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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for RHOXF1
Z-value: 0.67
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Transcription factors associated with RHOXF1
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_9268707 Show fit | 34.37 |
ENST00000318602.7
|
alpha-2-macroglobulin |
|
| chr11_-_5248294 Show fit | 26.24 |
ENST00000335295.4
|
hemoglobin, beta |
|
| chr12_-_91546926 Show fit | 22.98 |
ENST00000550758.1
|
decorin |
|
| chr12_-_91539918 Show fit | 20.03 |
ENST00000548218.1
|
decorin |
|
| chr16_+_222846 Show fit | 18.44 |
ENST00000251595.6
ENST00000397806.1 |
hemoglobin, alpha 2 |
|
| chr18_+_21693306 Show fit | 16.52 |
ENST00000540918.2
|
tetratricopeptide repeat domain 39C |
|
| chr16_+_226658 Show fit | 16.26 |
ENST00000320868.5
ENST00000397797.1 |
hemoglobin, alpha 1 |
|
| chr3_+_186383741 Show fit | 15.04 |
ENST00000232003.4
|
histidine-rich glycoprotein |
|
| chr16_-_20556492 Show fit | 14.88 |
ENST00000568098.1
|
acyl-CoA synthetase medium-chain family member 2B |
|
| chr8_-_27462822 Show fit | 14.63 |
ENST00000522098.1
|
clusterin |
Network of associatons between targets according to the STRING database.
First level regulatory network of RHOXF1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.8 | 58.1 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.4 | 41.1 | GO:0070268 | cornification(GO:0070268) |
| 5.9 | 35.2 | GO:1902847 | macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 2.7 | 35.2 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 1.3 | 34.7 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 8.6 | 34.2 | GO:0010900 | negative regulation of phosphatidylcholine catabolic process(GO:0010900) |
| 0.2 | 32.1 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.7 | 30.8 | GO:0003254 | regulation of membrane depolarization(GO:0003254) |
| 1.2 | 28.3 | GO:0030502 | negative regulation of bone mineralization(GO:0030502) |
| 0.8 | 26.6 | GO:0022400 | regulation of rhodopsin mediated signaling pathway(GO:0022400) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 124.5 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 114.1 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 106.8 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
| 2.8 | 45.4 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 2.7 | 45.4 | GO:0042627 | chylomicron(GO:0042627) |
| 0.2 | 44.3 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 3.1 | 43.0 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 10.6 | 42.5 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.3 | 35.0 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.2 | 25.7 | GO:0030018 | Z disc(GO:0030018) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 57.8 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.4 | 44.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 5.6 | 44.4 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 0.2 | 42.5 | GO:0044325 | ion channel binding(GO:0044325) |
| 1.7 | 34.6 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 11.5 | 34.4 | GO:0019959 | interleukin-8 binding(GO:0019959) |
| 5.7 | 34.1 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 1.1 | 27.9 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 4.1 | 24.3 | GO:0003873 | 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331) |
| 0.8 | 22.4 | GO:0005523 | tropomyosin binding(GO:0005523) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 150.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 59.5 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.9 | 52.5 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 26.9 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.3 | 18.8 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.4 | 18.4 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.2 | 17.9 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.3 | 16.3 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.4 | 16.2 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.3 | 16.2 | PID AURORA A PATHWAY | Aurora A signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 57.7 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 2.1 | 42.7 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.7 | 39.3 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.2 | 34.5 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.4 | 28.4 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 1.1 | 24.2 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.8 | 23.2 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.2 | 22.3 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.5 | 21.7 | REACTOME AMINE LIGAND BINDING RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.5 | 20.8 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |