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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for SOX8

Z-value: 0.35

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Transcription factors associated with SOX8

Gene Symbol Gene ID Gene Info
SOX8
ENSG00000005513.9 SRY-box transcription factor 8

Activity profile of SOX8 motif

Sorted Z-values of SOX8 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_153330322 15.51 ENST00000368738.3
S100A9
S100 calcium binding protein A9
chr2_+_233527443 12.14 ENST00000410095.1
EFHD1
EF-hand domain family, member D1
chr8_-_82359662 10.49 ENST00000519260.1
ENST00000256103.2
PMP2
peripheral myelin protein 2
chr12_-_15104040 9.86 ENST00000541644.1
ENST00000545895.1
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr2_-_175711133 9.68 ENST00000409597.1
ENST00000413882.1
CHN1
chimerin 1
chr6_-_32498046 8.56 ENST00000374975.3
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr14_-_106642049 8.40 ENST00000390605.2
IGHV1-18
immunoglobulin heavy variable 1-18
chr14_+_75745477 8.32 ENST00000303562.4
ENST00000554617.1
ENST00000554212.1
ENST00000535987.1
ENST00000555242.1
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr16_+_31271274 8.31 ENST00000287497.8
ENST00000544665.3
ITGAM
integrin, alpha M (complement component 3 receptor 3 subunit)
chr6_+_32605195 7.80 ENST00000374949.2
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr12_-_15103621 7.79 ENST00000536592.1
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr12_-_11548496 7.08 ENST00000389362.4
ENST00000565533.1
ENST00000546254.1
PRB2
PRB1
proline-rich protein BstNI subfamily 2
proline-rich protein BstNI subfamily 1
chr1_+_111415757 6.76 ENST00000429072.2
ENST00000271324.5
CD53
CD53 molecule
chr3_-_39322728 6.74 ENST00000541347.1
ENST00000412814.1
CX3CR1
chemokine (C-X3-C motif) receptor 1
chr22_-_50523760 6.72 ENST00000395876.2
MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr12_-_10282836 6.65 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
CLEC7A
C-type lectin domain family 7, member A
chr8_-_120605194 6.16 ENST00000522167.1
ENPP2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr5_-_179499108 5.96 ENST00000521389.1
RNF130
ring finger protein 130
chr7_+_80275752 5.92 ENST00000419819.2
CD36
CD36 molecule (thrombospondin receptor)
chr11_-_125366089 5.53 ENST00000366139.3
ENST00000278919.3
FEZ1
fasciculation and elongation protein zeta 1 (zygin I)
chr5_-_179499086 5.53 ENST00000261947.4
RNF130
ring finger protein 130
chr5_-_160279207 5.51 ENST00000327245.5
ATP10B
ATPase, class V, type 10B
chr2_+_219646462 5.31 ENST00000258415.4
CYP27A1
cytochrome P450, family 27, subfamily A, polypeptide 1
chr1_+_20959943 5.28 ENST00000321556.4
PINK1
PTEN induced putative kinase 1
chr6_+_32605134 5.14 ENST00000343139.5
ENST00000395363.1
ENST00000496318.1
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr14_+_95078714 5.04 ENST00000393078.3
ENST00000393080.4
ENST00000467132.1
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr8_+_21915368 4.86 ENST00000265800.5
ENST00000517418.1
DMTN
dematin actin binding protein
chr15_+_25101698 4.73 ENST00000400097.1
SNRPN
small nuclear ribonucleoprotein polypeptide N
chr11_+_128563652 4.69 ENST00000527786.2
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr1_-_38512450 4.53 ENST00000373012.2
POU3F1
POU class 3 homeobox 1
chr4_+_155484155 4.38 ENST00000509493.1
FGB
fibrinogen beta chain
chr2_+_89986318 4.36 ENST00000491977.1
IGKV2D-29
immunoglobulin kappa variable 2D-29
chr1_-_153029980 4.27 ENST00000392653.2
SPRR2A
small proline-rich protein 2A
chr7_+_80275621 4.23 ENST00000426978.1
ENST00000432207.1
CD36
CD36 molecule (thrombospondin receptor)
chr12_-_10007448 4.20 ENST00000538152.1
CLEC2B
C-type lectin domain family 2, member B
chr14_-_106967788 4.18 ENST00000390622.2
IGHV1-46
immunoglobulin heavy variable 1-46
chr1_-_200992827 4.07 ENST00000332129.2
ENST00000422435.2
KIF21B
kinesin family member 21B
chr8_-_86253888 4.07 ENST00000522389.1
ENST00000432364.2
ENST00000517618.1
CA1
carbonic anhydrase I
chr1_+_161475208 4.06 ENST00000367972.4
ENST00000271450.6
FCGR2A
Fc fragment of IgG, low affinity IIa, receptor (CD32)
chr7_+_139478030 4.04 ENST00000425687.1
ENST00000263552.6
ENST00000438104.1
ENST00000336425.5
TBXAS1
thromboxane A synthase 1 (platelet)
chr9_-_113761720 4.02 ENST00000541779.1
ENST00000374430.2
LPAR1
lysophosphatidic acid receptor 1
chr19_+_1269324 3.91 ENST00000589710.1
ENST00000588230.1
ENST00000413636.2
ENST00000586472.1
ENST00000589686.1
ENST00000444172.2
ENST00000587323.1
ENST00000320936.5
ENST00000587896.1
ENST00000589235.1
ENST00000591659.1
CIRBP
cold inducible RNA binding protein
chr18_-_77711625 3.89 ENST00000357575.4
ENST00000590381.1
ENST00000397778.2
PQLC1
PQ loop repeat containing 1
chr10_+_7745232 3.89 ENST00000358415.4
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr7_+_79998864 3.77 ENST00000435819.1
CD36
CD36 molecule (thrombospondin receptor)
chr2_+_102615416 3.73 ENST00000393414.2
IL1R2
interleukin 1 receptor, type II
chr5_+_140186647 3.71 ENST00000512229.2
ENST00000356878.4
ENST00000530339.1
PCDHA4
protocadherin alpha 4
chr11_+_128563948 3.70 ENST00000534087.2
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chrX_+_15767971 3.67 ENST00000479740.1
ENST00000454127.2
CA5B
carbonic anhydrase VB, mitochondrial
chr16_+_30075783 3.58 ENST00000412304.2
ALDOA
aldolase A, fructose-bisphosphate
chr19_+_19144384 3.57 ENST00000392335.2
ENST00000535612.1
ENST00000537263.1
ENST00000540707.1
ENST00000541725.1
ENST00000269932.6
ENST00000546344.1
ENST00000540792.1
ENST00000536098.1
ENST00000541898.1
ENST00000543877.1
ARMC6
armadillo repeat containing 6
chr15_+_80733570 3.57 ENST00000533983.1
ENST00000527771.1
ENST00000525103.1
ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr4_+_40192656 3.55 ENST00000505618.1
RHOH
ras homolog family member H
chr12_-_11508520 3.51 ENST00000545626.1
ENST00000500254.2
PRB1
proline-rich protein BstNI subfamily 1
chr14_-_107283278 3.43 ENST00000390639.2
IGHV7-81
immunoglobulin heavy variable 7-81 (non-functional)
chr22_-_42466782 3.31 ENST00000396398.3
ENST00000403363.1
ENST00000402937.1
NAGA
N-acetylgalactosaminidase, alpha-
chr19_-_45681482 3.28 ENST00000592647.1
ENST00000006275.4
ENST00000588062.1
ENST00000585934.1
TRAPPC6A
trafficking protein particle complex 6A
chr19_+_51728316 3.21 ENST00000436584.2
ENST00000421133.2
ENST00000391796.3
ENST00000262262.4
CD33
CD33 molecule
chr15_+_43985084 3.12 ENST00000434505.1
ENST00000411750.1
CKMT1A
creatine kinase, mitochondrial 1A
chr6_-_32160622 3.12 ENST00000487761.1
ENST00000375040.3
GPSM3
G-protein signaling modulator 3
chr19_+_18794470 3.09 ENST00000321949.8
ENST00000338797.6
CRTC1
CREB regulated transcription coactivator 1
chr7_-_80551671 3.06 ENST00000419255.2
ENST00000544525.1
SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr1_-_203274418 2.94 ENST00000457348.1
RP11-134P9.1
long intergenic non-protein coding RNA 1136
chr18_+_61442629 2.94 ENST00000398019.2
ENST00000540675.1
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr17_-_34207295 2.92 ENST00000463941.1
ENST00000293272.3
CCL5
chemokine (C-C motif) ligand 5
chr12_-_123201337 2.87 ENST00000528880.2
HCAR3
hydroxycarboxylic acid receptor 3
chr15_-_89755034 2.84 ENST00000563254.1
RLBP1
retinaldehyde binding protein 1
chr9_-_116837249 2.81 ENST00000466610.2
AMBP
alpha-1-microglobulin/bikunin precursor
chr2_-_89521942 2.79 ENST00000482769.1
IGKV2-28
immunoglobulin kappa variable 2-28
chr7_-_36634181 2.78 ENST00000538464.1
AOAH
acyloxyacyl hydrolase (neutrophil)
chr4_+_155484103 2.64 ENST00000302068.4
FGB
fibrinogen beta chain
chr3_-_49459865 2.64 ENST00000427987.1
AMT
aminomethyltransferase
chr3_+_137906154 2.63 ENST00000466749.1
ENST00000358441.2
ENST00000489213.1
ARMC8
armadillo repeat containing 8
chr1_+_152956549 2.59 ENST00000307122.2
SPRR1A
small proline-rich protein 1A
chr3_-_49459878 2.57 ENST00000546031.1
ENST00000458307.2
ENST00000430521.1
AMT
aminomethyltransferase
chr1_+_13516066 2.55 ENST00000332192.6
PRAMEF21
PRAME family member 21
chr15_+_43885252 2.53 ENST00000453782.1
ENST00000300283.6
ENST00000437924.1
ENST00000450086.2
CKMT1B
creatine kinase, mitochondrial 1B
chr22_+_24236191 2.52 ENST00000215754.7
MIF
macrophage migration inhibitory factor (glycosylation-inhibiting factor)
chr14_-_107049312 2.49 ENST00000390627.2
IGHV3-53
immunoglobulin heavy variable 3-53
chr4_+_156680153 2.46 ENST00000502959.1
ENST00000505764.1
ENST00000507146.1
ENST00000264424.8
ENST00000503520.1
GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr6_+_37012607 2.44 ENST00000423336.1
COX6A1P2
cytochrome c oxidase subunit VIa polypeptide 1 pseudogene 2
chr14_-_106733624 2.40 ENST00000390610.2
IGHV1-24
immunoglobulin heavy variable 1-24
chr7_-_38289173 2.36 ENST00000436911.2
TRGC2
T cell receptor gamma constant 2
chr5_+_140227048 2.32 ENST00000532602.1
PCDHA9
protocadherin alpha 9
chr16_+_30075595 2.30 ENST00000563060.2
ALDOA
aldolase A, fructose-bisphosphate
chr17_+_2240916 2.28 ENST00000574563.1
SGSM2
small G protein signaling modulator 2
chr11_+_125774362 2.28 ENST00000530414.1
ENST00000530129.2
DDX25
DEAD (Asp-Glu-Ala-Asp) box helicase 25
chr1_-_9811600 2.26 ENST00000435891.1
CLSTN1
calsyntenin 1
chr17_-_8021710 2.23 ENST00000380149.1
ENST00000448843.2
ALOXE3
arachidonate lipoxygenase 3
chr16_+_57769635 2.23 ENST00000379661.3
ENST00000562592.1
ENST00000566726.1
KATNB1
katanin p80 (WD repeat containing) subunit B 1
chr22_-_36903069 2.22 ENST00000216187.6
ENST00000423980.1
FOXRED2
FAD-dependent oxidoreductase domain containing 2
chr8_+_1993152 2.09 ENST00000262113.4
MYOM2
myomesin 2
chr16_+_87985029 2.08 ENST00000439677.1
ENST00000286122.7
ENST00000355163.5
ENST00000454563.1
ENST00000479780.2
ENST00000393208.2
ENST00000412691.1
ENST00000355022.4
BANP
BTG3 associated nuclear protein
chr8_-_91095099 2.08 ENST00000265431.3
CALB1
calbindin 1, 28kDa
chr6_+_31707725 2.06 ENST00000375755.3
ENST00000375742.3
ENST00000375750.3
ENST00000425703.1
ENST00000534153.4
ENST00000375703.3
ENST00000375740.3
MSH5
mutS homolog 5
chr1_+_192605252 2.05 ENST00000391995.2
ENST00000543215.1
RGS13
regulator of G-protein signaling 13
chr6_-_133079022 2.05 ENST00000525289.1
ENST00000326499.6
VNN2
vanin 2
chr16_+_30075463 2.03 ENST00000562168.1
ENST00000569545.1
ALDOA
aldolase A, fructose-bisphosphate
chr15_-_20170354 2.03 ENST00000338912.5
IGHV1OR15-9
immunoglobulin heavy variable 1/OR15-9 (non-functional)
chr13_-_47012325 2.02 ENST00000409879.2
KIAA0226L
KIAA0226-like
chr5_-_94417339 1.99 ENST00000429576.2
ENST00000508509.1
ENST00000510732.1
MCTP1
multiple C2 domains, transmembrane 1
chr15_+_34261089 1.96 ENST00000383263.5
CHRM5
cholinergic receptor, muscarinic 5
chr2_+_113816215 1.89 ENST00000346807.3
IL36RN
interleukin 36 receptor antagonist
chr18_+_71815743 1.89 ENST00000169551.6
ENST00000580087.1
TIMM21
translocase of inner mitochondrial membrane 21 homolog (yeast)
chr12_-_123187890 1.89 ENST00000328880.5
HCAR2
hydroxycarboxylic acid receptor 2
chr5_+_140792614 1.88 ENST00000398610.2
PCDHGA10
protocadherin gamma subfamily A, 10
chr1_+_158901329 1.87 ENST00000368140.1
ENST00000368138.3
ENST00000392254.2
ENST00000392252.3
ENST00000368135.4
PYHIN1
pyrin and HIN domain family, member 1
chr18_+_11857439 1.81 ENST00000602628.1
GNAL
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr9_-_139891165 1.81 ENST00000494426.1
CLIC3
chloride intracellular channel 3
chr3_+_137906353 1.79 ENST00000461822.1
ENST00000485396.1
ENST00000471453.1
ENST00000470821.1
ENST00000471709.1
ENST00000538260.1
ENST00000393058.3
ENST00000463485.1
ARMC8
armadillo repeat containing 8
chr4_+_156680143 1.77 ENST00000505154.1
GUCY1B3
guanylate cyclase 1, soluble, beta 3
chrX_+_100474906 1.76 ENST00000541709.1
DRP2
dystrophin related protein 2
chr18_-_3845321 1.73 ENST00000539435.1
ENST00000400147.2
DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr8_+_107738240 1.72 ENST00000449762.2
ENST00000297447.6
OXR1
oxidation resistance 1
chr8_+_1993173 1.70 ENST00000523438.1
MYOM2
myomesin 2
chr10_-_1779663 1.69 ENST00000381312.1
ADARB2
adenosine deaminase, RNA-specific, B2 (non-functional)
chr6_-_136788001 1.69 ENST00000544465.1
MAP7
microtubule-associated protein 7
chr4_-_47983519 1.65 ENST00000358519.4
ENST00000544810.1
ENST00000402813.3
CNGA1
cyclic nucleotide gated channel alpha 1
chr10_-_74114714 1.63 ENST00000338820.3
ENST00000394903.2
ENST00000444643.2
DNAJB12
DnaJ (Hsp40) homolog, subfamily B, member 12
chr3_+_137906109 1.57 ENST00000481646.1
ENST00000469044.1
ENST00000491704.1
ENST00000461600.1
ARMC8
armadillo repeat containing 8
chr12_+_29376673 1.51 ENST00000547116.1
FAR2
fatty acyl CoA reductase 2
chr1_-_13673511 1.48 ENST00000344998.3
ENST00000334600.6
PRAMEF14
PRAME family member 14
chr3_+_38347427 1.48 ENST00000273173.4
SLC22A14
solute carrier family 22, member 14
chr1_-_12958101 1.47 ENST00000235347.4
PRAMEF10
PRAME family member 10
chr12_-_9760482 1.45 ENST00000229402.3
KLRB1
killer cell lectin-like receptor subfamily B, member 1
chr17_-_66951474 1.44 ENST00000269080.2
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr17_-_73663245 1.42 ENST00000584999.1
ENST00000317905.5
ENST00000420326.2
ENST00000340830.5
RECQL5
RecQ protein-like 5
chr11_-_57177586 1.42 ENST00000529411.1
RP11-872D17.8
Uncharacterized protein
chr3_-_186288097 1.40 ENST00000446782.1
TBCCD1
TBCC domain containing 1
chr22_-_29784519 1.35 ENST00000357586.2
ENST00000356015.2
ENST00000432560.2
ENST00000317368.7
AP1B1
adaptor-related protein complex 1, beta 1 subunit
chr18_-_53253323 1.33 ENST00000540999.1
ENST00000563888.2
TCF4
transcription factor 4
chr4_-_144940477 1.33 ENST00000513128.1
ENST00000429670.2
ENST00000502664.1
GYPB
glycophorin B (MNS blood group)
chr4_+_95972822 1.32 ENST00000509540.1
ENST00000440890.2
BMPR1B
bone morphogenetic protein receptor, type IB
chr12_-_10282742 1.31 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
CLEC7A
C-type lectin domain family 7, member A
chr3_-_21792838 1.29 ENST00000281523.2
ZNF385D
zinc finger protein 385D
chr18_-_3845293 1.27 ENST00000400145.2
DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr15_+_62853562 1.26 ENST00000561311.1
TLN2
talin 2
chr2_-_228497888 1.25 ENST00000264387.4
ENST00000409066.1
C2orf83
chromosome 2 open reading frame 83
chr5_+_140800638 1.24 ENST00000398587.2
ENST00000518882.1
PCDHGA11
protocadherin gamma subfamily A, 11
chr6_-_138539627 1.24 ENST00000527246.2
PBOV1
prostate and breast cancer overexpressed 1
chr3_+_113465866 1.23 ENST00000273398.3
ENST00000538620.1
ENST00000496747.1
ENST00000475322.1
ATP6V1A
ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr11_-_129062093 1.23 ENST00000310343.9
ARHGAP32
Rho GTPase activating protein 32
chr6_-_49712147 1.23 ENST00000433368.2
ENST00000354620.4
CRISP3
cysteine-rich secretory protein 3
chr4_+_71248795 1.20 ENST00000304915.3
SMR3B
submaxillary gland androgen regulated protein 3B
chr18_+_32173276 1.19 ENST00000591816.1
ENST00000588125.1
ENST00000598334.1
ENST00000588684.1
ENST00000554864.3
ENST00000399121.5
ENST00000595022.1
ENST00000269190.7
ENST00000399097.3
DTNA
dystrobrevin, alpha
chr14_-_106471723 1.18 ENST00000390595.2
IGHV1-3
immunoglobulin heavy variable 1-3
chrX_-_9734004 1.14 ENST00000467482.1
ENST00000380929.2
GPR143
G protein-coupled receptor 143
chr18_-_5396271 1.14 ENST00000579951.1
EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr10_-_101825151 1.13 ENST00000441382.1
CPN1
carboxypeptidase N, polypeptide 1
chr12_+_29376592 1.12 ENST00000182377.4
FAR2
fatty acyl CoA reductase 2
chr20_+_32150140 1.12 ENST00000344201.3
ENST00000346541.3
ENST00000397800.1
ENST00000397798.2
ENST00000492345.1
CBFA2T2
core-binding factor, runt domain, alpha subunit 2; translocated to, 2
chr4_-_38858428 1.12 ENST00000436693.2
ENST00000508254.1
ENST00000514655.1
ENST00000506146.1
TLR6
TLR1
toll-like receptor 6
toll-like receptor 1
chr1_+_13742808 1.11 ENST00000602960.1
PRAMEF20
PRAME family member 20
chr15_-_58306295 1.11 ENST00000559517.1
ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr16_+_30387141 1.11 ENST00000566955.1
MYLPF
myosin light chain, phosphorylatable, fast skeletal muscle
chrX_-_132887729 1.08 ENST00000406757.2
GPC3
glypican 3
chr3_-_54962100 1.04 ENST00000273286.5
LRTM1
leucine-rich repeats and transmembrane domains 1
chr17_+_1646130 1.04 ENST00000453066.1
ENST00000324015.3
ENST00000450523.2
ENST00000453723.1
ENST00000382061.4
SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr14_+_88471468 1.03 ENST00000267549.3
GPR65
G protein-coupled receptor 65
chr6_-_22297730 1.03 ENST00000306482.1
PRL
prolactin
chr12_-_10151773 1.03 ENST00000298527.6
ENST00000348658.4
CLEC1B
C-type lectin domain family 1, member B
chr5_-_160973649 1.02 ENST00000393959.1
ENST00000517547.1
GABRB2
gamma-aminobutyric acid (GABA) A receptor, beta 2
chr17_-_34313685 1.00 ENST00000435911.2
ENST00000586216.1
ENST00000394509.4
CCL14
chemokine (C-C motif) ligand 14
chr3_-_58196939 0.98 ENST00000394549.2
ENST00000461914.3
DNASE1L3
deoxyribonuclease I-like 3
chr5_+_140739537 0.98 ENST00000522605.1
PCDHGB2
protocadherin gamma subfamily B, 2
chr18_-_53253112 0.98 ENST00000568673.1
ENST00000562847.1
ENST00000568147.1
TCF4
transcription factor 4
chr6_+_63921351 0.97 ENST00000370659.1
FKBP1C
FK506 binding protein 1C
chr7_-_14942283 0.96 ENST00000402815.1
DGKB
diacylglycerol kinase, beta 90kDa
chr16_-_30122717 0.95 ENST00000566613.1
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr14_+_22337014 0.95 ENST00000390436.2
TRAV13-1
T cell receptor alpha variable 13-1
chr19_+_22235279 0.95 ENST00000594363.1
ENST00000597927.1
ENST00000594947.1
ZNF257
zinc finger protein 257
chr4_-_69434245 0.94 ENST00000317746.2
UGT2B17
UDP glucuronosyltransferase 2 family, polypeptide B17
chr7_+_151771377 0.94 ENST00000434507.1
GALNT11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)
chr1_+_70876926 0.94 ENST00000370938.3
ENST00000346806.2
CTH
cystathionase (cystathionine gamma-lyase)
chr5_-_138534071 0.93 ENST00000394817.2
SIL1
SIL1 nucleotide exchange factor
chr9_+_2157655 0.92 ENST00000452193.1
SMARCA2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr22_-_50708781 0.90 ENST00000449719.2
ENST00000330651.6
MAPK11
mitogen-activated protein kinase 11
chr4_-_100356551 0.89 ENST00000209665.4
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr1_+_87012753 0.88 ENST00000370563.3
CLCA4
chloride channel accessory 4
chr12_+_56325812 0.87 ENST00000394147.1
ENST00000551156.1
ENST00000553783.1
ENST00000557080.1
ENST00000432422.3
ENST00000556001.1
DGKA
diacylglycerol kinase, alpha 80kDa
chr3_-_49851313 0.86 ENST00000333486.3
UBA7
ubiquitin-like modifier activating enzyme 7
chr16_-_90096309 0.86 ENST00000408886.2
C16orf3
chromosome 16 open reading frame 3
chr5_+_140753444 0.86 ENST00000517434.1
PCDHGA6
protocadherin gamma subfamily A, 6
chr18_-_11148587 0.86 ENST00000302079.6
ENST00000580640.1
ENST00000503781.3
PIEZO2
piezo-type mechanosensitive ion channel component 2
chr4_-_145061788 0.85 ENST00000512064.1
ENST00000512789.1
ENST00000504786.1
ENST00000503627.1
ENST00000535709.1
ENST00000324022.10
ENST00000360771.4
ENST00000283126.7
GYPA
GYPB
glycophorin A (MNS blood group)
glycophorin B (MNS blood group)
chr16_+_87636474 0.83 ENST00000284262.2
JPH3
junctophilin 3
chr5_-_132948216 0.83 ENST00000265342.7
FSTL4
follistatin-like 4
chr6_-_49712123 0.82 ENST00000263045.4
CRISP3
cysteine-rich secretory protein 3
chr6_+_27100811 0.81 ENST00000359193.2
HIST1H2AG
histone cluster 1, H2ag
chr12_+_113354341 0.81 ENST00000553152.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr3_-_52090461 0.79 ENST00000296483.6
ENST00000495880.1
DUSP7
dual specificity phosphatase 7
chr11_+_74862140 0.78 ENST00000525650.1
ENST00000454962.2
SLCO2B1
solute carrier organic anion transporter family, member 2B1
chr3_-_58196688 0.78 ENST00000486455.1
DNASE1L3
deoxyribonuclease I-like 3
chr8_+_38758737 0.78 ENST00000521746.1
ENST00000420274.1
PLEKHA2
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
chr2_-_207024233 0.77 ENST00000423725.1
ENST00000233190.6
NDUFS1
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr18_-_51750948 0.72 ENST00000583046.1
ENST00000398398.2
MBD2
methyl-CpG binding domain protein 2
chr1_-_109935819 0.71 ENST00000538502.1
SORT1
sortilin 1
chr2_+_166326157 0.70 ENST00000421875.1
ENST00000314499.7
ENST00000409664.1
CSRNP3
cysteine-serine-rich nuclear protein 3
chr11_+_60995849 0.69 ENST00000537932.1
PGA4
pepsinogen 4, group I (pepsinogen A)
chr1_-_67142710 0.67 ENST00000502413.2
AL139147.1
Uncharacterized protein

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 15.5 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
4.4 17.6 GO:0071461 cellular response to redox state(GO:0071461)
2.2 6.7 GO:0002881 negative regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002881)
2.0 13.9 GO:2000334 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
1.8 10.8 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
1.4 4.2 GO:0038060 nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
1.0 5.2 GO:0019464 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
1.0 8.3 GO:0001661 conditioned taste aversion(GO:0001661)
1.0 3.1 GO:1902630 regulation of membrane hyperpolarization(GO:1902630)
1.0 4.0 GO:1904566 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.9 3.7 GO:0050712 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.9 2.6 GO:0010025 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.8 4.9 GO:0070560 protein secretion by platelet(GO:0070560)
0.8 3.8 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.7 2.9 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.7 2.9 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.7 7.0 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.6 8.3 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.6 2.2 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.5 6.7 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.5 3.1 GO:0003350 pulmonary myocardium development(GO:0003350)
0.5 2.5 GO:0002905 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
0.5 1.4 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.5 3.3 GO:1903232 melanosome assembly(GO:1903232)
0.5 1.4 GO:0051684 maintenance of Golgi location(GO:0051684)
0.5 0.9 GO:2001184 positive regulation of interleukin-12 secretion(GO:2001184)
0.4 7.9 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.4 1.3 GO:0015888 thiamine transport(GO:0015888) thiamine transmembrane transport(GO:0071934)
0.4 3.3 GO:0016139 glycoside catabolic process(GO:0016139)
0.4 6.2 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.4 25.4 GO:0006910 phagocytosis, recognition(GO:0006910)
0.4 2.0 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.4 8.5 GO:0035855 megakaryocyte development(GO:0035855)
0.4 1.9 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.4 1.1 GO:0070340 detection of bacterial lipoprotein(GO:0042494) detection of triacyl bacterial lipopeptide(GO:0042495) detection of bacterial lipopeptide(GO:0070340)
0.4 2.2 GO:0051122 hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.3 3.9 GO:0006776 vitamin A metabolic process(GO:0006776)
0.3 1.9 GO:1902714 negative regulation of interferon-gamma secretion(GO:1902714)
0.3 0.9 GO:0099543 retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by trans-synaptic complex(GO:0099545)
0.3 0.9 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.3 6.8 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.3 1.1 GO:0043324 eye pigment biosynthetic process(GO:0006726) eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474) regulation of melanosome transport(GO:1902908)
0.3 3.1 GO:0006600 creatine metabolic process(GO:0006600)
0.3 0.8 GO:0031548 regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548)
0.3 9.7 GO:0008045 motor neuron axon guidance(GO:0008045)
0.3 1.1 GO:0072180 mesonephric duct morphogenesis(GO:0072180)
0.3 1.3 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.3 3.1 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.3 2.1 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
0.3 5.0 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.2 4.0 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.2 0.9 GO:0018352 protein-pyridoxal-5-phosphate linkage(GO:0018352)
0.2 3.9 GO:0034063 stress granule assembly(GO:0034063)
0.2 2.1 GO:0051026 chiasma assembly(GO:0051026)
0.2 1.1 GO:0030070 insulin processing(GO:0030070)
0.2 1.0 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.2 0.6 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.2 2.0 GO:0015939 pantothenate metabolic process(GO:0015939)
0.2 5.5 GO:0034204 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.2 0.9 GO:0018243 protein O-linked glycosylation via threonine(GO:0018243)
0.2 2.8 GO:0018298 porphyrin-containing compound catabolic process(GO:0006787) protein-chromophore linkage(GO:0018298) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.2 19.6 GO:0031295 T cell costimulation(GO:0031295)
0.2 1.1 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.2 1.4 GO:0042908 xenobiotic transport(GO:0042908)
0.2 0.5 GO:0001172 transcription, RNA-templated(GO:0001172)
0.2 4.5 GO:0032292 myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.1 1.0 GO:0010757 negative regulation of plasminogen activation(GO:0010757) positive regulation of cell-cell adhesion mediated by cadherin(GO:2000049)
0.1 1.9 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.1 0.6 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
0.1 1.7 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.1 0.4 GO:0014016 neuroblast differentiation(GO:0014016)
0.1 7.7 GO:0015701 bicarbonate transport(GO:0015701)
0.1 1.6 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.1 0.7 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.1 0.9 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.1 9.5 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 1.8 GO:0010623 programmed cell death involved in cell development(GO:0010623)
0.1 0.3 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.1 1.3 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.1 1.8 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.1 0.5 GO:0000720 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720) positive regulation of t-circle formation(GO:1904431)
0.1 4.6 GO:0018149 peptide cross-linking(GO:0018149)
0.1 2.0 GO:0007163 establishment or maintenance of cell polarity(GO:0007163)
0.1 4.2 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.1 1.2 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.1 0.4 GO:0006196 AMP catabolic process(GO:0006196)
0.1 3.5 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.1 2.3 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.1 0.5 GO:0030033 microvillus assembly(GO:0030033)
0.1 0.9 GO:0050974 detection of mechanical stimulus involved in sensory perception(GO:0050974)
0.1 8.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 1.0 GO:0030220 platelet formation(GO:0030220)
0.1 1.0 GO:0071420 cellular response to histamine(GO:0071420)
0.1 1.1 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.1 1.5 GO:0015695 organic cation transport(GO:0015695)
0.0 1.0 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 2.1 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 0.5 GO:0060371 regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371)
0.0 0.7 GO:0006346 chromatin silencing at rDNA(GO:0000183) methylation-dependent chromatin silencing(GO:0006346)
0.0 1.0 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0 1.9 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.0 0.2 GO:0021633 optic nerve structural organization(GO:0021633)
0.0 1.4 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.0 2.3 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 4.1 GO:0038096 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
0.0 0.1 GO:0001694 histamine biosynthetic process(GO:0001694)
0.0 0.5 GO:0060539 diaphragm development(GO:0060539)
0.0 0.3 GO:0070836 plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836)
0.0 0.8 GO:0035640 exploration behavior(GO:0035640)
0.0 4.4 GO:0002377 immunoglobulin production(GO:0002377)
0.0 0.1 GO:0036337 Fas signaling pathway(GO:0036337) regulation of Fas signaling pathway(GO:1902044)
0.0 2.1 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.4 GO:0098828 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.0 2.6 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 2.2 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.0 0.8 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.4 GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway(GO:0010804)
0.0 0.1 GO:0052695 cellular glucuronidation(GO:0052695)
0.0 3.2 GO:0006805 xenobiotic metabolic process(GO:0006805)
0.0 0.1 GO:0035947 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.0 0.4 GO:0044705 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.0 0.6 GO:0007183 SMAD protein complex assembly(GO:0007183)
0.0 0.1 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699) Sertoli cell proliferation(GO:0060011)
0.0 1.0 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.2 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.0 0.3 GO:0007586 digestion(GO:0007586)
0.0 0.2 GO:0045408 regulation of interleukin-6 biosynthetic process(GO:0045408)
0.0 1.7 GO:0007268 chemical synaptic transmission(GO:0007268) anterograde trans-synaptic signaling(GO:0098916) trans-synaptic signaling(GO:0099537)
0.0 0.9 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.4 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.2 GO:0090331 negative regulation of platelet aggregation(GO:0090331)
0.0 0.9 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.2 GO:0043562 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 0.8 GO:0001954 positive regulation of cell-matrix adhesion(GO:0001954)
0.0 1.3 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.0 0.5 GO:0050435 beta-amyloid metabolic process(GO:0050435)
0.0 0.3 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 0.8 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 2.6 GO:0007018 microtubule-based movement(GO:0007018)
0.0 0.2 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.0 0.9 GO:0007286 spermatid development(GO:0007286)
0.0 1.8 GO:0050808 synapse organization(GO:0050808)
0.0 0.7 GO:0010923 negative regulation of phosphatase activity(GO:0010923)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 8.3 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
1.0 8.3 GO:0035976 AP1 complex(GO:0035976)
1.0 21.5 GO:0042613 MHC class II protein complex(GO:0042613)
0.8 5.3 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.6 8.1 GO:0005577 fibrinogen complex(GO:0005577)
0.4 13.9 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.4 1.1 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
0.3 17.4 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.3 4.9 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.3 4.7 GO:0005687 U4 snRNP(GO:0005687)
0.3 3.3 GO:0030008 TRAPP complex(GO:0030008)
0.2 6.9 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.2 11.7 GO:0031430 M band(GO:0031430)
0.2 0.8 GO:0030314 junctional membrane complex(GO:0030314)
0.2 2.3 GO:0033391 chromatoid body(GO:0033391)
0.2 4.2 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.2 1.9 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.2 0.8 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
0.1 2.1 GO:0032300 mismatch repair complex(GO:0032300)
0.1 7.0 GO:0001772 immunological synapse(GO:0001772)
0.1 1.6 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 2.6 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1 1.3 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 1.2 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 4.6 GO:0001533 cornified envelope(GO:0001533)
0.1 4.9 GO:0043198 dendritic shaft(GO:0043198)
0.1 1.4 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 4.1 GO:0005871 kinesin complex(GO:0005871)
0.1 12.2 GO:0072562 blood microparticle(GO:0072562)
0.1 1.1 GO:0033270 paranode region of axon(GO:0033270)
0.1 0.5 GO:0070522 nucleotide-excision repair factor 1 complex(GO:0000110) ERCC4-ERCC1 complex(GO:0070522)
0.1 0.7 GO:0097486 multivesicular body lumen(GO:0097486)
0.1 7.6 GO:0005901 caveola(GO:0005901)
0.1 4.8 GO:1904724 tertiary granule lumen(GO:1904724)
0.1 0.5 GO:1990635 proximal dendrite(GO:1990635)
0.1 1.1 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 0.5 GO:0071439 clathrin complex(GO:0071439)
0.0 16.5 GO:0034774 secretory granule lumen(GO:0034774)
0.0 1.1 GO:0005859 muscle myosin complex(GO:0005859)
0.0 21.1 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 2.6 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 2.8 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.9 GO:0071564 npBAF complex(GO:0071564)
0.0 2.4 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 2.3 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 1.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 3.2 GO:0070821 tertiary granule membrane(GO:0070821)
0.0 8.9 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 0.5 GO:1904813 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0 3.4 GO:0005875 microtubule associated complex(GO:0005875)
0.0 1.0 GO:0031904 endosome lumen(GO:0031904)
0.0 0.5 GO:0000974 Prp19 complex(GO:0000974)
0.0 0.3 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.7 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 9.7 GO:0030425 dendrite(GO:0030425)
0.0 3.7 GO:0043209 myelin sheath(GO:0043209)
0.0 1.5 GO:0097060 synaptic membrane(GO:0097060)
0.0 4.5 GO:0030667 secretory granule membrane(GO:0030667)
0.0 2.8 GO:0044297 cell body(GO:0044297)
0.0 0.7 GO:0000792 heterochromatin(GO:0000792)
0.0 1.0 GO:0000786 nucleosome(GO:0000786)
0.0 2.3 GO:0032993 protein-DNA complex(GO:0032993)
0.0 3.1 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 11.0 GO:0031410 cytoplasmic vesicle(GO:0031410)
0.0 0.0 GO:0000333 telomerase catalytic core complex(GO:0000333)
0.0 1.4 GO:0016591 DNA-directed RNA polymerase II, holoenzyme(GO:0016591)
0.0 0.5 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 1.1 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.9 GO:0001726 ruffle(GO:0001726)
0.0 16.4 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 0.6 GO:0031901 early endosome membrane(GO:0031901)
0.0 22.8 GO:0016021 integral component of membrane(GO:0016021)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 15.5 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
2.3 13.9 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
2.2 6.7 GO:0016495 C-X3-C chemokine receptor activity(GO:0016495)
1.8 17.6 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
1.5 6.2 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
1.3 4.0 GO:0036134 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
1.3 5.2 GO:0004047 aminomethyltransferase activity(GO:0004047)
0.9 2.8 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
0.9 12.9 GO:0032395 MHC class II receptor activity(GO:0032395)
0.9 2.6 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.8 8.3 GO:0001851 complement component C3b binding(GO:0001851)
0.7 3.7 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.7 7.9 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.7 2.8 GO:0005502 11-cis retinal binding(GO:0005502)
0.7 2.8 GO:0019862 IgA binding(GO:0019862)
0.6 1.1 GO:0035663 Toll-like receptor 2 binding(GO:0035663)
0.6 2.2 GO:0051120 hepoxilin A3 synthase activity(GO:0051120)
0.5 4.1 GO:0004064 arylesterase activity(GO:0004064)
0.5 3.9 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.5 5.3 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.4 4.0 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.4 2.5 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.4 1.3 GO:0015403 thiamine transmembrane transporter activity(GO:0015234) thiamine uptake transmembrane transporter activity(GO:0015403)
0.4 2.9 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.4 2.0 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.4 2.0 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.4 1.9 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.4 8.0 GO:0038187 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.4 2.2 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.3 2.1 GO:0005499 vitamin D binding(GO:0005499)
0.3 1.0 GO:0005148 prolactin receptor binding(GO:0005148)
0.3 3.3 GO:0015925 galactosidase activity(GO:0015925)
0.3 17.4 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.3 8.6 GO:0042605 peptide antigen binding(GO:0042605)
0.3 1.1 GO:0060422 peptidyl-dipeptidase inhibitor activity(GO:0060422)
0.3 3.7 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.3 3.6 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.3 4.1 GO:0019864 IgG binding(GO:0019864)
0.2 1.4 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.2 1.4 GO:0009378 four-way junction helicase activity(GO:0009378)
0.2 0.9 GO:0035276 aldehyde oxidase activity(GO:0004031) ethanol binding(GO:0035276)
0.2 5.5 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.2 3.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.2 1.7 GO:0004000 adenosine deaminase activity(GO:0004000)
0.2 3.1 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.2 3.1 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.2 5.5 GO:0043015 gamma-tubulin binding(GO:0043015)
0.2 9.8 GO:0005504 fatty acid binding(GO:0005504)
0.2 9.7 GO:0046875 ephrin receptor binding(GO:0046875)
0.2 2.3 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.2 1.4 GO:0004111 creatine kinase activity(GO:0004111)
0.2 4.2 GO:0004383 guanylate cyclase activity(GO:0004383)
0.2 3.8 GO:0097493 muscle alpha-actinin binding(GO:0051371) structural molecule activity conferring elasticity(GO:0097493)
0.2 8.3 GO:0070412 R-SMAD binding(GO:0070412)
0.2 3.5 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.2 5.3 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.2 0.5 GO:0003968 RNA-directed RNA polymerase activity(GO:0003968)
0.1 1.6 GO:0043855 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.1 0.4 GO:0004947 bradykinin receptor activity(GO:0004947)
0.1 1.3 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 1.0 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.1 0.9 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.1 0.7 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.1 0.9 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.1 0.9 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.1 0.8 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
0.1 0.4 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.1 2.1 GO:0030983 mismatched DNA binding(GO:0030983)
0.1 1.8 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 1.1 GO:0016918 retinal binding(GO:0016918)
0.1 4.9 GO:0030507 spectrin binding(GO:0030507)
0.1 1.5 GO:0015101 organic cation transmembrane transporter activity(GO:0015101)
0.1 13.8 GO:0003823 antigen binding(GO:0003823)
0.1 1.1 GO:0035240 dopamine binding(GO:0035240)
0.1 5.5 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 8.9 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.1 0.8 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.1 0.9 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 1.1 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.1 0.5 GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.1 8.1 GO:0008565 protein transporter activity(GO:0008565)
0.1 7.0 GO:0051087 chaperone binding(GO:0051087)
0.1 0.9 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 3.3 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 1.6 GO:0030544 Hsp70 protein binding(GO:0030544)
0.1 6.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 0.9 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.1 2.6 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 4.1 GO:0003777 microtubule motor activity(GO:0003777)
0.1 2.4 GO:0019894 kinesin binding(GO:0019894)
0.1 0.8 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 1.2 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.4 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 3.4 GO:0002039 p53 binding(GO:0002039)
0.0 0.9 GO:0004707 MAP kinase activity(GO:0004707)
0.0 1.0 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.8 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.8 GO:0099604 calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.0 0.6 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.7 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.2 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.0 1.8 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.0 1.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.6 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 2.3 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.0 1.0 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.6 GO:0046965 retinoid X receptor binding(GO:0046965)
0.0 0.4 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.5 GO:0008242 omega peptidase activity(GO:0008242)
0.0 0.8 GO:0043236 laminin binding(GO:0043236)
0.0 0.3 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.5 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 2.2 GO:0050660 flavin adenine dinucleotide binding(GO:0050660)
0.0 0.2 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.5 GO:0070402 NADPH binding(GO:0070402)
0.0 0.4 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.4 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.0 5.6 GO:0030695 GTPase regulator activity(GO:0030695)
0.0 0.3 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 1.1 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.2 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.2 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.5 GO:0003774 motor activity(GO:0003774)
0.0 0.3 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 16.6 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.4 10.6 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.4 8.3 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.4 19.4 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.2 17.6 PID RHOA REG PATHWAY Regulation of RhoA activity
0.2 9.7 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.1 1.8 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 8.1 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 3.7 PID IL1 PATHWAY IL1-mediated signaling events
0.1 11.9 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 4.0 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.1 15.8 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.9 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 1.6 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 5.2 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.9 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 3.1 PID AP1 PATHWAY AP-1 transcription factor network
0.0 1.7 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.4 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 1.3 PID BMP PATHWAY BMP receptor signaling
0.0 0.6 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.8 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 0.3 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.0 0.1 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.7 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 0.7 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 21.5 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.5 5.3 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.5 7.7 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.5 9.2 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.4 6.7 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.2 30.9 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.2 0.8 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.2 7.9 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.2 1.8 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 8.7 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 13.9 REACTOME ANTIGEN PROCESSING CROSS PRESENTATION Genes involved in Antigen processing-Cross presentation
0.1 0.9 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 1.4 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 0.7 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 5.5 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 2.0 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 0.6 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.1 4.4 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.1 2.2 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 8.3 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.1 4.0 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 9.2 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 1.0 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 1.2 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 1.1 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 1.4 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.9 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 1.0 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 1.3 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.5 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 1.0 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.0 2.5 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 1.2 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.8 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.9 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.9 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 1.0 REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex
0.0 0.4 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.6 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.4 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.8 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.8 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.6 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.4 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 1.9 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.7 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.9 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport