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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for SOX3_SOX2
Z-value: 0.44
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Transcription factors associated with SOX3_SOX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX2 | hg19_v2_chr3_+_181429704_181429722 | 0.48 | 5.6e-14 | Click! |
| SOX3 | hg19_v2_chrX_-_139587225_139587234 | 0.17 | 1.3e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX3_SOX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 36.3 | 181.4 | GO:1904209 | regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) |
| 8.3 | 124.9 | GO:0030050 | vesicle transport along actin filament(GO:0030050) |
| 0.7 | 114.0 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 11.4 | 113.5 | GO:0051610 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 4.7 | 109.2 | GO:0070262 | peptidyl-serine dephosphorylation(GO:0070262) |
| 5.6 | 101.0 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 7.2 | 100.2 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
| 3.2 | 63.5 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 15.9 | 63.4 | GO:0031117 | positive regulation of microtubule depolymerization(GO:0031117) |
| 12.5 | 62.6 | GO:1905098 | negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 219.5 | GO:0030426 | growth cone(GO:0030426) |
| 27.3 | 191.1 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.6 | 156.6 | GO:0099572 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.8 | 126.1 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 1.2 | 123.9 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.1 | 111.0 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 3.1 | 105.7 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 6.5 | 104.0 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 1.1 | 89.7 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.3 | 89.2 | GO:0005874 | microtubule(GO:0005874) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 28.6 | 343.7 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.4 | 299.8 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.6 | 183.7 | GO:0015631 | tubulin binding(GO:0015631) |
| 1.1 | 134.0 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 1.0 | 106.2 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 2.0 | 90.2 | GO:0030507 | spectrin binding(GO:0030507) |
| 2.9 | 90.1 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.6 | 81.9 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 4.8 | 76.4 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
| 0.5 | 72.7 | GO:0005496 | steroid binding(GO:0005496) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.2 | 93.4 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 1.3 | 89.7 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 1.0 | 71.3 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 1.1 | 70.6 | PID ATR PATHWAY | ATR signaling pathway |
| 0.3 | 62.5 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.7 | 42.4 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.3 | 41.2 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 1.2 | 37.6 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.6 | 32.5 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.6 | 31.7 | PID FAS PATHWAY | FAS (CD95) signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.0 | 138.6 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 4.3 | 117.3 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 1.5 | 93.2 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 1.7 | 91.9 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.4 | 43.6 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.8 | 43.1 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 1.3 | 41.9 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 1.1 | 36.5 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.5 | 34.6 | REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE | Genes involved in Cell death signalling via NRAGE, NRIF and NADE |
| 0.3 | 33.0 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |