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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for SIX1_SIX3_SIX2

Z-value: 0.57

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Transcription factors associated with SIX1_SIX3_SIX2

Gene Symbol Gene ID Gene Info
ENSG00000126778.7 SIX homeobox 1
ENSG00000138083.3 SIX homeobox 3
ENSG00000170577.7 SIX homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SIX3hg19_v2_chr2_+_45168875_451689160.724.2e-36Click!
SIX2hg19_v2_chr2_-_45236540_452365770.677.2e-30Click!
SIX1hg19_v2_chr14_-_61124977_611250370.372.1e-08Click!

Activity profile of SIX1_SIX3_SIX2 motif

Sorted Z-values of SIX1_SIX3_SIX2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_139025875 15.19 ENST00000297534.6
chromosome 7 open reading frame 55
chr3_+_52448539 10.99 ENST00000461861.1
PHD finger protein 7
chr11_+_70244510 8.80 ENST00000346329.3
ENST00000301843.8
ENST00000376561.3
cortactin
chr16_-_28550348 8.78 ENST00000324873.6
nuclear protein, transcriptional regulator, 1
chr21_+_27011584 8.44 ENST00000400532.1
ENST00000480456.1
ENST00000312957.5
junctional adhesion molecule 2
chr3_+_42850959 8.22 ENST00000442925.1
ENST00000422265.1
ENST00000497921.1
ENST00000426937.1
atypical chemokine receptor 2
KRAB box domain containing 1
chr1_-_13390765 7.99 ENST00000357367.2
PRAME family member 8
chr17_+_1665345 7.93 ENST00000576406.1
ENST00000571149.1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr3_+_38323785 7.87 ENST00000466887.1
ENST00000448498.1
solute carrier family 22, member 14
chr1_-_183387723 7.66 ENST00000287713.6
nicotinamide nucleotide adenylyltransferase 2
chr16_-_28550320 7.53 ENST00000395641.2
nuclear protein, transcriptional regulator, 1
chr21_+_27011899 7.47 ENST00000425221.2
junctional adhesion molecule 2
chr14_+_75761099 7.41 ENST00000561000.1
ENST00000558575.1
RP11-293M10.5
chr17_-_41466555 7.40 ENST00000586231.1
long intergenic non-protein coding RNA 910
chr11_-_58499434 7.09 ENST00000344743.3
ENST00000278400.3
glycine-N-acyltransferase
chr1_-_158656488 6.96 ENST00000368147.4
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chrX_+_56259316 6.93 ENST00000468660.1
Kruppel-like factor 8
chr1_+_169337172 6.91 ENST00000367807.3
ENST00000367808.3
ENST00000329281.2
ENST00000420531.1
basic leucine zipper nuclear factor 1
chr1_-_149982624 6.75 ENST00000417191.1
ENST00000369135.4
OTU domain containing 7B
chr11_-_111794446 6.52 ENST00000527950.1
crystallin, alpha B
chr12_-_6798616 6.00 ENST00000355772.4
ENST00000417772.3
ENST00000396801.3
ENST00000396799.2
zinc finger protein 384
chr6_-_167797887 5.98 ENST00000476779.2
ENST00000460930.2
ENST00000397829.4
ENST00000366827.2
t-complex 10
chr11_+_71900572 5.69 ENST00000312293.4
folate receptor 1 (adult)
chr11_-_32452357 5.63 ENST00000379079.2
ENST00000530998.1
Wilms tumor 1
chr3_+_111718036 5.59 ENST00000455401.2
transgelin 3
chr1_+_152975488 5.56 ENST00000542696.1
small proline-rich protein 3
chr1_+_241695424 5.52 ENST00000366558.3
ENST00000366559.4
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr12_-_58220078 5.35 ENST00000549039.1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
chr1_-_207119738 5.03 ENST00000356495.4
polymeric immunoglobulin receptor
chr1_+_160709029 4.93 ENST00000444090.2
ENST00000441662.2
SLAM family member 7
chrX_+_13587712 4.82 ENST00000361306.1
ENST00000380602.3
EGF-like-domain, multiple 6
chr7_-_44198874 4.81 ENST00000395796.3
ENST00000345378.2
glucokinase (hexokinase 4)
chr1_+_160709055 4.81 ENST00000368043.3
ENST00000368042.3
ENST00000458602.2
ENST00000458104.2
SLAM family member 7
chr1_+_241695670 4.81 ENST00000366557.4
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr3_+_111718173 4.75 ENST00000494932.1
transgelin 3
chr1_-_13117736 4.58 ENST00000376192.5
ENST00000376182.1
PRAME family member 6
chr1_+_156698708 4.51 ENST00000519086.1
ribosomal RNA adenine dimethylase domain containing 1
chr3_+_111717600 4.37 ENST00000273368.4
transgelin 3
chr1_+_22964073 4.33 ENST00000402322.1
complement component 1, q subcomponent, A chain
chr1_+_182419261 4.33 ENST00000294854.8
ENST00000542961.1
regulator of G-protein signaling like 1
chr11_+_73661364 4.32 ENST00000339764.1
DnaJ (Hsp40) homolog, subfamily B, member 13
chr1_-_54665664 4.23 ENST00000542737.1
ENST00000537208.1
cytochrome b5 reductase-like
chr6_+_131894284 4.21 ENST00000368087.3
ENST00000356962.2
arginase 1
chr1_-_13115578 4.19 ENST00000414205.2
PRAME family member 6
chr5_-_132073210 4.19 ENST00000378735.1
ENST00000378746.4
kinesin family member 3A
chr15_-_90892669 4.07 ENST00000412799.2
GABA(A) receptors associated protein like 3, pseudogene
chr11_-_76155618 4.06 ENST00000530759.1
RP11-111M22.3
chr1_+_12916941 3.96 ENST00000240189.2
PRAME family member 2
chr1_+_196946680 3.94 ENST00000256785.4
complement factor H-related 5
chr12_-_118796910 3.92 ENST00000541186.1
ENST00000539872.1
TAO kinase 3
chr1_-_109618566 3.88 ENST00000338366.5
TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
chr1_-_85462623 3.85 ENST00000370608.3
mucolipin 2
chr6_+_88757507 3.83 ENST00000237201.1
sperm acrosome associated 1
chr6_-_52710893 3.79 ENST00000284562.2
glutathione S-transferase alpha 5
chr11_-_128712362 3.79 ENST00000392664.2
potassium inwardly-rectifying channel, subfamily J, member 1
chr15_+_40331456 3.76 ENST00000504245.1
ENST00000560341.1
SRP14 antisense RNA1 (head to head)
chr11_-_2906979 3.73 ENST00000380725.1
ENST00000313407.6
ENST00000430149.2
ENST00000440480.2
ENST00000414822.3
cyclin-dependent kinase inhibitor 1C (p57, Kip2)
chr18_-_51750948 3.71 ENST00000583046.1
ENST00000398398.2
methyl-CpG binding domain protein 2
chr3_+_184529929 3.71 ENST00000287546.4
ENST00000437079.3
vacuolar protein sorting 8 homolog (S. cerevisiae)
chr13_-_46679185 3.70 ENST00000439329.3
carboxypeptidase B2 (plasma)
chr1_-_12946025 3.64 ENST00000235349.5
PRAME family member 4
chr2_+_105953972 3.59 ENST00000410049.1
chromosome 2 open reading frame 49
chr1_+_13359819 3.59 ENST00000376168.1
PRAME family member 5
chr9_+_6716478 3.58 ENST00000452643.1
RP11-390F4.3
chr2_+_234826016 3.54 ENST00000324695.4
ENST00000433712.2
transient receptor potential cation channel, subfamily M, member 8
chr11_-_76155700 3.50 ENST00000572035.1
RP11-111M22.3
chr10_+_7745303 3.47 ENST00000429820.1
ENST00000379587.4
inter-alpha-trypsin inhibitor heavy chain 2
chr1_-_12958101 3.45 ENST00000235347.4
PRAME family member 10
chr1_+_35225339 3.43 ENST00000339480.1
gap junction protein, beta 4, 30.3kDa
chr13_-_46679144 3.42 ENST00000181383.4
carboxypeptidase B2 (plasma)
chr12_+_57857475 3.40 ENST00000528467.1
GLI family zinc finger 1
chr7_+_100551239 3.29 ENST00000319509.7
mucin 3A, cell surface associated
chr1_+_158901329 3.29 ENST00000368140.1
ENST00000368138.3
ENST00000392254.2
ENST00000392252.3
ENST00000368135.4
pyrin and HIN domain family, member 1
chr19_-_50316517 3.27 ENST00000313777.4
ENST00000445575.2
fuzzy planar cell polarity protein
chr9_+_132427883 3.22 ENST00000372469.4
paired related homeobox 2
chrX_+_114524275 3.21 ENST00000371921.1
ENST00000451986.2
ENST00000371920.3
leucine zipper protein 4
chr19_+_45445491 3.20 ENST00000592954.1
ENST00000419266.2
ENST00000589057.1
apolipoprotein C-IV
APOC4-APOC2 readthrough (NMD candidate)
chr1_+_15256230 3.18 ENST00000376028.4
ENST00000400798.2
kazrin, periplakin interacting protein
chr11_-_35547151 3.17 ENST00000378878.3
ENST00000529303.1
ENST00000278360.3
peptidase domain containing associated with muscle regeneration 1
chr11_+_64323428 3.17 ENST00000377581.3
solute carrier family 22 (organic anion/urate transporter), member 11
chr11_+_12132117 3.16 ENST00000256194.4
microtubule associated monooxygenase, calponin and LIM domain containing 2
chr17_-_6915646 3.16 ENST00000574377.1
ENST00000399541.2
ENST00000399540.2
ENST00000575727.1
ENST00000573939.1
Uncharacterized protein
chr15_+_80733570 3.15 ENST00000533983.1
ENST00000527771.1
ENST00000525103.1
aryl-hydrocarbon receptor nuclear translocator 2
chr1_+_196946664 3.14 ENST00000367414.5
complement factor H-related 5
chr11_+_64323098 3.10 ENST00000301891.4
solute carrier family 22 (organic anion/urate transporter), member 11
chr10_+_104613980 3.06 ENST00000339834.5
chromosome 10 open reading frame 32
chr11_-_71791518 3.05 ENST00000537217.1
ENST00000366394.3
ENST00000358965.6
ENST00000546131.1
ENST00000543937.1
ENST00000368959.5
ENST00000541641.1
nuclear mitotic apparatus protein 1
chr10_+_7745232 3.05 ENST00000358415.4
inter-alpha-trypsin inhibitor heavy chain 2
chr22_+_19710468 3.02 ENST00000366425.3
glycoprotein Ib (platelet), beta polypeptide
chr1_+_160709076 2.99 ENST00000359331.4
ENST00000495334.1
SLAM family member 7
chr11_+_64323156 2.96 ENST00000377585.3
solute carrier family 22 (organic anion/urate transporter), member 11
chr3_+_184529948 2.94 ENST00000436792.2
ENST00000446204.2
ENST00000422105.1
vacuolar protein sorting 8 homolog (S. cerevisiae)
chr14_+_95047725 2.93 ENST00000554760.1
ENST00000554866.1
ENST00000329597.7
ENST00000556775.1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr5_+_125758813 2.86 ENST00000285689.3
ENST00000515200.1
GRAM domain containing 3
chr1_+_16330723 2.86 ENST00000329454.2
chromosome 1 open reading frame 64
chr2_-_73053126 2.82 ENST00000272427.6
ENST00000410104.1
exocyst complex component 6B
chr1_+_150245177 2.77 ENST00000369098.3
chromosome 1 open reading frame 54
chr19_+_2867325 2.76 ENST00000307635.2
ENST00000586426.1
zinc finger protein 556
chr1_+_12976450 2.75 ENST00000361079.2
PRAME family member 7
chr12_+_110011571 2.75 ENST00000539696.1
ENST00000228510.3
ENST00000392727.3
mevalonate kinase
chr19_-_3600549 2.72 ENST00000589966.1
thromboxane A2 receptor
chrX_+_138612889 2.72 ENST00000218099.2
ENST00000394090.2
coagulation factor IX
chr10_+_48255253 2.68 ENST00000357718.4
ENST00000344416.5
ENST00000456111.2
ENST00000374258.3
annexin A8
Protein LOC100996760
chr16_+_1306060 2.65 ENST00000397534.2
tryptase delta 1
chr22_-_44258360 2.62 ENST00000330884.4
ENST00000249130.5
sulfotransferase family 4A, member 1
chr10_+_47746929 2.56 ENST00000340243.6
ENST00000374277.5
ENST00000449464.2
ENST00000538825.1
ENST00000335083.5
annexin A8-like 2
Protein LOC100996760
chr3_-_10452359 2.54 ENST00000452124.1
ATPase, Ca++ transporting, plasma membrane 2
chr1_+_13736907 2.53 ENST00000316412.5
PRAME family member 20
chr19_+_45445524 2.52 ENST00000591600.1
apolipoprotein C-IV
chr17_-_59668550 2.51 ENST00000521764.1
nascent polypeptide-associated complex alpha subunit 2
chr10_-_47173994 2.45 ENST00000414655.2
ENST00000545298.1
ENST00000359178.4
ENST00000358140.4
ENST00000503031.1
annexin A8-like 1
long intergenic non-protein coding RNA 842
chr1_+_26737292 2.45 ENST00000254231.4
lin-28 homolog A (C. elegans)
chr12_+_81471816 2.44 ENST00000261206.3
acyl-CoA synthetase short-chain family member 3
chrX_+_101906294 2.43 ENST00000361600.5
ENST00000415986.1
ENST00000444152.1
ENST00000537097.1
G protein-coupled receptor associated sorting protein 1
chr13_+_28712614 2.38 ENST00000380958.3
PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr13_+_53226963 2.38 ENST00000343788.6
ENST00000535397.1
ENST00000310528.8
SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)
chr10_+_5005445 2.38 ENST00000380872.4
aldo-keto reductase family 1, member C1
chr20_+_36946029 2.37 ENST00000417318.1
bactericidal/permeability-increasing protein
chr19_+_57999079 2.37 ENST00000426954.2
ENST00000354197.4
ENST00000523882.1
ENST00000520540.1
ENST00000519310.1
ENST00000442920.2
ENST00000523312.1
ENST00000424930.2
zinc finger protein 419
chr19_+_57999101 2.35 ENST00000347466.6
ENST00000523138.1
ENST00000415379.2
ENST00000521754.1
ENST00000221735.7
ENST00000518999.1
ENST00000521137.1
zinc finger protein 419
chr3_+_149191723 2.35 ENST00000305354.4
transmembrane 4 L six family member 4
chr3_+_35722487 2.34 ENST00000441454.1
cAMP-regulated phosphoprotein, 21kDa
chr19_+_55476620 2.31 ENST00000543010.1
ENST00000391721.4
ENST00000339757.7
NLR family, pyrin domain containing 2
chr19_+_42055879 2.31 ENST00000407170.2
ENST00000601116.1
ENST00000595395.1
carcinoembryonic antigen-related cell adhesion molecule 21
AC006129.2
chr16_-_15463926 2.31 ENST00000432570.2
nuclear pore complex interacting protein family, member A5
chr1_+_12851545 2.30 ENST00000332296.7
PRAME family member 1
chr1_-_12891264 2.27 ENST00000535591.1
ENST00000437584.1
PRAME family member 11
chr14_-_95942173 2.27 ENST00000334258.5
ENST00000557275.1
ENST00000553340.1
spectrin repeat containing, nuclear envelope family member 3
chr11_-_49230144 2.26 ENST00000343844.4
folate hydrolase (prostate-specific membrane antigen) 1
chr8_+_18248786 2.26 ENST00000520116.1
N-acetyltransferase 2 (arylamine N-acetyltransferase)
chr16_+_27214802 2.25 ENST00000380948.2
ENST00000286096.4
lysine (K)-specific demethylase 8
chr11_+_117947782 2.23 ENST00000522307.1
ENST00000523251.1
ENST00000437212.3
ENST00000522824.1
ENST00000522151.1
transmembrane protease, serine 4
chr8_-_19540086 2.21 ENST00000332246.6
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr19_-_11039261 2.13 ENST00000590329.1
ENST00000587943.1
ENST00000585858.1
ENST00000586748.1
ENST00000586575.1
ENST00000253031.2
Yip1 domain family, member 2
chr17_+_4675175 2.12 ENST00000270560.3
transmembrane 4 L six family member 5
chr2_+_48844973 2.12 ENST00000403751.3
general transcription factor IIA, 1-like
chr20_+_34700333 2.12 ENST00000441639.1
erythrocyte membrane protein band 4.1-like 1
chrX_+_101470280 2.10 ENST00000395088.2
ENST00000330252.5
ENST00000333110.5
nuclear RNA export factor 2
t-complex 11 family, X-linked 1
chrX_+_8432871 2.09 ENST00000381032.1
ENST00000453306.1
ENST00000444481.1
variable charge, X-linked 3B
chr8_+_18248755 2.09 ENST00000286479.3
N-acetyltransferase 2 (arylamine N-acetyltransferase)
chr16_-_68014732 2.09 ENST00000268793.4
dipeptidase 3
chr16_+_56666563 2.08 ENST00000570233.1
metallothionein 1M
chr8_-_18666360 2.08 ENST00000286485.8
pleckstrin and Sec7 domain containing 3
chr6_+_73076432 2.08 ENST00000414192.2
regulating synaptic membrane exocytosis 1
chr9_-_79307096 2.07 ENST00000376717.2
ENST00000223609.6
ENST00000443509.2
prune homolog 2 (Drosophila)
chr15_+_62853562 2.07 ENST00000561311.1
talin 2
chr11_-_59633951 2.04 ENST00000257264.3
transcobalamin I (vitamin B12 binding protein, R binder family)
chr7_-_6866401 2.03 ENST00000316731.8
CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
chr1_+_26737253 2.00 ENST00000326279.6
lin-28 homolog A (C. elegans)
chr16_+_56642041 2.00 ENST00000245185.5
metallothionein 2A
chr7_-_14880892 1.99 ENST00000406247.3
ENST00000399322.3
ENST00000258767.5
diacylglycerol kinase, beta 90kDa
chr11_-_44972476 1.99 ENST00000527685.1
ENST00000308212.5
tumor protein p53 inducible protein 11
chr9_-_34662651 1.98 ENST00000259631.4
chemokine (C-C motif) ligand 27
chr19_+_41594377 1.98 ENST00000330436.3
cytochrome P450, family 2, subfamily A, polypeptide 13
chr12_+_69186125 1.96 ENST00000399333.3
HCG1774533, isoform CRA_a; PRO2268; Uncharacterized protein
chr4_+_155484155 1.96 ENST00000509493.1
fibrinogen beta chain
chr11_+_125365110 1.96 ENST00000527818.1
AP000708.1
chr7_-_73133959 1.95 ENST00000395155.3
ENST00000395154.3
ENST00000222812.3
ENST00000395156.3
syntaxin 1A (brain)
chr9_-_6645628 1.93 ENST00000321612.6
glycine dehydrogenase (decarboxylating)
chr7_+_75677354 1.93 ENST00000461263.2
ENST00000315758.5
ENST00000443006.1
malate dehydrogenase 2, NAD (mitochondrial)
chr2_-_232395169 1.91 ENST00000305141.4
neuromedin U receptor 1
chr5_+_125758865 1.90 ENST00000542322.1
ENST00000544396.1
GRAM domain containing 3
chr1_+_120049826 1.88 ENST00000369413.3
ENST00000235547.6
ENST00000528909.1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
chr11_-_44972390 1.86 ENST00000395648.3
ENST00000531928.2
tumor protein p53 inducible protein 11
chr18_+_61575200 1.84 ENST00000238508.3
serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr3_-_9834375 1.82 ENST00000343450.2
ENST00000301964.2
transcriptional adaptor 3
chr2_-_114514181 1.82 ENST00000409342.1
solute carrier family 35, member F5
chr19_-_15344243 1.82 ENST00000602233.1
epoxide hydrolase 3
chr1_-_13007420 1.81 ENST00000376189.1
PRAME family member 6
chr11_-_44972418 1.81 ENST00000525680.1
ENST00000528290.1
ENST00000530035.1
tumor protein p53 inducible protein 11
chr2_+_48844937 1.80 ENST00000448460.1
ENST00000437125.1
ENST00000430487.2
general transcription factor IIA, 1-like
chr1_-_154150651 1.79 ENST00000302206.5
tropomyosin 3
chr2_-_152589670 1.78 ENST00000604864.1
ENST00000603639.1
nebulin
chr10_+_51549498 1.77 ENST00000358559.2
ENST00000298239.6
microseminoprotein, beta-
chr1_-_159046617 1.75 ENST00000368130.4
absent in melanoma 2
chr11_-_71791435 1.75 ENST00000351960.6
ENST00000541719.1
ENST00000535111.1
nuclear mitotic apparatus protein 1
chr10_+_5005598 1.74 ENST00000442997.1
aldo-keto reductase family 1, member C1
chr12_-_89919965 1.74 ENST00000548729.1
POC1B-GALNT4 readthrough
chr5_+_81575281 1.72 ENST00000380167.4
ATPase, H+ transporting, lysosomal accessory protein 1-like
chr8_-_19540266 1.72 ENST00000311540.4
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr11_+_117947724 1.67 ENST00000534111.1
transmembrane protease, serine 4
chr12_-_89920030 1.67 ENST00000413530.1
ENST00000547474.1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4)
POC1B-GALNT4 readthrough
chr2_+_211342432 1.67 ENST00000430249.2
carbamoyl-phosphate synthase 1, mitochondrial
chr6_-_136847099 1.67 ENST00000438100.2
microtubule-associated protein 7
chr8_+_99129513 1.65 ENST00000522319.1
ENST00000401707.2
processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
chr19_-_48389651 1.64 ENST00000222002.3
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr18_-_11148587 1.63 ENST00000302079.6
ENST00000580640.1
ENST00000503781.3
piezo-type mechanosensitive ion channel component 2
chr21_+_35736302 1.62 ENST00000290310.3
potassium voltage-gated channel, Isk-related family, member 2
chr11_+_114168085 1.61 ENST00000541754.1
nicotinamide N-methyltransferase
chr17_+_43213004 1.61 ENST00000586346.1
ENST00000398322.3
ENST00000592162.1
ENST00000376955.4
ENST00000321854.8
acyl-CoA binding domain containing 4
chr19_+_15852203 1.61 ENST00000305892.1
olfactory receptor, family 10, subfamily H, member 3
chr7_+_29519486 1.60 ENST00000409041.4
chimerin 2
chr16_+_451826 1.59 ENST00000219481.5
ENST00000397710.1
ENST00000424398.2
2,4-dienoyl CoA reductase 2, peroxisomal
chr12_-_58135903 1.59 ENST00000257897.3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr3_-_46506358 1.58 ENST00000417439.1
ENST00000431944.1
lactotransferrin
chr19_+_46800289 1.58 ENST00000377670.4
hypoxia inducible factor 3, alpha subunit
chr19_-_11039188 1.57 ENST00000588347.1
Yip1 domain family, member 2
chr1_+_196743912 1.56 ENST00000367425.4
complement factor H-related 3
chr9_-_21077939 1.55 ENST00000380232.2
interferon, beta 1, fibroblast
chr11_-_118134997 1.55 ENST00000278937.2
myelin protein zero-like 2

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX1_SIX3_SIX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 10.3 GO:0019805 quinolinate biosynthetic process(GO:0019805)
1.9 5.7 GO:0060974 neural crest cell migration involved in heart formation(GO:0003147) cell migration involved in heart formation(GO:0060974) anterior neural tube closure(GO:0061713)
1.8 7.1 GO:0003331 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
1.6 4.8 GO:1902846 regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846)
1.6 7.9 GO:0071279 cellular response to cobalt ion(GO:0071279)
1.4 5.6 GO:0072302 posterior mesonephric tubule development(GO:0072166) negative regulation of metanephric glomerulus development(GO:0072299) negative regulation of metanephric glomerular mesangial cell proliferation(GO:0072302)
1.3 1.3 GO:0030168 platelet activation(GO:0030168)
1.3 16.3 GO:2000194 regulation of female gonad development(GO:2000194)
1.1 3.2 GO:0019417 sulfur oxidation(GO:0019417)
1.0 9.2 GO:0015747 urate transport(GO:0015747)
1.0 5.0 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
1.0 3.9 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276) chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.9 2.7 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.9 2.7 GO:0038193 thromboxane A2 signaling pathway(GO:0038193)
0.9 2.7 GO:1900138 negative regulation of phospholipase A2 activity(GO:1900138)
0.9 4.5 GO:0010587 miRNA catabolic process(GO:0010587)
0.9 7.7 GO:0006531 aspartate metabolic process(GO:0006531)
0.9 3.4 GO:0007418 ventral midline development(GO:0007418) smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938)
0.8 6.8 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.8 4.2 GO:1902023 L-arginine import(GO:0043091) arginine import(GO:0090467) L-arginine transport(GO:1902023)
0.8 3.3 GO:2000314 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of neural crest formation(GO:0090299) negative regulation of neural crest formation(GO:0090301) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313) negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314)
0.8 5.7 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.8 8.8 GO:0006930 substrate-dependent cell migration, cell extension(GO:0006930)
0.8 3.8 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.7 5.0 GO:0071395 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.7 3.5 GO:0050955 thermoception(GO:0050955)
0.7 2.1 GO:0030187 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.7 4.8 GO:0009732 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.7 2.7 GO:1902159 regulation of cyclic nucleotide-gated ion channel activity(GO:1902159)
0.6 2.9 GO:0061107 seminal vesicle development(GO:0061107)
0.5 3.7 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
0.5 5.3 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.5 1.6 GO:2000308 iron assimilation(GO:0033212) iron assimilation by chelation and transport(GO:0033214) positive regulation of bone mineralization involved in bone maturation(GO:1900159) negative regulation of tumor necrosis factor (ligand) superfamily member 11 production(GO:2000308)
0.5 4.7 GO:0042048 olfactory behavior(GO:0042048)
0.5 3.1 GO:0034201 arginine biosynthetic process(GO:0006526) response to oleic acid(GO:0034201)
0.5 7.1 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.5 1.0 GO:2001183 negative regulation of interleukin-10 secretion(GO:2001180) negative regulation of interleukin-12 secretion(GO:2001183)
0.5 2.0 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.5 2.0 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.5 4.6 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)
0.4 1.8 GO:0007525 somatic muscle development(GO:0007525)
0.4 2.4 GO:0052055 modulation by symbiont of host molecular function(GO:0052055) modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422)
0.4 0.8 GO:0018894 dibenzo-p-dioxin metabolic process(GO:0018894)
0.4 1.2 GO:0032474 otolith morphogenesis(GO:0032474)
0.4 1.9 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.4 2.3 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.4 1.1 GO:0035621 ER to Golgi ceramide transport(GO:0035621)
0.4 6.5 GO:0007021 tubulin complex assembly(GO:0007021)
0.4 1.1 GO:1990535 regulation of intracellular calcium activated chloride channel activity(GO:1902938) neuron projection maintenance(GO:1990535)
0.3 2.4 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290) positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.3 2.7 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.3 2.3 GO:0060011 Sertoli cell proliferation(GO:0060011)
0.3 1.2 GO:0032218 riboflavin transport(GO:0032218)
0.3 2.0 GO:0009804 coumarin metabolic process(GO:0009804)
0.3 2.3 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.3 9.6 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.3 1.6 GO:0016078 tRNA catabolic process(GO:0016078)
0.3 1.1 GO:2000570 T-helper 2 cell activation(GO:0035712) regulation of T-helper 2 cell activation(GO:2000569) positive regulation of T-helper 2 cell activation(GO:2000570)
0.3 1.1 GO:2001153 regulation of renal water transport(GO:2001151) positive regulation of renal water transport(GO:2001153)
0.3 1.6 GO:0002725 negative regulation of T cell cytokine production(GO:0002725)
0.3 1.8 GO:0070269 pyroptosis(GO:0070269)
0.2 1.2 GO:1900005 positive regulation of serine-type endopeptidase activity(GO:1900005) positive regulation of serine-type peptidase activity(GO:1902573)
0.2 2.4 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.2 4.1 GO:0043562 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.2 2.1 GO:1902412 regulation of mitotic cytokinesis(GO:1902412)
0.2 0.9 GO:0044467 glial cell-derived neurotrophic factor secretion(GO:0044467) regulation of glial cell-derived neurotrophic factor secretion(GO:1900166) positive regulation of glial cell-derived neurotrophic factor secretion(GO:1900168)
0.2 1.8 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.2 4.5 GO:0031167 rRNA methylation(GO:0031167)
0.2 2.4 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.2 1.1 GO:1903423 positive regulation of synaptic vesicle endocytosis(GO:1900244) positive regulation of synaptic vesicle recycling(GO:1903423)
0.2 1.1 GO:2000418 positive regulation of eosinophil migration(GO:2000418)
0.2 0.8 GO:0042231 interleukin-13 biosynthetic process(GO:0042231)
0.2 8.1 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.2 2.0 GO:0015889 cobalamin transport(GO:0015889)
0.2 2.4 GO:0043031 negative regulation of macrophage activation(GO:0043031)
0.2 1.2 GO:0038161 prolactin signaling pathway(GO:0038161)
0.2 2.0 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.2 1.0 GO:0036414 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.2 1.3 GO:0008218 bioluminescence(GO:0008218)
0.2 1.1 GO:0030450 regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959)
0.2 2.1 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.2 2.8 GO:0042711 maternal behavior(GO:0042711) parental behavior(GO:0060746)
0.2 2.8 GO:0032703 negative regulation of interleukin-2 production(GO:0032703)
0.2 0.7 GO:0070309 lens fiber cell morphogenesis(GO:0070309)
0.2 1.9 GO:0006108 malate metabolic process(GO:0006108)
0.2 0.6 GO:0061092 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.2 0.6 GO:0070253 somatostatin secretion(GO:0070253)
0.2 1.1 GO:0007320 insemination(GO:0007320)
0.2 0.5 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.2 0.9 GO:0001575 globoside metabolic process(GO:0001575)
0.2 0.6 GO:0035617 stress granule disassembly(GO:0035617)
0.2 1.5 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.2 2.3 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.2 1.1 GO:0044245 polysaccharide digestion(GO:0044245)
0.1 1.3 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.1 3.0 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.1 2.8 GO:0005513 detection of calcium ion(GO:0005513)
0.1 1.5 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.1 1.2 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.1 1.9 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.1 0.9 GO:2001268 positive regulation of keratinocyte migration(GO:0051549) negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001268)
0.1 4.3 GO:0035082 axoneme assembly(GO:0035082)
0.1 5.0 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.1 5.0 GO:1902475 L-alpha-amino acid transmembrane transport(GO:1902475)
0.1 4.3 GO:0010039 response to iron ion(GO:0010039)
0.1 2.1 GO:0098828 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.1 4.3 GO:0034035 purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.1 1.2 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902)
0.1 0.6 GO:0071799 response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.1 2.1 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.1 2.1 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.1 0.3 GO:0097156 fasciculation of motor neuron axon(GO:0097156)
0.1 1.3 GO:0042574 retinal metabolic process(GO:0042574)
0.1 0.6 GO:0097105 presynaptic membrane assembly(GO:0097105)
0.1 6.7 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
0.1 4.8 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1 1.5 GO:0002052 positive regulation of neuroblast proliferation(GO:0002052)
0.1 2.1 GO:0071294 cellular response to zinc ion(GO:0071294)
0.1 1.1 GO:0098703 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.1 5.6 GO:0018149 peptide cross-linking(GO:0018149)
0.1 1.2 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.1 8.3 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.1 5.3 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.1 2.3 GO:0050718 positive regulation of interleukin-1 beta secretion(GO:0050718)
0.1 3.8 GO:0010107 potassium ion import(GO:0010107)
0.1 4.6 GO:0016266 O-glycan processing(GO:0016266)
0.1 0.6 GO:1990592 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.1 1.3 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.1 1.6 GO:0050974 detection of mechanical stimulus involved in sensory perception(GO:0050974)
0.1 1.4 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.4 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.1 0.3 GO:0034334 adherens junction maintenance(GO:0034334)
0.1 1.1 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.1 0.3 GO:0002934 desmosome organization(GO:0002934)
0.1 1.4 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.1 1.0 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518)
0.1 9.0 GO:0006805 xenobiotic metabolic process(GO:0006805)
0.1 0.6 GO:0010885 regulation of cholesterol storage(GO:0010885) positive regulation of cholesterol storage(GO:0010886)
0.1 3.8 GO:0006749 glutathione metabolic process(GO:0006749)
0.1 0.3 GO:2000639 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.1 0.7 GO:0006706 steroid catabolic process(GO:0006706)
0.1 12.4 GO:0007162 negative regulation of cell adhesion(GO:0007162)
0.1 2.4 GO:0032801 receptor catabolic process(GO:0032801)
0.1 2.1 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.1 1.6 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.1 0.7 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.1 0.8 GO:2000179 positive regulation of neural precursor cell proliferation(GO:2000179)
0.1 2.3 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.1 0.2 GO:0060423 foregut regionalization(GO:0060423) lung field specification(GO:0060424) primary lung bud formation(GO:0060431) lung induction(GO:0060492)
0.1 2.0 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 4.8 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 1.4 GO:0007202 activation of phospholipase C activity(GO:0007202)
0.0 35.4 GO:0045596 negative regulation of cell differentiation(GO:0045596)
0.0 0.9 GO:0010226 response to lithium ion(GO:0010226)
0.0 1.8 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.0 1.7 GO:0015988 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.0 0.5 GO:0015074 DNA integration(GO:0015074)
0.0 0.3 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.0 1.5 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 3.5 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
0.0 0.6 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.5 GO:0007398 ectoderm development(GO:0007398)
0.0 0.6 GO:0006312 mitotic recombination(GO:0006312)
0.0 0.9 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 7.5 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.0 0.7 GO:0032006 regulation of TOR signaling(GO:0032006)
0.0 0.5 GO:0051145 smooth muscle cell differentiation(GO:0051145)
0.0 1.7 GO:0015701 bicarbonate transport(GO:0015701)
0.0 1.2 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.9 GO:0050832 defense response to fungus(GO:0050832)
0.0 6.2 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 0.2 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.0 1.8 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.0 1.0 GO:0007140 male meiosis(GO:0007140)
0.0 0.2 GO:0045839 negative regulation of mitotic nuclear division(GO:0045839)
0.0 0.2 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.4 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.0 0.4 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.0 0.4 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 2.5 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.6 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.9 GO:0006869 lipid transport(GO:0006869)
0.0 0.1 GO:0044065 regulation of respiratory system process(GO:0044065)
0.0 1.6 GO:0042177 negative regulation of protein catabolic process(GO:0042177)
0.0 1.1 GO:1902017 regulation of cilium assembly(GO:1902017)
0.0 0.5 GO:0035987 endodermal cell differentiation(GO:0035987)
0.0 0.5 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 9.8 GO:0007417 central nervous system development(GO:0007417)
0.0 1.4 GO:0007267 cell-cell signaling(GO:0007267)
0.0 1.2 GO:0007030 Golgi organization(GO:0007030)
0.0 0.1 GO:0048240 sperm capacitation(GO:0048240)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.8 GO:0061673 cortical microtubule(GO:0055028) mitotic spindle astral microtubule(GO:0061673)
1.2 3.6 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
1.1 5.3 GO:0033263 CORVET complex(GO:0033263)
1.0 4.2 GO:0016939 kinesin II complex(GO:0016939)
1.0 7.0 GO:0032437 cuticular plate(GO:0032437)
1.0 2.9 GO:0036029 protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183)
0.9 4.3 GO:0005602 complement component C1 complex(GO:0005602)
0.8 2.4 GO:0031251 PAN complex(GO:0031251)
0.7 7.9 GO:0043203 axon hillock(GO:0043203)
0.6 1.9 GO:0005960 glycine cleavage complex(GO:0005960)
0.6 6.1 GO:1990023 mitotic spindle midzone(GO:1990023)
0.5 3.9 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.5 2.0 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.4 1.8 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.4 6.8 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.4 2.1 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.4 6.5 GO:0097512 cardiac myofibril(GO:0097512)
0.4 2.5 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.2 1.6 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.2 1.6 GO:0097013 phagocytic vesicle lumen(GO:0097013)
0.2 1.0 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.2 1.9 GO:0097425 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.2 3.4 GO:0005922 connexon complex(GO:0005922)
0.2 1.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.2 5.7 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.2 2.3 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.2 3.8 GO:0002080 acrosomal membrane(GO:0002080)
0.2 8.7 GO:0001533 cornified envelope(GO:0001533)
0.2 2.0 GO:0005577 fibrinogen complex(GO:0005577)
0.1 1.3 GO:0098839 postsynaptic density membrane(GO:0098839)
0.1 5.7 GO:0097542 ciliary tip(GO:0097542)
0.1 1.7 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 2.8 GO:0000145 exocyst(GO:0000145)
0.1 4.9 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 1.3 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 1.8 GO:0000124 SAGA complex(GO:0000124)
0.1 4.1 GO:0000421 autophagosome membrane(GO:0000421)
0.1 1.3 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.1 14.0 GO:0005796 Golgi lumen(GO:0005796)
0.1 15.9 GO:0005923 bicellular tight junction(GO:0005923)
0.1 3.9 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.1 1.4 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 1.8 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 10.5 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.1 0.7 GO:0031931 TORC1 complex(GO:0031931)
0.1 5.7 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 1.2 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 15.5 GO:0032993 protein-DNA complex(GO:0032993)
0.1 3.7 GO:0016235 aggresome(GO:0016235)
0.1 0.3 GO:0030057 desmosome(GO:0030057)
0.1 0.5 GO:0070852 cell body fiber(GO:0070852)
0.1 6.6 GO:0035578 azurophil granule lumen(GO:0035578)
0.1 4.3 GO:0036126 sperm flagellum(GO:0036126)
0.1 4.0 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 0.9 GO:0046930 pore complex(GO:0046930)
0.1 12.4 GO:0043209 myelin sheath(GO:0043209)
0.1 10.8 GO:0005802 trans-Golgi network(GO:0005802)
0.1 2.1 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.4 GO:0033270 paranode region of axon(GO:0033270)
0.0 4.8 GO:0005604 basement membrane(GO:0005604)
0.0 0.6 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 0.3 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 1.3 GO:0031902 late endosome membrane(GO:0031902)
0.0 0.2 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 1.9 GO:0005871 kinesin complex(GO:0005871)
0.0 1.2 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 2.6 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 5.2 GO:0055037 recycling endosome(GO:0055037)
0.0 1.2 GO:0031904 endosome lumen(GO:0031904)
0.0 1.0 GO:0030286 dynein complex(GO:0030286)
0.0 2.7 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.0 1.3 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 1.5 GO:0005902 microvillus(GO:0005902)
0.0 1.7 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 3.6 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 6.5 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.4 GO:0000792 heterochromatin(GO:0000792)
0.0 3.4 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 1.6 GO:0035579 specific granule membrane(GO:0035579)
0.0 0.2 GO:0005642 annulate lamellae(GO:0005642)
0.0 1.5 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.3 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 1.1 GO:0031225 anchored component of membrane(GO:0031225)
0.0 11.2 GO:0005615 extracellular space(GO:0005615)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 7.7 GO:0004515 nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
1.4 5.7 GO:0061714 folic acid receptor activity(GO:0061714)
1.3 3.9 GO:0008955 peptidoglycan glycosyltransferase activity(GO:0008955)
1.2 5.0 GO:0047023 androsterone dehydrogenase activity(GO:0047023)
1.1 5.6 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
1.1 4.3 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
1.1 5.4 GO:0008420 CTD phosphatase activity(GO:0008420)
1.0 3.1 GO:0004088 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.9 9.2 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.9 2.7 GO:0004960 thromboxane receptor activity(GO:0004960) thromboxane A2 receptor activity(GO:0004961)
0.9 4.5 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.8 3.3 GO:0030197 extracellular matrix constituent, lubricant activity(GO:0030197)
0.8 2.3 GO:0032090 Pyrin domain binding(GO:0032090)
0.8 3.0 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.7 10.3 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.7 6.8 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.6 3.8 GO:0003796 lysozyme activity(GO:0003796)
0.6 8.2 GO:0019957 C-C chemokine binding(GO:0019957)
0.6 3.8 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.6 5.0 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.6 1.9 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854) steroid delta-isomerase activity(GO:0004769)
0.6 4.8 GO:0019158 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.6 2.4 GO:0008112 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
0.6 2.3 GO:1904493 Ac-Asp-Glu binding(GO:1904492) tetrahydrofolyl-poly(glutamate) polymer binding(GO:1904493)
0.5 1.6 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.5 8.8 GO:0005522 profilin binding(GO:0005522)
0.5 0.9 GO:0008035 high-density lipoprotein particle binding(GO:0008035)
0.4 7.9 GO:0015101 organic cation transmembrane transporter activity(GO:0015101)
0.4 4.5 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.4 1.5 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.4 1.9 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.4 4.2 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.4 5.2 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.4 4.8 GO:0051011 microtubule minus-end binding(GO:0051011)
0.3 1.0 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.3 1.3 GO:0005502 11-cis retinal binding(GO:0005502)
0.3 2.9 GO:0032190 acrosin binding(GO:0032190)
0.3 1.2 GO:0032217 riboflavin transporter activity(GO:0032217)
0.3 1.2 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.3 1.1 GO:0017089 glycolipid transporter activity(GO:0017089) ceramide binding(GO:0097001)
0.3 2.3 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.3 7.1 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.3 1.6 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.3 2.1 GO:0008172 S-methyltransferase activity(GO:0008172)
0.3 1.1 GO:0008422 beta-glucosidase activity(GO:0008422)
0.2 2.0 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.2 3.2 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.2 1.2 GO:0004925 prolactin receptor activity(GO:0004925)
0.2 1.6 GO:0050294 steroid sulfotransferase activity(GO:0050294)
0.2 7.2 GO:0005212 structural constituent of eye lens(GO:0005212)
0.2 3.2 GO:0016594 glycine binding(GO:0016594)
0.2 3.1 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.2 1.8 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.2 3.7 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.2 2.0 GO:0031419 cobalamin binding(GO:0031419)
0.2 0.6 GO:0015616 DNA translocase activity(GO:0015616)
0.2 0.6 GO:0004958 prostaglandin F receptor activity(GO:0004958)
0.2 1.1 GO:0042577 lipid phosphatase activity(GO:0042577)
0.2 1.1 GO:1903135 cupric ion binding(GO:1903135)
0.2 5.0 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.2 0.8 GO:0034875 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.2 2.6 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.2 0.9 GO:0043199 sulfate binding(GO:0043199)
0.2 2.0 GO:0046870 cadmium ion binding(GO:0046870)
0.2 2.4 GO:0016405 CoA-ligase activity(GO:0016405)
0.2 0.9 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.2 15.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 1.4 GO:0003696 satellite DNA binding(GO:0003696)
0.1 2.0 GO:0070330 aromatase activity(GO:0070330)
0.1 1.6 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.1 3.2 GO:0071949 FAD binding(GO:0071949)
0.1 3.7 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 2.4 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 1.0 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 2.1 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.1 3.9 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.1 2.7 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 2.0 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 1.6 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 2.1 GO:0016805 dipeptidase activity(GO:0016805)
0.1 1.2 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.1 1.2 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.1 20.9 GO:0051015 actin filament binding(GO:0051015)
0.1 1.3 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 1.1 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 8.9 GO:0016410 N-acyltransferase activity(GO:0016410)
0.1 1.3 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.1 0.6 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.1 0.9 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 3.8 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 1.9 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 0.9 GO:0015643 toxic substance binding(GO:0015643)
0.1 3.2 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 8.5 GO:0005262 calcium channel activity(GO:0005262)
0.1 1.3 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.1 0.8 GO:0019215 intermediate filament binding(GO:0019215)
0.1 5.7 GO:0005319 lipid transporter activity(GO:0005319)
0.1 0.3 GO:0070996 type 1 melanocortin receptor binding(GO:0070996)
0.1 1.0 GO:0048156 tau protein binding(GO:0048156)
0.1 1.6 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.1 3.5 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 1.1 GO:0051787 misfolded protein binding(GO:0051787)
0.1 1.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 1.1 GO:0016004 phospholipase activator activity(GO:0016004)
0.1 1.7 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 0.6 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.1 0.6 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 0.3 GO:0050816 phosphothreonine binding(GO:0050816)
0.1 2.6 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 1.4 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.5 GO:0015144 carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476)
0.0 6.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 23.7 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 0.3 GO:0005353 fructose transmembrane transporter activity(GO:0005353)
0.0 0.6 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 1.3 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 3.4 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.7 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 1.0 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.7 GO:0001671 ATPase activator activity(GO:0001671)
0.0 1.2 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 1.0 GO:0003777 microtubule motor activity(GO:0003777)
0.0 2.2 GO:0005518 collagen binding(GO:0005518)
0.0 4.5 GO:0005178 integrin binding(GO:0005178)
0.0 1.8 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.8 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 0.6 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 2.8 GO:0005179 hormone activity(GO:0005179)
0.0 0.3 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 2.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 1.5 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 2.8 GO:0051082 unfolded protein binding(GO:0051082)
0.0 3.4 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.4 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.6 GO:0017091 AU-rich element binding(GO:0017091)
0.0 5.1 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 0.9 GO:0051087 chaperone binding(GO:0051087)
0.0 0.2 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.4 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 1.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.5 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.8 GO:0005249 voltage-gated potassium channel activity(GO:0005249)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 9.1 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.2 16.8 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.1 4.0 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 1.6 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.1 7.6 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 9.2 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 6.9 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.1 2.0 PID NETRIN PATHWAY Netrin-mediated signaling events
0.1 22.0 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 5.2 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 12.9 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.0 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 3.8 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.1 5.6 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 2.1 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 1.1 PID CD40 PATHWAY CD40/CD40L signaling
0.0 1.6 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 1.1 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 2.0 PID AP1 PATHWAY AP-1 transcription factor network
0.0 2.1 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.0 1.6 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 1.1 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 1.2 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 1.4 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 2.5 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.0 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 7.3 NABA MATRISOME ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.0 0.6 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.6 PID E2F PATHWAY E2F transcription factor network
0.0 0.3 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.4 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.6 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 0.7 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.9 PID CMYB PATHWAY C-MYB transcription factor network
0.0 1.1 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.5 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 0.2 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 10.3 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.4 9.2 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.4 4.3 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.3 4.8 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.3 5.7 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.3 2.8 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.2 4.0 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.2 7.0 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 3.4 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.2 2.1 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.2 19.0 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.2 2.3 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.1 2.0 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 4.4 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.1 3.9 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 15.9 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.1 2.0 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.1 2.7 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.1 1.1 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 2.5 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 3.1 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 3.8 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.1 2.7 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 0.8 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 4.0 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 1.6 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 5.4 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 5.5 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 1.6 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.1 1.8 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.1 1.9 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 1.8 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.1 1.3 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 0.7 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 1.1 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 0.6 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.1 3.6 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 1.9 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 1.2 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 1.8 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.2 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 2.1 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 0.9 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 1.4 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.2 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 1.0 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.5 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 1.7 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 5.4 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.9 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 1.1 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 1.0 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.4 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 1.6 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 1.3 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 1.1 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 0.6 REACTOME KINESINS Genes involved in Kinesins
0.0 1.7 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 1.1 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 1.1 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 6.7 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway
0.0 0.8 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.3 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.9 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.3 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.0 2.7 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 0.2 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 0.5 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation