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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for RORC

Z-value: 0.26

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Transcription factors associated with RORC

Gene Symbol Gene ID Gene Info
RORC
ENSG00000143365.12 RAR related orphan receptor C

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RORChg19_v2_chr1_-_151804222_151804228,
hg19_v2_chr1_-_151804314_151804348,
hg19_v2_chr1_-_151798546_151798590		-0.027.4e-01Click!

Activity profile of RORC motif

Sorted Z-values of RORC motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_7167980 5.55 ENST00000360817.5
ENST00000402681.3
C1S
complement component 1, s subcomponent
chr1_-_153522562 5.51 ENST00000368714.1
S100A4
S100 calcium binding protein A4
chr19_-_10450287 3.16 ENST00000589261.1
ENST00000590569.1
ENST00000589580.1
ENST00000589249.1
ICAM3
intercellular adhesion molecule 3
chr9_-_110251836 3.12 ENST00000374672.4
KLF4
Kruppel-like factor 4 (gut)
chr14_-_23451467 2.23 ENST00000555074.1
ENST00000361265.4
RP11-298I3.5
AJUBA
RP11-298I3.5
ajuba LIM protein
chr11_-_19223523 1.94 ENST00000265968.3
CSRP3
cysteine and glycine-rich protein 3 (cardiac LIM protein)
chr11_-_64527425 1.85 ENST00000377432.3
PYGM
phosphorylase, glycogen, muscle
chr12_+_93963590 1.81 ENST00000340600.2
SOCS2
suppressor of cytokine signaling 2
chr12_+_93964158 1.70 ENST00000549206.1
SOCS2
suppressor of cytokine signaling 2
chr1_+_104198377 1.62 ENST00000370083.4
AMY1A
amylase, alpha 1A (salivary)
chr4_+_140586922 1.45 ENST00000265498.1
ENST00000506797.1
MGST2
microsomal glutathione S-transferase 2
chr1_-_211752073 1.43 ENST00000367001.4
SLC30A1
solute carrier family 30 (zinc transporter), member 1
chr1_+_26869597 1.37 ENST00000530003.1
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr10_-_121296045 1.36 ENST00000392865.1
RGS10
regulator of G-protein signaling 10
chr2_+_119699864 1.36 ENST00000541757.1
ENST00000412481.1
MARCO
macrophage receptor with collagenous structure
chr2_+_119699742 1.33 ENST00000327097.4
MARCO
macrophage receptor with collagenous structure
chr2_+_160590469 1.26 ENST00000409591.1
MARCH7
membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
chr17_-_46623441 1.15 ENST00000330070.4
HOXB2
homeobox B2
chr16_-_1821496 1.05 ENST00000564628.1
ENST00000563498.1
NME3
NME/NM23 nucleoside diphosphate kinase 3
chr3_-_65583561 1.01 ENST00000460329.2
MAGI1
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr2_+_162016804 0.95 ENST00000392749.2
ENST00000440506.1
TANK
TRAF family member-associated NFKB activator
chr2_+_162016916 0.95 ENST00000405852.1
TANK
TRAF family member-associated NFKB activator
chr6_+_43738444 0.86 ENST00000324450.6
ENST00000417285.2
ENST00000413642.3
ENST00000372055.4
ENST00000482630.2
ENST00000425836.2
ENST00000372064.4
ENST00000372077.4
ENST00000519767.1
VEGFA
vascular endothelial growth factor A
chr11_+_13299186 0.84 ENST00000527998.1
ENST00000396441.3
ENST00000533520.1
ENST00000529825.1
ENST00000389707.4
ENST00000401424.1
ENST00000529388.1
ENST00000530357.1
ENST00000403290.1
ENST00000361003.4
ENST00000389708.3
ENST00000403510.3
ENST00000482049.1
ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr16_+_1832902 0.83 ENST00000262302.9
ENST00000563136.1
ENST00000565987.1
ENST00000543305.1
ENST00000568287.1
ENST00000565134.1
NUBP2
nucleotide binding protein 2
chr1_-_149908710 0.82 ENST00000439741.2
ENST00000361405.6
ENST00000406732.3
MTMR11
myotubularin related protein 11
chr3_+_185304059 0.66 ENST00000427465.2
SENP2
SUMO1/sentrin/SMT3 specific peptidase 2
chr16_-_67514982 0.64 ENST00000565835.1
ENST00000540149.1
ENST00000290949.3
ATP6V0D1
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
chr12_+_56414795 0.62 ENST00000431367.2
IKZF4
IKAROS family zinc finger 4 (Eos)
chr1_+_236849754 0.61 ENST00000542672.1
ENST00000366578.4
ACTN2
actinin, alpha 2
chr20_-_33732952 0.60 ENST00000541621.1
EDEM2
ER degradation enhancer, mannosidase alpha-like 2
chr19_-_49140692 0.58 ENST00000222122.5
DBP
D site of albumin promoter (albumin D-box) binding protein
chr10_-_105845674 0.57 ENST00000353479.5
ENST00000369733.3
COL17A1
collagen, type XVII, alpha 1
chr7_+_20686946 0.56 ENST00000443026.2
ENST00000406935.1
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr10_+_102295616 0.56 ENST00000299163.6
HIF1AN
hypoxia inducible factor 1, alpha subunit inhibitor
chr5_+_177557997 0.54 ENST00000313386.4
ENST00000515098.1
ENST00000542098.1
ENST00000502814.1
ENST00000507457.1
ENST00000508647.1
RMND5B
required for meiotic nuclear division 5 homolog B (S. cerevisiae)
chr3_+_185303962 0.53 ENST00000296257.5
SENP2
SUMO1/sentrin/SMT3 specific peptidase 2
chr1_-_185286461 0.51 ENST00000367498.3
IVNS1ABP
influenza virus NS1A binding protein
chr8_-_95449155 0.47 ENST00000481490.2
FSBP
fibrinogen silencer binding protein
chr1_+_114447763 0.46 ENST00000369563.3
DCLRE1B
DNA cross-link repair 1B
chr20_-_44007014 0.42 ENST00000372726.3
ENST00000537995.1
TP53TG5
TP53 target 5
chr7_-_128415844 0.40 ENST00000249389.2
OPN1SW
opsin 1 (cone pigments), short-wave-sensitive
chr2_+_162016827 0.37 ENST00000429217.1
ENST00000406287.1
ENST00000402568.1
TANK
TRAF family member-associated NFKB activator
chr17_-_3030875 0.34 ENST00000328890.2
OR1G1
olfactory receptor, family 1, subfamily G, member 1
chr4_-_170948361 0.32 ENST00000393702.3
MFAP3L
microfibrillar-associated protein 3-like
chr19_+_1269324 0.28 ENST00000589710.1
ENST00000588230.1
ENST00000413636.2
ENST00000586472.1
ENST00000589686.1
ENST00000444172.2
ENST00000587323.1
ENST00000320936.5
ENST00000587896.1
ENST00000589235.1
ENST00000591659.1
CIRBP
cold inducible RNA binding protein
chr2_-_30144432 0.26 ENST00000389048.3
ALK
anaplastic lymphoma receptor tyrosine kinase
chr7_+_97736197 0.20 ENST00000297293.5
LMTK2
lemur tyrosine kinase 2
chrX_-_110655391 0.16 ENST00000356915.2
ENST00000356220.3
DCX
doublecortin
chrX_-_49089771 0.16 ENST00000376251.1
ENST00000323022.5
ENST00000376265.2
CACNA1F
calcium channel, voltage-dependent, L type, alpha 1F subunit
chr1_-_217311090 0.15 ENST00000493603.1
ENST00000366940.2
ESRRG
estrogen-related receptor gamma
chr3_-_184095923 0.14 ENST00000445696.2
ENST00000204615.7
THPO
thrombopoietin
chr4_+_110749143 0.12 ENST00000317735.4
RRH
retinal pigment epithelium-derived rhodopsin homolog
chr14_+_21785693 0.10 ENST00000382933.4
ENST00000557351.1
RPGRIP1
retinitis pigmentosa GTPase regulator interacting protein 1
chr12_-_82152444 0.08 ENST00000549325.1
ENST00000550584.2
PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr18_-_23671139 0.05 ENST00000579061.1
ENST00000542420.2
SS18
synovial sarcoma translocation, chromosome 18
chr3_+_45986511 0.03 ENST00000458629.1
ENST00000457814.1
CXCR6
chemokine (C-X-C motif) receptor 6
chr19_+_55385731 0.03 ENST00000469767.1
ENST00000355524.3
ENST00000391725.3
ENST00000345937.4
ENST00000353758.4
ENST00000359272.4
ENST00000391723.3
ENST00000391724.3
FCAR
Fc fragment of IgA, receptor for
chr19_-_49140609 0.03 ENST00000601104.1
DBP
D site of albumin promoter (albumin D-box) binding protein
chr1_+_159796534 0.03 ENST00000289707.5
SLAMF8
SLAM family member 8

Network of associatons between targets according to the STRING database.

First level regulatory network of RORC

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.1 GO:0071409 negative regulation of muscle hyperplasia(GO:0014740) cellular response to cycloheximide(GO:0071409)
0.5 1.9 GO:0035995 detection of muscle stretch(GO:0035995)
0.4 5.6 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.4 1.1 GO:0021569 rhombomere 3 development(GO:0021569)
0.4 2.3 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.3 2.2 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.3 1.4 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.3 0.9 GO:1903570 regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
0.2 0.8 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
0.2 0.6 GO:0036511 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.2 1.4 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.2 3.5 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.2 0.6 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.2 0.5 GO:0031627 telomeric loop formation(GO:0031627)
0.2 0.6 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.1 1.2 GO:0016926 protein desumoylation(GO:0016926)
0.1 0.6 GO:0048749 compound eye development(GO:0048749)
0.1 1.1 GO:0006228 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.1 1.4 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.1 1.5 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.1 0.3 GO:0036269 swimming behavior(GO:0036269)
0.1 2.7 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.1 1.3 GO:0002643 regulation of tolerance induction(GO:0002643)
0.1 1.9 GO:0005980 glycogen catabolic process(GO:0005980)
0.0 0.1 GO:0038163 thrombopoietin-mediated signaling pathway(GO:0038163)
0.0 0.8 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.5 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.6 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.0 5.5 GO:0001837 epithelial to mesenchymal transition(GO:0001837)
0.0 0.6 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 3.2 GO:0002223 stimulatory C-type lectin receptor signaling pathway(GO:0002223)
0.0 0.3 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.2 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0034657 GID complex(GO:0034657)
0.1 0.8 GO:0033391 chromatoid body(GO:0033391)
0.1 3.1 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.8 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.6 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 3.3 GO:0005581 collagen trimer(GO:0005581)
0.0 5.6 GO:0072562 blood microparticle(GO:0072562)
0.0 0.6 GO:0031143 pseudopodium(GO:0031143)
0.0 0.6 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 2.2 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.4 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 1.2 GO:0030315 T-tubule(GO:0030315)
0.0 1.9 GO:0030018 Z disc(GO:0030018)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.1 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.6 3.5 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.5 1.5 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.5 1.9 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.4 1.6 GO:0016160 amylase activity(GO:0016160)
0.4 2.3 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.3 0.6 GO:0051373 FATZ binding(GO:0051373)
0.3 1.2 GO:0070137 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.3 5.5 GO:0050786 RAGE receptor binding(GO:0050786)
0.2 1.9 GO:0031433 telethonin binding(GO:0031433)
0.2 2.2 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 0.9 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.1 0.6 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 2.7 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.1 1.4 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 0.6 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.1 0.6 GO:0071532 ankyrin repeat binding(GO:0071532)
0.1 0.8 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.1 0.5 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.1 0.6 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.1 1.1 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.5 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 1.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.3 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.0 0.3 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 1.4 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 1.0 GO:0051393 alpha-actinin binding(GO:0051393)
0.0 0.2 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 5.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 3.2 GO:0005178 integrin binding(GO:0005178)
0.0 0.8 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.0 GO:0019862 IgA binding(GO:0019862)
0.0 0.6 GO:0043425 bHLH transcription factor binding(GO:0043425)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 3.2 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.9 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 3.5 PID IL2 1PATHWAY IL2-mediated signaling events
0.0 0.8 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 1.2 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 3.1 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.6 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 5.6 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.6 NABA COLLAGENS Genes encoding collagen proteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 5.6 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.2 3.1 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 1.6 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 1.4 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.1 3.5 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.1 1.9 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 2.3 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 2.0 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS Genes involved in CREB phosphorylation through the activation of Ras
0.0 0.5 REACTOME OPSINS Genes involved in Opsins
0.0 0.9 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 1.5 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.6 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 3.2 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.8 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.6 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.6 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 0.6 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.6 REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen