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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for SOX9
Z-value: 0.78
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Transcription factors associated with SOX9
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX9 | hg19_v2_chr17_+_70117153_70117174 | 0.32 | 1.3e-06 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX9
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.2 | 55.8 | GO:1905098 | negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
| 0.3 | 55.7 | GO:0030705 | cytoskeleton-dependent intracellular transport(GO:0030705) |
| 5.9 | 53.2 | GO:0071787 | endoplasmic reticulum tubular network assembly(GO:0071787) |
| 14.7 | 44.0 | GO:0051086 | chaperone mediated protein folding independent of cofactor(GO:0051086) |
| 3.2 | 38.6 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
| 1.7 | 35.9 | GO:0051764 | actin crosslink formation(GO:0051764) |
| 0.1 | 35.2 | GO:0002283 | neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312) |
| 0.6 | 26.9 | GO:2000816 | negative regulation of mitotic sister chromatid separation(GO:2000816) |
| 1.7 | 25.5 | GO:0090168 | Golgi reassembly(GO:0090168) |
| 1.9 | 24.8 | GO:2000587 | negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 175.5 | GO:0005874 | microtubule(GO:0005874) |
| 2.7 | 53.2 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 3.4 | 44.0 | GO:0002199 | zona pellucida receptor complex(GO:0002199) |
| 0.4 | 38.9 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.2 | 36.5 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.8 | 36.1 | GO:0002102 | podosome(GO:0002102) |
| 0.3 | 28.3 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.1 | 26.6 | GO:0031256 | leading edge membrane(GO:0031256) |
| 1.1 | 25.4 | GO:0032156 | septin cytoskeleton(GO:0032156) |
| 2.7 | 21.2 | GO:0042382 | paraspeckles(GO:0042382) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 126.6 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.2 | 99.1 | GO:0045296 | cadherin binding(GO:0045296) |
| 1.1 | 40.8 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.1 | 39.0 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.2 | 37.4 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.7 | 33.1 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.6 | 28.8 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.1 | 25.2 | GO:0005516 | calmodulin binding(GO:0005516) |
| 1.8 | 24.8 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
| 0.9 | 21.2 | GO:0070402 | NADPH binding(GO:0070402) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 61.5 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.9 | 55.1 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 3.0 | 54.4 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.5 | 37.8 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.6 | 35.1 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.7 | 25.5 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.1 | 16.3 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.3 | 16.0 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.2 | 15.0 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.2 | 15.0 | SIG PIP3 SIGNALING IN CARDIAC MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 102.4 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 1.0 | 49.0 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 1.2 | 37.6 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.3 | 36.6 | REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.4 | 29.4 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.3 | 28.0 | REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS | Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins |
| 1.0 | 25.5 | REACTOME DESTABILIZATION OF MRNA BY KSRP | Genes involved in Destabilization of mRNA by KSRP |
| 0.3 | 20.7 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.5 | 20.5 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.7 | 19.4 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |