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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for REST

Z-value: 1.30

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Transcription factors associated with REST

Gene Symbol Gene ID Gene Info
REST
ENSG00000084093.11 RE1 silencing transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RESThg19_v2_chr4_+_57774042_57774114-0.428.4e-11Click!

Activity profile of REST motif

Sorted Z-values of REST motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr20_+_44657845 78.67 ENST00000243964.3
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr4_+_158141806 78.24 ENST00000393815.2
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr4_+_158141843 76.64 ENST00000509417.1
ENST00000296526.7
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr4_+_158141899 73.98 ENST00000264426.9
ENST00000506284.1
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr14_+_93389425 72.93 ENST00000216492.5
ENST00000334654.4
CHGA
chromogranin A (parathyroid secretory protein 1)
chr12_+_175930 71.12 ENST00000538872.1
ENST00000326261.4
IQSEC3
IQ motif and Sec7 domain 3
chrX_-_47479246 68.50 ENST00000295987.7
ENST00000340666.4
SYN1
synapsin I
chr1_+_65775204 66.84 ENST00000371069.4
DNAJC6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr12_+_113229452 62.82 ENST00000389385.4
RPH3A
rabphilin 3A homolog (mouse)
chr12_+_113229737 61.90 ENST00000551052.1
ENST00000415485.3
RPH3A
rabphilin 3A homolog (mouse)
chr1_+_33352036 61.88 ENST00000373467.3
HPCA
hippocalcin
chr20_+_5892037 61.81 ENST00000378961.4
CHGB
chromogranin B (secretogranin 1)
chr12_+_113229543 60.27 ENST00000447659.2
RPH3A
rabphilin 3A homolog (mouse)
chr17_+_42385927 57.97 ENST00000426726.3
ENST00000590941.1
ENST00000225441.7
RUNDC3A
RUN domain containing 3A
chr15_+_75287861 56.48 ENST00000425597.3
ENST00000562327.1
ENST00000568018.1
ENST00000562212.1
ENST00000567920.1
ENST00000566872.1
ENST00000361900.6
ENST00000545456.1
SCAMP5
secretory carrier membrane protein 5
chr15_-_83378638 52.61 ENST00000261722.3
AP3B2
adaptor-related protein complex 3, beta 2 subunit
chrX_-_49056635 51.37 ENST00000472598.1
ENST00000538567.1
ENST00000479808.1
ENST00000263233.4
SYP
synaptophysin
chr17_+_30813576 50.16 ENST00000313401.3
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr1_-_241520385 45.32 ENST00000366564.1
RGS7
regulator of G-protein signaling 7
chr11_-_66115032 45.02 ENST00000311181.4
B3GNT1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
chr15_-_83378526 44.85 ENST00000535348.1
ENST00000535359.1
AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr2_-_51259292 39.31 ENST00000401669.2
NRXN1
neurexin 1
chr8_-_57358432 37.92 ENST00000517415.1
ENST00000314922.3
PENK
proenkephalin
chr2_-_51259229 36.99 ENST00000405472.3
NRXN1
neurexin 1
chr10_+_26505594 36.82 ENST00000259271.3
GAD2
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr10_-_102790852 35.89 ENST00000470414.1
ENST00000370215.3
PDZD7
PDZ domain containing 7
chr15_-_83378611 34.37 ENST00000542200.1
AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr2_-_51259641 33.11 ENST00000406316.2
ENST00000405581.1
NRXN1
neurexin 1
chr10_-_50970322 33.09 ENST00000374103.4
OGDHL
oxoglutarate dehydrogenase-like
chr16_+_5008290 31.42 ENST00000251170.7
SEC14L5
SEC14-like 5 (S. cerevisiae)
chr2_-_51259528 31.30 ENST00000404971.1
NRXN1
neurexin 1
chr10_-_50970382 28.87 ENST00000419399.1
ENST00000432695.1
OGDHL
oxoglutarate dehydrogenase-like
chr9_+_140033862 27.14 ENST00000350902.5
ENST00000371550.4
ENST00000371546.4
ENST00000371555.4
ENST00000371553.3
ENST00000371559.4
ENST00000371560.3
GRIN1
glutamate receptor, ionotropic, N-methyl D-aspartate 1
chr3_-_48700310 25.46 ENST00000164024.4
ENST00000544264.1
CELSR3
cadherin, EGF LAG seven-pass G-type receptor 3
chrX_+_153237740 25.05 ENST00000369982.4
TMEM187
transmembrane protein 187
chr3_+_62304712 25.00 ENST00000494481.1
C3orf14
chromosome 3 open reading frame 14
chr19_-_55691472 24.70 ENST00000537500.1
SYT5
synaptotagmin V
chr19_-_55691614 23.87 ENST00000592470.1
ENST00000354308.3
SYT5
synaptotagmin V
chr11_+_45907177 23.26 ENST00000241014.2
MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1
chr9_-_139096955 21.57 ENST00000371748.5
LHX3
LIM homeobox 3
chr2_-_47798044 20.53 ENST00000327876.4
KCNK12
potassium channel, subfamily K, member 12
chrX_-_153141302 20.21 ENST00000361699.4
ENST00000543994.1
ENST00000370057.3
ENST00000538883.1
ENST00000361981.3
L1CAM
L1 cell adhesion molecule
chr3_+_62304648 20.15 ENST00000462069.1
ENST00000232519.5
ENST00000465142.1
C3orf14
chromosome 3 open reading frame 14
chr1_-_151689259 19.78 ENST00000420342.1
ENST00000290583.4
CELF3
CUGBP, Elav-like family member 3
chr16_+_3019246 19.33 ENST00000318782.8
ENST00000293978.8
PAQR4
progestin and adipoQ receptor family member IV
chr19_-_3971050 19.31 ENST00000545797.2
ENST00000596311.1
DAPK3
death-associated protein kinase 3
chr1_+_154540246 17.33 ENST00000368476.3
CHRNB2
cholinergic receptor, nicotinic, beta 2 (neuronal)
chrX_-_153237258 16.39 ENST00000310441.7
HCFC1
host cell factor C1 (VP16-accessory protein)
chr16_+_335680 16.26 ENST00000435833.1
PDIA2
protein disulfide isomerase family A, member 2
chr8_-_91095099 15.49 ENST00000265431.3
CALB1
calbindin 1, 28kDa
chr2_+_46524537 15.43 ENST00000263734.3
EPAS1
endothelial PAS domain protein 1
chr10_+_26505179 15.42 ENST00000376261.3
GAD2
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr6_+_154360616 14.12 ENST00000229768.5
ENST00000419506.2
ENST00000524163.1
ENST00000414028.2
ENST00000435918.2
ENST00000337049.4
OPRM1
opioid receptor, mu 1
chr17_-_3301704 13.69 ENST00000322608.2
OR1E1
olfactory receptor, family 1, subfamily E, member 1
chr2_-_30143525 13.65 ENST00000431873.1
ALK
anaplastic lymphoma receptor tyrosine kinase
chr15_-_27018884 13.47 ENST00000299267.4
GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr6_+_25652432 13.30 ENST00000377961.2
SCGN
secretagogin, EF-hand calcium binding protein
chr6_+_110299501 12.10 ENST00000414000.2
GPR6
G protein-coupled receptor 6
chr10_-_79398250 11.84 ENST00000286627.5
KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr9_-_123812542 11.20 ENST00000223642.1
C5
complement component 5
chr7_+_154862028 11.11 ENST00000287907.2
HTR5A
5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
chr10_-_44880491 10.94 ENST00000374426.2
ENST00000395795.4
ENST00000395794.2
ENST00000374429.2
ENST00000395793.3
ENST00000343575.6
CXCL12
chemokine (C-X-C motif) ligand 12
chr19_-_11639931 10.48 ENST00000592312.1
ENST00000590480.1
ENST00000585318.1
ENST00000252440.7
ENST00000417981.2
ENST00000270517.7
ECSIT
ECSIT signalling integrator
chr5_+_71014990 9.13 ENST00000296777.4
CARTPT
CART prepropeptide
chr10_+_102790980 9.08 ENST00000393459.1
ENST00000224807.5
SFXN3
sideroflexin 3
chr12_+_52695617 8.56 ENST00000293525.5
KRT86
keratin 86
chr6_+_154360553 8.52 ENST00000452687.2
OPRM1
opioid receptor, mu 1
chr4_+_96012614 8.50 ENST00000264568.4
BMPR1B
bone morphogenetic protein receptor, type IB
chr11_+_22359562 7.80 ENST00000263160.3
SLC17A6
solute carrier family 17 (vesicular glutamate transporter), member 6
chr7_+_150748288 7.62 ENST00000490540.1
ASIC3
acid-sensing (proton-gated) ion channel 3
chr7_-_100808843 6.61 ENST00000249330.2
VGF
VGF nerve growth factor inducible
chr19_-_11639910 6.49 ENST00000588998.1
ENST00000586149.1
ECSIT
ECSIT signalling integrator
chr1_+_171750776 5.83 ENST00000458517.1
ENST00000362019.3
ENST00000367737.5
ENST00000361735.3
METTL13
methyltransferase like 13
chr5_+_175298487 5.28 ENST00000393745.3
CPLX2
complexin 2
chr6_+_154360476 5.21 ENST00000428397.2
OPRM1
opioid receptor, mu 1
chr1_-_40105617 4.91 ENST00000372852.3
HEYL
hes-related family bHLH transcription factor with YRPW motif-like
chr4_-_175750364 4.87 ENST00000340217.5
ENST00000274093.3
GLRA3
glycine receptor, alpha 3
chr11_-_6677018 4.78 ENST00000299441.3
DCHS1
dachsous cadherin-related 1
chr1_-_175712665 4.41 ENST00000263525.2
TNR
tenascin R
chr3_+_120626919 4.36 ENST00000273666.6
ENST00000471454.1
ENST00000472879.1
ENST00000497029.1
ENST00000492541.1
STXBP5L
syntaxin binding protein 5-like
chr10_-_79398127 4.32 ENST00000372443.1
KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr20_-_60795296 4.27 ENST00000340177.5
HRH3
histamine receptor H3
chr11_-_125773085 4.17 ENST00000227474.3
ENST00000534158.1
ENST00000529801.1
PUS3
pseudouridylate synthase 3
chr12_+_71833756 3.67 ENST00000536515.1
ENST00000540815.2
LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr17_-_3337135 3.25 ENST00000248384.1
OR1E2
olfactory receptor, family 1, subfamily E, member 2
chr14_-_94759408 3.19 ENST00000554723.1
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr20_+_36012051 3.18 ENST00000373567.2
SRC
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr14_-_94759361 2.93 ENST00000393096.1
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr20_-_60795316 2.90 ENST00000317393.6
HRH3
histamine receptor H3
chr5_-_151304337 2.86 ENST00000455880.2
ENST00000545569.1
ENST00000274576.4
GLRA1
glycine receptor, alpha 1
chr7_-_100808394 1.85 ENST00000445482.2
VGF
VGF nerve growth factor inducible
chr6_+_153071925 1.75 ENST00000367244.3
ENST00000367243.3
VIP
vasoactive intestinal peptide
chr3_-_8686479 1.65 ENST00000544814.1
ENST00000427408.1
SSUH2
ssu-2 homolog (C. elegans)
chr6_+_154360357 1.46 ENST00000330432.7
ENST00000360422.4
OPRM1
opioid receptor, mu 1
chr12_-_57443886 1.43 ENST00000300119.3
MYO1A
myosin IA
chr2_+_226265364 0.84 ENST00000272907.6
NYAP2
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chr1_+_212606219 0.70 ENST00000366988.3
NENF
neudesin neurotrophic factor
chr20_-_62284766 0.68 ENST00000370053.1
STMN3
stathmin-like 3
chr14_-_94759595 0.17 ENST00000261994.4
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10

Network of associatons between targets according to the STRING database.

First level regulatory network of REST

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
24.3 72.9 GO:1901899 dense core granule biogenesis(GO:0061110) positive regulation of relaxation of cardiac muscle(GO:1901899) regulation of dense core granule biogenesis(GO:2000705)
19.7 78.7 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
17.6 140.7 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
16.7 50.2 GO:0021718 superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
13.6 27.1 GO:0021586 pons maturation(GO:0021586)
12.4 61.9 GO:1902075 cellular response to salt(GO:1902075)
9.5 37.9 GO:0051866 general adaptation syndrome(GO:0051866)
8.7 52.2 GO:0006540 glutamate decarboxylation to succinate(GO:0006540)
8.2 131.8 GO:0048490 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
7.6 68.5 GO:0097091 synaptic vesicle clustering(GO:0097091)
7.4 66.8 GO:0016191 synaptic vesicle uncoating(GO:0016191)
7.3 29.3 GO:0061358 negative regulation of Wnt protein secretion(GO:0061358)
6.4 25.5 GO:0036515 serotonergic neuron axon guidance(GO:0036515)
5.6 231.6 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
5.2 228.9 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
5.1 51.4 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
5.1 35.9 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
4.8 58.0 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
4.6 9.1 GO:0070093 negative regulation of glucagon secretion(GO:0070093)
4.3 17.3 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) synaptic transmission involved in micturition(GO:0060084)
4.1 16.4 GO:0019046 release from viral latency(GO:0019046)
3.7 11.2 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
3.6 21.6 GO:0021523 somatic motor neuron differentiation(GO:0021523)
3.6 71.1 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
3.4 13.6 GO:0036269 swimming behavior(GO:0036269)
3.1 59.3 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
2.9 23.3 GO:0007258 JUN phosphorylation(GO:0007258)
2.8 11.1 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
2.2 10.9 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
1.9 15.4 GO:0043129 surfactant homeostasis(GO:0043129)
1.9 20.5 GO:0030322 stabilization of membrane potential(GO:0030322)
1.8 16.2 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
1.7 15.5 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
1.7 8.5 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
1.6 4.9 GO:2000824 negative regulation of androgen receptor activity(GO:2000824)
1.6 62.0 GO:0006099 tricarboxylic acid cycle(GO:0006099)
1.6 16.3 GO:0006621 protein retention in ER lumen(GO:0006621)
1.6 4.8 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
1.5 7.6 GO:0015891 iron chelate transport(GO:0015688) siderophore transport(GO:0015891) detection of chemical stimulus involved in sensory perception of pain(GO:0050968)
1.1 19.3 GO:0031033 myosin filament organization(GO:0031033)
1.1 19.8 GO:0030575 nuclear body organization(GO:0030575)
1.0 13.4 GO:0060080 inhibitory postsynaptic potential(GO:0060080)
1.0 7.2 GO:0014050 negative regulation of glutamate secretion(GO:0014050) regulation of serotonin secretion(GO:0014062) negative regulation of serotonin secretion(GO:0014063)
0.9 6.3 GO:0008218 bioluminescence(GO:0008218)
0.9 4.4 GO:0048690 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.9 7.8 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.9 12.1 GO:0090520 sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520)
0.8 4.2 GO:0031119 tRNA pseudouridine synthesis(GO:0031119) mRNA pseudouridine synthesis(GO:1990481)
0.8 3.2 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
0.6 4.9 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.5 8.5 GO:0002021 response to dietary excess(GO:0002021)
0.3 16.9 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.3 20.2 GO:0045773 positive regulation of axon extension(GO:0045773)
0.2 17.0 GO:0010257 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.2 1.8 GO:0070459 regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579) prolactin secretion(GO:0070459)
0.2 1.8 GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.1 45.3 GO:0006457 protein folding(GO:0006457)
0.1 4.4 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.1 61.8 GO:0043687 post-translational protein modification(GO:0043687)
0.1 0.7 GO:0032096 negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099)
0.1 9.1 GO:0055072 iron ion homeostasis(GO:0055072)
0.1 0.7 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.1 8.6 GO:0070268 cornification(GO:0070268)
0.1 1.4 GO:0030033 microvillus assembly(GO:0030033)
0.0 5.8 GO:0032259 methylation(GO:0032259)
0.0 1.7 GO:0042476 odontogenesis(GO:0042476)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
45.8 228.9 GO:0098843 postsynaptic endocytic zone(GO:0098843)
12.5 50.2 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
12.0 131.8 GO:0030123 AP-3 adaptor complex(GO:0030123)
12.0 35.9 GO:0002139 stereocilia coupling link(GO:0002139)
10.5 126.2 GO:0060077 inhibitory synapse(GO:0060077)
8.9 62.0 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
7.8 46.7 GO:1990769 proximal neuron projection(GO:1990769)
6.3 37.9 GO:0032280 symmetric synapse(GO:0032280)
5.6 61.9 GO:0044327 dendritic spine head(GO:0044327)
4.3 72.9 GO:0042583 chromaffin granule(GO:0042583)
3.8 300.6 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
3.0 27.1 GO:0098839 postsynaptic density membrane(GO:0098839)
2.9 23.3 GO:0044294 dendritic growth cone(GO:0044294)
2.1 68.5 GO:0000795 synaptonemal complex(GO:0000795)
1.6 4.9 GO:0016935 glycine-gated chloride channel complex(GO:0016935)
1.5 140.7 GO:0042734 presynaptic membrane(GO:0042734)
1.5 4.4 GO:0072534 perineuronal net(GO:0072534)
1.5 78.7 GO:0043198 dendritic shaft(GO:0043198)
1.4 20.2 GO:0044295 axonal growth cone(GO:0044295)
1.3 16.4 GO:0048188 Set1C/COMPASS complex(GO:0048188)
1.2 11.2 GO:0005579 membrane attack complex(GO:0005579)
1.1 29.3 GO:0032839 dendrite cytoplasm(GO:0032839)
0.8 45.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.7 17.3 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.7 8.5 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.4 13.5 GO:1902711 GABA-A receptor complex(GO:1902711)
0.3 66.3 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.3 92.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.2 8.6 GO:0045095 keratin filament(GO:0045095)
0.2 15.5 GO:0043197 dendritic spine(GO:0043197)
0.2 16.2 GO:0005901 caveola(GO:0005901)
0.1 20.7 GO:0005884 actin filament(GO:0005884)
0.1 11.1 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 37.8 GO:0030133 transport vesicle(GO:0030133)
0.0 15.4 GO:0016607 nuclear speck(GO:0016607)
0.0 17.0 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 1.8 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 101.2 GO:0016021 integral component of membrane(GO:0016021)
0.0 31.9 GO:0005886 plasma membrane(GO:0005886)
0.0 9.1 GO:0030141 secretory granule(GO:0030141)
0.0 0.7 GO:0030426 growth cone(GO:0030426)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
19.1 228.9 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
16.8 185.0 GO:0008430 selenium binding(GO:0008430)
16.7 50.2 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
12.4 62.0 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
8.8 140.7 GO:0097109 neuroligin family protein binding(GO:0097109)
8.3 58.0 GO:0010853 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
7.5 52.2 GO:0004351 glutamate decarboxylase activity(GO:0004351)
7.3 29.3 GO:0004979 beta-endorphin receptor activity(GO:0004979) morphine receptor activity(GO:0038047)
7.2 78.7 GO:0022820 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
6.5 45.3 GO:0031681 G-protein beta-subunit binding(GO:0031681)
5.4 27.1 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
5.4 37.9 GO:0001515 opioid peptide activity(GO:0001515)
2.7 71.1 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
2.6 15.5 GO:0005499 vitamin D binding(GO:0005499)
2.5 19.8 GO:0097322 7SK snRNA binding(GO:0097322)
2.3 16.2 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
2.1 20.5 GO:0022841 potassium ion leak channel activity(GO:0022841)
1.9 13.6 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
1.9 23.3 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
1.5 7.7 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
1.5 7.6 GO:0044736 acid-sensing ion channel activity(GO:0044736)
1.4 16.4 GO:0043996 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
1.4 16.3 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
1.3 13.5 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
1.3 19.3 GO:0008140 cAMP response element binding protein binding(GO:0008140)
1.2 4.9 GO:0035939 microsatellite binding(GO:0035939)
1.0 12.1 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
1.0 54.6 GO:0042169 SH2 domain binding(GO:0042169)
0.9 8.5 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.9 46.7 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.9 11.1 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.8 7.2 GO:0004969 histamine receptor activity(GO:0004969)
0.7 17.3 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.7 10.9 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.7 81.1 GO:0005179 hormone activity(GO:0005179)
0.5 66.8 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.5 4.2 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.4 7.8 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313) acidic amino acid transmembrane transporter activity(GO:0015172)
0.4 15.4 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.3 11.2 GO:0008009 chemokine activity(GO:0008009)
0.3 16.9 GO:0004984 olfactory receptor activity(GO:0004984)
0.2 231.9 GO:0005215 transporter activity(GO:0005215)
0.1 17.0 GO:0016651 oxidoreductase activity, acting on NAD(P)H(GO:0016651)
0.1 21.6 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.1 61.9 GO:0019900 kinase binding(GO:0019900)
0.1 35.9 GO:0046982 protein heterodimerization activity(GO:0046982)
0.1 5.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 5.8 GO:0008168 methyltransferase activity(GO:0008168)
0.0 4.4 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 4.5 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 1.4 GO:0003774 motor activity(GO:0003774)
0.0 8.6 GO:0005198 structural molecule activity(GO:0005198)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 228.9 PID NCADHERIN PATHWAY N-cadherin signaling events
1.7 73.4 PID REELIN PATHWAY Reelin signaling pathway
0.3 37.9 PID AP1 PATHWAY AP-1 transcription factor network
0.3 15.4 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.3 20.2 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.3 29.3 PID IL4 2PATHWAY IL4-mediated signaling events
0.2 3.2 ST STAT3 PATHWAY STAT3 Pathway
0.2 10.9 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.2 16.3 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 8.5 PID BMP PATHWAY BMP receptor signaling
0.1 9.1 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 6.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 4.4 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
10.7 256.0 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
3.8 68.5 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
2.6 52.2 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
1.9 66.8 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
1.8 50.2 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
1.4 19.3 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
1.4 45.0 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
1.0 17.3 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.9 11.1 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.8 20.2 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.8 29.3 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.7 86.5 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.5 21.2 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.5 46.7 REACTOME REGULATION OF INSULIN SECRETION Genes involved in Regulation of Insulin Secretion
0.5 91.1 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.4 15.4 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.4 3.2 REACTOME ADP SIGNALLING THROUGH P2RY1 Genes involved in ADP signalling through P2Y purinoceptor 1
0.4 16.9 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.3 8.5 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.2 17.0 REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION Genes involved in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
0.1 1.8 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.1 4.9 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription