ISMARA results: SIX6

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for SIX6

Z-value: 0.31

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Transcription factors associated with SIX6

Gene Symbol	Gene ID	Gene Info
SIX6 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000184302.6	SIX homeobox 6

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SIX6	hg19_v2_chr14_+_60975644_60975673	0.38	5.9e-09	Click!

Activity profile of SIX6 motif

Sorted Z-values of SIX6 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chrX_+_64708615 Show fit	21.90	ENST00000338957.4 ENST00000423889.3	ZC3H12B Ensembl NCBI GeneCards UniProt NextProt Show fit	zinc finger CCCH-type containing 12B
chr8_+_84824920 Show fit	16.88	ENST00000523678.1	RP11-120I21.2 Ensembl NCBI GeneCards UniProt NextProt Show fit	RP11-120I21.2
chr18_+_74240610 Show fit	16.40	ENST00000578092.1 ENST00000578613.1 ENST00000583578.1	LINC00908 Ensembl NCBI GeneCards UniProt NextProt Show fit	long intergenic non-protein coding RNA 908
chr4_+_113739244 Show fit	10.31	ENST00000503271.1 ENST00000503423.1 ENST00000506722.1	ANK2 Ensembl NCBI GeneCards UniProt NextProt Show fit	ankyrin 2, neuronal
chrX_+_8433376 Show fit	8.57	ENST00000440654.2 ENST00000381029.4	VCX3B Ensembl NCBI GeneCards UniProt NextProt Show fit	variable charge, X-linked 3B
chr2_-_100939195 Show fit	8.25	ENST00000393437.3	LONRF2 Ensembl NCBI GeneCards UniProt NextProt Show fit	LON peptidase N-terminal domain and ring finger 2
chr1_+_21880560 Show fit	7.06	ENST00000425315.2	ALPL Ensembl NCBI GeneCards UniProt NextProt Show fit	alkaline phosphatase, liver/bone/kidney
chr3_+_8543533 Show fit	6.73	ENST00000454244.1	LMCD1 Ensembl NCBI GeneCards UniProt NextProt Show fit	LIM and cysteine-rich domains 1
chrY_-_16098393 Show fit	6.54	ENST00000250825.4	VCY Ensembl NCBI GeneCards UniProt NextProt Show fit	variable charge, Y-linked
chr2_-_88427568 Show fit	6.50	ENST00000393750.3 ENST00000295834.3	FABP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	fatty acid binding protein 1, liver

Showing 1 to 10 of 120 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX6

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	16.7	GO:0090305	nucleic acid phosphodiester bond hydrolysis(GO:0090305)
0.0	14.8	GO:0007420	brain development(GO:0007420)
0.2	14.1	GO:0042267	natural killer cell mediated cytotoxicity(GO:0042267)
1.4	11.3	GO:0006689	ganglioside catabolic process(GO:0006689)
3.4	10.3	GO:0036371	protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.5	9.2	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.1	8.2	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.3	7.7	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
2.4	7.1	GO:0071529	cementum mineralization(GO:0071529)
0.6	6.5	GO:0032000	positive regulation of fatty acid beta-oxidation(GO:0032000)

Showing 1 to 10 of 63 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	49.1	GO:0016021	integral component of membrane(GO:0016021)
0.2	11.7	GO:0031430	M band(GO:0031430)
0.0	10.1	GO:0031012	extracellular matrix(GO:0031012)
1.2	7.1	GO:0065010	extracellular membrane-bounded organelle(GO:0065010)
0.8	6.5	GO:0045179	apical cortex(GO:0045179)
0.1	6.3	GO:0060170	ciliary membrane(GO:0060170)
0.1	5.6	GO:0031519	PcG protein complex(GO:0031519)
1.1	4.5	GO:0038038	G-protein coupled receptor homodimeric complex(GO:0038038)
0.0	4.4	GO:0032580	Golgi cisterna membrane(GO:0032580)
0.1	4.3	GO:0005868	cytoplasmic dynein complex(GO:0005868)

Showing 1 to 10 of 28 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	21.9	GO:0004519	endonuclease activity(GO:0004519)
2.8	11.3	GO:0052795	exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.2	10.3	GO:0030507	spectrin binding(GO:0030507)
0.7	9.2	GO:0005132	type I interferon receptor binding(GO:0005132)
0.2	8.2	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624)
1.0	7.1	GO:0004035	alkaline phosphatase activity(GO:0004035)
0.9	6.5	GO:0005324	long-chain fatty acid transporter activity(GO:0005324)
0.3	6.3	GO:0019864	IgG binding(GO:0019864)
0.7	5.6	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.2	5.0	GO:0004806	triglyceride lipase activity(GO:0004806)

Showing 1 to 10 of 50 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.8	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.1	5.7	PID PLK1 PATHWAY	PLK1 signaling events
0.0	3.5	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	3.2	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
0.0	2.6	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
0.0	2.6	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0	2.2	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.0	2.2	PID IL4 2PATHWAY	IL4-mediated signaling events
0.0	2.2	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.1	2.1	PID IL27 PATHWAY	IL27-mediated signaling events

Showing 1 to 10 of 12 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	11.3	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.1	10.8	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.0	6.5	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression
0.1	6.3	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends
0.1	4.8	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.2	4.5	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0	3.8	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.1	3.7	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1	3.2	REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	Genes involved in ABC-family proteins mediated transport
0.0	2.8	REACTOME NUCLEAR SIGNALING BY ERBB4	Genes involved in Nuclear signaling by ERBB4

Showing 1 to 10 of 24 entries

Results for SIX6

Z-value: 0.31

Motif logo

Transcription factors associated with SIX6

Activity-expression correlation:

Activity profile of SIX6 motif

Sorted Z-values of SIX6 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX6

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: