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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for RFX5

Z-value: 0.27

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Transcription factors associated with RFX5

Gene Symbol Gene ID Gene Info
RFX5
ENSG00000143390.13 regulatory factor X5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RFX5hg19_v2_chr1_-_151319710_1513198330.551.2e-18Click!

Activity profile of RFX5 motif

Sorted Z-values of RFX5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_32557610 76.97 ENST00000360004.5
HLA-DRB1
major histocompatibility complex, class II, DR beta 1
chr6_+_33043703 75.99 ENST00000418931.2
ENST00000535465.1
HLA-DPB1
major histocompatibility complex, class II, DP beta 1
chr5_-_149792295 70.60 ENST00000518797.1
ENST00000524315.1
ENST00000009530.7
ENST00000377795.3
CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr6_-_32498046 64.95 ENST00000374975.3
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr6_-_32920794 63.68 ENST00000395305.3
ENST00000395303.3
ENST00000374843.4
ENST00000429234.1
HLA-DMA
XXbac-BPG181M17.5
major histocompatibility complex, class II, DM alpha
Uncharacterized protein
chr6_+_32821924 43.85 ENST00000374859.2
ENST00000453265.2
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr6_-_32634425 36.64 ENST00000399082.3
ENST00000399079.3
ENST00000374943.4
ENST00000434651.2
HLA-DQB1
major histocompatibility complex, class II, DQ beta 1
chr6_-_32908792 33.72 ENST00000418107.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chr6_-_32812420 33.01 ENST00000374881.2
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8
chr6_-_32731299 29.97 ENST00000435145.2
ENST00000437316.2
HLA-DQB2
major histocompatibility complex, class II, DQ beta 2
chr6_+_32812568 29.55 ENST00000414474.1
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr6_-_32821599 24.30 ENST00000354258.4
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr6_-_32784687 17.46 ENST00000447394.1
ENST00000438763.2
HLA-DOB
major histocompatibility complex, class II, DO beta
chr11_-_6640585 16.59 ENST00000533371.1
ENST00000528657.1
ENST00000436873.2
ENST00000299427.6
TPP1
tripeptidyl peptidase I
chr1_+_249132462 13.64 ENST00000306562.3
ZNF672
zinc finger protein 672
chr6_+_26440700 13.47 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
BTN3A3
butyrophilin, subfamily 3, member A3
chr6_-_32731243 13.13 ENST00000427449.1
ENST00000411527.1
HLA-DQB2
major histocompatibility complex, class II, DQ beta 2
chr11_+_8008867 12.98 ENST00000309828.4
ENST00000449102.2
EIF3F
eukaryotic translation initiation factor 3, subunit F
chr6_-_32908765 12.90 ENST00000416244.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chr6_+_26383404 12.63 ENST00000416795.2
ENST00000494184.1
BTN2A2
butyrophilin, subfamily 2, member A2
chr6_+_26458171 11.70 ENST00000493173.1
ENST00000541522.1
ENST00000429381.1
ENST00000469185.1
BTN2A1
butyrophilin, subfamily 2, member A1
chr6_+_26458152 11.40 ENST00000312541.5
BTN2A1
butyrophilin, subfamily 2, member A1
chr6_+_26365443 10.50 ENST00000527422.1
ENST00000356386.2
ENST00000396934.3
ENST00000377708.2
ENST00000396948.1
ENST00000508906.2
BTN3A2
butyrophilin, subfamily 3, member A2
chr15_+_45003675 9.71 ENST00000558401.1
ENST00000559916.1
ENST00000544417.1
B2M
beta-2-microglobulin
chr3_+_43328004 9.44 ENST00000454177.1
ENST00000429705.2
ENST00000296088.7
ENST00000437827.1
SNRK
SNF related kinase
chr13_-_47012325 8.94 ENST00000409879.2
KIAA0226L
KIAA0226-like
chr6_+_26383318 8.35 ENST00000469230.1
ENST00000490025.1
ENST00000356709.4
ENST00000352867.2
ENST00000493275.1
ENST00000472507.1
ENST00000482536.1
ENST00000432533.2
ENST00000482842.1
BTN2A2
butyrophilin, subfamily 2, member A2
chr6_-_133079022 7.23 ENST00000525289.1
ENST00000326499.6
VNN2
vanin 2
chr19_+_19496624 6.04 ENST00000494516.2
ENST00000360315.3
ENST00000252577.5
GATAD2A
GATA zinc finger domain containing 2A
chr2_-_242088850 5.65 ENST00000358649.4
ENST00000452907.1
ENST00000403638.3
ENST00000539818.1
ENST00000415234.1
ENST00000234040.4
PASK
PAS domain containing serine/threonine kinase
chr19_+_45418067 5.42 ENST00000589078.1
ENST00000586638.1
APOC1
apolipoprotein C-I
chr3_+_196466710 4.10 ENST00000327134.3
PAK2
p21 protein (Cdc42/Rac)-activated kinase 2
chr4_-_83719884 3.95 ENST00000282709.4
ENST00000273908.4
SCD5
stearoyl-CoA desaturase 5
chr22_-_30987837 3.79 ENST00000335214.6
PES1
pescadillo ribosomal biogenesis factor 1
chr6_-_30181133 3.73 ENST00000454678.2
ENST00000434785.1
TRIM26
tripartite motif containing 26
chr6_-_30181156 3.55 ENST00000418026.1
ENST00000416596.1
ENST00000453195.1
TRIM26
tripartite motif containing 26
chr11_-_72433346 3.08 ENST00000334211.8
ARAP1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr4_-_143227088 2.22 ENST00000511838.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr1_+_181003067 2.13 ENST00000434571.2
ENST00000367579.3
ENST00000282990.6
ENST00000367580.5
MR1
major histocompatibility complex, class I-related
chr6_-_24666819 2.08 ENST00000341060.3
TDP2
tyrosyl-DNA phosphodiesterase 2
chr6_-_24667180 1.86 ENST00000545995.1
TDP2
tyrosyl-DNA phosphodiesterase 2
chr4_-_143226979 1.71 ENST00000514525.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr16_+_67381263 1.67 ENST00000541146.1
ENST00000563189.1
ENST00000290940.7
LRRC36
leucine rich repeat containing 36
chr16_+_67381289 1.64 ENST00000435835.3
LRRC36
leucine rich repeat containing 36
chr19_+_45417921 1.20 ENST00000252491.4
ENST00000592885.1
ENST00000589781.1
APOC1
apolipoprotein C-I
chr19_+_36103631 1.18 ENST00000203166.5
ENST00000379045.2
HAUS5
HAUS augmin-like complex, subunit 5
chr1_+_36549676 0.94 ENST00000207457.3
TEKT2
tektin 2 (testicular)
chr1_-_202936394 0.35 ENST00000367249.4
CYB5R1
cytochrome b5 reductase 1
chr19_+_3933579 0.23 ENST00000593949.1
NMRK2
nicotinamide riboside kinase 2

Network of associatons between targets according to the STRING database.

First level regulatory network of RFX5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
37.5 187.3 GO:0002399 MHC class II protein complex assembly(GO:0002399)
14.1 70.6 GO:0002906 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
6.1 24.3 GO:0046967 cytosol to ER transport(GO:0046967)
5.8 17.5 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
4.9 9.7 GO:0002428 antigen processing and presentation of peptide antigen via MHC class Ib(GO:0002428)
1.8 224.8 GO:0031295 T cell costimulation(GO:0031295)
1.7 6.6 GO:0010900 negative regulation of phosphatidylcholine catabolic process(GO:0010900)
1.5 21.0 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.9 5.7 GO:0070092 regulation of glucagon secretion(GO:0070092)
0.9 95.9 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.8 3.1 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
0.8 13.0 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.7 7.2 GO:0015939 pantothenate metabolic process(GO:0015939)
0.6 10.5 GO:0072643 interferon-gamma secretion(GO:0072643)
0.4 7.3 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.4 3.8 GO:0007000 nucleolus organization(GO:0007000)
0.3 16.6 GO:0043171 peptide catabolic process(GO:0043171)
0.1 0.9 GO:0060294 cilium movement involved in cell motility(GO:0060294)
0.1 13.5 GO:0002456 T cell mediated immunity(GO:0002456)
0.1 3.9 GO:0046949 fatty-acyl-CoA biosynthetic process(GO:0046949)
0.1 2.1 GO:0032620 interleukin-17 production(GO:0032620)
0.1 6.0 GO:0006306 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.1 3.9 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0 9.4 GO:0030099 myeloid cell differentiation(GO:0030099)
0.0 3.9 GO:0006302 double-strand break repair(GO:0006302)
0.0 0.2 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
23.6 496.0 GO:0042613 MHC class II protein complex(GO:0042613)
13.3 106.4 GO:1990111 spermatoproteasome complex(GO:1990111)
4.1 24.3 GO:0042825 TAP complex(GO:0042825)
1.9 9.7 GO:0031905 early endosome lumen(GO:0031905)
1.4 13.0 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.6 3.8 GO:0070545 PeBoW complex(GO:0070545)
0.3 6.6 GO:0042627 chylomicron(GO:0042627)
0.2 2.1 GO:0042611 MHC protein complex(GO:0042611)
0.2 6.0 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 1.2 GO:0070652 HAUS complex(GO:0070652)
0.1 16.6 GO:0043202 lysosomal lumen(GO:0043202)
0.1 3.9 GO:0016235 aggresome(GO:0016235)
0.0 7.2 GO:0031225 anchored component of membrane(GO:0031225)
0.0 3.1 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.9 GO:0036126 sperm flagellum(GO:0036126)
0.0 0.4 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 51.6 GO:0016021 integral component of membrane(GO:0016021)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
14.1 70.6 GO:0042289 MHC class II protein binding(GO:0042289)
8.1 242.2 GO:0042605 peptide antigen binding(GO:0042605)
7.5 97.2 GO:0032395 MHC class II receptor activity(GO:0032395)
4.2 110.3 GO:0023026 MHC class II protein complex binding(GO:0023026)
3.5 106.4 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
2.8 16.6 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
1.4 7.2 GO:0017159 pantetheine hydrolase activity(GO:0017159)
1.3 3.9 GO:0004768 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
1.3 3.9 GO:0036317 tyrosyl-RNA phosphodiesterase activity(GO:0036317) 5'-tyrosyl-DNA phosphodiesterase activity(GO:0070260)
0.8 6.6 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.8 3.9 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.3 13.0 GO:0031369 translation initiation factor binding(GO:0031369)
0.2 3.1 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.2 2.1 GO:0032393 MHC class I receptor activity(GO:0032393)
0.1 4.1 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.1 0.2 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262) ribosylnicotinate kinase activity(GO:0061769)
0.0 9.4 GO:0000287 magnesium ion binding(GO:0000287)
0.0 0.4 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0 6.0 GO:0030674 protein binding, bridging(GO:0030674)
0.0 5.7 GO:0035091 phosphatidylinositol binding(GO:0035091)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 77.0 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 9.7 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 24.3 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 4.1 PID MYC PATHWAY C-MYC pathway
0.1 3.9 PID CD40 PATHWAY CD40/CD40L signaling
0.1 6.0 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 3.1 PID RHOA REG PATHWAY Regulation of RhoA activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
9.5 217.9 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
2.4 9.7 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
1.6 24.3 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
1.5 198.4 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
1.3 95.9 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.3 3.9 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.3 4.1 REACTOME REGULATION OF APOPTOSIS Genes involved in Regulation of Apoptosis
0.2 16.6 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.2 13.0 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 3.1 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases