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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for RFX5
Z-value: 0.27
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Transcription factors associated with RFX5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RFX5 | hg19_v2_chr1_-_151319710_151319833 | 0.55 | 1.2e-18 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_32557610 Show fit | 76.97 |
ENST00000360004.5
|
major histocompatibility complex, class II, DR beta 1 |
|
| chr6_+_33043703 Show fit | 75.99 |
ENST00000418931.2
ENST00000535465.1 |
major histocompatibility complex, class II, DP beta 1 |
|
| chr5_-_149792295 Show fit | 70.60 |
ENST00000518797.1
ENST00000524315.1 ENST00000009530.7 ENST00000377795.3 |
CD74 molecule, major histocompatibility complex, class II invariant chain |
|
| chr6_-_32498046 Show fit | 64.95 |
ENST00000374975.3
|
major histocompatibility complex, class II, DR beta 5 |
|
| chr6_-_32920794 Show fit | 63.68 |
ENST00000395305.3
ENST00000395303.3 ENST00000374843.4 ENST00000429234.1 |
major histocompatibility complex, class II, DM alpha Uncharacterized protein |
|
| chr6_+_32821924 Show fit | 43.85 |
ENST00000374859.2
ENST00000453265.2 |
proteasome (prosome, macropain) subunit, beta type, 9 |
|
| chr6_-_32634425 Show fit | 36.64 |
ENST00000399082.3
ENST00000399079.3 ENST00000374943.4 ENST00000434651.2 |
major histocompatibility complex, class II, DQ beta 1 |
|
| chr6_-_32908792 Show fit | 33.72 |
ENST00000418107.2
|
major histocompatibility complex, class II, DM beta |
|
| chr6_-_32812420 Show fit | 33.01 |
ENST00000374881.2
|
proteasome (prosome, macropain) subunit, beta type, 8 |
|
| chr6_-_32731299 Show fit | 29.97 |
ENST00000435145.2
ENST00000437316.2 |
major histocompatibility complex, class II, DQ beta 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of RFX5
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 224.8 | GO:0031295 | T cell costimulation(GO:0031295) |
| 37.5 | 187.3 | GO:0002399 | MHC class II protein complex assembly(GO:0002399) |
| 0.9 | 95.9 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 14.1 | 70.6 | GO:0002906 | mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906) |
| 6.1 | 24.3 | GO:0046967 | cytosol to ER transport(GO:0046967) |
| 1.5 | 21.0 | GO:0046007 | negative regulation of activated T cell proliferation(GO:0046007) |
| 5.8 | 17.5 | GO:0002581 | negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) |
| 0.3 | 16.6 | GO:0043171 | peptide catabolic process(GO:0043171) |
| 0.1 | 13.5 | GO:0002456 | T cell mediated immunity(GO:0002456) |
| 0.8 | 13.0 | GO:0075522 | IRES-dependent viral translational initiation(GO:0075522) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 23.6 | 496.0 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 13.3 | 106.4 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.0 | 51.6 | GO:0016021 | integral component of membrane(GO:0016021) |
| 4.1 | 24.3 | GO:0042825 | TAP complex(GO:0042825) |
| 0.1 | 16.6 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 1.4 | 13.0 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
| 1.9 | 9.7 | GO:0031905 | early endosome lumen(GO:0031905) |
| 0.0 | 7.2 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.3 | 6.6 | GO:0042627 | chylomicron(GO:0042627) |
| 0.2 | 6.0 | GO:0090545 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.1 | 242.2 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 4.2 | 110.3 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
| 3.5 | 106.4 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 7.5 | 97.2 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 14.1 | 70.6 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 2.8 | 16.6 | GO:0008240 | tripeptidyl-peptidase activity(GO:0008240) |
| 0.3 | 13.0 | GO:0031369 | translation initiation factor binding(GO:0031369) |
| 0.0 | 9.4 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 1.4 | 7.2 | GO:0017159 | pantetheine hydrolase activity(GO:0017159) |
| 0.8 | 6.6 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 77.0 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 24.3 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 9.7 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.1 | 6.0 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.1 | 4.1 | PID MYC PATHWAY | C-MYC pathway |
| 0.1 | 3.9 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.0 | 3.1 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.5 | 217.9 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 1.5 | 198.4 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 1.3 | 95.9 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 1.6 | 24.3 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.2 | 16.6 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.2 | 13.0 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 2.4 | 9.7 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.3 | 4.1 | REACTOME REGULATION OF APOPTOSIS | Genes involved in Regulation of Apoptosis |
| 0.3 | 3.9 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.0 | 3.1 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |