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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for SIX4
Z-value: 0.36
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Transcription factors associated with SIX4
Network of associatons between targets according to the STRING database.
First level regulatory network of SIX4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 20.4 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.5 | 5.5 | GO:0033227 | dsRNA transport(GO:0033227) |
| 0.7 | 5.2 | GO:1902715 | positive regulation of interferon-gamma secretion(GO:1902715) |
| 0.0 | 4.2 | GO:0006413 | translational initiation(GO:0006413) |
| 1.3 | 3.9 | GO:2000854 | positive regulation of corticosterone secretion(GO:2000854) |
| 0.1 | 3.9 | GO:0045540 | regulation of cholesterol biosynthetic process(GO:0045540) |
| 0.0 | 3.7 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 0.1 | 3.3 | GO:0006904 | vesicle docking involved in exocytosis(GO:0006904) |
| 0.9 | 2.8 | GO:1900369 | transcription, RNA-templated(GO:0001172) regulation of RNA interference(GO:1900368) negative regulation of RNA interference(GO:1900369) positive regulation of protein localization to nucleolus(GO:1904751) |
| 0.0 | 2.8 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 14.9 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 6.5 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.1 | 4.4 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.4 | 3.9 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 0.0 | 3.7 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 3.3 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.0 | 2.9 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.7 | 2.8 | GO:0000333 | telomerase catalytic core complex(GO:0000333) |
| 0.0 | 2.0 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.0 | 1.9 | GO:0030658 | transport vesicle membrane(GO:0030658) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 14.9 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.9 | 5.5 | GO:0051033 | nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033) |
| 0.2 | 5.5 | GO:0008329 | signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187) |
| 0.1 | 4.9 | GO:0019213 | deacetylase activity(GO:0019213) |
| 0.1 | 4.2 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.1 | 4.0 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.1 | 3.9 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.2 | 3.7 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.0 | 3.5 | GO:0001046 | core promoter sequence-specific DNA binding(GO:0001046) |
| 0.0 | 3.3 | GO:0019003 | GDP binding(GO:0019003) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 3.9 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 3.7 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 2.8 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.0 | 2.4 | PID ENDOTHELIN PATHWAY | Endothelins |
| 0.0 | 1.7 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 1.6 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 1.5 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 1.3 | PID FGF PATHWAY | FGF signaling pathway |
| 0.0 | 1.0 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.3 | REACTOME G ALPHA Q SIGNALLING EVENTS | Genes involved in G alpha (q) signalling events |
| 0.0 | 4.4 | REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | Genes involved in Cell surface interactions at the vascular wall |
| 0.1 | 4.3 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.3 | 3.9 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.1 | 3.2 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 0.0 | 1.9 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.1 | 1.6 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.0 | 1.6 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.0 | 1.5 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 1.3 | REACTOME SIGNALING BY FGFR3 MUTANTS | Genes involved in Signaling by FGFR3 mutants |