ISMARA results: RXRA_NR2F6

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for RXRA_NR2F6_NR2C2

Z-value: 0.70

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Transcription factors associated with RXRA_NR2F6_NR2C2

Gene Symbol	Gene ID	Gene Info
RXRA Ensembl NCBI GeneCards UniProt NextProt	ENSG00000186350.8	retinoid X receptor alpha
NR2F6 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000160113.5	nuclear receptor subfamily 2 group F member 6
NR2C2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000177463.11	nuclear receptor subfamily 2 group C member 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NR2F6	hg19_v2_chr19_-_17356697_17356762	0.41	2.1e-10	Click!
NR2C2	hg19_v2_chr3_+_14989076_14989113, hg19_v2_chr3_+_14989186_14989236	-0.37	1.7e-08	Click!
RXRA	hg19_v2_chr9_+_137218362_137218426, hg19_v2_chr9_+_137298396_137298431	-0.10	1.4e-01	Click!

Activity profile of RXRA_NR2F6_NR2C2 motif

Sorted Z-values of RXRA_NR2F6_NR2C2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_+_132413739 Show fit	30.51	ENST00000443358.2	PUS1 Ensembl NCBI GeneCards UniProt NextProt Show fit	pseudouridylate synthase 1
chr12_+_132413798 Show fit	25.18	ENST00000440818.2 ENST00000542167.2 ENST00000538037.1 ENST00000456665.2	PUS1 Ensembl NCBI GeneCards UniProt NextProt Show fit	pseudouridylate synthase 1
chr12_+_132413765 Show fit	22.84	ENST00000376649.3 ENST00000322060.5	PUS1 Ensembl NCBI GeneCards UniProt NextProt Show fit	pseudouridylate synthase 1
chr8_-_80942061 Show fit	22.47	ENST00000519386.1	MRPS28 Ensembl NCBI GeneCards UniProt NextProt Show fit	mitochondrial ribosomal protein S28
chr19_+_50919056 Show fit	22.21	ENST00000599632.1	CTD-2545M3.6 Ensembl NCBI GeneCards UniProt NextProt Show fit	CTD-2545M3.6
chr6_+_24775153 Show fit	19.93	ENST00000356509.3 ENST00000230056.3	GMNN Ensembl NCBI GeneCards UniProt NextProt Show fit	geminin, DNA replication inhibitor
chr12_+_96252706 Show fit	19.53	ENST00000266735.5 ENST00000553192.1 ENST00000552085.1	SNRPF Ensembl NCBI GeneCards UniProt NextProt Show fit	small nuclear ribonucleoprotein polypeptide F
chr3_-_119396193 Show fit	19.40	ENST00000484810.1 ENST00000497116.1 ENST00000261070.2	COX17 Ensembl NCBI GeneCards UniProt NextProt Show fit	COX17 cytochrome c oxidase copper chaperone
chr8_-_80942139 Show fit	19.32	ENST00000521434.1 ENST00000519120.1 ENST00000520946.1	MRPS28 Ensembl NCBI GeneCards UniProt NextProt Show fit	mitochondrial ribosomal protein S28
chr7_-_72936531 Show fit	17.17	ENST00000339594.4	BAZ1B Ensembl NCBI GeneCards UniProt NextProt Show fit	bromodomain adjacent to zinc finger domain, 1B

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of RXRA_NR2F6_NR2C2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	88.8	GO:0070126	mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
26.2	78.5	GO:0070902	mitochondrial tRNA pseudouridine synthesis(GO:0070902)
0.8	59.1	GO:0033108	mitochondrial respiratory chain complex assembly(GO:0033108)
2.0	35.3	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
2.0	30.5	GO:0030150	protein import into mitochondrial matrix(GO:0030150)
2.9	28.8	GO:1900029	positive regulation of ruffle assembly(GO:1900029)
0.5	24.0	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.3	20.8	GO:0042273	ribosomal large subunit biogenesis(GO:0042273)
3.3	19.9	GO:0071163	DNA replication preinitiation complex assembly(GO:0071163)
0.6	19.5	GO:0008334	histone mRNA metabolic process(GO:0008334)

Showing 1 to 10 of 212 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	145.0	GO:0005759	mitochondrial matrix(GO:0005759)
2.2	59.2	GO:0005763	organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.2	32.0	GO:0072562	blood microparticle(GO:0072562)
0.8	29.6	GO:0000315	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.6	29.5	GO:0031430	M band(GO:0031430)
0.1	29.0	GO:0005743	mitochondrial inner membrane(GO:0005743)
6.5	25.8	GO:0001405	presequence translocase-associated import motor(GO:0001405)
0.4	25.0	GO:0030964	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.4	24.0	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
4.5	22.7	GO:0045272	plasma membrane respiratory chain complex I(GO:0045272)

Showing 1 to 10 of 107 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
26.2	78.5	GO:0004730	pseudouridylate synthase activity(GO:0004730)
3.6	42.6	GO:0000774	adenyl-nucleotide exchange factor activity(GO:0000774)
0.0	36.6	GO:0003723	RNA binding(GO:0003723)
3.3	35.8	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.2	32.7	GO:0051082	unfolded protein binding(GO:0051082)
0.1	26.3	GO:0003735	structural constituent of ribosome(GO:0003735)
0.5	25.0	GO:0008137	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
3.4	24.0	GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
2.3	22.9	GO:0036042	long-chain fatty acyl-CoA binding(GO:0036042)
1.2	22.3	GO:0051537	2 iron, 2 sulfur cluster binding(GO:0051537)

Showing 1 to 10 of 153 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	41.6	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.4	31.7	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.4	28.2	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.3	17.8	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.3	15.8	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.3	14.6	PID IL1 PATHWAY	IL1-mediated signaling events
0.3	12.2	PID MYC PATHWAY	C-MYC pathway
0.2	10.6	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.3	9.3	SIG CHEMOTAXIS	Genes related to chemotaxis
0.1	6.0	PID CMYB PATHWAY	C-MYB transcription factor network

Showing 1 to 10 of 35 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.5	95.4	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
1.0	51.1	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.4	36.6	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.4	29.4	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.4	24.0	REACTOME G1 PHASE	Genes involved in G1 Phase
1.2	23.5	REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX	Genes involved in Association of licensing factors with the pre-replicative complex
1.2	19.5	REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.4	19.0	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.5	18.7	REACTOME PYRIMIDINE METABOLISM	Genes involved in Pyrimidine metabolism
0.8	17.5	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling

Showing 1 to 10 of 77 entries

Results for RXRA_NR2F6_NR2C2

Z-value: 0.70

Motif logo

Transcription factors associated with RXRA_NR2F6_NR2C2

Activity-expression correlation:

Activity profile of RXRA_NR2F6_NR2C2 motif

Sorted Z-values of RXRA_NR2F6_NR2C2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of RXRA_NR2F6_NR2C2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: