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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for SPDEF
Z-value: 1.36
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Transcription factors associated with SPDEF
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SPDEF | hg19_v2_chr6_-_34524093_34524135 | -0.36 | 2.9e-08 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_-_56082455 Show fit | 50.34 |
ENST00000578794.1
|
Uncharacterized protein |
|
| chr14_-_69864993 Show fit | 46.16 |
ENST00000555373.1
|
enhancer of rudimentary homolog (Drosophila) |
|
| chr2_+_198380763 Show fit | 37.67 |
ENST00000448447.2
ENST00000409360.1 |
MOB family member 4, phocein |
|
| chr14_-_24615805 Show fit | 35.02 |
ENST00000560410.1
|
proteasome (prosome, macropain) activator subunit 2 (PA28 beta) |
|
| chr12_-_102513843 Show fit | 33.35 |
ENST00000551744.2
ENST00000552283.1 |
nucleoporin 37kDa |
|
| chr1_+_84944926 Show fit | 27.56 |
ENST00000370656.1
ENST00000370654.5 |
ribosome production factor 1 homolog (S. cerevisiae) |
|
| chr14_-_64010046 Show fit | 27.46 |
ENST00000337537.3
|
protein phosphatase 2, regulatory subunit B', epsilon isoform |
|
| chr15_-_59949693 Show fit | 27.00 |
ENST00000396063.1
ENST00000396064.3 ENST00000484743.1 ENST00000559706.1 ENST00000396060.2 |
general transcription factor IIA, 2, 12kDa |
|
| chr1_-_193028632 Show fit | 26.30 |
ENST00000421683.1
|
ubiquitin carboxyl-terminal hydrolase L5 |
|
| chr8_-_101964265 Show fit | 26.07 |
ENST00000395958.2
|
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta |
Network of associatons between targets according to the STRING database.
First level regulatory network of SPDEF
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 102.1 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 4.2 | 66.7 | GO:0021670 | lateral ventricle development(GO:0021670) |
| 0.6 | 62.6 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
| 1.0 | 58.2 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 1.3 | 53.7 | GO:0006221 | pyrimidine nucleotide biosynthetic process(GO:0006221) |
| 0.9 | 51.2 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 2.7 | 46.0 | GO:1903504 | regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504) |
| 1.0 | 44.3 | GO:0051123 | RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123) |
| 2.8 | 35.9 | GO:1901838 | positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838) |
| 2.3 | 35.1 | GO:0090168 | Golgi reassembly(GO:0090168) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.7 | 76.9 | GO:0031011 | Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202) |
| 2.4 | 73.8 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.0 | 68.2 | GO:0070062 | extracellular exosome(GO:0070062) |
| 8.3 | 66.5 | GO:0005672 | transcription factor TFIIA complex(GO:0005672) |
| 3.5 | 63.4 | GO:0034709 | methylosome(GO:0034709) |
| 0.7 | 60.5 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 2.0 | 56.1 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 9.2 | 55.1 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 4.5 | 54.3 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 3.3 | 53.0 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 107.0 | GO:0051015 | actin filament binding(GO:0051015) |
| 3.3 | 66.7 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.6 | 57.8 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.8 | 55.5 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 7.9 | 55.1 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 5.4 | 54.3 | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 1.2 | 51.5 | GO:0001103 | RNA polymerase II repressing transcription factor binding(GO:0001103) |
| 1.6 | 47.1 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.3 | 43.1 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 1.9 | 42.3 | GO:0042609 | CD4 receptor binding(GO:0042609) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 53.7 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.6 | 36.4 | PID BMP PATHWAY | BMP receptor signaling |
| 0.2 | 32.5 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.6 | 29.3 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.5 | 27.4 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 1.1 | 23.2 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.4 | 18.5 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.5 | 17.6 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
| 0.2 | 15.8 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.2 | 14.8 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 102.1 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
| 1.3 | 95.5 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 2.1 | 87.7 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.7 | 84.4 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.5 | 71.0 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 1.4 | 53.0 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 3.1 | 48.9 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 0.7 | 44.3 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 1.6 | 39.1 | REACTOME ADP SIGNALLING THROUGH P2RY12 | Genes involved in ADP signalling through P2Y purinoceptor 12 |
| 0.6 | 36.0 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |