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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for SP100
Z-value: 0.77
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Transcription factors associated with SP100
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SP100 | hg19_v2_chr2_+_231280908_231280945 | 0.30 | 6.8e-06 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SP100
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 80.5 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 0.6 | 71.9 | GO:0007062 | sister chromatid cohesion(GO:0007062) |
| 4.0 | 71.5 | GO:0000920 | cell separation after cytokinesis(GO:0000920) |
| 2.6 | 54.5 | GO:1902166 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166) |
| 0.9 | 42.0 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 12.5 | 37.4 | GO:0006435 | threonyl-tRNA aminoacylation(GO:0006435) |
| 0.5 | 36.1 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 0.9 | 35.9 | GO:0007029 | endoplasmic reticulum organization(GO:0007029) |
| 5.3 | 32.0 | GO:0035407 | histone H3-T11 phosphorylation(GO:0035407) |
| 0.5 | 29.7 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 62.2 | GO:0005871 | kinesin complex(GO:0005871) |
| 10.9 | 43.6 | GO:1990423 | RZZ complex(GO:1990423) |
| 0.1 | 41.4 | GO:0005730 | nucleolus(GO:0005730) |
| 0.4 | 37.4 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.2 | 36.7 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 1.1 | 34.5 | GO:0005838 | proteasome regulatory particle(GO:0005838) |
| 8.3 | 33.2 | GO:0031417 | NatC complex(GO:0031417) |
| 0.4 | 31.7 | GO:0000794 | condensed nuclear chromosome(GO:0000794) |
| 0.5 | 31.0 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 2.4 | 28.3 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 72.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.6 | 47.0 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.0 | 39.4 | GO:0003723 | RNA binding(GO:0003723) |
| 12.5 | 37.4 | GO:0004829 | threonine-tRNA ligase activity(GO:0004829) |
| 3.5 | 34.7 | GO:0030911 | TPR domain binding(GO:0030911) |
| 5.3 | 32.0 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
| 0.7 | 31.2 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.6 | 29.7 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.9 | 27.2 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 9.0 | 27.1 | GO:0004618 | phosphoglycerate kinase activity(GO:0004618) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 63.7 | PID AURORA B PATHWAY | Aurora B signaling |
| 2.3 | 32.0 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.2 | 26.3 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.7 | 25.5 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.5 | 24.9 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.8 | 24.6 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.5 | 23.4 | PID MYC PATHWAY | C-MYC pathway |
| 0.4 | 22.3 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.5 | 17.5 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.2 | 16.3 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 80.5 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.8 | 69.6 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 2.3 | 59.5 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.9 | 59.2 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |
| 0.6 | 47.4 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.4 | 46.6 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 1.4 | 44.8 | REACTOME SEMA3A PAK DEPENDENT AXON REPULSION | Genes involved in Sema3A PAK dependent Axon repulsion |
| 1.2 | 42.7 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 1.2 | 41.1 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.5 | 37.0 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |