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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for RREB1
Z-value: 0.01
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Transcription factors associated with RREB1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RREB1 | hg19_v2_chr6_+_7108210_7108264 | 0.17 | 1.1e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RREB1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 24.2 | GO:0006228 | UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051) |
| 0.3 | 6.5 | GO:1902236 | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236) |
| 1.0 | 6.2 | GO:0030421 | defecation(GO:0030421) |
| 0.3 | 5.4 | GO:0033234 | negative regulation of protein sumoylation(GO:0033234) |
| 1.3 | 5.1 | GO:0071492 | cellular response to UV-A(GO:0071492) |
| 0.3 | 4.7 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 1.5 | 4.6 | GO:2000276 | negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) negative regulation of oxidative phosphorylation uncoupler activity(GO:2000276) |
| 0.4 | 4.6 | GO:0035986 | senescence-associated heterochromatin focus assembly(GO:0035986) |
| 1.5 | 4.4 | GO:0002894 | positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type II hypersensitivity(GO:0002894) |
| 0.6 | 4.4 | GO:2000546 | positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 26.5 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.1 | 11.3 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 10.4 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.0 | 6.9 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 6.8 | GO:0042641 | actomyosin(GO:0042641) |
| 0.3 | 6.1 | GO:0043220 | Schmidt-Lanterman incisure(GO:0043220) |
| 0.4 | 4.6 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.1 | 4.3 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.1 | 4.0 | GO:0032420 | stereocilium(GO:0032420) |
| 0.0 | 4.0 | GO:0005903 | brush border(GO:0005903) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 24.2 | GO:1901612 | cardiolipin binding(GO:1901612) |
| 0.0 | 13.9 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 9.0 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.6 | 7.3 | GO:0089720 | caspase binding(GO:0089720) |
| 0.1 | 7.1 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
| 0.0 | 6.8 | GO:0008201 | heparin binding(GO:0008201) |
| 0.0 | 6.6 | GO:0008022 | protein C-terminus binding(GO:0008022) |
| 0.0 | 6.6 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.0 | 6.2 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.2 | 5.5 | GO:0071837 | HMG box domain binding(GO:0071837) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 8.0 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 7.2 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 7.0 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 4.9 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 4.6 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 4.5 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.2 | 4.4 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.1 | 4.0 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.2 | 3.9 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.1 | 3.9 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 24.2 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.2 | 5.2 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.4 | 4.7 | REACTOME SIGNALING BY FGFR3 MUTANTS | Genes involved in Signaling by FGFR3 mutants |
| 0.2 | 4.6 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.2 | 4.4 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.1 | 4.2 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.1 | 3.6 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.2 | 3.5 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.1 | 3.2 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.1 | 2.8 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |