87 ENST00000409813.3
DGKD
diacylglycerol kinase, delta 130kDa
chr7_+_143078652 3.55 ENST00000354434.4
ENST00000449423.2
ZYX
zyxin
chr19_+_50180317 3.37 ENST00000534465.1
PRMT1
protein arginine methyltransferase 1
chr12_+_104682496 3.30 ENST00000378070.4
TXNRD1
thioredoxin reductase 1
chr3_+_148709128 3.23 ENST00000345003.4
ENST00000296048.6
ENST00000483267.1
GYG1
glycogenin 1
chr3_+_148709310 3.12 ENST00000484197.1
ENST00000492285.2
ENST00000461191.1
GYG1
glycogenin 1
chr12_+_69979446 3.12 ENST00000543146.2
CCT2
chaperonin containing TCP1, subunit 2 (beta)
chr15_-_66797172 2.88 ENST00000569438.1
ENST00000569696.1
ENST00000307961.6
RPL4
ribosomal protein L4
chr9_-_70488865 2.79 ENST00000377392.5
CBWD5
COBW domain containing 5
chr10_-_105677886 2.78 ENST00000224950.3
OBFC1
oligonucleotide/oligosaccharide-binding fold containing 1
chr10_-_105212141 2.58 ENST00000369788.3
CALHM2
calcium homeostasis modulator 2
chr7_-_23571586 2.37 ENST00000538367.1
ENST00000392502.4
ENST00000297071.4
TRA2A
transformer 2 alpha homolog (Drosophila)
chr10_+_88728189 2.35 ENST00000416348.1
ADIRF
adipogenesis regulatory factor
chr1_+_55107449 2.28 ENST00000421030.2
ENST00000545244.1
ENST00000339553.5
ENST00000409996.1
ENST00000454855.2
MROH7
maestro heat-like repeat family member 7
chr20_-_61569296 2.21 ENST00000370371.4
DIDO1
death inducer-obliterator 1
chr3_+_16926441 2.21 ENST00000418129.2
ENST00000396755.2
PLCL2
phospholipase C-like 2
chr20_+_61569463 2.20 ENST00000266069.3
GID8
GID complex subunit 8
chr11_+_58910295 2.05 ENST00000420244.1
FAM111A
family with sequence similarity 111, member A
chr17_+_42634844 1.83 ENST00000315323.3
FZD2
frizzled family receptor 2
chr17_+_7788104 1.78 ENST00000380358.4
CHD3
chromodomain helicase DNA binding protein 3
chr6_-_32160622 1.77 ENST00000487761.1
ENST00000375040.3
GPSM3
G-protein signaling modulator 3
chr11_+_47279504 1.74 ENST00000441012.2
ENST00000437276.1
ENST00000436029.1
ENST00000467728.1
ENST00000405853.3
NR1H3
nuclear receptor subfamily 1, group H, member 3
chr4_+_667307 1.59 ENST00000506838.1
MYL5
myosin, light chain 5, regulatory
chr9_+_96338647 1.51 ENST00000359246.4
PHF2
PHD finger protein 2
chr4_-_83295103 1.48 ENST00000313899.7
ENST00000352301.4
ENST00000509107.1
ENST00000353341.4
ENST00000541060.1
HNRNPD
heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
chr15_+_45315302 1.38 ENST00000267814.9
SORD
sorbitol dehydrogenase
chr5_-_180688105 1.32 ENST00000327767.4
TRIM52
tripartite motif containing 52
chr7_+_90893783 1.30 ENST00000287934.2
FZD1
frizzled family receptor 1
chr1_+_172502336 1.24 ENST00000263688.3
SUCO
SUN domain containing ossification factor
chr10_+_123923105 1.22 ENST00000368999.1
TACC2
transforming, acidic coiled-coil containing protein 2
chr16_+_15068955 1.13 ENST00000396410.4
ENST00000569715.1
ENST00000450288.2
PDXDC1
pyridoxal-dependent decarboxylase domain containing 1
chr15_+_66797627 0.99 ENST00000565627.1
ENST00000564179.1
ZWILCH
zwilch kinetochore protein
chr1_+_43232913 0.82 ENST00000372525.5
ENST00000536543.1
C1orf50
chromosome 1 open reading frame 50
chr5_-_34916871 0.75 ENST00000382038.2
RAD1
RAD1 homolog (S. pombe)
chr20_-_61569227 0.66 ENST00000266070.4
ENST00000395335.2
ENST00000266071.5
DIDO1
death inducer-obliterator 1
chr11_+_19138670 0.65 ENST00000446113.2
ENST00000399351.3
ZDHHC13
zinc finger, DHHC-type containing 13
chr1_-_43232649 0.64 ENST00000372526.2
ENST00000236040.4
ENST00000296388.5
ENST00000397054.3
LEPRE1
leucine proline-enriched proteoglycan (leprecan) 1
chr4_+_667686 0.60 ENST00000505477.1
MYL5
myosin, light chain 5, regulatory
chr2_-_8723918 0.60 ENST00000454224.1
AC011747.4
AC011747.4
chr13_+_52436111 0.60 ENST00000242819.4
CCDC70
coiled-coil domain containing 70
chrX_-_73072534 0.52 ENST00000429829.1
XIST
X inactive specific transcript (non-protein coding)
chr14_+_32030582 0.52 ENST00000550649.1
ENST00000281081.7
NUBPL
nucleotide binding protein-like
chr1_+_27114418 0.49 ENST00000078527.4
PIGV
phosphatidylinositol glycan anchor biosynthesis, class V
chr19_-_11639910 0.41 ENST00000588998.1
ENST00000586149.1
ECSIT
ECSIT signalling integrator
chr5_-_102455801 0.35 ENST00000508629.1
ENST00000399004.2
GIN1
gypsy retrotransposon integrase 1
chr7_-_38398721 0.29 ENST00000390346.2
TRGV3
T cell receptor gamma variable 3
chr5_+_159343688 0.25 ENST00000306675.3
ADRA1B
adrenoceptor alpha 1B
chr12_+_15475331 0.23 ENST00000281171.4
PTPRO
protein tyrosine phosphatase, receptor type, O
chr12_+_15475462 0.19 ENST00000543886.1
ENST00000348962.2
PTPRO
protein tyrosine phosphatase, receptor type, O
chrX_+_15808569 0.15 ENST00000380308.3
ENST00000307771.7
ZRSR2
zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2
chr1_+_27114589 0.12 ENST00000431541.1
ENST00000449950.2
ENST00000374145.1
PIGV
phosphatidylinositol glycan anchor biosynthesis, class V
chr14_+_24025194 0.09 ENST00000404535.3
ENST00000288014.6
THTPA
thiamine triphosphatase

Network of associatons between targets according to the STRING database.

First level regulatory network of PRDM4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.5 22.5 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
1.2 4.8 GO:1900241 metanephric glomerular mesangial cell development(GO:0072255) reversible differentiation(GO:0090677) cell dedifferentiation involved in phenotypic switching(GO:0090678) positive regulation of phenotypic switching(GO:1900241) regulation of vascular smooth muscle cell dedifferentiation(GO:1905174) positive regulation of vascular smooth muscle cell dedifferentiation(GO:1905176) vascular smooth muscle cell dedifferentiation(GO:1990936)
1.0 3.1 GO:0051086 chaperone mediated protein folding independent of cofactor(GO:0051086)
0.7 2.2 GO:0001923 B-1 B cell differentiation(GO:0001923)
0.6 1.7 GO:0090341 negative regulation of secretion of lysosomal enzymes(GO:0090341)
0.6 3.4 GO:0046985 positive regulation of hemoglobin biosynthetic process(GO:0046985)
0.5 1.5 GO:0061188 negative regulation of chromatin silencing at rDNA(GO:0061188)
0.5 1.5 GO:1901355 response to rapamycin(GO:1901355)
0.5 1.4 GO:0006059 hexitol metabolic process(GO:0006059)
0.4 1.3 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.4 2.3 GO:0072719 cellular response to cisplatin(GO:0072719)
0.4 3.3 GO:0001887 selenium compound metabolic process(GO:0001887)
0.3 1.8 GO:0003150 muscular septum morphogenesis(GO:0003150)
0.2 0.8 GO:0033313 meiotic cell cycle checkpoint(GO:0033313)
0.2 3.9 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.2 4.6 GO:0030252 growth hormone secretion(GO:0030252)
0.2 6.4 GO:0005980 glycogen catabolic process(GO:0005980)
0.1 0.4 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.1 1.8 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.1 15.1 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.1 0.3 GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001994)
0.1 8.5 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.0 1.2 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.0 0.7 GO:1903830 magnesium ion transmembrane transport(GO:1903830)
0.0 0.6 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 0.4 GO:0015074 DNA integration(GO:0015074)
0.0 2.9 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 2.1 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.1 GO:0042357 thiamine diphosphate metabolic process(GO:0042357)
0.0 1.8 GO:0032508 DNA duplex unwinding(GO:0032508)
0.0 0.5 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 1.0 GO:0007093 mitotic cell cycle checkpoint(GO:0007093)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:1990423 RZZ complex(GO:1990423)
0.2 3.1 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.2 0.8 GO:0030896 checkpoint clamp complex(GO:0030896)
0.2 3.4 GO:0034709 methylosome(GO:0034709)
0.1 0.6 GO:0031501 mannosyltransferase complex(GO:0031501)
0.1 1.3 GO:1990909 Wnt signalosome(GO:1990909)
0.1 8.5 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 2.2 GO:0005859 muscle myosin complex(GO:0005859)
0.1 1.8 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 1.2 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 4.8 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 2.9 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 5.4 GO:0043202 lysosomal lumen(GO:0043202)
0.0 0.1 GO:0089701 U2AF(GO:0089701)
0.0 1.8 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0 3.1 GO:0001650 fibrillar center(GO:0001650)
0.0 0.7 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.0 1.5 GO:0000777 condensed chromosome kinetochore(GO:0000777)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 16.3 GO:0008420 CTD phosphatase activity(GO:0008420)
1.6 6.4 GO:0008466 glycogenin glucosyltransferase activity(GO:0008466)
1.4 23.9 GO:0003680 AT DNA binding(GO:0003680)
1.1 3.3 GO:0098626 methylselenol reductase activity(GO:0098625) methylseleninic acid reductase activity(GO:0098626)
0.6 3.4 GO:0044020 histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.5 4.8 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.4 1.7 GO:0032810 sterol response element binding(GO:0032810)
0.2 3.9 GO:0004143 diacylglycerol kinase activity(GO:0004143) diacylglycerol binding(GO:0019992)
0.2 4.6 GO:0005024 transforming growth factor beta-activated receptor activity(GO:0005024)
0.2 0.6 GO:0004376 glycolipid mannosyltransferase activity(GO:0004376)
0.1 3.1 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 0.8 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.1 2.2 GO:0050811 GABA receptor binding(GO:0050811)
0.1 3.1 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 0.3 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.1 1.5 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.1 1.8 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.7 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.4 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 1.8 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.1 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.0 2.2 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 1.1 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 1.4 GO:0051287 NAD binding(GO:0051287)
0.0 2.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.5 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 16.3 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.2 8.5 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.2 4.8 PID S1P S1P1 PATHWAY S1P1 pathway
0.1 3.1 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 1.7 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.8 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 4.6 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.8 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 2.2 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 6.4 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 8.8 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 3.1 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.1 3.3 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 3.9 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 2.9 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 4.8 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.6 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 3.1 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 2.9 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 1.5 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0 0.8 REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS Genes involved in Activation of ATR in response to replication stress
0.0 1.0 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase