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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for RAD21_SMC3

Z-value: 0.47

Motif logo

Transcription factors associated with RAD21_SMC3

Gene Symbol Gene ID Gene Info
ENSG00000164754.8 RAD21 cohesin complex component
ENSG00000108055.9 structural maintenance of chromosomes 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SMC3hg19_v2_chr10_+_112327425_112327516-0.393.5e-09Click!
RAD21hg19_v2_chr8_-_117886955_117887105-0.367.0e-08Click!

Activity profile of RAD21_SMC3 motif

Sorted Z-values of RAD21_SMC3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr16_-_30032610 24.13 ENST00000574405.1
double C2-like domains, alpha
chr13_-_88323218 18.98 ENST00000436290.2
ENST00000453832.2
ENST00000606590.1
MIR4500 host gene (non-protein coding)
chr3_-_138763734 16.11 ENST00000413199.1
ENST00000502927.2
proline rich 23C
chr1_+_10270863 15.65 ENST00000377093.4
ENST00000263934.6
kinesin family member 1B
chr5_-_136834982 15.58 ENST00000510689.1
ENST00000394945.1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
chr8_+_24772455 14.46 ENST00000433454.2
neurofilament, medium polypeptide
chr1_+_10003486 13.78 ENST00000403197.1
ENST00000377205.1
nicotinamide nucleotide adenylyltransferase 1
chr1_-_35325400 12.51 ENST00000521580.2
small integral membrane protein 12
chr16_-_19897455 12.42 ENST00000568214.1
ENST00000569479.1
G protein-coupled receptor, family C, group 5, member B
chr1_-_156390128 11.79 ENST00000368242.3
chromosome 1 open reading frame 61
chr9_+_130965651 11.78 ENST00000475805.1
ENST00000341179.7
ENST00000372923.3
dynamin 1
chr9_+_130965677 11.55 ENST00000393594.3
ENST00000486160.1
dynamin 1
chr7_+_156742399 11.01 ENST00000275820.3
nucleolar protein with MIF4G domain 1
chr8_-_67341208 10.54 ENST00000499642.1
RP11-346I3.4
chr17_+_16593539 10.01 ENST00000340621.5
ENST00000399273.1
ENST00000443444.2
ENST00000360524.8
ENST00000456009.1
coiled-coil domain containing 144A
chr10_-_79789291 9.98 ENST00000372371.3
polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
chr19_+_37407212 9.57 ENST00000427117.1
ENST00000587130.1
ENST00000333987.7
ENST00000415168.1
ENST00000444991.1
zinc finger protein 568
chr11_-_64490634 9.50 ENST00000377559.3
ENST00000265459.6
neurexin 2
chrX_+_11776410 9.35 ENST00000361672.2
male-specific lethal 3 homolog (Drosophila)
chr4_+_7045042 9.22 ENST00000310074.7
ENST00000512388.1
transcriptional adaptor 2B
chr5_-_118324200 8.98 ENST00000515439.3
ENST00000510708.1
DTW domain containing 2
chr5_+_157170703 8.87 ENST00000286307.5
LSM11, U7 small nuclear RNA associated
chr1_-_212208842 8.12 ENST00000366992.3
ENST00000366993.3
ENST00000440600.2
ENST00000366994.3
integrator complex subunit 7
chr22_+_22901750 7.82 ENST00000407120.1
Uncharacterized protein
chr19_-_58400148 7.80 ENST00000595048.1
ENST00000600634.1
ENST00000595295.1
ENST00000596604.1
ENST00000597342.1
ENST00000597807.1
zinc finger protein 814
chr11_-_104480019 7.70 ENST00000536529.1
ENST00000545630.1
ENST00000538641.1
RP11-886D15.1
chr7_+_302918 7.49 ENST00000599994.1
Protein LOC100996433
chr5_+_35617940 7.41 ENST00000282469.6
ENST00000509059.1
ENST00000356031.3
ENST00000510777.1
sperm flagellar 2
chr10_+_17272608 7.28 ENST00000421459.2
vimentin
chr2_+_113342163 6.44 ENST00000409719.1
coiled-coil-helix-coiled-coil-helix domain containing 5
chr1_-_170043709 6.41 ENST00000367767.1
ENST00000361580.2
ENST00000538366.1
kinesin-associated protein 3
chr2_+_103089756 6.40 ENST00000295269.4
solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4
chr22_+_19705928 6.19 ENST00000383045.3
ENST00000438754.2
septin 5
chr19_-_6481776 6.02 ENST00000543576.1
ENST00000590173.1
ENST00000381480.2
DENN/MADD domain containing 1C
chr17_-_37308824 6.01 ENST00000415163.1
ENST00000441877.1
ENST00000444911.2
plexin domain containing 1
chr11_+_120039685 5.91 ENST00000530303.1
ENST00000319763.1
Uncharacterized protein
chr19_-_48823332 5.90 ENST00000315396.7
coiled-coil domain containing 114
chr11_-_85565906 5.89 ENST00000544076.1
CDNA FLJ26432 fis, clone KDN01418; Uncharacterized protein
chr7_-_91509986 5.80 ENST00000456229.1
ENST00000442961.1
ENST00000406735.2
ENST00000419292.1
ENST00000351870.3
mitochondrial transcription termination factor
chr6_+_127587755 5.74 ENST00000368314.1
ENST00000476956.1
ENST00000609447.1
ENST00000356799.2
ENST00000477776.1
ENST00000609944.1
ring finger protein 146
chr7_-_100171270 5.50 ENST00000538735.1
Sin3A-associated protein, 25kDa
chr10_-_15413035 5.49 ENST00000378116.4
ENST00000455654.1
family with sequence similarity 171, member A1
chr2_-_232395169 5.47 ENST00000305141.4
neuromedin U receptor 1
chr8_-_66474884 5.43 ENST00000520902.1
CTD-3025N20.2
chr16_+_48657361 5.43 ENST00000565072.1
RP11-42I10.1
chr19_-_19754354 5.35 ENST00000587238.1
GEM interacting protein
chr19_-_58400372 5.22 ENST00000597832.1
ENST00000435989.2
zinc finger protein 814
chr5_-_146833485 5.22 ENST00000398514.3
dihydropyrimidinase-like 3
chr11_-_130786400 5.20 ENST00000265909.4
sorting nexin 19
chr19_-_49339080 5.07 ENST00000595764.1
hydroxysteroid (17-beta) dehydrogenase 14
chr17_+_45810594 5.05 ENST00000177694.1
T-box 21
chr17_-_37309480 5.05 ENST00000539608.1
plexin domain containing 1
chr16_+_1756162 5.03 ENST00000250894.4
ENST00000356010.5
mitogen-activated protein kinase 8 interacting protein 3
chr5_+_54455946 5.01 ENST00000503787.1
ENST00000296734.6
ENST00000515370.1
glutathione peroxidase 8 (putative)
chr21_+_41239243 4.92 ENST00000328619.5
Purkinje cell protein 4
chr19_+_47852538 4.86 ENST00000328771.4
DEAH (Asp-Glu-Ala-His) box polypeptide 34
chr3_+_5163905 4.83 ENST00000256496.3
ENST00000419534.2
ADP-ribosylation factor-like 8B
chr19_-_22034809 4.80 ENST00000594012.1
ENST00000595461.1
ENST00000596899.1
zinc finger protein 43
chr4_+_71570430 4.78 ENST00000417478.2
RUN and FYVE domain containing 3
chr15_-_38856836 4.76 ENST00000450598.2
ENST00000559830.1
ENST00000558164.1
ENST00000310803.5
RAS guanyl releasing protein 1 (calcium and DAG-regulated)
chr20_+_3801162 4.74 ENST00000379573.2
ENST00000379567.2
ENST00000455742.1
ENST00000246041.2
adaptor-related protein complex 5, sigma 1 subunit
chr5_-_140998481 4.71 ENST00000518047.1
diaphanous-related formin 1
chr19_-_19754404 4.70 ENST00000587205.1
ENST00000445806.2
ENST00000203556.4
GEM interacting protein
chr17_-_41466555 4.67 ENST00000586231.1
long intergenic non-protein coding RNA 910
chr16_-_49315731 4.63 ENST00000219197.6
cerebellin 1 precursor
chr10_+_99332529 4.63 ENST00000455090.1
ankyrin repeat domain 2 (stretch responsive muscle)
chr1_+_178511876 4.57 ENST00000367638.1
ENST00000367636.4
chromosome 1 open reading frame 220
C1ORF220
chr12_+_13197218 4.55 ENST00000197268.8
KIAA1467
chr8_+_28480246 4.51 ENST00000523149.1
exostosin-like glycosyltransferase 3
chr17_-_4890919 4.48 ENST00000572543.1
ENST00000381311.5
ENST00000348066.3
ENST00000358183.4
calmodulin binding transcription activator 2
chr12_-_102224457 4.47 ENST00000549165.1
ENST00000549940.1
ENST00000392919.4
N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
chr11_-_117103208 4.46 ENST00000320934.3
ENST00000530269.1
proprotein convertase subtilisin/kexin type 7
chr17_+_76356516 4.45 ENST00000592569.1
RP11-806H10.4
chr9_+_91933726 4.40 ENST00000534113.2
SECIS binding protein 2
chr19_-_49149553 4.30 ENST00000084798.4
carbonic anhydrase XI
chr6_-_41747595 4.28 ENST00000373018.3
fibroblast growth factor receptor substrate 3
chr19_+_8478154 4.18 ENST00000381035.4
ENST00000595142.1
ENST00000601724.1
ENST00000393944.1
ENST00000215555.2
ENST00000601283.1
ENST00000595213.1
membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
chr17_-_8868991 4.17 ENST00000447110.1
phosphoinositide-3-kinase, regulatory subunit 5
chr14_-_75079026 4.17 ENST00000261978.4
latent transforming growth factor beta binding protein 2
chr22_+_22786288 4.16 ENST00000390301.2
immunoglobulin lambda variable 1-36
chr6_+_127588020 4.14 ENST00000309649.3
ENST00000610162.1
ENST00000610153.1
ENST00000608991.1
ENST00000480444.1
ring finger protein 146
chr5_+_140254884 4.14 ENST00000398631.2
protocadherin alpha 12
chrX_+_77166172 4.12 ENST00000343533.5
ENST00000350425.4
ENST00000341514.6
ATPase, Cu++ transporting, alpha polypeptide
chr16_+_58533951 4.10 ENST00000566192.1
ENST00000565088.1
ENST00000568640.1
ENST00000563978.1
ENST00000569923.1
ENST00000356752.4
ENST00000563799.1
ENST00000562999.1
ENST00000570248.1
ENST00000562731.1
ENST00000568424.1
NDRG family member 4
chr15_-_64338521 4.07 ENST00000457488.1
ENST00000558069.1
death-associated protein kinase 2
chr10_+_99332198 4.05 ENST00000307518.5
ENST00000298808.5
ENST00000370655.1
ankyrin repeat domain 2 (stretch responsive muscle)
chrX_+_11776278 4.01 ENST00000312196.4
ENST00000337339.2
male-specific lethal 3 homolog (Drosophila)
chr2_-_132559234 4.01 ENST00000303798.2
chromosome 2 open reading frame 27B
chr17_-_8286484 4.01 ENST00000582556.1
ENST00000584164.1
ENST00000293842.5
ENST00000584343.1
ENST00000578812.1
ENST00000583011.1
ribosomal protein L26
chr5_+_148521381 3.96 ENST00000504238.1
actin binding LIM protein family, member 3
chr12_-_7245125 3.93 ENST00000542285.1
ENST00000540610.1
complement component 1, r subcomponent
chr9_-_134615443 3.92 ENST00000372195.1
Rap guanine nucleotide exchange factor (GEF) 1
chr17_-_34890759 3.91 ENST00000431794.3
myosin XIX
chr8_-_48651648 3.91 ENST00000408965.3
CCAAT/enhancer binding protein (C/EBP), delta
chr1_+_18081804 3.90 ENST00000375406.1
actin-like 8
chr17_-_7518145 3.84 ENST00000250113.7
ENST00000571597.1
fragile X mental retardation, autosomal homolog 2
chr19_-_46318486 3.74 ENST00000597055.1
radial spoke head 6 homolog A (Chlamydomonas)
chr8_-_101571933 3.74 ENST00000520311.1
ankyrin repeat domain 46
chr9_-_94712434 3.69 ENST00000375708.3
receptor tyrosine kinase-like orphan receptor 2
chr2_-_166060552 3.67 ENST00000283254.7
ENST00000453007.1
sodium channel, voltage-gated, type III, alpha subunit
chrX_-_30326445 3.65 ENST00000378963.1
nuclear receptor subfamily 0, group B, member 1
chrX_+_153029633 3.64 ENST00000538966.1
ENST00000361971.5
ENST00000538776.1
ENST00000538543.1
plexin B3
chr12_+_53773944 3.62 ENST00000551969.1
ENST00000327443.4
Sp1 transcription factor
chr15_+_71185148 3.56 ENST00000443425.2
ENST00000560755.1
leucine rich repeat containing 49
chrX_+_11776701 3.52 ENST00000476743.1
ENST00000421368.2
ENST00000398527.2
male-specific lethal 3 homolog (Drosophila)
chr17_-_1090599 3.52 ENST00000544583.2
active BCR-related
chr9_+_100174344 3.52 ENST00000422139.2
tudor domain containing 7
chr11_+_2421718 3.47 ENST00000380996.5
ENST00000333256.6
ENST00000380992.1
ENST00000437110.1
ENST00000435795.1
tumor suppressing subtransferable candidate 4
chr5_+_148521136 3.47 ENST00000506113.1
actin binding LIM protein family, member 3
chr17_+_43971643 3.46 ENST00000344290.5
ENST00000262410.5
ENST00000351559.5
ENST00000340799.5
ENST00000535772.1
ENST00000347967.5
microtubule-associated protein tau
chr19_+_12949251 3.46 ENST00000251472.4
microtubule associated serine/threonine kinase 1
chr16_+_23569021 3.42 ENST00000567212.1
ENST00000567264.1
ubiquitin family domain containing 1
chr8_-_146012660 3.42 ENST00000343459.4
ENST00000429371.2
ENST00000534445.1
zinc finger protein 34
chr22_-_22292934 3.42 ENST00000538191.1
ENST00000424647.1
ENST00000407142.1
protein phosphatase, Mg2+/Mn2+ dependent, 1F
chr22_-_22307199 3.41 ENST00000397495.4
ENST00000263212.5
protein phosphatase, Mg2+/Mn2+ dependent, 1F
chr2_-_74710078 3.41 ENST00000290418.4
coiled-coil domain containing 142
chr16_+_30759700 3.41 ENST00000328273.7
phosphorylase kinase, gamma 2 (testis)
chr17_-_4890649 3.36 ENST00000361571.5
calmodulin binding transcription activator 2
chr17_+_43972010 3.34 ENST00000334239.8
ENST00000446361.3
microtubule-associated protein tau
chr3_-_183735731 3.33 ENST00000334444.6
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
chr17_-_26220366 3.32 ENST00000460380.2
ENST00000508862.1
ENST00000379102.3
ENST00000582441.1
LYR motif containing 9
Uncharacterized protein
chr6_+_31105426 3.32 ENST00000547221.1
psoriasis susceptibility 1 candidate 1
chr2_+_166095898 3.31 ENST00000424833.1
ENST00000375437.2
ENST00000357398.3
sodium channel, voltage-gated, type II, alpha subunit
chr16_+_89642120 3.29 ENST00000268720.5
ENST00000319518.8
copine VII
chr10_-_6622258 3.26 ENST00000263125.5
protein kinase C, theta
chr15_-_79103757 3.25 ENST00000388820.4
ADAM metallopeptidase with thrombospondin type 1 motif, 7
chr2_-_175351744 3.20 ENST00000295500.4
ENST00000392552.2
ENST00000392551.2
G protein-coupled receptor 155
chr4_+_56814968 3.20 ENST00000422247.2
centrosomal protein 135kDa
chr3_+_50712672 3.19 ENST00000266037.9
dedicator of cytokinesis 3
chr9_+_133884469 3.07 ENST00000361069.4
laminin, gamma 3
chr8_-_145669791 3.02 ENST00000409379.3
tonsoku-like, DNA repair protein
chr17_-_9862772 3.01 ENST00000580865.1
ENST00000583882.1
growth arrest-specific 7
chrX_+_49020121 3.00 ENST00000415364.1
ENST00000376338.3
ENST00000425285.1
MAGI family member, X-linked
chr22_+_23040274 3.00 ENST00000390306.2
immunoglobulin lambda variable 2-23
chr14_+_22446680 2.99 ENST00000390443.3
T cell receptor alpha variable 8-6
chr5_+_148521046 2.95 ENST00000326685.7
ENST00000356541.3
ENST00000309868.7
actin binding LIM protein family, member 3
chr9_-_140317605 2.93 ENST00000479452.1
ENST00000465160.2
exonuclease 3'-5' domain containing 3
chr2_+_131113609 2.92 ENST00000347849.3
protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
chr10_-_6622201 2.90 ENST00000539722.1
ENST00000397176.2
protein kinase C, theta
chr14_-_91526922 2.87 ENST00000418736.2
ENST00000261991.3
ribosomal protein S6 kinase, 90kDa, polypeptide 5
chr2_-_166060571 2.86 ENST00000360093.3
sodium channel, voltage-gated, type III, alpha subunit
chr9_-_139922726 2.80 ENST00000265662.5
ENST00000371605.3
ATP-binding cassette, sub-family A (ABC1), member 2
chr9_-_139922631 2.78 ENST00000341511.6
ATP-binding cassette, sub-family A (ABC1), member 2
chr12_-_121410095 2.77 ENST00000539163.1
AC079602.1
chr3_-_194991876 2.73 ENST00000310380.6
xyloside xylosyltransferase 1
chr10_-_30024716 2.68 ENST00000375398.2
ENST00000375400.3
supervillin
chr19_-_22034770 2.66 ENST00000598381.1
zinc finger protein 43
chr15_-_71407806 2.64 ENST00000566432.1
ENST00000567117.1
cancer/testis antigen 62
chr7_-_19748640 2.61 ENST00000222567.5
TWIST neighbor
chr9_+_139560197 2.58 ENST00000371698.3
EGF-like-domain, multiple 7
chr15_-_34659349 2.54 ENST00000314891.6
lysophosphatidylcholine acyltransferase 4
chr11_-_118436606 2.51 ENST00000530872.1
intraflagellar transport 46 homolog (Chlamydomonas)
chr11_+_7110165 2.49 ENST00000306904.5
RNA binding motif protein, X-linked-like 2
chr4_+_128886424 2.49 ENST00000398965.1
chromosome 4 open reading frame 29
chr10_-_49732281 2.48 ENST00000374170.1
Rho GTPase activating protein 22
chr1_+_168148273 2.47 ENST00000367830.3
TIP41, TOR signaling pathway regulator-like (S. cerevisiae)
chr21_-_36262032 2.45 ENST00000325074.5
ENST00000399237.2
runt-related transcription factor 1
chr12_+_53440753 2.43 ENST00000379902.3
tensin like C1 domain containing phosphatase (tensin 2)
chr7_-_37488834 2.39 ENST00000310758.4
engulfment and cell motility 1
chr11_+_67033881 2.39 ENST00000308595.5
ENST00000526285.1
adrenergic, beta, receptor kinase 1
chr14_+_22337014 2.38 ENST00000390436.2
T cell receptor alpha variable 13-1
chr16_-_2390704 2.36 ENST00000301732.5
ENST00000382381.3
ATP-binding cassette, sub-family A (ABC1), member 3
chr14_+_24630465 2.35 ENST00000557894.1
ENST00000559284.1
ENST00000560275.1
interferon regulatory factor 9
chr9_+_100174232 2.33 ENST00000355295.4
tudor domain containing 7
chr5_+_140165876 2.31 ENST00000504120.2
ENST00000394633.3
ENST00000378133.3
protocadherin alpha 1
chr11_-_64510409 2.30 ENST00000394429.1
ENST00000394428.1
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr1_+_37940153 2.30 ENST00000373087.6
zinc finger CCCH-type containing 12A
chr7_-_122526799 2.28 ENST00000334010.7
ENST00000313070.7
Ca++-dependent secretion activator 2
chr11_-_63536113 2.27 ENST00000433688.1
ENST00000546282.2
chromosome 11 open reading frame 95
RP11-466C23.4
chr19_-_46318561 2.26 ENST00000221538.3
radial spoke head 6 homolog A (Chlamydomonas)
chr5_-_140998616 2.26 ENST00000389054.3
ENST00000398562.2
ENST00000389057.5
ENST00000398566.3
ENST00000398557.4
ENST00000253811.6
diaphanous-related formin 1
chr16_-_790887 2.25 ENST00000540986.1
nuclear prelamin A recognition factor-like
chr16_-_790982 2.24 ENST00000301694.5
ENST00000251588.2
nuclear prelamin A recognition factor-like
chr14_-_77787198 2.20 ENST00000261534.4
protein-O-mannosyltransferase 2
chr12_+_121078355 2.20 ENST00000316803.3
calcium binding protein 1
chr3_+_134514093 2.16 ENST00000398015.3
EPH receptor B1
chr12_-_65515334 2.15 ENST00000286574.4
WNT inhibitory factor 1
chr19_-_6279932 2.12 ENST00000252674.7
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
chr12_-_1058685 2.12 ENST00000397230.2
ENST00000542785.1
ENST00000544742.1
ENST00000536177.1
ENST00000539046.1
ENST00000541619.1
RAD52 homolog (S. cerevisiae)
chr22_-_22901636 2.10 ENST00000406503.1
ENST00000439106.1
ENST00000402697.1
ENST00000543184.1
ENST00000398743.2
preferentially expressed antigen in melanoma
chr6_+_138188551 2.09 ENST00000237289.4
ENST00000433680.1
tumor necrosis factor, alpha-induced protein 3
chr17_+_47653178 2.09 ENST00000328741.5
neurexophilin 3
chr8_-_101571964 2.08 ENST00000520552.1
ENST00000521345.1
ENST00000523000.1
ENST00000335659.3
ENST00000358990.3
ENST00000519597.1
ankyrin repeat domain 46
chr19_+_45842445 2.08 ENST00000598357.1
Uncharacterized protein
chr4_+_128886532 2.07 ENST00000444616.1
ENST00000388795.5
chromosome 4 open reading frame 29
chr15_+_63340775 2.07 ENST00000559281.1
ENST00000317516.7
tropomyosin 1 (alpha)
chr17_+_1958388 2.05 ENST00000399849.3
hypermethylated in cancer 1
chr15_-_71407833 2.04 ENST00000449977.2
cancer/testis antigen 62
chr6_-_41703296 1.97 ENST00000373033.1
transcription factor EB
chr1_-_146644036 1.97 ENST00000425272.2
protein kinase, AMP-activated, beta 2 non-catalytic subunit
chr15_-_58358607 1.96 ENST00000249750.4
aldehyde dehydrogenase 1 family, member A2
chr4_+_75858318 1.95 ENST00000307428.7
prostate androgen-regulated mucin-like protein 1
chr8_+_42128812 1.94 ENST00000520810.1
ENST00000416505.2
ENST00000519735.1
ENST00000520835.1
ENST00000379708.3
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
chr9_+_91933407 1.94 ENST00000375807.3
ENST00000339901.4
SECIS binding protein 2
chr2_+_220492373 1.93 ENST00000317151.3
solute carrier family 4 (anion exchanger), member 3
chr6_-_11044509 1.92 ENST00000354666.3
ELOVL fatty acid elongase 2
chr7_-_99679324 1.92 ENST00000292393.5
ENST00000413658.2
ENST00000412947.1
ENST00000441298.1
ENST00000449785.1
ENST00000299667.4
ENST00000424697.1
zinc finger protein 3
chr10_-_76868931 1.91 ENST00000372700.3
ENST00000473072.2
ENST00000491677.2
ENST00000607131.1
ENST00000372702.3
dual specificity phosphatase 13
chr7_-_122526499 1.91 ENST00000412584.2
Ca++-dependent secretion activator 2
chr2_+_231729615 1.90 ENST00000326427.6
ENST00000335005.6
ENST00000326407.6
integral membrane protein 2C

Network of associatons between targets according to the STRING database.

First level regulatory network of RAD21_SMC3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
7.8 23.3 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
5.2 15.7 GO:1904647 response to rotenone(GO:1904647)
4.8 14.5 GO:0033693 neurofilament bundle assembly(GO:0033693)
2.1 6.4 GO:0046586 regulation of calcium-dependent cell-cell adhesion(GO:0046586)
2.1 2.1 GO:0070428 regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428)
1.8 8.9 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
1.7 5.2 GO:1990502 dense core granule maturation(GO:1990502)
1.7 3.4 GO:0045819 positive regulation of glycogen catabolic process(GO:0045819)
1.5 6.2 GO:2000569 T-helper 2 cell activation(GO:0035712) regulation of T-helper 2 cell activation(GO:2000569) positive regulation of T-helper 2 cell activation(GO:2000570)
1.5 13.8 GO:0006531 aspartate metabolic process(GO:0006531)
1.4 6.8 GO:0090258 negative regulation of mitochondrial fission(GO:0090258)
1.2 11.2 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
1.2 3.6 GO:0071284 cellular response to lead ion(GO:0071284)
1.2 9.5 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
1.2 3.5 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314)
1.1 5.6 GO:0032377 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.9 4.6 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) positive regulation of long term synaptic depression(GO:1900454)
0.9 6.2 GO:0016080 synaptic vesicle targeting(GO:0016080)
0.8 3.3 GO:1903597 negative regulation of gap junction assembly(GO:1903597)
0.8 4.0 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.8 4.8 GO:0032252 secretory granule localization(GO:0032252)
0.8 2.3 GO:0000294 nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay(GO:0000294) negative regulation by host of viral genome replication(GO:0044828)
0.7 3.7 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.7 12.4 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.7 2.2 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170) trans-synaptic signaling by trans-synaptic complex(GO:0099545)
0.7 4.2 GO:1990504 dense core granule exocytosis(GO:1990504)
0.7 7.6 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.7 6.8 GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387)
0.7 4.1 GO:2000418 positive regulation of eosinophil migration(GO:2000418)
0.7 2.7 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
0.7 8.1 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.7 11.2 GO:2000291 regulation of myoblast proliferation(GO:2000291)
0.6 3.2 GO:0043988 histone H3-S28 phosphorylation(GO:0043988) histone H2A phosphorylation(GO:1990164)
0.6 1.9 GO:0060168 positive regulation of adenosine receptor signaling pathway(GO:0060168)
0.6 3.7 GO:2000819 regulation of nucleotide-excision repair(GO:2000819)
0.6 1.8 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.6 24.1 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.6 1.7 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290)
0.5 7.0 GO:0035372 protein localization to microtubule(GO:0035372)
0.5 11.0 GO:0048820 hair follicle maturation(GO:0048820)
0.5 5.2 GO:0033299 secretion of lysosomal enzymes(GO:0033299)
0.5 6.4 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.5 5.9 GO:0036158 outer dynein arm assembly(GO:0036158)
0.5 2.9 GO:0036166 phenotypic switching(GO:0036166) regulation of phenotypic switching(GO:1900239)
0.5 1.9 GO:1903347 negative regulation of bicellular tight junction assembly(GO:1903347)
0.5 1.4 GO:0071907 determination of digestive tract left/right asymmetry(GO:0071907)
0.5 15.7 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.5 1.4 GO:1901202 negative regulation of extracellular matrix assembly(GO:1901202)
0.5 2.8 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.5 0.5 GO:0000189 MAPK import into nucleus(GO:0000189)
0.5 3.6 GO:0010593 negative regulation of lamellipodium assembly(GO:0010593)
0.4 5.8 GO:2001135 regulation of endocytic recycling(GO:2001135)
0.4 2.2 GO:1904098 regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100)
0.4 1.3 GO:0071301 cellular response to vitamin B1(GO:0071301) response to formaldehyde(GO:1904404)
0.4 2.1 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.4 6.8 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.4 1.7 GO:0036159 inner dynein arm assembly(GO:0036159)
0.4 6.7 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.4 5.9 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.4 2.7 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.4 4.6 GO:0038180 nerve growth factor signaling pathway(GO:0038180)
0.4 1.9 GO:0044026 DNA hypermethylation(GO:0044026)
0.4 4.5 GO:0032364 oxygen homeostasis(GO:0032364)
0.4 1.1 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.4 1.1 GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib(GO:0002476)
0.4 1.1 GO:0033242 regulation of cellular amine catabolic process(GO:0033241) negative regulation of cellular amine catabolic process(GO:0033242) negative regulation of the force of heart contraction(GO:0098736) regulation of arginine catabolic process(GO:1900081) negative regulation of arginine catabolic process(GO:1900082) regulation of citrulline biosynthetic process(GO:1903248) negative regulation of citrulline biosynthetic process(GO:1903249) negative regulation of cellular amino acid biosynthetic process(GO:2000283)
0.3 1.4 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
0.3 1.0 GO:0071529 cementum mineralization(GO:0071529)
0.3 5.1 GO:0048304 positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.3 3.6 GO:0033327 Leydig cell differentiation(GO:0033327)
0.3 3.2 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.3 1.9 GO:0034626 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.3 1.3 GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001994)
0.3 1.6 GO:1990834 response to odorant(GO:1990834)
0.3 0.9 GO:1902809 skeletal muscle fiber differentiation(GO:0098528) regulation of skeletal muscle fiber differentiation(GO:1902809)
0.3 1.5 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.3 0.9 GO:0031627 telomeric loop formation(GO:0031627)
0.3 7.8 GO:0003299 muscle hypertrophy in response to stress(GO:0003299) cardiac muscle adaptation(GO:0014887) cardiac muscle hypertrophy in response to stress(GO:0014898)
0.3 1.4 GO:0090650 response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)
0.3 31.5 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.3 5.9 GO:0051764 actin crosslink formation(GO:0051764)
0.3 3.5 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.3 1.3 GO:0099551 synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551)
0.3 1.0 GO:2000980 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.3 0.8 GO:0036118 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.3 3.3 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.2 5.8 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.2 1.0 GO:1901490 regulation of lymphangiogenesis(GO:1901490)
0.2 3.1 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.2 1.9 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.2 11.8 GO:0051865 protein autoubiquitination(GO:0051865)
0.2 7.7 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.2 1.8 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.2 1.1 GO:0002865 negative regulation of acute inflammatory response to antigenic stimulus(GO:0002865)
0.2 2.0 GO:0035799 ureter maturation(GO:0035799)
0.2 4.8 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.2 3.2 GO:0050890 cognition(GO:0050890)
0.2 1.0 GO:0003051 angiotensin-mediated drinking behavior(GO:0003051) operant conditioning(GO:0035106)
0.2 3.6 GO:0034380 high-density lipoprotein particle assembly(GO:0034380)
0.2 1.8 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.2 0.6 GO:0070781 response to biotin(GO:0070781)
0.2 10.0 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.2 1.1 GO:1904259 regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.2 5.1 GO:0015012 heparan sulfate proteoglycan biosynthetic process(GO:0015012)
0.2 0.2 GO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process(GO:0044336)
0.2 1.0 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.2 1.3 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.2 0.6 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.2 13.1 GO:0010812 negative regulation of cell-substrate adhesion(GO:0010812)
0.2 0.8 GO:0042997 negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.2 2.6 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.1 2.7 GO:0060828 regulation of canonical Wnt signaling pathway(GO:0060828)
0.1 0.4 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.1 2.5 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.1 0.6 GO:0002501 peptide antigen assembly with MHC protein complex(GO:0002501) peptide antigen assembly with MHC class II protein complex(GO:0002503)
0.1 2.1 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.1 1.4 GO:1904424 regulation of GTP binding(GO:1904424)
0.1 5.0 GO:0007257 activation of JUN kinase activity(GO:0007257)
0.1 7.1 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.1 4.2 GO:0097435 fibril organization(GO:0097435)
0.1 1.2 GO:0035791 platelet-derived growth factor receptor-beta signaling pathway(GO:0035791)
0.1 2.4 GO:0006853 carnitine shuttle(GO:0006853)
0.1 1.2 GO:1904263 positive regulation of TORC1 signaling(GO:1904263)
0.1 1.4 GO:0035878 nail development(GO:0035878)
0.1 3.6 GO:0014002 astrocyte development(GO:0014002)
0.1 3.9 GO:0042994 cytoplasmic sequestering of transcription factor(GO:0042994)
0.1 2.5 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 4.5 GO:0016486 peptide hormone processing(GO:0016486)
0.1 0.4 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.1 1.8 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.1 2.9 GO:1903846 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.1 1.0 GO:0045023 G0 to G1 transition(GO:0045023)
0.1 4.2 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.1 0.7 GO:0045079 negative regulation of chemokine biosynthetic process(GO:0045079)
0.1 0.4 GO:0061047 foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492) positive regulation of branching involved in lung morphogenesis(GO:0061047)
0.1 1.4 GO:0030575 nuclear body organization(GO:0030575)
0.1 8.1 GO:0021510 spinal cord development(GO:0021510)
0.1 0.7 GO:0071351 interleukin-18-mediated signaling pathway(GO:0035655) cellular response to interleukin-18(GO:0071351)
0.1 1.6 GO:0006020 inositol metabolic process(GO:0006020)
0.1 0.8 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.1 0.8 GO:0015697 quaternary ammonium group transport(GO:0015697)
0.1 0.8 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.1 0.8 GO:0002911 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911)
0.1 0.6 GO:0045591 positive regulation of regulatory T cell differentiation(GO:0045591)
0.1 1.2 GO:0048266 behavioral response to pain(GO:0048266)
0.1 1.3 GO:0036148 phosphatidylglycerol acyl-chain remodeling(GO:0036148)
0.1 0.4 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.1 3.2 GO:0006362 transcription elongation from RNA polymerase I promoter(GO:0006362)
0.1 2.4 GO:0016601 Rac protein signal transduction(GO:0016601)
0.1 5.0 GO:0032418 lysosome localization(GO:0032418)
0.1 0.3 GO:0002266 follicular dendritic cell activation(GO:0002266) follicular dendritic cell differentiation(GO:0002268)
0.1 2.5 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.1 3.8 GO:0015701 bicarbonate transport(GO:0015701)
0.1 0.9 GO:2000574 regulation of microtubule motor activity(GO:2000574)
0.1 4.0 GO:1901185 negative regulation of ERBB signaling pathway(GO:1901185)
0.1 1.1 GO:0022038 corpus callosum development(GO:0022038)
0.1 3.3 GO:0016266 O-glycan processing(GO:0016266)
0.1 0.4 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.1 1.7 GO:0019216 regulation of lipid metabolic process(GO:0019216)
0.1 1.3 GO:0070932 histone H3 deacetylation(GO:0070932)
0.1 0.6 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.1 2.1 GO:0007040 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.1 0.4 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.1 1.9 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 0.8 GO:0015732 prostaglandin transport(GO:0015732)
0.1 1.5 GO:0097178 ruffle assembly(GO:0097178)
0.0 0.7 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.0 1.1 GO:0034204 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.0 0.5 GO:0060605 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0 1.7 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.0 2.0 GO:0042308 negative regulation of protein import into nucleus(GO:0042308) negative regulation of protein import(GO:1904590)
0.0 0.9 GO:0034389 lipid particle organization(GO:0034389)
0.0 1.6 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.0 0.4 GO:0044458 motile cilium assembly(GO:0044458)
0.0 0.3 GO:0014029 neural crest formation(GO:0014029)
0.0 1.2 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.2 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602)
0.0 1.6 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.0 0.8 GO:0046546 male gonad development(GO:0008584) development of primary male sexual characteristics(GO:0046546)
0.0 3.9 GO:0031638 zymogen activation(GO:0031638)
0.0 1.6 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.6 GO:0030818 negative regulation of cAMP biosynthetic process(GO:0030818)
0.0 1.0 GO:0001954 positive regulation of cell-matrix adhesion(GO:0001954)
0.0 1.3 GO:0048477 oogenesis(GO:0048477)
0.0 2.1 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 1.8 GO:1902017 regulation of cilium assembly(GO:1902017)
0.0 2.1 GO:0006687 glycosphingolipid metabolic process(GO:0006687)
0.0 2.4 GO:0071357 type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.0 0.3 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0 0.1 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.0 0.7 GO:0002042 cell migration involved in sprouting angiogenesis(GO:0002042)
0.0 1.8 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.0 2.2 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 2.6 GO:0048839 inner ear development(GO:0048839)
0.0 1.4 GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.0 2.7 GO:0007519 skeletal muscle tissue development(GO:0007519)
0.0 0.6 GO:0051693 actin filament capping(GO:0051693)
0.0 0.6 GO:0060348 bone development(GO:0060348)
0.0 0.7 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 2.4 GO:0051384 response to glucocorticoid(GO:0051384)
0.0 0.3 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.0 0.7 GO:0006298 mismatch repair(GO:0006298)
0.0 0.7 GO:0046847 filopodium assembly(GO:0046847)
0.0 0.2 GO:0042737 drug catabolic process(GO:0042737)
0.0 1.8 GO:0006470 protein dephosphorylation(GO:0006470)
0.0 0.2 GO:0032802 low-density lipoprotein particle receptor catabolic process(GO:0032802)
0.0 0.3 GO:0006337 nucleosome disassembly(GO:0006337)
0.0 0.3 GO:0051194 positive regulation of glycolytic process(GO:0045821) positive regulation of cofactor metabolic process(GO:0051194) positive regulation of coenzyme metabolic process(GO:0051197)
0.0 0.2 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.4 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 0.9 GO:0021915 neural tube development(GO:0021915)
0.0 0.9 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0 0.1 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.0 0.4 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336) DNA replication-independent nucleosome organization(GO:0034724)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 16.9 GO:0072487 MSL complex(GO:0072487)
1.6 6.4 GO:1990075 kinesin II complex(GO:0016939) periciliary membrane compartment(GO:1990075)
1.4 4.2 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
1.4 6.8 GO:0045298 tubulin complex(GO:0045298)
1.1 14.5 GO:0097418 neurofibrillary tangle(GO:0097418)
1.1 8.9 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
1.1 1.1 GO:0034680 integrin alpha10-beta1 complex(GO:0034680)
0.9 8.1 GO:0032039 integrator complex(GO:0032039)
0.7 5.9 GO:0036157 outer dynein arm(GO:0036157)
0.7 6.5 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.7 18.7 GO:0033268 node of Ranvier(GO:0033268)
0.7 2.6 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.6 4.5 GO:0097361 CIA complex(GO:0097361)
0.6 2.4 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.6 9.2 GO:0030914 STAGA complex(GO:0030914)
0.5 5.8 GO:0033391 chromatoid body(GO:0033391)
0.5 1.5 GO:0034678 integrin alpha8-beta1 complex(GO:0034678)
0.5 1.5 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.5 5.6 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.5 23.8 GO:0001917 photoreceptor inner segment(GO:0001917)
0.4 2.7 GO:0036449 microtubule minus-end(GO:0036449)
0.4 2.3 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.4 3.4 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.4 15.7 GO:1904115 axon cytoplasm(GO:1904115)
0.3 3.6 GO:0042788 polysomal ribosome(GO:0042788)
0.3 1.6 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
0.3 0.9 GO:0016938 kinesin I complex(GO:0016938)
0.3 2.4 GO:0097208 alveolar lamellar body(GO:0097208)
0.3 1.5 GO:0005858 axonemal dynein complex(GO:0005858)
0.2 3.6 GO:0005662 DNA replication factor A complex(GO:0005662)
0.2 21.5 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.2 4.3 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.2 5.3 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.2 3.7 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.2 1.2 GO:1990130 EGO complex(GO:0034448) Iml1 complex(GO:1990130) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.2 4.8 GO:0071437 invadopodium(GO:0071437)
0.2 0.6 GO:0005652 nuclear lamina(GO:0005652)
0.2 1.4 GO:0046581 intercellular canaliculus(GO:0046581)
0.2 2.3 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.2 1.5 GO:0031083 BLOC-1 complex(GO:0031083)
0.2 6.3 GO:0042629 mast cell granule(GO:0042629)
0.2 1.1 GO:0042825 TAP complex(GO:0042825)
0.2 1.4 GO:0000322 storage vacuole(GO:0000322)
0.2 1.0 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.2 2.3 GO:0035631 CD40 receptor complex(GO:0035631)
0.2 6.0 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.2 4.6 GO:0051233 spindle midzone(GO:0051233)
0.1 6.2 GO:0001772 immunological synapse(GO:0001772)
0.1 7.2 GO:0031941 filamentous actin(GO:0031941)
0.1 2.1 GO:0005869 dynactin complex(GO:0005869)
0.1 3.9 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.1 1.1 GO:0045180 basal cortex(GO:0045180)
0.1 2.5 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 8.6 GO:0043195 terminal bouton(GO:0043195)
0.1 0.6 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 13.2 GO:0032587 ruffle membrane(GO:0032587)
0.1 10.2 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 1.2 GO:0005614 interstitial matrix(GO:0005614)
0.1 4.9 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.1 5.2 GO:0045171 intercellular bridge(GO:0045171)
0.1 0.9 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 1.8 GO:0032982 myosin filament(GO:0032982)
0.1 3.4 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.1 5.0 GO:0016459 myosin complex(GO:0016459)
0.1 1.5 GO:0097546 ciliary base(GO:0097546)
0.1 0.6 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.1 0.8 GO:0031045 dense core granule(GO:0031045)
0.1 6.3 GO:0042734 presynaptic membrane(GO:0042734)
0.1 1.7 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.1 1.4 GO:0031527 filopodium membrane(GO:0031527)
0.1 21.0 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 0.3 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.1 0.7 GO:0097440 apical dendrite(GO:0097440)
0.1 0.9 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 8.6 GO:0031674 I band(GO:0031674)
0.1 5.2 GO:0005882 intermediate filament(GO:0005882)
0.1 6.8 GO:0031901 early endosome membrane(GO:0031901)
0.1 6.2 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 4.7 GO:0005814 centriole(GO:0005814)
0.1 0.2 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.0 4.1 GO:0005776 autophagosome(GO:0005776)
0.0 1.4 GO:0036379 striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.0 0.5 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 2.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 2.4 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 11.1 GO:0043235 receptor complex(GO:0043235)
0.0 13.4 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 3.3 GO:0005770 late endosome(GO:0005770)
0.0 1.3 GO:0005769 early endosome(GO:0005769)
0.0 3.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.4 GO:0016234 inclusion body(GO:0016234)
0.0 0.3 GO:0008091 spectrin(GO:0008091)
0.0 6.9 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.3 GO:0030666 endocytic vesicle membrane(GO:0030666)
0.0 1.3 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.2 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 1.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 2.7 GO:0098793 presynapse(GO:0098793)
0.0 1.5 GO:0001726 ruffle(GO:0001726)
0.0 0.8 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 3.3 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.2 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 2.5 GO:0032993 protein-DNA complex(GO:0032993)
0.0 0.4 GO:0016235 aggresome(GO:0016235)
0.0 0.3 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.8 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 13.8 GO:0004515 nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
3.0 8.9 GO:0071209 U7 snRNA binding(GO:0071209)
2.9 8.7 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
1.7 5.2 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
1.7 6.8 GO:0099609 microtubule lateral binding(GO:0099609)
1.5 1.5 GO:0052851 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
1.4 4.1 GO:0032767 copper-dependent protein binding(GO:0032767)
1.2 7.3 GO:1990254 keratin filament binding(GO:1990254)
1.1 6.3 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.9 7.7 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.8 2.5 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.8 5.1 GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.7 5.9 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.7 4.2 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.7 6.8 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.7 6.7 GO:0015385 sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.7 2.6 GO:0001054 RNA polymerase I activity(GO:0001054)
0.6 15.6 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.6 3.6 GO:0051022 GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022)
0.6 9.5 GO:0097109 neuroligin family protein binding(GO:0097109)
0.6 1.7 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.5 3.3 GO:0008240 tripeptidyl-peptidase activity(GO:0008240) peptidyl-dipeptidase activity(GO:0008241)
0.5 2.7 GO:0042285 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.5 2.7 GO:0031708 endothelin B receptor binding(GO:0031708)
0.5 9.1 GO:0019992 diacylglycerol binding(GO:0019992)
0.5 1.5 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.5 1.9 GO:0008384 IkappaB kinase activity(GO:0008384)
0.5 1.9 GO:0031685 adenosine receptor binding(GO:0031685)
0.5 1.8 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.5 24.1 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.5 2.7 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.4 5.3 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.4 1.3 GO:0061663 NEDD8 ligase activity(GO:0061663)
0.4 10.4 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.4 1.3 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.4 1.2 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.4 4.2 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.4 3.4 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.4 19.3 GO:0019894 kinesin binding(GO:0019894)
0.4 1.1 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.4 2.2 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.4 2.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.4 1.1 GO:0036487 nitric-oxide synthase inhibitor activity(GO:0036487)
0.3 2.8 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.3 4.7 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.3 3.9 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.3 1.9 GO:0102337 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.3 1.6 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.3 4.3 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.3 0.9 GO:0051765 inositol tetrakisphosphate 1-kinase activity(GO:0047325) inositol tetrakisphosphate kinase activity(GO:0051765) inositol-1,3,4-trisphosphate 6-kinase activity(GO:0052725) inositol-1,3,4-trisphosphate 5-kinase activity(GO:0052726) inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity(GO:0052825) inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity(GO:0052830) inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity(GO:0052831) inositol-3,4,6-trisphosphate 1-kinase activity(GO:0052835)
0.3 3.3 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.3 1.1 GO:0022865 transmembrane electron transfer carrier(GO:0022865)
0.3 1.1 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433)
0.3 1.3 GO:0060175 brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
0.3 0.8 GO:0031859 platelet activating factor receptor binding(GO:0031859)
0.3 0.8 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.3 4.3 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.2 1.4 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.2 6.2 GO:0004697 protein kinase C activity(GO:0004697)
0.2 5.3 GO:0001056 RNA polymerase III activity(GO:0001056)
0.2 0.9 GO:0035473 lipase binding(GO:0035473)
0.2 1.1 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.2 15.2 GO:0035064 methylated histone binding(GO:0035064)
0.2 3.8 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.2 2.1 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.2 3.8 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.2 6.5 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.2 5.2 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.2 0.6 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.2 0.7 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.2 2.0 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.2 1.4 GO:0097322 7SK snRNA binding(GO:0097322)
0.2 4.8 GO:0043014 alpha-tubulin binding(GO:0043014)
0.2 5.0 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.2 0.6 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.2 0.6 GO:0050509 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity(GO:0050509)
0.1 4.3 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 1.0 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.1 39.7 GO:0008017 microtubule binding(GO:0008017)
0.1 2.3 GO:0035613 RNA stem-loop binding(GO:0035613) mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 1.5 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.1 9.2 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.1 0.3 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.1 1.2 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.1 0.8 GO:0005329 dopamine transmembrane transporter activity(GO:0005329)
0.1 0.8 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 1.2 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 2.9 GO:0071837 HMG box domain binding(GO:0071837)
0.1 3.3 GO:0000217 DNA secondary structure binding(GO:0000217)
0.1 0.7 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.1 1.3 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 1.6 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 2.5 GO:0036041 long-chain fatty acid binding(GO:0036041)
0.1 1.8 GO:0005003 ephrin receptor activity(GO:0005003)
0.1 1.4 GO:0031701 angiotensin receptor binding(GO:0031701) type 1 angiotensin receptor binding(GO:0031702)
0.1 1.4 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 0.9 GO:0070840 dynein complex binding(GO:0070840)
0.1 3.5 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.1 2.1 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 0.6 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.1 3.9 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1 1.6 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 1.4 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.1 0.4 GO:0071532 ankyrin repeat binding(GO:0071532)
0.1 2.9 GO:0008408 3'-5' exonuclease activity(GO:0008408)
0.1 2.9 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.1 4.3 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.1 1.1 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 1.0 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 0.6 GO:0009374 biotin binding(GO:0009374)
0.1 2.2 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 1.8 GO:0043236 laminin binding(GO:0043236)
0.1 7.0 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.1 5.6 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 1.4 GO:0005523 tropomyosin binding(GO:0005523)
0.0 14.1 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 1.9 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.9 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.7 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.0 1.7 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 24.8 GO:0003779 actin binding(GO:0003779)
0.0 0.9 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 5.6 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.6 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.6 GO:0001163 RNA polymerase I regulatory region DNA binding(GO:0001013) RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.0 0.8 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 0.2 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.3 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.2 GO:0016015 morphogen activity(GO:0016015)
0.0 6.6 GO:0003823 antigen binding(GO:0003823)
0.0 1.9 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.2 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 1.7 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.4 GO:0005536 glucose binding(GO:0005536)
0.0 16.6 GO:0005509 calcium ion binding(GO:0005509)
0.0 10.1 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 0.8 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.6 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 23.3 GO:0001071 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 0.4 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.5 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.4 GO:0005109 frizzled binding(GO:0005109)
0.0 2.8 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.2 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 1.4 GO:0035091 phosphatidylinositol binding(GO:0035091)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 26.9 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.4 6.8 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.3 15.6 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.2 18.1 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.2 6.0 PID WNT SIGNALING PATHWAY Wnt signaling network
0.2 2.8 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.2 4.3 PID LPA4 PATHWAY LPA4-mediated signaling events
0.2 5.0 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.2 3.4 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.2 3.6 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.2 8.5 PID AURORA A PATHWAY Aurora A signaling
0.1 4.2 PID EPHA FWDPATHWAY EPHA forward signaling
0.1 7.3 PID AURORA B PATHWAY Aurora B signaling
0.1 2.4 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.1 4.2 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 1.4 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.1 6.7 PID SHP2 PATHWAY SHP2 signaling
0.1 17.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.9 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.1 1.2 PID S1P S1P4 PATHWAY S1P4 pathway
0.1 3.1 ST GA12 PATHWAY G alpha 12 Pathway
0.1 3.3 ST GAQ PATHWAY G alpha q Pathway
0.1 3.3 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 3.4 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.1 2.7 PID ENDOTHELIN PATHWAY Endothelins
0.1 3.6 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 3.8 PID RHOA PATHWAY RhoA signaling pathway
0.1 2.1 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.1 2.9 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 3.1 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 2.5 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 0.3 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 2.0 PID NCADHERIN PATHWAY N-cadherin signaling events
0.1 1.1 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 5.1 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.6 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.0 1.4 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.0 1.0 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 2.7 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.9 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.1 PID EPO PATHWAY EPO signaling pathway
0.0 10.5 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 5.4 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.8 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.7 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 0.2 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 5.2 NABA MATRISOME ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.0 0.8 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.3 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.4 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.4 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.4 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 23.3 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.8 0.8 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.4 14.1 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.4 7.9 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.4 15.2 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.3 4.1 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.3 10.4 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.3 7.3 REACTOME KINESINS Genes involved in Kinesins
0.2 5.9 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.2 5.3 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.2 4.3 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.2 13.8 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.2 2.3 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.2 1.3 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.2 4.1 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.2 4.6 REACTOME ARMS MEDIATED ACTIVATION Genes involved in ARMS-mediated activation
0.2 3.6 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 4.2 REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.1 3.4 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 3.8 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 2.4 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 1.9 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.1 2.7 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.1 0.8 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.1 5.2 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 2.2 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.1 10.3 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 1.3 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.1 4.3 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.1 3.5 REACTOME CA DEPENDENT EVENTS Genes involved in Ca-dependent events
0.1 2.3 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.1 6.3 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 6.1 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.2 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.1 0.8 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 2.1 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.1 2.7 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 1.3 REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE Genes involved in NGF signalling via TRKA from the plasma membrane
0.1 3.1 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 6.4 REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
0.1 8.9 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.0 1.4 REACTOME FRS2 MEDIATED CASCADE Genes involved in FRS2-mediated cascade
0.0 0.8 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 1.6 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 2.7 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.8 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 2.4 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.8 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.0 1.4 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.0 1.3 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.8 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 5.7 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway
0.0 1.8 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.6 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.3 REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.0 1.5 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.2 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.6 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.6 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.7 REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH Genes involved in NCAM signaling for neurite out-growth
0.0 0.2 REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING Genes involved in Activation of Kainate Receptors upon glutamate binding
0.0 0.6 REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE Genes involved in MyD88:Mal cascade initiated on plasma membrane