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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for SPIB
Z-value: 0.36
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Transcription factors associated with SPIB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SPIB | hg19_v2_chr19_+_50922187_50922215 | 0.39 | 2.1e-09 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_15114492 Show fit | 143.03 |
ENST00000541546.1
|
Rho GDP dissociation inhibitor (GDI) beta |
|
| chr1_-_160681593 Show fit | 122.48 |
ENST00000368045.3
ENST00000368046.3 |
CD48 molecule |
|
| chr12_-_15114603 Show fit | 91.99 |
ENST00000228945.4
|
Rho GDP dissociation inhibitor (GDI) beta |
|
| chr1_-_31230650 Show fit | 90.05 |
ENST00000294507.3
|
lysosomal protein transmembrane 5 |
|
| chr16_+_30194916 Show fit | 88.03 |
ENST00000570045.1
ENST00000565497.1 ENST00000570244.1 |
coronin, actin binding protein, 1A |
|
| chr3_-_121379739 Show fit | 82.42 |
ENST00000428394.2
ENST00000314583.3 |
hematopoietic cell-specific Lyn substrate 1 |
|
| chr5_+_169064245 Show fit | 75.38 |
ENST00000256935.8
|
dedicator of cytokinesis 2 |
|
| chr13_+_31309645 Show fit | 67.19 |
ENST00000380490.3
|
arachidonate 5-lipoxygenase-activating protein |
|
| chr7_+_74188309 Show fit | 65.58 |
ENST00000289473.4
ENST00000433458.1 |
neutrophil cytosolic factor 1 |
|
| chr22_+_37309662 Show fit | 60.36 |
ENST00000403662.3
ENST00000262825.5 |
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) |
Network of associatons between targets according to the STRING database.
First level regulatory network of SPIB
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 58.8 | 235.0 | GO:0071461 | cellular response to redox state(GO:0071461) |
| 1.6 | 164.2 | GO:0032945 | negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672) |
| 7.6 | 128.6 | GO:2000251 | positive regulation of actin cytoskeleton reorganization(GO:2000251) |
| 1.5 | 124.8 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 9.8 | 118.1 | GO:0048298 | positive regulation of isotype switching to IgA isotypes(GO:0048298) |
| 0.7 | 110.9 | GO:0002223 | stimulatory C-type lectin receptor signaling pathway(GO:0002223) |
| 0.9 | 108.2 | GO:0002819 | regulation of adaptive immune response(GO:0002819) |
| 0.8 | 108.2 | GO:1990823 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 4.9 | 98.6 | GO:0002523 | leukocyte migration involved in inflammatory response(GO:0002523) |
| 0.2 | 96.4 | GO:0043547 | positive regulation of GTPase activity(GO:0043547) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 213.0 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 1.2 | 163.6 | GO:0032587 | ruffle membrane(GO:0032587) |
| 1.0 | 154.6 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 6.9 | 137.2 | GO:0001891 | phagocytic cup(GO:0001891) |
| 1.4 | 125.8 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.1 | 121.2 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.4 | 115.2 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.2 | 110.3 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.2 | 103.8 | GO:0005667 | transcription factor complex(GO:0005667) |
| 20.2 | 101.0 | GO:0034688 | integrin alphaM-beta2 complex(GO:0034688) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 23.5 | 235.0 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.1 | 139.9 | GO:0004872 | receptor activity(GO:0004872) molecular transducer activity(GO:0060089) |
| 0.7 | 134.0 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
| 2.7 | 130.3 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.4 | 117.1 | GO:0003924 | GTPase activity(GO:0003924) |
| 3.8 | 116.4 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 6.4 | 114.6 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 14.4 | 101.0 | GO:0030369 | ICAM-3 receptor activity(GO:0030369) |
| 2.3 | 100.4 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 5.5 | 88.0 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 235.0 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 3.5 | 187.0 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 2.6 | 186.1 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 3.3 | 170.0 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 2.0 | 142.2 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 1.8 | 141.9 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 3.7 | 128.2 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 2.8 | 114.6 | PID RAS PATHWAY | Regulation of Ras family activation |
| 4.7 | 112.2 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.3 | 110.1 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 271.1 | REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | Genes involved in Cell surface interactions at the vascular wall |
| 1.6 | 267.7 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 5.9 | 211.8 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 1.8 | 181.2 | REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 3.4 | 156.2 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 1.2 | 135.1 | REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements |
| 2.9 | 109.6 | REACTOME GPVI MEDIATED ACTIVATION CASCADE | Genes involved in GPVI-mediated activation cascade |
| 1.1 | 88.2 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 2.2 | 86.6 | REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS | Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis |
| 3.6 | 74.7 | REACTOME CTLA4 INHIBITORY SIGNALING | Genes involved in CTLA4 inhibitory signaling |