ISMARA results: RXRG

Project

GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

Navigation

Downloads

Results for RXRG

Z-value: 0.33

Motif logo

Transcription factors associated with RXRG

Gene Symbol	Gene ID	Gene Info
RXRG Ensembl NCBI GeneCards UniProt NextProt	ENSG00000143171.8	retinoid X receptor gamma

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
RXRG	hg19_v2_chr1_-_165414414_165414433	0.18	8.9e-03	Click!

Activity profile of RXRG motif

Sorted Z-values of RXRG motif

Top targets:

Search:

Show entries

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr17_-_27278304 Show fit	17.86	ENST00000577226.1	PHF12 Ensembl NCBI GeneCards UniProt NextProt Show fit	PHD finger protein 12
chr16_+_222846 Show fit	12.78	ENST00000251595.6 ENST00000397806.1	HBA2 Ensembl NCBI GeneCards UniProt NextProt Show fit	hemoglobin, alpha 2
chr12_-_54982420 Show fit	9.37	ENST00000257905.8	PPP1R1A Ensembl NCBI GeneCards UniProt NextProt Show fit	protein phosphatase 1, regulatory (inhibitor) subunit 1A
chr8_-_70983506 Show fit	9.15	ENST00000276594.2	PRDM14 Ensembl NCBI GeneCards UniProt NextProt Show fit	PR domain containing 14
chr17_+_7211280 Show fit	9.11	ENST00000419711.2 ENST00000571955.1 ENST00000573714.1	EIF5A Ensembl NCBI GeneCards UniProt NextProt Show fit	eukaryotic translation initiation factor 5A
chr9_+_139873264 Show fit	8.52	ENST00000446677.1	PTGDS Ensembl NCBI GeneCards UniProt NextProt Show fit	prostaglandin D2 synthase 21kDa (brain)
chr12_-_54982300 Show fit	8.40	ENST00000547431.1	PPP1R1A Ensembl NCBI GeneCards UniProt NextProt Show fit	protein phosphatase 1, regulatory (inhibitor) subunit 1A
chr19_-_1174226 Show fit	8.38	ENST00000587024.1 ENST00000361757.3	SBNO2 Ensembl NCBI GeneCards UniProt NextProt Show fit	strawberry notch homolog 2 (Drosophila)
chr11_+_125774362 Show fit	7.45	ENST00000530414.1 ENST00000530129.2	DDX25 Ensembl NCBI GeneCards UniProt NextProt Show fit	DEAD (Asp-Glu-Ala-Asp) box helicase 25
chr20_-_44539538 Show fit	7.43	ENST00000372420.1	PLTP Ensembl NCBI GeneCards UniProt NextProt Show fit	phospholipid transfer protein

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of RXRG

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	18.1	GO:0005977	glycogen metabolic process(GO:0005977)
2.1	16.6	GO:0006452	translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
2.5	15.0	GO:0010732	protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
4.5	13.6	GO:2000777	positive regulation of oocyte maturation(GO:1900195) negative regulation of NLRP3 inflammasome complex assembly(GO:1900226) positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia(GO:2000777)
0.2	12.0	GO:0043268	positive regulation of potassium ion transport(GO:0043268)
3.1	9.2	GO:0030718	germ-line stem cell population maintenance(GO:0030718)
1.0	9.1	GO:0016080	synaptic vesicle targeting(GO:0016080)
0.5	9.0	GO:0019371	cyclooxygenase pathway(GO:0019371)
1.4	8.4	GO:0071105	response to interleukin-11(GO:0071105)
2.7	8.1	GO:0071557	histone H3-K27 demethylation(GO:0071557)

Showing 1 to 10 of 321 entries

Gene overrepresentation in cellular_component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	48.8	GO:0005615	extracellular space(GO:0005615)
0.8	19.0	GO:0016580	Sin3 complex(GO:0016580)
0.8	15.0	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
0.2	14.3	GO:0043195	terminal bouton(GO:0043195)
1.5	13.6	GO:0072687	meiotic spindle(GO:0072687)
0.6	12.1	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.2	11.3	GO:0031594	neuromuscular junction(GO:0031594)
0.1	10.0	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.8	9.8	GO:0005642	annulate lamellae(GO:0005642)
0.1	9.1	GO:0005604	basement membrane(GO:0005604)

Showing 1 to 10 of 146 entries

Gene overrepresentation in molecular_function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	25.3	GO:0005525	GTP binding(GO:0005525)
0.1	21.4	GO:0044325	ion channel binding(GO:0044325)
0.4	17.9	GO:0001106	RNA polymerase II transcription corepressor activity(GO:0001106)
2.2	17.8	GO:0004865	protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1	14.4	GO:0005179	hormone activity(GO:0005179)
0.7	13.8	GO:0017070	U6 snRNA binding(GO:0017070)
4.5	13.6	GO:0034739	histone deacetylase activity (H4-K16 specific)(GO:0034739)
0.1	11.4	GO:0003707	steroid hormone receptor activity(GO:0003707)
0.0	10.7	GO:0008289	lipid binding(GO:0008289)
0.2	10.4	GO:0017080	sodium channel regulator activity(GO:0017080)

Showing 1 to 10 of 220 entries

Gene overrepresentation in C2:CP category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	19.7	ST JNK MAPK PATHWAY	JNK MAPK Pathway
0.3	17.7	PID VEGFR1 PATHWAY	VEGFR1 specific signals
0.1	16.4	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.4	14.8	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.0	10.0	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2	9.8	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.4	9.3	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.0	9.0	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.2	8.7	NABA COLLAGENS	Genes encoding collagen proteins
0.3	7.9	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.

Showing 1 to 10 of 61 entries

Gene overrepresentation in C2:CP:REACTOME category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	16.6	REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION	Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.3	13.8	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.4	11.6	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1	9.8	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.2	8.6	REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1	Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.2	8.0	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1	7.9	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0	7.6	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.3	7.4	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.1	7.4	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions

Showing 1 to 10 of 91 entries

Results for RXRG

Z-value: 0.33

Motif logo

Transcription factors associated with RXRG

Activity-expression correlation:

Activity profile of RXRG motif

Sorted Z-values of RXRG motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of RXRG

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: