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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for PRRX1_ALX4_PHOX2A
Z-value: 0.38
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Transcription factors associated with PRRX1_ALX4_PHOX2A
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ALX4 | hg19_v2_chr11_-_44331679_44331716 | 0.28 | 2.1e-05 | Click! |
| PRRX1 | hg19_v2_chr1_+_170633047_170633084 | 0.23 | 8.1e-04 | Click! |
| PHOX2A | hg19_v2_chr11_-_71955210_71955227, hg19_v2_chr11_-_71952236_71952319 | 0.04 | 5.7e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PRRX1_ALX4_PHOX2A
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 12.1 | 36.2 | GO:2000097 | regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 0.2 | 30.6 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.7 | 27.9 | GO:0051491 | positive regulation of filopodium assembly(GO:0051491) |
| 2.1 | 24.7 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 1.2 | 23.2 | GO:0030277 | maintenance of gastrointestinal epithelium(GO:0030277) |
| 0.3 | 17.2 | GO:0060997 | dendritic spine morphogenesis(GO:0060997) |
| 0.4 | 15.9 | GO:0006699 | bile acid biosynthetic process(GO:0006699) |
| 0.4 | 13.8 | GO:0045898 | regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) |
| 1.7 | 12.2 | GO:0070294 | renal sodium ion absorption(GO:0070294) |
| 2.0 | 12.1 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 31.8 | GO:0043025 | neuronal cell body(GO:0043025) |
| 1.3 | 29.3 | GO:0044295 | axonal growth cone(GO:0044295) |
| 1.8 | 24.7 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.1 | 16.2 | GO:0043204 | perikaryon(GO:0043204) |
| 0.1 | 15.5 | GO:0044306 | neuron projection terminus(GO:0044306) |
| 0.1 | 14.0 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.7 | 11.6 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.1 | 11.5 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 10.8 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.3 | 9.5 | GO:0099738 | cell cortex region(GO:0099738) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 36.4 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.3 | 30.2 | GO:0005262 | calcium channel activity(GO:0005262) |
| 0.4 | 26.4 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.0 | 19.8 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.5 | 16.5 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.2 | 16.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 1.2 | 15.4 | GO:0015248 | sterol transporter activity(GO:0015248) |
| 1.1 | 14.5 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.1 | 14.0 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.5 | 12.2 | GO:0017081 | chloride channel regulator activity(GO:0017081) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 21.3 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.2 | 20.1 | PID FOXO PATHWAY | FoxO family signaling |
| 0.2 | 19.5 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 14.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 10.7 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 8.0 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 6.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 5.5 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.1 | 4.6 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
| 0.1 | 3.7 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 24.7 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.4 | 14.2 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.2 | 11.0 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.5 | 10.9 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.2 | 9.1 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 6.9 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.3 | 5.5 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.1 | 5.2 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.4 | 4.9 | REACTOME SEROTONIN RECEPTORS | Genes involved in Serotonin receptors |
| 0.2 | 4.9 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |