ISMARA results: SMAD2

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for SMAD2

Z-value: 1.38

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Transcription factors associated with SMAD2

Gene Symbol	Gene ID	Gene Info
SMAD2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000175387.11	SMAD family member 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SMAD2	hg19_v2_chr18_-_45457478_45457517	-0.41	3.4e-10	Click!

Activity profile of SMAD2 motif

Sorted Z-values of SMAD2 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr8_+_94241867 Show fit	42.24	ENST00000598428.1	AC016885.1 Ensembl NCBI GeneCards UniProt NextProt Show fit	Uncharacterized protein
chr16_-_70719925 Show fit	21.11	ENST00000338779.6	MTSS1L Ensembl NCBI GeneCards UniProt NextProt Show fit	metastasis suppressor 1-like
chrX_-_107018969 Show fit	17.48	ENST00000372383.4	TSC22D3 Ensembl NCBI GeneCards UniProt NextProt Show fit	TSC22 domain family, member 3
chr22_+_24891210 Show fit	17.18	ENST00000382760.2	UPB1 Ensembl NCBI GeneCards UniProt NextProt Show fit	ureidopropionase, beta
chr2_+_113033164 Show fit	16.24	ENST00000409871.1 ENST00000343936.4	ZC3H6 Ensembl NCBI GeneCards UniProt NextProt Show fit	zinc finger CCCH-type containing 6
chr12_+_53443963 Show fit	12.52	ENST00000546602.1 ENST00000552570.1 ENST00000549700.1	TENC1 Ensembl NCBI GeneCards UniProt NextProt Show fit	tensin like C1 domain containing phosphatase (tensin 2)
chr2_-_220173685 Show fit	12.35	ENST00000423636.2 ENST00000442029.1 ENST00000412847.1	PTPRN Ensembl NCBI GeneCards UniProt NextProt Show fit	protein tyrosine phosphatase, receptor type, N
chrX_+_38420783 Show fit	11.79	ENST00000422612.2 ENST00000286824.6 ENST00000545599.1	TSPAN7 Ensembl NCBI GeneCards UniProt NextProt Show fit	tetraspanin 7
chr19_+_56186557 Show fit	11.46	ENST00000270460.6	EPN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	epsin 1
chr19_+_56186606 Show fit	10.99	ENST00000085079.7	EPN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	epsin 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of SMAD2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.3	26.1	GO:0070235	regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236)
0.4	22.5	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059)
0.4	18.4	GO:0097178	ruffle assembly(GO:0097178)
5.7	17.2	GO:0019482	beta-alanine metabolic process(GO:0019482)
3.4	16.9	GO:0051941	regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920)
0.3	16.5	GO:0051058	negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
5.1	15.3	GO:1990502	dense core granule maturation(GO:1990502)
0.0	12.9	GO:0016032	viral process(GO:0016032)
0.2	10.4	GO:0006904	vesicle docking involved in exocytosis(GO:0006904)
3.1	9.4	GO:0090035	regulation of chaperone-mediated protein complex assembly(GO:0090034) positive regulation of chaperone-mediated protein complex assembly(GO:0090035)

Showing 1 to 10 of 118 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	52.5	GO:0005887	integral component of plasma membrane(GO:0005887)
0.0	31.0	GO:0005730	nucleolus(GO:0005730)
0.3	25.9	GO:0005905	clathrin-coated pit(GO:0005905)
0.2	21.1	GO:0030864	cortical actin cytoskeleton(GO:0030864)
0.1	19.9	GO:0008021	synaptic vesicle(GO:0008021)
0.8	16.9	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
0.9	16.5	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	16.0	GO:0043235	receptor complex(GO:0043235)
0.0	15.0	GO:0005615	extracellular space(GO:0005615)
0.1	12.1	GO:0043197	dendritic spine(GO:0043197)

Showing 1 to 10 of 62 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	31.9	GO:0003677	DNA binding(GO:0003677)
2.9	26.1	GO:0043426	MRF binding(GO:0043426)
0.5	21.1	GO:0003785	actin monomer binding(GO:0003785)
0.1	19.6	GO:0030246	carbohydrate binding(GO:0030246)
0.3	17.2	GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
1.2	16.9	GO:1990239	steroid hormone binding(GO:1990239)
0.3	15.3	GO:0030507	spectrin binding(GO:0030507)
0.0	14.1	GO:0030695	GTPase regulator activity(GO:0030695)
0.0	12.3	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.0	10.0	GO:0005509	calcium ion binding(GO:0005509)

Showing 1 to 10 of 89 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	23.4	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0	9.9	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.1	9.7	PID SHP2 PATHWAY	SHP2 signaling
0.2	9.4	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.1	8.8	PID ATF2 PATHWAY	ATF-2 transcription factor network
0.1	8.6	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.2	7.3	NABA COLLAGENS	Genes encoding collagen proteins
0.1	6.8	PID IL4 2PATHWAY	IL4-mediated signaling events
0.1	6.7	PID RAS PATHWAY	Regulation of Ras family activation
0.3	5.3	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events

Showing 1 to 10 of 23 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	23.7	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
1.2	17.2	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.4	14.2	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.3	11.6	REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER	Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.3	8.2	REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.1	7.3	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.3	6.9	REACTOME SYNTHESIS OF PC	Genes involved in Synthesis of PC
0.2	6.2	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.0	6.1	REACTOME TOLL RECEPTOR CASCADES	Genes involved in Toll Receptor Cascades
0.1	5.5	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines

Showing 1 to 10 of 40 entries

Results for SMAD2

Z-value: 1.38

Motif logo

Transcription factors associated with SMAD2

Activity-expression correlation:

Activity profile of SMAD2 motif

Sorted Z-values of SMAD2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of SMAD2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: