ISMARA results: SOX30

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for SOX30

Z-value: 0.13

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Transcription factors associated with SOX30

Gene Symbol	Gene ID	Gene Info
SOX30 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000039600.6	SRY-box transcription factor 30

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SOX30	hg19_v2_chr5_-_157079428_157079452, hg19_v2_chr5_-_157079372_157079395	0.18	6.9e-03	Click!

Activity profile of SOX30 motif

Sorted Z-values of SOX30 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_+_11081828 Show fit	12.48	ENST00000381847.3 ENST00000396400.3	PRH2 Ensembl NCBI GeneCards UniProt NextProt Show fit	proline-rich protein HaeIII subfamily 2
chr12_-_11036844 Show fit	12.28	ENST00000428168.2	PRH1 Ensembl NCBI GeneCards UniProt NextProt Show fit	proline-rich protein HaeIII subfamily 1
chr12_-_11548496 Show fit	12.25	ENST00000389362.4 ENST00000565533.1 ENST00000546254.1	PRB2 Ensembl NCBI GeneCards UniProt NextProt Show fit PRB1 Ensembl NCBI GeneCards UniProt NextProt Show fit	proline-rich protein BstNI subfamily 2 proline-rich protein BstNI subfamily 1
chr12_-_11508520 Show fit	11.33	ENST00000545626.1 ENST00000500254.2	PRB1 Ensembl NCBI GeneCards UniProt NextProt Show fit	proline-rich protein BstNI subfamily 1
chr12_-_11463353 Show fit	10.69	ENST00000279575.1 ENST00000535904.1 ENST00000445719.2	PRB4 Ensembl NCBI GeneCards UniProt NextProt Show fit	proline-rich protein BstNI subfamily 4
chr12_-_11002063 Show fit	9.87	ENST00000544994.1 ENST00000228811.4 ENST00000540107.1	PRR4 Ensembl NCBI GeneCards UniProt NextProt Show fit	proline rich 4 (lacrimal)
chr12_-_11422630 Show fit	7.13	ENST00000381842.3 ENST00000538488.1	PRB3 Ensembl NCBI GeneCards UniProt NextProt Show fit	proline-rich protein BstNI subfamily 3
chr12_-_11422739 Show fit	6.75	ENST00000279573.7	PRB3 Ensembl NCBI GeneCards UniProt NextProt Show fit	proline-rich protein BstNI subfamily 3
chr1_+_244998602 Show fit	5.28	ENST00000411948.2	COX20 Ensembl NCBI GeneCards UniProt NextProt Show fit	COX20 cytochrome C oxidase assembly factor
chr6_-_134639180 Show fit	4.91	ENST00000367858.5	SGK1 Ensembl NCBI GeneCards UniProt NextProt Show fit	serum/glucocorticoid regulated kinase 1

Showing 1 to 10 of 93 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX30

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	16.8	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2	13.9	GO:0050829	defense response to Gram-negative bacterium(GO:0050829)
0.2	10.4	GO:0048384	retinoic acid receptor signaling pathway(GO:0048384)
0.1	9.9	GO:0001895	retina homeostasis(GO:0001895)
0.4	5.3	GO:0097034	mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.7	4.9	GO:0070294	renal sodium ion absorption(GO:0070294)
0.0	4.0	GO:0070527	platelet aggregation(GO:0070527)
0.0	4.0	GO:0018105	peptidyl-serine phosphorylation(GO:0018105)
0.2	3.3	GO:1902083	negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.8	2.4	GO:2000097	chronological cell aging(GO:0001300) regulation of smooth muscle cell-matrix adhesion(GO:2000097)

Showing 1 to 10 of 46 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	42.1	GO:0005576	extracellular region(GO:0005576)
0.0	20.5	GO:0005615	extracellular space(GO:0005615)
0.0	16.2	GO:0005887	integral component of plasma membrane(GO:0005887)
0.0	10.1	GO:0005667	transcription factor complex(GO:0005667)
0.0	5.2	GO:0016607	nuclear speck(GO:0016607)
0.0	3.3	GO:0005814	centriole(GO:0005814)
0.1	2.4	GO:0044295	axonal growth cone(GO:0044295)
0.0	2.4	GO:1904724	tertiary granule lumen(GO:1904724)
0.0	2.4	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.0	2.4	GO:0005913	cell-cell adherens junction(GO:0005913)

Showing 1 to 10 of 23 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	16.3	GO:0005509	calcium ion binding(GO:0005509)
0.7	10.4	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.1	5.1	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.2	4.9	GO:0017081	chloride channel regulator activity(GO:0017081)
0.0	4.0	GO:0000287	magnesium ion binding(GO:0000287)
0.0	2.7	GO:0005262	calcium channel activity(GO:0005262)
0.0	2.6	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.1	2.4	GO:0019198	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1	2.2	GO:0004016	adenylate cyclase activity(GO:0004016)
0.1	1.7	GO:0005522	profilin binding(GO:0005522)

Showing 1 to 10 of 37 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	23.6	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2	10.4	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.1	5.9	PID FOXO PATHWAY	FoxO family signaling
0.0	3.8	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0	3.3	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.1	2.5	PID NECTIN PATHWAY	Nectin adhesion pathway
0.0	2.4	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.0	2.1	ST JNK MAPK PATHWAY	JNK MAPK Pathway
0.0	1.0	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.0	1.0	PID ENDOTHELIN PATHWAY	Endothelins

Showing 1 to 10 of 12 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Total log-likelihood	Term	Description
2.4	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
2.4	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
1.7	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
1.3	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
1.2	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
1.0	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.9	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.8	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.7	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.7	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism

Showing 1 to 10 of 13 entries

Results for SOX30

Z-value: 0.13

Motif logo

Transcription factors associated with SOX30

Activity-expression correlation:

Activity profile of SOX30 motif

Sorted Z-values of SOX30 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX30

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: