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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for SMAD1
Z-value: 1.00
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Transcription factors associated with SMAD1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SMAD1 | hg19_v2_chr4_+_146402925_146402957 | -0.52 | 2.0e-16 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_106209368 Show fit | 116.24 |
ENST00000390548.2
ENST00000390549.2 ENST00000390542.2 |
immunoglobulin heavy constant gamma 1 (G1m marker) |
|
| chr6_-_33048483 Show fit | 99.78 |
ENST00000419277.1
|
major histocompatibility complex, class II, DP alpha 1 |
|
| chr14_-_106111127 Show fit | 78.25 |
ENST00000390545.2
|
immunoglobulin heavy constant gamma 2 (G2m marker) |
|
| chr14_-_106237742 Show fit | 67.27 |
ENST00000390551.2
|
immunoglobulin heavy constant gamma 3 (G3m marker) |
|
| chr21_-_46330545 Show fit | 66.19 |
ENST00000320216.6
ENST00000397852.1 |
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) |
|
| chr14_-_106092403 Show fit | 65.38 |
ENST00000390543.2
|
immunoglobulin heavy constant gamma 4 (G4m marker) |
|
| chr6_+_33043703 Show fit | 62.62 |
ENST00000418931.2
ENST00000535465.1 |
major histocompatibility complex, class II, DP beta 1 |
|
| chr6_+_33048222 Show fit | 58.98 |
ENST00000428835.1
|
major histocompatibility complex, class II, DP beta 1 |
|
| chr16_+_222846 Show fit | 51.56 |
ENST00000251595.6
ENST00000397806.1 |
hemoglobin, alpha 2 |
|
| chr19_+_39897453 Show fit | 48.41 |
ENST00000597629.1
ENST00000248673.3 ENST00000594045.1 ENST00000594442.1 |
ZFP36 ring finger protein |
Network of associatons between targets according to the STRING database.
First level regulatory network of SMAD1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.2 | 724.7 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 6.6 | 616.4 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 3.4 | 379.7 | GO:0031295 | T cell costimulation(GO:0031295) |
| 1.9 | 246.6 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.4 | 239.3 | GO:0043547 | positive regulation of GTPase activity(GO:0043547) |
| 7.1 | 141.6 | GO:0002523 | leukocyte migration involved in inflammatory response(GO:0002523) |
| 2.5 | 125.3 | GO:0050853 | B cell receptor signaling pathway(GO:0050853) |
| 10.6 | 95.1 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
| 11.8 | 94.2 | GO:0002774 | Fc receptor mediated inhibitory signaling pathway(GO:0002774) |
| 4.8 | 86.8 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 681.9 | GO:0005615 | extracellular space(GO:0005615) |
| 14.0 | 659.1 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 16.0 | 337.0 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 2.1 | 317.8 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.2 | 261.0 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
| 1.0 | 183.6 | GO:0019897 | extrinsic component of plasma membrane(GO:0019897) |
| 5.6 | 162.7 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 23.4 | 140.7 | GO:0034687 | integrin alphaL-beta2 complex(GO:0034687) |
| 0.7 | 131.7 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 1.0 | 122.7 | GO:0005796 | Golgi lumen(GO:0005796) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.4 | 765.2 | GO:0003823 | antigen binding(GO:0003823) |
| 13.2 | 727.8 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 1.5 | 333.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 8.5 | 246.8 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.3 | 245.5 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.5 | 207.1 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 14.4 | 202.3 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 21.0 | 147.3 | GO:0030369 | ICAM-3 receptor activity(GO:0030369) |
| 0.2 | 118.6 | GO:0004888 | transmembrane signaling receptor activity(GO:0004888) |
| 8.9 | 115.9 | GO:0005344 | oxygen transporter activity(GO:0005344) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.3 | 274.5 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 2.7 | 239.9 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 2.9 | 228.0 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.8 | 201.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 1.1 | 183.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 2.3 | 129.8 | PID BCR 5PATHWAY | BCR signaling pathway |
| 4.3 | 108.3 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 1.3 | 73.9 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 1.3 | 72.7 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 1.0 | 62.4 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.7 | 459.6 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 1.1 | 438.8 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 16.8 | 385.6 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 1.0 | 179.9 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 1.9 | 121.0 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 1.9 | 111.1 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.8 | 105.1 | REACTOME G ALPHA Q SIGNALLING EVENTS | Genes involved in G alpha (q) signalling events |
| 10.2 | 102.2 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 2.0 | 83.3 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 1.5 | 81.5 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |