Project
GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for RFX7_RFX4_RFX1
Z-value: 1.28
Motif logo
Transcription factors associated with RFX7_RFX4_RFX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RFX1 | hg19_v2_chr19_-_14117074_14117141 | 0.35 | 1.0e-07 | Click! |
| RFX7 | hg19_v2_chr15_-_56535464_56535521 | 0.25 | 2.3e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RFX7_RFX4_RFX1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 50.8 | 203.2 | GO:0090299 | fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of neural crest formation(GO:0090299) negative regulation of neural crest formation(GO:0090301) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313) negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314) |
| 2.4 | 109.7 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
| 12.0 | 84.2 | GO:0060294 | cilium movement involved in cell motility(GO:0060294) |
| 3.1 | 55.6 | GO:0019614 | catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424) |
| 1.1 | 52.5 | GO:0007019 | microtubule depolymerization(GO:0007019) |
| 7.2 | 50.7 | GO:0001539 | cilium or flagellum-dependent cell motility(GO:0001539) |
| 4.1 | 49.0 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
| 1.7 | 48.9 | GO:0006884 | cell volume homeostasis(GO:0006884) |
| 9.8 | 48.8 | GO:0070829 | response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829) |
| 8.1 | 40.4 | GO:0035617 | stress granule disassembly(GO:0035617) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 191.8 | GO:0042995 | cell projection(GO:0042995) |
| 1.8 | 140.5 | GO:0036126 | sperm flagellum(GO:0036126) |
| 0.2 | 102.4 | GO:0010008 | endosome membrane(GO:0010008) |
| 7.1 | 99.7 | GO:0005858 | axonemal dynein complex(GO:0005858) |
| 0.2 | 77.8 | GO:0005815 | microtubule organizing center(GO:0005815) |
| 0.4 | 69.6 | GO:0030426 | growth cone(GO:0030426) |
| 1.2 | 65.5 | GO:0016235 | aggresome(GO:0016235) |
| 2.9 | 63.5 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.2 | 57.6 | GO:0045202 | synapse(GO:0045202) |
| 3.8 | 45.3 | GO:0033010 | paranodal junction(GO:0033010) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.7 | 91.9 | GO:0045503 | dynein light chain binding(GO:0045503) |
| 1.1 | 80.5 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 0.3 | 64.9 | GO:0008017 | microtubule binding(GO:0008017) |
| 7.7 | 61.3 | GO:0004565 | beta-galactosidase activity(GO:0004565) |
| 7.9 | 55.6 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
| 2.2 | 48.9 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 9.8 | 48.8 | GO:0004489 | methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489) |
| 4.6 | 36.8 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 1.1 | 34.3 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 2.6 | 33.8 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 40.2 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
| 0.8 | 32.7 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 1.0 | 25.2 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.7 | 25.0 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.4 | 23.2 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.3 | 21.4 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.3 | 20.2 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.2 | 19.9 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.3 | 19.8 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.3 | 19.0 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 70.1 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 1.4 | 39.4 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 1.4 | 32.7 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.4 | 29.7 | REACTOME NUCLEAR SIGNALING BY ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 1.6 | 25.3 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 1.2 | 24.9 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.4 | 23.9 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.7 | 16.6 | REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 0.0 | 15.6 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.6 | 14.8 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |