Project
GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for SOX21
Z-value: 0.37
Motif logo
Transcription factors associated with SOX21
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX21 | hg19_v2_chr13_-_95364389_95364389 | -0.27 | 4.6e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX21
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.0 | 27.0 | GO:0051311 | meiotic metaphase I plate congression(GO:0043060) meiotic spindle midzone assembly(GO:0051257) meiotic metaphase plate congression(GO:0051311) |
| 0.2 | 25.7 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.4 | 18.8 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.1 | 15.7 | GO:0042100 | B cell proliferation(GO:0042100) |
| 1.6 | 13.1 | GO:1900625 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 0.5 | 9.4 | GO:0045838 | positive regulation of membrane potential(GO:0045838) |
| 0.2 | 9.4 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.1 | 9.1 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.8 | 6.2 | GO:0075525 | viral translational termination-reinitiation(GO:0075525) |
| 1.2 | 5.8 | GO:0016998 | cell wall macromolecule catabolic process(GO:0016998) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.0 | 27.0 | GO:0005715 | late recombination nodule(GO:0005715) |
| 0.2 | 25.7 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 18.8 | GO:0010008 | endosome membrane(GO:0010008) |
| 2.2 | 15.7 | GO:0019815 | B cell receptor complex(GO:0019815) |
| 1.9 | 13.1 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.1 | 10.2 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.7 | 6.2 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
| 0.1 | 5.8 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 4.1 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.1 | 4.0 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 27.0 | GO:0032137 | guanine/thymine mispair binding(GO:0032137) |
| 0.1 | 25.7 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.4 | 18.8 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.0 | 15.6 | GO:0042803 | protein homodimerization activity(GO:0042803) |
| 0.4 | 13.1 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 10.4 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 10.2 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.9 | 9.4 | GO:0015038 | glutathione disulfide oxidoreductase activity(GO:0015038) |
| 0.1 | 6.2 | GO:0031369 | translation initiation factor binding(GO:0031369) |
| 1.0 | 5.8 | GO:0003796 | lysozyme activity(GO:0003796) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 27.0 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.2 | 20.6 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.4 | 18.8 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.4 | 13.1 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.1 | 9.4 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 5.8 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 4.0 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 3.3 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.0 | 1.8 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 1.4 | PID IL12 2PATHWAY | IL12-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 30.5 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 0.3 | 27.0 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.6 | 21.0 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.3 | 15.7 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.7 | 13.1 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.3 | 9.4 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.3 | 6.2 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 5.8 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.2 | 3.3 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |
| 0.0 | 2.8 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |