ISMARA results: REST

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for REST

Z-value: 1.30

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Transcription factors associated with REST

Gene Symbol	Gene ID	Gene Info
REST Ensembl NCBI GeneCards UniProt NextProt	ENSG00000084093.11	RE1 silencing transcription factor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
REST	hg19_v2_chr4_+_57774042_57774114	-0.42	8.4e-11	Click!

Activity profile of REST motif

Sorted Z-values of REST motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr20_+_44657845 Show fit	78.67	ENST00000243964.3	SLC12A5 Ensembl NCBI GeneCards UniProt NextProt Show fit	solute carrier family 12 (potassium/chloride transporter), member 5
chr4_+_158141806 Show fit	78.24	ENST00000393815.2	GRIA2 Ensembl NCBI GeneCards UniProt NextProt Show fit	glutamate receptor, ionotropic, AMPA 2
chr4_+_158141843 Show fit	76.64	ENST00000509417.1 ENST00000296526.7	GRIA2 Ensembl NCBI GeneCards UniProt NextProt Show fit	glutamate receptor, ionotropic, AMPA 2
chr4_+_158141899 Show fit	73.98	ENST00000264426.9 ENST00000506284.1	GRIA2 Ensembl NCBI GeneCards UniProt NextProt Show fit	glutamate receptor, ionotropic, AMPA 2
chr14_+_93389425 Show fit	72.93	ENST00000216492.5 ENST00000334654.4	CHGA Ensembl NCBI GeneCards UniProt NextProt Show fit	chromogranin A (parathyroid secretory protein 1)
chr12_+_175930 Show fit	71.12	ENST00000538872.1 ENST00000326261.4	IQSEC3 Ensembl NCBI GeneCards UniProt NextProt Show fit	IQ motif and Sec7 domain 3
chrX_-_47479246 Show fit	68.50	ENST00000295987.7 ENST00000340666.4	SYN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	synapsin I
chr1_+_65775204 Show fit	66.84	ENST00000371069.4	DNAJC6 Ensembl NCBI GeneCards UniProt NextProt Show fit	DnaJ (Hsp40) homolog, subfamily C, member 6
chr12_+_113229452 Show fit	62.82	ENST00000389385.4	RPH3A Ensembl NCBI GeneCards UniProt NextProt Show fit	rabphilin 3A homolog (mouse)
chr12_+_113229737 Show fit	61.90	ENST00000551052.1 ENST00000415485.3	RPH3A Ensembl NCBI GeneCards UniProt NextProt Show fit	rabphilin 3A homolog (mouse)

Showing 1 to 10 of 99 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of REST

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.6	231.6	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
5.2	228.9	GO:0035235	ionotropic glutamate receptor signaling pathway(GO:0035235)
17.6	140.7	GO:0097116	gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
8.2	131.8	GO:0048490	anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
19.7	78.7	GO:0030644	cellular chloride ion homeostasis(GO:0030644)
24.3	72.9	GO:1901899	dense core granule biogenesis(GO:0061110) positive regulation of relaxation of cardiac muscle(GO:1901899) regulation of dense core granule biogenesis(GO:2000705)
3.6	71.1	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
7.6	68.5	GO:0097091	synaptic vesicle clustering(GO:0097091)
7.4	66.8	GO:0016191	synaptic vesicle uncoating(GO:0016191)
1.6	62.0	GO:0006099	tricarboxylic acid cycle(GO:0006099)

Showing 1 to 10 of 66 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.8	300.6	GO:0030672	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
45.8	228.9	GO:0098843	postsynaptic endocytic zone(GO:0098843)
1.5	140.7	GO:0042734	presynaptic membrane(GO:0042734)
12.0	131.8	GO:0030123	AP-3 adaptor complex(GO:0030123)
10.5	126.2	GO:0060077	inhibitory synapse(GO:0060077)
0.0	101.2	GO:0016021	integral component of membrane(GO:0016021)
0.3	92.8	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
1.5	78.7	GO:0043198	dendritic shaft(GO:0043198)
4.3	72.9	GO:0042583	chromaffin granule(GO:0042583)
2.1	68.5	GO:0000795	synaptonemal complex(GO:0000795)

Showing 1 to 10 of 41 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	231.9	GO:0005215	transporter activity(GO:0005215)
19.1	228.9	GO:0004971	AMPA glutamate receptor activity(GO:0004971)
16.8	185.0	GO:0008430	selenium binding(GO:0008430)
8.8	140.7	GO:0097109	neuroligin family protein binding(GO:0097109)
0.7	81.1	GO:0005179	hormone activity(GO:0005179)
7.2	78.7	GO:0022820	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
2.7	71.1	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.5	66.8	GO:0004725	protein tyrosine phosphatase activity(GO:0004725)
12.4	62.0	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1	61.9	GO:0019900	kinase binding(GO:0019900)

Showing 1 to 10 of 52 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.0	228.9	PID NCADHERIN PATHWAY	N-cadherin signaling events
1.7	73.4	PID REELIN PATHWAY	Reelin signaling pathway
0.3	37.9	PID AP1 PATHWAY	AP-1 transcription factor network
0.3	29.3	PID IL4 2PATHWAY	IL4-mediated signaling events
0.3	20.2	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.2	16.3	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.3	15.4	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.2	10.9	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.1	9.1	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.1	8.5	PID BMP PATHWAY	BMP receptor signaling

Showing 1 to 10 of 13 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
10.7	256.0	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.5	91.1	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.7	86.5	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
3.8	68.5	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
1.9	66.8	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
2.6	52.2	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
1.8	50.2	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.5	46.7	REACTOME REGULATION OF INSULIN SECRETION	Genes involved in Regulation of Insulin Secretion
1.4	45.0	REACTOME KERATAN SULFATE BIOSYNTHESIS	Genes involved in Keratan sulfate biosynthesis
0.8	29.3	REACTOME G PROTEIN ACTIVATION	Genes involved in G-protein activation

Showing 1 to 10 of 22 entries

Results for REST

Z-value: 1.30

Motif logo

Transcription factors associated with REST

Activity-expression correlation:

Activity profile of REST motif

Sorted Z-values of REST motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of REST

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: