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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for SOX7
Z-value: 1.07
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Transcription factors associated with SOX7
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX7 | hg19_v2_chr8_-_10588010_10588030 | 0.69 | 5.5e-32 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX7
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 17.5 | GO:0042908 | xenobiotic transport(GO:0042908) |
| 2.8 | 14.1 | GO:0072233 | thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233) |
| 1.7 | 11.6 | GO:0009753 | response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395) |
| 0.3 | 9.1 | GO:0030488 | tRNA methylation(GO:0030488) |
| 0.1 | 7.6 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.3 | 7.3 | GO:0034389 | lipid particle organization(GO:0034389) |
| 0.6 | 7.2 | GO:0006570 | tyrosine metabolic process(GO:0006570) |
| 0.1 | 6.9 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.3 | 6.4 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 0.4 | 5.9 | GO:0031167 | rRNA methylation(GO:0031167) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 17.5 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.2 | 14.1 | GO:0060170 | ciliary membrane(GO:0060170) |
| 0.5 | 11.3 | GO:0071004 | U2-type prespliceosome(GO:0071004) |
| 0.0 | 8.0 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 7.3 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.1 | 6.9 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.2 | 6.4 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 1.8 | 5.4 | GO:0033150 | perinuclear theca(GO:0033011) cytoskeletal calyx(GO:0033150) |
| 0.0 | 5.4 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.1 | 4.8 | GO:0044322 | endoplasmic reticulum quality control compartment(GO:0044322) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 17.5 | GO:0008559 | xenobiotic-transporting ATPase activity(GO:0008559) |
| 0.8 | 14.1 | GO:0019864 | IgG binding(GO:0019864) |
| 1.9 | 11.6 | GO:0047115 | phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086) trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity(GO:0047115) |
| 0.2 | 8.0 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.0 | 7.6 | GO:0003823 | antigen binding(GO:0003823) |
| 1.2 | 7.2 | GO:0004447 | iodide peroxidase activity(GO:0004447) |
| 0.1 | 6.9 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.5 | 6.4 | GO:0008503 | benzodiazepine receptor activity(GO:0008503) |
| 0.3 | 6.3 | GO:0008175 | tRNA methyltransferase activity(GO:0008175) |
| 1.2 | 5.9 | GO:0000179 | rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.5 | PID RHODOPSIN PATHWAY | Visual signal transduction: Rods |
| 0.0 | 3.1 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 3.0 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 17.5 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.3 | 7.2 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.2 | 6.4 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 5.7 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 4.8 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.2 | 4.2 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.1 | 4.2 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.0 | 3.1 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.1 | 3.0 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |