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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for RFX3_RFX2
Z-value: 1.78
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Transcription factors associated with RFX3_RFX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RFX2 | hg19_v2_chr19_-_6110474_6110551 | 0.60 | 1.8e-22 | Click! |
| RFX3 | hg19_v2_chr9_-_3525968_3526016 | 0.38 | 5.3e-09 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RFX3_RFX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 32.1 | 192.4 | GO:0010732 | protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734) |
| 17.7 | 159.1 | GO:0002318 | myeloid progenitor cell differentiation(GO:0002318) |
| 4.5 | 153.0 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 8.2 | 147.1 | GO:0044458 | motile cilium assembly(GO:0044458) |
| 3.6 | 139.7 | GO:2000300 | regulation of synaptic vesicle exocytosis(GO:2000300) |
| 0.3 | 133.5 | GO:0048232 | spermatogenesis(GO:0007283) male gamete generation(GO:0048232) |
| 6.6 | 132.3 | GO:0002021 | response to dietary excess(GO:0002021) |
| 5.6 | 128.2 | GO:0034389 | lipid particle organization(GO:0034389) |
| 11.1 | 122.2 | GO:0036159 | inner dynein arm assembly(GO:0036159) |
| 29.0 | 116.2 | GO:0061528 | negative regulation of gamma-aminobutyric acid secretion(GO:0014053) aspartate secretion(GO:0061528) regulation of aspartate secretion(GO:1904448) positive regulation of aspartate secretion(GO:1904450) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 216.0 | GO:0097014 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 9.6 | 192.4 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 3.3 | 177.8 | GO:0016235 | aggresome(GO:0016235) |
| 0.5 | 174.2 | GO:0005874 | microtubule(GO:0005874) |
| 12.1 | 144.7 | GO:0033010 | paranodal junction(GO:0033010) |
| 0.2 | 126.6 | GO:0043005 | neuron projection(GO:0043005) |
| 30.7 | 122.7 | GO:0097224 | sperm connecting piece(GO:0097224) |
| 29.0 | 116.2 | GO:0032144 | 4-aminobutyrate transaminase complex(GO:0032144) |
| 1.1 | 97.7 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 1.5 | 90.8 | GO:0036064 | ciliary basal body(GO:0036064) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.4 | 242.2 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.1 | 223.6 | GO:0046872 | metal ion binding(GO:0046872) |
| 0.7 | 188.1 | GO:0008017 | microtubule binding(GO:0008017) |
| 3.5 | 165.6 | GO:0030507 | spectrin binding(GO:0030507) |
| 2.9 | 143.6 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 6.1 | 139.7 | GO:0070008 | serine-type exopeptidase activity(GO:0070008) |
| 0.8 | 136.4 | GO:0005178 | integrin binding(GO:0005178) |
| 1.1 | 124.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 10.2 | 122.7 | GO:0032027 | myosin light chain binding(GO:0032027) |
| 1.1 | 117.0 | GO:0008013 | beta-catenin binding(GO:0008013) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 198.3 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 2.7 | 141.7 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 1.7 | 111.9 | ST ADRENERGIC | Adrenergic Pathway |
| 1.1 | 60.4 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.4 | 49.9 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.6 | 37.5 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.5 | 32.8 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.5 | 31.0 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.6 | 29.5 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
| 0.1 | 21.0 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 169.2 | REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | Genes involved in Cell surface interactions at the vascular wall |
| 1.0 | 166.5 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.3 | 120.1 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 2.9 | 101.0 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 2.0 | 92.5 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 3.7 | 82.1 | REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| 1.4 | 73.6 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 1.1 | 73.0 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 2.4 | 65.1 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.7 | 63.3 | REACTOME ER PHAGOSOME PATHWAY | Genes involved in ER-Phagosome pathway |