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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for SHOX
Z-value: 0.33
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Transcription factors associated with SHOX
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_117748138 Show fit | 23.84 |
ENST00000527717.1
|
FXYD domain containing ion transport regulator 6 |
|
| chr11_-_117747607 Show fit | 23.45 |
ENST00000540359.1
ENST00000539526.1 |
FXYD domain containing ion transport regulator 6 |
|
| chrX_-_13835147 Show fit | 23.17 |
ENST00000493677.1
ENST00000355135.2 |
glycoprotein M6B |
|
| chr11_-_117747434 Show fit | 23.07 |
ENST00000529335.2
ENST00000530956.1 ENST00000260282.4 |
FXYD domain containing ion transport regulator 6 |
|
| chr11_-_111794446 Show fit | 14.61 |
ENST00000527950.1
|
crystallin, alpha B |
|
| chr12_-_16761007 Show fit | 13.03 |
ENST00000354662.1
ENST00000441439.2 |
LIM domain only 3 (rhombotin-like 2) |
|
| chr3_+_111718036 Show fit | 9.34 |
ENST00000455401.2
|
transgelin 3 |
|
| chr3_+_111718173 Show fit | 9.33 |
ENST00000494932.1
|
transgelin 3 |
|
| chr13_-_36429763 Show fit | 8.92 |
ENST00000379893.1
|
doublecortin-like kinase 1 |
|
| chr3_+_111717600 Show fit | 8.80 |
ENST00000273368.4
|
transgelin 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of SHOX
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 65.1 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 4.3 | 25.9 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
| 2.3 | 23.2 | GO:0051581 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.8 | 17.3 | GO:0001829 | trophectodermal cell differentiation(GO:0001829) |
| 0.8 | 14.6 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.0 | 11.5 | GO:0051056 | regulation of small GTPase mediated signal transduction(GO:0051056) |
| 0.1 | 9.7 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.5 | 9.0 | GO:0009756 | carbohydrate mediated signaling(GO:0009756) |
| 0.4 | 8.9 | GO:0021952 | central nervous system projection neuron axonogenesis(GO:0021952) |
| 0.8 | 8.4 | GO:0016198 | axon choice point recognition(GO:0016198) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 59.4 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
| 0.1 | 36.2 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.1 | 21.1 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.1 | 16.2 | GO:0045121 | membrane raft(GO:0045121) |
| 0.9 | 14.6 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.1 | 9.6 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.1 | 8.4 | GO:0044291 | cell-cell contact zone(GO:0044291) |
| 1.2 | 8.2 | GO:0032584 | growth cone membrane(GO:0032584) |
| 0.1 | 6.9 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.3 | 6.0 | GO:0031045 | dense core granule(GO:0031045) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 68.7 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.1 | 24.1 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 16.1 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.5 | 14.6 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.3 | 9.0 | GO:0038187 | signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187) |
| 0.1 | 8.8 | GO:0005057 | receptor signaling protein activity(GO:0005057) |
| 0.2 | 8.5 | GO:0070888 | E-box binding(GO:0070888) |
| 0.8 | 7.9 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) |
| 0.6 | 7.8 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.0 | 7.7 | GO:0005509 | calcium ion binding(GO:0005509) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 13.1 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.1 | 10.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 7.1 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.2 | 6.9 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.1 | 6.0 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 5.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 5.4 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.0 | 3.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 3.1 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.1 | 3.0 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.9 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.2 | 6.9 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 6.9 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 5.5 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 4.4 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.2 | 4.3 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.1 | 4.2 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.2 | 3.6 | REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS | Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis |
| 0.2 | 3.3 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.1 | 2.3 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |