ISMARA results: SOX5

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for SOX5

Z-value: 0.86

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Transcription factors associated with SOX5

Gene Symbol	Gene ID	Gene Info
SOX5 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000134532.11	SRY-box transcription factor 5

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SOX5	hg19_v2_chr12_-_23737534_23737550, hg19_v2_chr12_-_24103954_24103972	0.40	6.2e-10	Click!

Activity profile of SOX5 motif

Sorted Z-values of SOX5 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_-_6233828 Show fit	15.92	ENST00000572068.1 ENST00000261405.5	VWF Ensembl NCBI GeneCards UniProt NextProt Show fit	von Willebrand factor
chr14_-_92414055 Show fit	15.84	ENST00000342058.4	FBLN5 Ensembl NCBI GeneCards UniProt NextProt Show fit	fibulin 5
chr14_-_92413727 Show fit	14.81	ENST00000267620.10	FBLN5 Ensembl NCBI GeneCards UniProt NextProt Show fit	fibulin 5
chr7_+_111846741 Show fit	12.97	ENST00000421043.1 ENST00000425229.1 ENST00000450657.1	ZNF277 Ensembl NCBI GeneCards UniProt NextProt Show fit	zinc finger protein 277
chrX_-_13835147 Show fit	12.29	ENST00000493677.1 ENST00000355135.2	GPM6B Ensembl NCBI GeneCards UniProt NextProt Show fit	glycoprotein M6B
chr7_+_30960915 Show fit	10.83	ENST00000441328.2 ENST00000409899.1 ENST00000409611.1	AQP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	aquaporin 1 (Colton blood group)
chr18_-_52989217 Show fit	10.82	ENST00000570287.2	TCF4 Ensembl NCBI GeneCards UniProt NextProt Show fit	transcription factor 4
chr15_+_84115868 Show fit	10.54	ENST00000427482.2	SH3GL3 Ensembl NCBI GeneCards UniProt NextProt Show fit	SH3-domain GRB2-like 3
chr6_-_152957944 Show fit	10.26	ENST00000423061.1	SYNE1 Ensembl NCBI GeneCards UniProt NextProt Show fit	spectrin repeat containing, nuclear envelope 1
chr2_+_203499901 Show fit	10.17	ENST00000303116.6 ENST00000392238.2	FAM117B Ensembl NCBI GeneCards UniProt NextProt Show fit	family with sequence similarity 117, member B

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX5

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.2	38.0	GO:0048251	elastic fiber assembly(GO:0048251)
0.2	19.5	GO:0032760	positive regulation of tumor necrosis factor production(GO:0032760)
0.1	18.0	GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.3	15.7	GO:0043268	positive regulation of potassium ion transport(GO:0043268)
2.0	15.6	GO:0060414	aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1	14.3	GO:0006367	transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0	13.9	GO:0050890	cognition(GO:0050890)
1.6	12.9	GO:0007258	JUN phosphorylation(GO:0007258)
1.2	12.3	GO:0051612	negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
2.0	12.2	GO:0030421	defecation(GO:0030421)

Showing 1 to 10 of 125 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.8	38.0	GO:0071953	elastic fiber(GO:0071953)
0.2	32.2	GO:0032993	protein-DNA complex(GO:0032993)
0.6	27.6	GO:0009925	basal plasma membrane(GO:0009925)
0.1	16.5	GO:0030027	lamellipodium(GO:0030027)
0.2	15.6	GO:0097610	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
1.1	13.2	GO:0033093	Weibel-Palade body(GO:0033093)
0.1	12.7	GO:0043204	perikaryon(GO:0043204)
0.0	12.2	GO:0043025	neuronal cell body(GO:0043025)
1.6	11.5	GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
3.6	10.8	GO:0020005	symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005)

Showing 1 to 10 of 58 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	38.0	GO:0005178	integrin binding(GO:0005178)
1.8	23.3	GO:0001011	transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.2	19.1	GO:0003707	steroid hormone receptor activity(GO:0003707)
0.3	16.9	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
1.1	16.5	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.5	15.9	GO:0019865	immunoglobulin binding(GO:0019865)
0.1	15.7	GO:0044325	ion channel binding(GO:0044325)
3.1	15.6	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.3	14.1	GO:0005159	insulin-like growth factor receptor binding(GO:0005159)
0.1	13.5	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)

Showing 1 to 10 of 84 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	73.8	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.2	25.5	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.4	22.1	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.2	16.5	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.3	14.1	PID ER NONGENOMIC PATHWAY	Plasma membrane estrogen receptor signaling
0.3	12.2	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.1	11.1	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.3	10.6	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1	10.4	PID PDGFRB PATHWAY	PDGFR-beta signaling pathway
0.1	9.0	PID CASPASE PATHWAY	Caspase cascade in apoptosis

Showing 1 to 10 of 39 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	22.7	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.9	15.9	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.2	14.6	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.6	11.9	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.1	11.8	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.8	10.8	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.4	9.9	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.3	9.9	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.1	9.6	REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	Genes involved in Apoptotic cleavage of cellular proteins
0.1	8.6	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events

Showing 1 to 10 of 35 entries

Results for SOX5

Z-value: 0.86

Motif logo

Transcription factors associated with SOX5

Activity-expression correlation:

Activity profile of SOX5 motif

Sorted Z-values of SOX5 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX5

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: