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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for SIX5_SMARCC2_HCFC1
Z-value: 0.71
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Transcription factors associated with SIX5_SMARCC2_HCFC1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000177045.6 | SIX homeobox 5 | |
| ENSG00000139613.7 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2 | |
| ENSG00000172534.9 | host cell factor C1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SMARCC2 | hg19_v2_chr12_-_56583332_56583369 | 0.42 | 6.9e-11 | Click! |
| HCFC1 | hg19_v2_chrX_-_153236819_153236978, hg19_v2_chrX_-_153236620_153236684, hg19_v2_chrX_-_153237258_153237295 | 0.42 | 1.6e-10 | Click! |
| SIX5 | hg19_v2_chr19_-_46272106_46272115 | -0.40 | 7.4e-10 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SIX5_SMARCC2_HCFC1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 162.5 | GO:0006888 | ER to Golgi vesicle-mediated transport(GO:0006888) |
| 2.2 | 161.9 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 4.0 | 158.3 | GO:0042407 | cristae formation(GO:0042407) |
| 14.0 | 154.0 | GO:2000580 | positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
| 6.9 | 130.5 | GO:0032802 | low-density lipoprotein particle receptor catabolic process(GO:0032802) |
| 5.4 | 86.9 | GO:0006107 | oxaloacetate metabolic process(GO:0006107) |
| 15.1 | 75.4 | GO:0070682 | proteasome regulatory particle assembly(GO:0070682) |
| 2.8 | 75.1 | GO:0043101 | purine-containing compound salvage(GO:0043101) |
| 12.3 | 61.5 | GO:1904578 | response to thapsigargin(GO:1904578) cellular response to thapsigargin(GO:1904579) |
| 6.7 | 60.1 | GO:0045716 | positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 180.5 | GO:0070062 | extracellular exosome(GO:0070062) |
| 5.5 | 166.3 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.6 | 133.8 | GO:0043209 | myelin sheath(GO:0043209) |
| 6.8 | 129.1 | GO:0036020 | endolysosome membrane(GO:0036020) |
| 6.4 | 121.5 | GO:0008540 | proteasome regulatory particle, base subcomplex(GO:0008540) |
| 2.6 | 105.1 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.2 | 102.5 | GO:0005740 | mitochondrial envelope(GO:0005740) |
| 11.2 | 78.5 | GO:0061617 | MICOS complex(GO:0061617) |
| 12.5 | 75.1 | GO:1902560 | GMP reductase complex(GO:1902560) |
| 0.9 | 63.6 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.7 | 154.8 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 5.9 | 130.5 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.6 | 122.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.2 | 112.2 | GO:0032947 | protein complex scaffold(GO:0032947) |
| 1.9 | 84.8 | GO:0044769 | ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) |
| 0.2 | 81.0 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) |
| 12.5 | 75.1 | GO:0003920 | GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657) |
| 1.6 | 63.8 | GO:0051721 | protein phosphatase 2A binding(GO:0051721) |
| 11.9 | 59.5 | GO:0030060 | L-malate dehydrogenase activity(GO:0030060) |
| 14.5 | 58.1 | GO:0031871 | proteinase activated receptor binding(GO:0031871) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 69.9 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 1.3 | 67.3 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.5 | 64.4 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.8 | 58.4 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 1.9 | 57.2 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 1.0 | 54.2 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 2.9 | 51.8 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 1.8 | 51.1 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 1.2 | 50.8 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 1.9 | 49.5 | PID ARF 3PATHWAY | Arf1 pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 201.2 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 2.2 | 177.8 | REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |
| 6.6 | 145.2 | REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 3.6 | 83.7 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 2.8 | 79.8 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 3.0 | 75.1 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 1.1 | 66.9 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.7 | 51.7 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.5 | 44.4 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 1.5 | 44.3 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |