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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for SPIC

Z-value: 0.52

Motif logo

Transcription factors associated with SPIC

Gene Symbol Gene ID Gene Info
ENSG00000166211.6 Spi-C transcription factor

Activity profile of SPIC motif

Sorted Z-values of SPIC motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_121379739 67.66 ENST00000428394.2
ENST00000314583.3
hematopoietic cell-specific Lyn substrate 1
chr12_-_15114603 58.42 ENST00000228945.4
Rho GDP dissociation inhibitor (GDI) beta
chr16_+_30194916 55.19 ENST00000570045.1
ENST00000565497.1
ENST00000570244.1
coronin, actin binding protein, 1A
chr1_-_160681593 51.35 ENST00000368045.3
ENST00000368046.3
CD48 molecule
chr12_-_15114492 50.41 ENST00000541546.1
Rho GDP dissociation inhibitor (GDI) beta
chr12_+_54892550 49.15 ENST00000545638.2
NCK-associated protein 1-like
chr13_-_46756351 48.29 ENST00000323076.2
lymphocyte cytosolic protein 1 (L-plastin)
chr19_+_49838653 47.81 ENST00000598095.1
ENST00000426897.2
ENST00000323906.4
ENST00000535669.2
ENST00000597602.1
ENST00000595660.1
CD37 molecule
chr6_+_31554826 46.39 ENST00000376089.2
ENST00000396112.2
leukocyte specific transcript 1
chr6_-_32557610 45.85 ENST00000360004.5
major histocompatibility complex, class II, DR beta 1
chr4_-_103682071 44.81 ENST00000505239.1
mannosidase, beta A, lysosomal
chr19_-_10446449 43.29 ENST00000592439.1
intercellular adhesion molecule 3
chr13_+_31309645 40.77 ENST00000380490.3
arachidonate 5-lipoxygenase-activating protein
chr19_-_8642289 39.96 ENST00000596675.1
ENST00000338257.8
myosin IF
chr12_+_25205666 39.63 ENST00000547044.1
lymphoid-restricted membrane protein
chr1_-_31230650 38.73 ENST00000294507.3
lysosomal protein transmembrane 5
chr12_+_25205568 38.24 ENST00000548766.1
ENST00000556887.1
lymphoid-restricted membrane protein
chr14_-_23285011 37.59 ENST00000397532.3
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr14_-_23285069 37.40 ENST00000554758.1
ENST00000397528.4
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr1_-_183560011 37.18 ENST00000367536.1
neutrophil cytosolic factor 2
chr22_+_23247030 36.84 ENST00000390324.2
immunoglobulin lambda joining 3
chr22_+_37309662 36.05 ENST00000403662.3
ENST00000262825.5
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
chr22_+_37257015 35.51 ENST00000447071.1
ENST00000248899.6
ENST00000397147.4
neutrophil cytosolic factor 4, 40kDa
chrX_-_107018969 35.26 ENST00000372383.4
TSC22 domain family, member 3
chr16_-_88717482 35.00 ENST00000261623.3
cytochrome b-245, alpha polypeptide
chr4_-_74853897 34.79 ENST00000296028.3
pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
chr17_-_29641104 33.98 ENST00000577894.1
ENST00000330927.4
ecotropic viral integration site 2B
chr1_+_111415757 33.90 ENST00000429072.2
ENST00000271324.5
CD53 molecule
chr12_+_7055767 32.42 ENST00000447931.2
protein tyrosine phosphatase, non-receptor type 6
chr7_+_74188309 32.40 ENST00000289473.4
ENST00000433458.1
neutrophil cytosolic factor 1
chr21_-_46340884 31.48 ENST00000302347.5
ENST00000517819.1
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr6_+_31582961 31.45 ENST00000376059.3
ENST00000337917.7
allograft inflammatory factor 1
chr16_+_81812863 31.08 ENST00000359376.3
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr21_-_46340770 30.16 ENST00000397854.3
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr16_-_88717423 29.92 ENST00000568278.1
ENST00000569359.1
ENST00000567174.1
cytochrome b-245, alpha polypeptide
chr19_-_10450328 29.79 ENST00000160262.5
intercellular adhesion molecule 3
chr1_-_150738261 29.50 ENST00000448301.2
ENST00000368985.3
cathepsin S
chr12_+_54891495 29.43 ENST00000293373.6
NCK-associated protein 1-like
chr19_-_39826639 29.23 ENST00000602185.1
ENST00000598034.1
ENST00000601387.1
ENST00000595636.1
ENST00000253054.8
ENST00000594700.1
ENST00000597595.1
glia maturation factor, gamma
chr12_+_7055631 29.08 ENST00000543115.1
ENST00000399448.1
protein tyrosine phosphatase, non-receptor type 6
chr6_+_31554779 28.89 ENST00000376090.2
leukocyte specific transcript 1
chr19_-_10450287 28.77 ENST00000589261.1
ENST00000590569.1
ENST00000589580.1
ENST00000589249.1
intercellular adhesion molecule 3
chr2_+_143886877 28.67 ENST00000295095.6
Rho GTPase activating protein 15
chr1_-_25256368 28.46 ENST00000308873.6
runt-related transcription factor 3
chr17_-_29641084 27.78 ENST00000544462.1
ecotropic viral integration site 2B
chr19_-_39108568 26.95 ENST00000586296.1
mitogen-activated protein kinase kinase kinase kinase 1
chr11_+_1874200 24.79 ENST00000311604.3
lymphocyte-specific protein 1
chr10_-_98031310 24.73 ENST00000427367.2
ENST00000413476.2
B-cell linker
chrX_-_47489244 24.21 ENST00000469388.1
ENST00000396992.3
ENST00000377005.2
complement factor properdin
chr1_-_183559693 23.80 ENST00000367535.3
ENST00000413720.1
ENST00000418089.1
neutrophil cytosolic factor 2
chr17_-_20370847 23.79 ENST00000423676.3
ENST00000324290.5
lectin, galactoside-binding, soluble, 9B
chr19_+_13261216 23.46 ENST00000587885.1
ENST00000292433.3
immediate early response 2
chr5_-_140013275 23.24 ENST00000512545.1
ENST00000302014.6
ENST00000401743.2
CD14 molecule
chr17_+_72462525 22.67 ENST00000360141.3
CD300a molecule
chr6_+_31553978 22.54 ENST00000376096.1
ENST00000376099.1
ENST00000376110.3
leukocyte specific transcript 1
chr11_-_615570 22.49 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
interferon regulatory factor 7
chr19_+_42381337 22.18 ENST00000597454.1
ENST00000444740.2
CD79a molecule, immunoglobulin-associated alpha
chr11_-_615942 22.02 ENST00000397562.3
ENST00000330243.5
ENST00000397570.1
ENST00000397574.2
interferon regulatory factor 7
chr2_+_233925064 21.57 ENST00000359570.5
ENST00000538935.1
inositol polyphosphate-5-phosphatase, 145kDa
chr19_-_54784937 21.35 ENST00000434421.1
ENST00000314446.5
ENST00000391749.4
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
chr10_-_98031265 21.13 ENST00000224337.5
ENST00000371176.2
B-cell linker
chr9_+_134000948 20.69 ENST00000359428.5
ENST00000411637.2
ENST00000451030.1
nucleoporin 214kDa
chr16_+_31271274 20.68 ENST00000287497.8
ENST00000544665.3
integrin, alpha M (complement component 3 receptor 3 subunit)
chr19_-_39108552 20.58 ENST00000591517.1
mitogen-activated protein kinase kinase kinase kinase 1
chr6_+_31554612 20.36 ENST00000211921.7
leukocyte specific transcript 1
chr3_+_16926441 20.24 ENST00000418129.2
ENST00000396755.2
phospholipase C-like 2
chr6_-_133079022 19.97 ENST00000525289.1
ENST00000326499.6
vanin 2
chr5_-_130970723 19.85 ENST00000308008.6
ENST00000296859.6
ENST00000507093.1
ENST00000510071.1
ENST00000509018.1
ENST00000307984.5
Rap guanine nucleotide exchange factor (GEF) 6
chr12_-_7656357 19.78 ENST00000396620.3
ENST00000432237.2
ENST00000359156.4
CD163 molecule
chr7_+_150264365 19.36 ENST00000255945.2
ENST00000461940.1
GTPase, IMAP family member 4
chr19_-_39108643 19.31 ENST00000396857.2
mitogen-activated protein kinase kinase kinase kinase 1
chr14_+_88471468 19.17 ENST00000267549.3
G protein-coupled receptor 65
chr17_+_34431212 19.16 ENST00000394495.1
chemokine (C-C motif) ligand 4
chr4_-_103682145 19.14 ENST00000226578.4
mannosidase, beta A, lysosomal
chr3_-_50375657 18.78 ENST00000395126.3
Ras association (RalGDS/AF-6) domain family member 1
chr18_-_47813940 18.54 ENST00000586837.1
ENST00000412036.2
ENST00000589940.1
CXXC finger protein 1
chr1_-_150552006 18.46 ENST00000307940.3
ENST00000369026.2
myeloid cell leukemia sequence 1 (BCL2-related)
chr12_+_25205446 18.33 ENST00000557489.1
ENST00000354454.3
ENST00000536173.1
lymphoid-restricted membrane protein
chr17_+_42422662 18.30 ENST00000593167.1
ENST00000585512.1
ENST00000591740.1
ENST00000592783.1
ENST00000587387.1
ENST00000588237.1
ENST00000589265.1
granulin
chr1_+_161475208 18.28 ENST00000367972.4
ENST00000271450.6
Fc fragment of IgG, low affinity IIa, receptor (CD32)
chr11_-_72463421 18.24 ENST00000393609.3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr7_-_76829125 18.18 ENST00000248598.5
fibrinogen-like 2
chr17_+_72462766 17.97 ENST00000392625.3
ENST00000361933.3
ENST00000310828.5
CD300a molecule
chr2_-_231084820 17.84 ENST00000258382.5
ENST00000338556.3
SP110 nuclear body protein
chrX_+_24072833 17.53 ENST00000253039.4
eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
chr5_+_178977546 17.52 ENST00000319449.4
ENST00000377001.2
RUN and FYVE domain containing 1
chr16_-_88851618 17.50 ENST00000301015.9
piezo-type mechanosensitive ion channel component 1
chr1_-_153518270 17.46 ENST00000354332.4
ENST00000368716.4
S100 calcium binding protein A4
chr11_-_60719213 17.45 ENST00000227880.3
solute carrier family 15 (oligopeptide transporter), member 3
chr12_+_7060432 17.43 ENST00000318974.9
ENST00000456013.1
protein tyrosine phosphatase, non-receptor type 6
chr6_+_31553901 17.35 ENST00000418507.2
ENST00000438075.2
ENST00000376100.3
ENST00000376111.4
leukocyte specific transcript 1
chr5_-_150603679 17.35 ENST00000355417.2
coiled-coil domain containing 69
chr4_+_8201091 17.31 ENST00000382521.3
ENST00000245105.3
ENST00000457650.2
ENST00000539824.1
SH3 domain and tetratricopeptide repeats 1
chr6_+_27114861 17.11 ENST00000377459.1
histone cluster 1, H2ah
chrY_+_2709527 17.00 ENST00000250784.8
ribosomal protein S4, Y-linked 1
chr19_+_859654 16.90 ENST00000592860.1
complement factor D (adipsin)
chr11_+_5710919 16.62 ENST00000379965.3
ENST00000425490.1
tripartite motif containing 22
chr19_-_36233332 16.59 ENST00000592537.1
ENST00000246532.1
ENST00000344990.3
ENST00000588992.1
IGF-like family receptor 1
chr19_+_55084438 16.48 ENST00000439534.1
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
chr16_-_21663919 16.38 ENST00000569602.1
immunoglobulin superfamily, member 6
chr16_+_30205225 16.36 ENST00000345535.4
ENST00000251303.6
SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae)
chr19_+_41903709 16.36 ENST00000542943.1
ENST00000457836.2
branched chain keto acid dehydrogenase E1, alpha polypeptide
chr2_+_68592305 16.25 ENST00000234313.7
pleckstrin
chr6_+_31554456 16.05 ENST00000339530.4
leukocyte specific transcript 1
chr16_+_29465822 15.99 ENST00000330181.5
ENST00000351581.4
SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)
chr2_+_182321925 15.92 ENST00000339307.4
ENST00000397033.2
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
chr19_-_51875894 15.90 ENST00000600427.1
ENST00000595217.1
ENST00000221978.5
natural killer cell group 7 sequence
chr22_-_37880543 15.86 ENST00000442496.1
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr19_+_859425 15.75 ENST00000327726.6
complement factor D (adipsin)
chr10_+_97471508 15.71 ENST00000453258.2
ectonucleoside triphosphate diphosphohydrolase 1
chr14_-_89883412 15.66 ENST00000557258.1
forkhead box N3
chr19_+_6772710 15.57 ENST00000304076.2
ENST00000602142.1
ENST00000596764.1
vav 1 guanine nucleotide exchange factor
chr3_+_151986709 15.54 ENST00000495875.2
ENST00000493459.1
ENST00000324210.5
ENST00000459747.1
muscleblind-like splicing regulator 1
chr20_-_4795747 15.48 ENST00000379376.2
Ras association (RalGDS/AF-6) domain family member 2
chr1_-_161519579 15.40 ENST00000426740.1
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
chr20_+_2821340 15.31 ENST00000380445.3
ENST00000380469.3
vacuolar protein sorting 16 homolog (S. cerevisiae)
chr14_+_21423611 15.26 ENST00000304625.2
ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
chr21_-_15918618 15.01 ENST00000400564.1
ENST00000400566.1
SAM domain, SH3 domain and nuclear localization signals 1
chr19_+_1041212 14.83 ENST00000433129.1
ATP-binding cassette, sub-family A (ABC1), member 7
chr12_-_8218997 14.81 ENST00000307637.4
complement component 3a receptor 1
chr1_+_161632937 14.60 ENST00000236937.9
ENST00000367961.4
ENST00000358671.5
Fc fragment of IgG, low affinity IIb, receptor (CD32)
chr1_-_161519682 14.55 ENST00000367969.3
ENST00000443193.1
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
chr7_+_100450328 14.49 ENST00000540482.1
ENST00000418037.1
ENST00000428758.1
ENST00000275729.3
ENST00000415287.1
ENST00000354161.3
ENST00000416675.1
solute carrier family 12, member 9
chr19_+_55128576 14.47 ENST00000396331.1
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
chr2_-_231084659 14.36 ENST00000258381.6
ENST00000358662.4
ENST00000455674.1
ENST00000392048.3
SP110 nuclear body protein
chr19_+_55141861 14.36 ENST00000396327.3
ENST00000324602.7
ENST00000434867.2
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
chr19_-_13213662 14.30 ENST00000264824.4
lymphoblastic leukemia derived sequence 1
chr1_+_181057638 14.19 ENST00000367577.4
immediate early response 5
chr2_-_231084617 14.08 ENST00000409815.2
SP110 nuclear body protein
chr19_+_35645618 13.96 ENST00000392218.2
ENST00000543307.1
ENST00000392219.2
ENST00000541435.2
ENST00000590686.1
ENST00000342879.3
ENST00000588699.1
FXYD domain containing ion transport regulator 5
chrY_+_15016725 13.86 ENST00000336079.3
DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
chr15_-_90358048 13.62 ENST00000300060.6
ENST00000560137.1
alanyl (membrane) aminopeptidase
chr19_+_55141948 13.41 ENST00000396332.4
ENST00000427581.2
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
chr7_-_150329421 13.38 ENST00000493969.1
ENST00000328902.5
GTPase, IMAP family member 6
chr2_+_89998789 13.29 ENST00000453166.2
immunoglobulin kappa variable 2D-28
chr15_-_80263506 13.27 ENST00000335661.6
BCL2-related protein A1
chr17_-_76123101 13.19 ENST00000392467.3
transmembrane channel-like 6
chr11_-_64647144 12.95 ENST00000359393.2
ENST00000433803.1
ENST00000411683.1
EH-domain containing 1
chr17_-_34625719 12.93 ENST00000422211.2
ENST00000542124.1
chemokine (C-C motif) ligand 3-like 1
chr17_-_34524157 12.69 ENST00000378354.4
ENST00000394484.1
chemokine (C-C motif) ligand 3-like 3
chr2_+_89999259 12.63 ENST00000558026.1
immunoglobulin kappa variable 2D-28
chr6_+_31554636 12.50 ENST00000433492.1
leukocyte specific transcript 1
chr15_+_77287426 12.36 ENST00000558012.1
ENST00000267939.5
ENST00000379595.3
proline-serine-threonine phosphatase interacting protein 1
chr14_+_91581011 12.31 ENST00000523894.1
ENST00000522322.1
ENST00000523771.1
chromosome 14 open reading frame 159
chr16_-_21663950 11.91 ENST00000268389.4
immunoglobulin superfamily, member 6
chr16_-_15736881 11.89 ENST00000540441.2
KIAA0430
chr11_+_43380459 11.80 ENST00000299240.6
ENST00000039989.4
tetratricopeptide repeat domain 17
chr3_-_49142504 11.71 ENST00000306125.6
ENST00000420147.2
glutaminyl-tRNA synthetase
chr1_+_149230680 11.65 ENST00000443018.1
RP11-403I13.5
chr18_-_11908329 11.58 ENST00000344987.7
ENST00000588103.1
ENST00000588191.1
ENST00000317235.7
ENST00000309976.9
ENST00000588186.1
ENST00000589267.1
metallophosphoesterase 1
chr3_+_158519654 11.15 ENST00000415822.2
ENST00000392813.4
ENST00000264266.8
major facilitator superfamily domain containing 1
chr19_-_18391708 11.10 ENST00000600972.1
jun D proto-oncogene
chr2_+_202125219 11.05 ENST00000323492.7
caspase 8, apoptosis-related cysteine peptidase
chr19_+_46010674 10.84 ENST00000245932.6
ENST00000592139.1
ENST00000590603.1
vasodilator-stimulated phosphoprotein
chr3_+_5229356 10.71 ENST00000256497.4
ER degradation enhancer, mannosidase alpha-like 1
chr17_+_18380051 10.70 ENST00000581545.1
ENST00000582333.1
ENST00000328114.6
ENST00000412421.2
ENST00000583322.1
ENST00000584941.1
lectin, galactoside-binding, soluble, 9C
chr15_-_65282274 10.41 ENST00000204566.2
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
chr11_+_65408273 10.40 ENST00000394227.3
signal-induced proliferation-associated 1
chr17_+_37356555 10.12 ENST00000579374.1
ribosomal protein L19
chr1_+_202830876 10.09 ENST00000456105.2
RP11-480I12.7
chr7_+_108210012 9.97 ENST00000249356.3
DnaJ (Hsp40) homolog, subfamily B, member 9
chr12_-_6772303 9.96 ENST00000396807.4
ENST00000446105.2
ENST00000341550.4
inhibitor of growth family, member 4
chr17_+_37356528 9.93 ENST00000225430.4
ribosomal protein L19
chr17_+_37356586 9.91 ENST00000579260.1
ENST00000582193.1
ribosomal protein L19
chr14_+_23340822 9.90 ENST00000359591.4
low density lipoprotein receptor-related protein 10
chr19_-_19754404 9.90 ENST00000587205.1
ENST00000445806.2
ENST00000203556.4
GEM interacting protein
chr1_+_158985457 9.84 ENST00000567661.1
ENST00000474473.1
interferon, gamma-inducible protein 16
chr18_+_21033239 9.77 ENST00000581585.1
ENST00000577501.1
RIO kinase 3
chr19_+_35645817 9.71 ENST00000423817.3
FXYD domain containing ion transport regulator 5
chr16_+_89627061 9.67 ENST00000311528.5
ENST00000563270.1
ENST00000567815.1
ENST00000452368.3
ENST00000467736.1
ENST00000393099.3
ribosomal protein L13
chrX_+_11776701 9.67 ENST00000476743.1
ENST00000421368.2
ENST00000398527.2
male-specific lethal 3 homolog (Drosophila)
chr6_+_106534192 9.66 ENST00000369091.2
ENST00000369096.4
PR domain containing 1, with ZNF domain
chr19_+_51728316 9.57 ENST00000436584.2
ENST00000421133.2
ENST00000391796.3
ENST00000262262.4
CD33 molecule
chr2_-_152146385 9.52 ENST00000414946.1
ENST00000243346.5
N-myc (and STAT) interactor
chr19_+_852291 9.47 ENST00000263621.1
elastase, neutrophil expressed
chr6_+_14117872 9.25 ENST00000379153.3
CD83 molecule
chr16_-_15736953 9.25 ENST00000548025.1
ENST00000551742.1
ENST00000602337.1
ENST00000344181.3
ENST00000396368.3
KIAA0430
chr16_-_87799505 9.25 ENST00000353170.5
ENST00000561825.1
ENST00000270583.5
ENST00000562261.1
ENST00000347925.5
kelch domain containing 4
chr19_-_6481776 9.25 ENST00000543576.1
ENST00000590173.1
ENST00000381480.2
DENN/MADD domain containing 1C
chr6_-_99873145 9.24 ENST00000369239.5
ENST00000438806.1
PNN-interacting serine/arginine-rich protein
chr17_-_34417479 9.23 ENST00000225245.5
chemokine (C-C motif) ligand 3
chr19_+_17970693 9.21 ENST00000600147.1
ENST00000599898.1
ribosomal protein L18a
chr1_+_6640108 9.20 ENST00000377674.4
ENST00000488936.1
zinc finger and BTB domain containing 48
chr10_-_27149904 9.18 ENST00000376166.1
ENST00000376138.3
ENST00000355394.4
ENST00000346832.5
ENST00000376134.3
ENST00000376137.4
ENST00000536334.1
ENST00000490841.2
abl-interactor 1
chr16_+_69796209 9.08 ENST00000359154.2
ENST00000561780.1
ENST00000563659.1
ENST00000448661.1
WW domain containing E3 ubiquitin protein ligase 2
chr18_-_61089665 9.08 ENST00000238497.5
vacuolar protein sorting 4 homolog B (S. cerevisiae)
chr1_-_153919128 8.94 ENST00000361217.4
DENN/MADD domain containing 4B
chr11_-_62380199 8.71 ENST00000419857.1
ENST00000394773.2
echinoderm microtubule associated protein like 3
chr18_-_53253323 8.65 ENST00000540999.1
ENST00000563888.2
transcription factor 4
chr1_-_47069955 8.63 ENST00000341183.5
ENST00000496619.1
MAP kinase interacting serine/threonine kinase 1
chr3_-_49142178 8.63 ENST00000452739.1
ENST00000414533.1
ENST00000417025.1
glutaminyl-tRNA synthetase
chr10_-_121302195 8.60 ENST00000369103.2
regulator of G-protein signaling 10
chr17_-_79269067 8.57 ENST00000288439.5
ENST00000374759.3
solute carrier family 38, member 10
chr7_-_99097863 8.53 ENST00000426306.2
ENST00000337673.6
zinc finger protein 394
chr9_+_134065506 8.45 ENST00000483497.2
nucleoporin 214kDa
chr9_+_125132803 8.42 ENST00000540753.1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr11_+_2421718 8.37 ENST00000380996.5
ENST00000333256.6
ENST00000380992.1
ENST00000437110.1
ENST00000435795.1
tumor suppressing subtransferable candidate 4
chr3_+_47324424 8.36 ENST00000437353.1
ENST00000232766.5
ENST00000455924.2
kelch-like family member 18
chr14_-_74417096 8.22 ENST00000286544.3
family with sequence similarity 161, member B
chr2_+_202122703 8.15 ENST00000447616.1
ENST00000358485.4
caspase 8, apoptosis-related cysteine peptidase

Network of associatons between targets according to the STRING database.

First level regulatory network of SPIC

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
27.2 108.8 GO:0071461 cellular response to redox state(GO:0071461)
19.6 78.6 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376) actin polymerization-dependent cell motility(GO:0070358)
18.6 74.3 GO:0033277 abortive mitotic cell cycle(GO:0033277)
17.2 51.7 GO:0002316 follicular B cell differentiation(GO:0002316)
17.0 85.1 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
13.8 55.2 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
13.0 64.9 GO:1904845 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
12.5 75.0 GO:1990822 basic amino acid transmembrane transport(GO:1990822)
12.2 36.7 GO:0038043 interleukin-5-mediated signaling pathway(GO:0038043)
10.6 42.2 GO:0035548 gamma-delta T cell activation involved in immune response(GO:0002290) negative regulation of interferon-beta secretion(GO:0035548) regulation of gamma-delta T cell activation involved in immune response(GO:2001191) positive regulation of gamma-delta T cell activation involved in immune response(GO:2001193)
9.2 45.8 GO:0002399 MHC class II protein complex assembly(GO:0002399)
7.9 23.7 GO:0046586 regulation of calcium-dependent cell-cell adhesion(GO:0046586)
7.2 21.6 GO:0045658 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
6.8 20.3 GO:0006425 glutaminyl-tRNA aminoacylation(GO:0006425)
6.7 20.2 GO:0001923 B-1 B cell differentiation(GO:0001923)
6.5 6.5 GO:1904124 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
6.4 19.2 GO:0052053 modulation by virus of host molecular function(GO:0039506) suppression by virus of host molecular function(GO:0039507) suppression by virus of host catalytic activity(GO:0039513) modulation by virus of host catalytic activity(GO:0039516) suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process(GO:0039650) negative regulation by symbiont of host catalytic activity(GO:0052053) negative regulation by symbiont of host molecular function(GO:0052056) modulation by symbiont of host catalytic activity(GO:0052148)
6.3 31.5 GO:0014738 regulation of muscle hyperplasia(GO:0014738)
5.8 23.2 GO:0071727 toll-like receptor TLR1:TLR2 signaling pathway(GO:0038123) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727)
5.3 21.3 GO:0002774 Fc receptor mediated inhibitory signaling pathway(GO:0002774)
5.2 67.7 GO:0045651 positive regulation of macrophage differentiation(GO:0045651)
5.0 35.3 GO:0070236 regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236)
4.9 14.8 GO:1902994 regulation of phospholipid efflux(GO:1902994) positive regulation of phospholipid efflux(GO:1902995)
4.8 33.7 GO:0033625 positive regulation of integrin activation(GO:0033625)
4.6 18.2 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
4.5 95.5 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
4.5 40.6 GO:2001300 lipoxin metabolic process(GO:2001300)
4.4 17.8 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
4.2 12.7 GO:0045404 interleukin-4 biosynthetic process(GO:0042097) regulation of interleukin-4 biosynthetic process(GO:0045402) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
4.1 28.4 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
4.0 63.9 GO:0009313 oligosaccharide catabolic process(GO:0009313)
4.0 15.9 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
3.8 122.0 GO:0045730 respiratory burst(GO:0045730)
3.6 25.1 GO:0051126 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) negative regulation of actin nucleation(GO:0051126)
3.2 22.7 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
3.2 12.7 GO:0036510 trimming of terminal mannose on C branch(GO:0036510)
3.2 9.5 GO:0032687 negative regulation of interferon-alpha production(GO:0032687)
3.1 18.5 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
3.0 9.1 GO:0090611 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611) negative regulation of exosomal secretion(GO:1903542) regulation of centriole elongation(GO:1903722)
3.0 17.9 GO:0010940 positive regulation of necrotic cell death(GO:0010940)
2.9 66.8 GO:0000185 activation of MAPKKK activity(GO:0000185)
2.8 48.3 GO:0071803 positive regulation of podosome assembly(GO:0071803)
2.8 69.6 GO:0006957 complement activation, alternative pathway(GO:0006957)
2.7 16.4 GO:1904431 positive regulation of t-circle formation(GO:1904431)
2.7 10.8 GO:1904379 maintenance of unfolded protein(GO:0036506) protein localization to cytosolic proteasome complex(GO:1904327) maintenance of unfolded protein involved in ERAD pathway(GO:1904378) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379)
2.6 25.7 GO:0015939 pantothenate metabolic process(GO:0015939)
2.5 10.0 GO:0043983 histone H4-K12 acetylation(GO:0043983)
2.5 17.3 GO:0097319 fructose transport(GO:0015755) fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539)
2.4 16.8 GO:0051136 regulation of NK T cell differentiation(GO:0051136)
2.4 4.8 GO:0006438 valyl-tRNA aminoacylation(GO:0006438)
2.4 14.3 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
2.1 4.2 GO:0060559 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
2.1 10.4 GO:0042631 cellular response to water deprivation(GO:0042631)
2.1 12.4 GO:0052565 response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565)
2.0 46.8 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
2.0 5.9 GO:0097327 response to antineoplastic agent(GO:0097327)
1.9 17.2 GO:0043152 induction of bacterial agglutination(GO:0043152)
1.9 5.7 GO:0052027 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
1.9 11.2 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
1.8 5.5 GO:0070902 mitochondrial tRNA pseudouridine synthesis(GO:0070902)
1.8 5.4 GO:0030309 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
1.7 153.4 GO:0032945 negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)
1.7 10.2 GO:0019060 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
1.7 5.1 GO:0090283 regulation of protein glycosylation in Golgi(GO:0090283)
1.6 8.1 GO:0097029 mature conventional dendritic cell differentiation(GO:0097029)
1.6 6.3 GO:0018094 protein polyglycylation(GO:0018094)
1.5 17.0 GO:0002315 marginal zone B cell differentiation(GO:0002315)
1.5 9.3 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
1.5 6.1 GO:0019086 late viral transcription(GO:0019086)
1.5 3.1 GO:0032661 regulation of interleukin-18 production(GO:0032661)
1.5 44.9 GO:0010447 response to acidic pH(GO:0010447)
1.5 2.9 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
1.4 5.7 GO:0060010 Sertoli cell fate commitment(GO:0060010)
1.4 14.3 GO:0001955 blood vessel maturation(GO:0001955)
1.4 7.1 GO:0019805 tryptophan catabolic process to kynurenine(GO:0019441) quinolinate biosynthetic process(GO:0019805)
1.4 5.6 GO:0034445 regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445)
1.3 18.5 GO:0034498 early endosome to Golgi transport(GO:0034498)
1.3 15.5 GO:1901223 negative regulation of NIK/NF-kappaB signaling(GO:1901223)
1.3 22.8 GO:0035855 megakaryocyte development(GO:0035855)
1.3 1.3 GO:1903094 regulation of protein K48-linked deubiquitination(GO:1903093) negative regulation of protein K48-linked deubiquitination(GO:1903094) negative regulation of ubiquitin-specific protease activity(GO:2000157)
1.2 14.8 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
1.2 8.6 GO:0043654 recognition of apoptotic cell(GO:0043654)
1.2 6.0 GO:1903026 transcription factor catabolic process(GO:0036369) negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
1.2 10.7 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
1.2 7.1 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948) regulation of receptor catabolic process(GO:2000644)
1.2 19.8 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
1.2 15.0 GO:0050869 negative regulation of B cell activation(GO:0050869)
1.1 5.5 GO:0031642 negative regulation of myelination(GO:0031642)
1.1 3.3 GO:0061188 negative regulation of chromatin silencing at rDNA(GO:0061188)
1.1 6.5 GO:0070383 DNA cytosine deamination(GO:0070383)
1.1 5.3 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
1.0 6.2 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
1.0 3.1 GO:0032887 regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846)
1.0 3.0 GO:0034471 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000472) rRNA 5'-end processing(GO:0000967) ncRNA 5'-end processing(GO:0034471)
1.0 27.3 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
1.0 7.0 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
1.0 8.0 GO:0051601 exocyst localization(GO:0051601)
1.0 15.7 GO:0034656 nucleobase-containing small molecule catabolic process(GO:0034656)
1.0 1.0 GO:0051462 cortisol secretion(GO:0043400) regulation of cortisol secretion(GO:0051462)
1.0 4.8 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.9 1.9 GO:0009146 purine nucleoside triphosphate catabolic process(GO:0009146)
0.9 2.8 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.9 6.3 GO:0007000 transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript(GO:0001180) nucleolus organization(GO:0007000)
0.9 7.1 GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'(GO:0034427)
0.9 5.3 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.9 4.3 GO:0035063 nuclear speck organization(GO:0035063)
0.8 2.5 GO:1901668 regulation of superoxide dismutase activity(GO:1901668)
0.8 2.5 GO:0090149 mitochondrial membrane fission(GO:0090149)
0.8 7.3 GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387)
0.8 3.1 GO:0043321 regulation of natural killer cell degranulation(GO:0043321) positive regulation of natural killer cell degranulation(GO:0043323)
0.8 7.6 GO:0002115 store-operated calcium entry(GO:0002115)
0.7 22.1 GO:0034142 toll-like receptor 4 signaling pathway(GO:0034142)
0.7 4.4 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.7 2.1 GO:0097359 UDP-glucosylation(GO:0097359)
0.7 4.8 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.7 3.4 GO:0042989 sequestering of actin monomers(GO:0042989)
0.7 17.6 GO:0006958 complement activation, classical pathway(GO:0006958)
0.7 6.8 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.7 3.4 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.7 7.3 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.7 12.4 GO:0045954 positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
0.6 5.2 GO:0035897 proteolysis in other organism(GO:0035897)
0.6 6.3 GO:0045023 G0 to G1 transition(GO:0045023)
0.6 24.1 GO:0097421 liver regeneration(GO:0097421)
0.6 4.3 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.6 6.0 GO:1903943 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.6 97.0 GO:0006906 vesicle fusion(GO:0006906)
0.6 8.4 GO:0034447 very-low-density lipoprotein particle clearance(GO:0034447)
0.6 3.5 GO:0060701 negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) negative regulation of ribonuclease activity(GO:0060701) negative regulation of endoribonuclease activity(GO:0060702) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.6 2.3 GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925)
0.6 59.9 GO:0030183 B cell differentiation(GO:0030183)
0.6 4.5 GO:1902570 protein localization to nucleolus(GO:1902570)
0.6 91.9 GO:0038096 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
0.6 5.6 GO:2000304 positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.6 3.9 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.5 2.2 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.5 1.6 GO:0003352 regulation of cilium movement(GO:0003352) regulation of cilium beat frequency(GO:0003356) regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
0.5 2.1 GO:0045872 positive regulation of rhodopsin gene expression(GO:0045872)
0.5 6.9 GO:0010826 negative regulation of centrosome duplication(GO:0010826)
0.5 2.1 GO:0048631 regulation of skeletal muscle tissue growth(GO:0048631)
0.5 5.1 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.5 16.4 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.5 9.7 GO:0051255 spindle midzone assembly(GO:0051255)
0.5 1.5 GO:0001300 chronological cell aging(GO:0001300)
0.5 18.0 GO:0006506 GPI anchor metabolic process(GO:0006505) GPI anchor biosynthetic process(GO:0006506)
0.5 23.1 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.5 8.6 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.5 8.4 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.5 6.1 GO:0002227 innate immune response in mucosa(GO:0002227)
0.5 0.9 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.5 3.7 GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424)
0.5 7.9 GO:0006622 protein targeting to lysosome(GO:0006622)
0.5 3.7 GO:0040034 regulation of development, heterochronic(GO:0040034) regulation of timing of cell differentiation(GO:0048505)
0.5 2.3 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.5 1.8 GO:0060684 epithelial-mesenchymal cell signaling(GO:0060684)
0.4 4.5 GO:0031573 intra-S DNA damage checkpoint(GO:0031573)
0.4 7.5 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.4 9.2 GO:0010833 telomere maintenance via telomere lengthening(GO:0010833)
0.4 9.2 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.4 3.5 GO:0032790 ribosome disassembly(GO:0032790)
0.4 1.2 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.4 21.9 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.4 36.3 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
0.4 0.4 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.4 37.0 GO:0002819 regulation of adaptive immune response(GO:0002819)
0.4 5.4 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.4 9.4 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.4 9.8 GO:0045824 negative regulation of innate immune response(GO:0045824)
0.4 3.3 GO:0008340 determination of adult lifespan(GO:0008340)
0.4 3.9 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.4 65.4 GO:0006909 phagocytosis(GO:0006909)
0.4 1.1 GO:0038163 endomitotic cell cycle(GO:0007113) thrombopoietin-mediated signaling pathway(GO:0038163) positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.4 8.8 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.3 1.4 GO:0060671 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.3 1.7 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.3 8.0 GO:0000460 maturation of 5.8S rRNA(GO:0000460)
0.3 6.3 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.3 3.3 GO:0021562 vestibulocochlear nerve development(GO:0021562)
0.3 1.0 GO:1901873 regulation of post-translational protein modification(GO:1901873)
0.3 1.3 GO:0060125 negative regulation of growth hormone secretion(GO:0060125)
0.3 47.4 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.3 6.4 GO:0050855 regulation of B cell receptor signaling pathway(GO:0050855)
0.3 13.6 GO:0043171 peptide catabolic process(GO:0043171)
0.3 12.3 GO:0006536 glutamate metabolic process(GO:0006536)
0.3 5.1 GO:0009435 NAD biosynthetic process(GO:0009435)
0.3 0.9 GO:0019605 benzoate metabolic process(GO:0018874) butyrate metabolic process(GO:0019605)
0.3 2.9 GO:0021859 pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.3 7.3 GO:0006825 copper ion transport(GO:0006825)
0.3 2.5 GO:0034162 toll-like receptor 9 signaling pathway(GO:0034162)
0.3 4.3 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.3 5.4 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.3 1.9 GO:0010818 T cell chemotaxis(GO:0010818)
0.3 0.8 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.3 1.8 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.3 3.9 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.3 2.6 GO:0051014 actin filament severing(GO:0051014)
0.3 5.0 GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway(GO:0070423)
0.2 5.5 GO:0000132 establishment of mitotic spindle orientation(GO:0000132)
0.2 10.4 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.2 1.0 GO:0002281 macrophage activation involved in immune response(GO:0002281)
0.2 2.0 GO:1901673 regulation of mitotic spindle assembly(GO:1901673)
0.2 13.7 GO:0006968 cellular defense response(GO:0006968)
0.2 26.6 GO:1990823 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.2 1.1 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
0.2 12.8 GO:0051865 protein autoubiquitination(GO:0051865)
0.2 3.3 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.2 3.0 GO:0044803 multi-organism membrane organization(GO:0044803)
0.2 1.1 GO:0071502 cellular response to temperature stimulus(GO:0071502)
0.2 0.8 GO:0001757 somite specification(GO:0001757)
0.2 1.6 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.2 1.2 GO:0061737 leukotriene signaling pathway(GO:0061737)
0.2 5.7 GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059)
0.2 0.8 GO:2000825 positive regulation of androgen receptor activity(GO:2000825)
0.2 14.3 GO:0038034 signal transduction in absence of ligand(GO:0038034) extrinsic apoptotic signaling pathway in absence of ligand(GO:0097192)
0.2 12.0 GO:0006953 acute-phase response(GO:0006953)
0.2 7.4 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.2 0.6 GO:0070857 regulation of bile acid biosynthetic process(GO:0070857)
0.2 6.2 GO:0070206 protein trimerization(GO:0070206)
0.2 1.3 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.2 0.5 GO:0019918 peptidyl-arginine methylation, to symmetrical-dimethyl arginine(GO:0019918)
0.2 5.7 GO:0006298 mismatch repair(GO:0006298)
0.2 0.3 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.2 0.8 GO:0071233 cellular response to leucine(GO:0071233) cellular response to leucine starvation(GO:1990253)
0.2 1.2 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.2 2.6 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.1 3.6 GO:0008334 histone mRNA metabolic process(GO:0008334)
0.1 1.3 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.1 3.3 GO:0010667 negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.1 4.0 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 2.4 GO:2000052 positive regulation of non-canonical Wnt signaling pathway(GO:2000052)
0.1 1.8 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.1 2.1 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.1 8.0 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.1 1.1 GO:0044872 lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.1 3.7 GO:0015012 heparan sulfate proteoglycan biosynthetic process(GO:0015012)
0.1 2.3 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.1 3.6 GO:0001881 receptor recycling(GO:0001881)
0.1 1.1 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.1 1.5 GO:0016180 snRNA processing(GO:0016180)
0.1 1.0 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.1 0.6 GO:0006290 pyrimidine dimer repair(GO:0006290) activation of JNKK activity(GO:0007256)
0.1 6.5 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 12.8 GO:0071774 response to fibroblast growth factor(GO:0071774)
0.1 5.7 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.1 0.8 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 1.4 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.1 12.9 GO:0001837 epithelial to mesenchymal transition(GO:0001837)
0.1 2.8 GO:0007035 vacuolar acidification(GO:0007035)
0.1 11.8 GO:0044782 cilium organization(GO:0044782)
0.1 7.7 GO:0001843 neural tube closure(GO:0001843) tube closure(GO:0060606)
0.1 4.2 GO:0016266 O-glycan processing(GO:0016266)
0.1 2.5 GO:0002076 osteoblast development(GO:0002076)
0.1 13.1 GO:0043484 regulation of RNA splicing(GO:0043484)
0.1 0.3 GO:0015888 thiamine transport(GO:0015888) thiamine transmembrane transport(GO:0071934)
0.1 1.9 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.1 0.8 GO:0070995 NADPH oxidation(GO:0070995)
0.1 15.3 GO:0002250 adaptive immune response(GO:0002250)
0.1 0.8 GO:0035247 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919) peptidyl-arginine omega-N-methylation(GO:0035247)
0.1 0.3 GO:0046532 regulation of photoreceptor cell differentiation(GO:0046532)
0.1 35.5 GO:0002283 neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.1 0.7 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.1 0.7 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.1 4.5 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.1 1.5 GO:0045648 positive regulation of erythrocyte differentiation(GO:0045648)
0.1 1.1 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.1 10.9 GO:0015992 proton transport(GO:0015992)
0.1 1.8 GO:0030199 collagen fibril organization(GO:0030199)
0.1 8.0 GO:0007269 neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
0.1 19.9 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.1 7.6 GO:1902476 chloride transmembrane transport(GO:1902476)
0.1 4.0 GO:0006306 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.1 1.5 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.1 0.1 GO:0046068 cGMP metabolic process(GO:0046068)
0.1 7.5 GO:0007265 Ras protein signal transduction(GO:0007265)
0.1 7.3 GO:0048839 inner ear development(GO:0048839)
0.1 0.7 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.1 0.4 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.1 0.2 GO:1902961 regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902959) positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) regulation of aspartic-type peptidase activity(GO:1905245) positive regulation of aspartic-type peptidase activity(GO:1905247)
0.1 1.6 GO:0036297 interstrand cross-link repair(GO:0036297)
0.1 4.1 GO:0030100 regulation of endocytosis(GO:0030100)
0.1 1.9 GO:0015701 bicarbonate transport(GO:0015701)
0.1 0.5 GO:0035878 nail development(GO:0035878)
0.1 0.4 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.0 0.3 GO:0034379 very-low-density lipoprotein particle assembly(GO:0034379)
0.0 10.0 GO:0045666 positive regulation of neuron differentiation(GO:0045666)
0.0 1.3 GO:0045732 positive regulation of protein catabolic process(GO:0045732)
0.0 1.4 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.0 0.4 GO:0000963 mitochondrial RNA processing(GO:0000963)
0.0 0.2 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 1.1 GO:0045776 negative regulation of blood pressure(GO:0045776)
0.0 0.3 GO:0021516 dorsal spinal cord development(GO:0021516)
0.0 2.5 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 1.4 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.3 GO:0097352 autophagosome maturation(GO:0097352) vacuole fusion(GO:0097576)
0.0 0.1 GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway(GO:0033143) regulation of intracellular estrogen receptor signaling pathway(GO:0033146)
0.0 0.5 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.0 0.1 GO:1904381 Golgi apparatus mannose trimming(GO:1904381)
0.0 1.1 GO:0009060 aerobic respiration(GO:0009060)
0.0 2.3 GO:0050900 leukocyte migration(GO:0050900)
0.0 0.3 GO:1901655 cellular response to ketone(GO:1901655)
0.0 0.0 GO:0035523 protein K29-linked deubiquitination(GO:0035523) protein K33-linked deubiquitination(GO:1990168)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
16.5 132.0 GO:0032010 phagolysosome(GO:0032010)
16.5 82.3 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
9.7 29.1 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
7.5 149.8 GO:0001891 phagocytic cup(GO:0001891)
7.2 101.4 GO:0031209 SCAR complex(GO:0031209)
7.2 78.9 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
5.0 64.9 GO:0043020 NADPH oxidase complex(GO:0043020)
4.5 31.7 GO:0036021 endolysosome lumen(GO:0036021)
4.3 13.0 GO:0020016 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
4.0 20.1 GO:0005602 complement component C1 complex(GO:0005602)
4.0 15.9 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
3.4 17.0 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
3.3 16.4 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
3.2 22.2 GO:0019815 B cell receptor complex(GO:0019815)
3.2 9.5 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
2.7 10.8 GO:0072379 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
2.6 10.2 GO:0036502 Derlin-1-VIMP complex(GO:0036502)
2.5 40.0 GO:0016461 unconventional myosin complex(GO:0016461)
2.3 174.7 GO:0035577 azurophil granule membrane(GO:0035577)
2.2 17.8 GO:0030688 preribosome, small subunit precursor(GO:0030688)
2.2 45.8 GO:0042613 MHC class II protein complex(GO:0042613)
1.9 5.6 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
1.8 5.5 GO:0036194 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
1.8 24.5 GO:0030897 HOPS complex(GO:0030897)
1.7 6.8 GO:0055087 Ski complex(GO:0055087)
1.6 90.5 GO:0001772 immunological synapse(GO:0001772)
1.4 5.7 GO:0043625 delta DNA polymerase complex(GO:0043625)
1.4 18.5 GO:0097136 Bcl-2 family protein complex(GO:0097136)
1.4 25.2 GO:0097342 ripoptosome(GO:0097342)
1.4 18.2 GO:0005577 fibrinogen complex(GO:0005577)
1.4 11.1 GO:0035976 AP1 complex(GO:0035976)
1.4 9.7 GO:0072487 MSL complex(GO:0072487)
1.4 17.6 GO:0048188 Set1C/COMPASS complex(GO:0048188)
1.3 5.1 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
1.3 5.1 GO:0005797 Golgi medial cisterna(GO:0005797)
1.1 23.1 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
1.0 3.1 GO:0031251 PAN complex(GO:0031251)
1.0 3.1 GO:0055028 cortical microtubule(GO:0055028) mitotic spindle astral microtubule(GO:0061673)
1.0 7.1 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
1.0 3.0 GO:0019034 viral replication complex(GO:0019034)
1.0 1.0 GO:0071159 NF-kappaB complex(GO:0071159)
0.9 28.3 GO:0031258 lamellipodium membrane(GO:0031258)
0.9 7.9 GO:0044754 autolysosome(GO:0044754)
0.9 77.3 GO:0070821 tertiary granule membrane(GO:0070821)
0.9 4.3 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.9 4.3 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.8 1.7 GO:0032021 NELF complex(GO:0032021)
0.8 69.8 GO:1904724 tertiary granule lumen(GO:1904724)
0.7 8.9 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.7 8.5 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.7 12.4 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.7 5.4 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.6 5.5 GO:0031616 spindle pole centrosome(GO:0031616)
0.6 8.5 GO:0090543 Flemming body(GO:0090543)
0.6 4.8 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.6 6.4 GO:0042588 zymogen granule(GO:0042588)
0.5 7.6 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.5 55.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.5 12.4 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.5 1.5 GO:0072563 endothelial microparticle(GO:0072563)
0.5 2.4 GO:1990393 3M complex(GO:1990393)
0.5 72.7 GO:0031225 anchored component of membrane(GO:0031225)
0.5 4.1 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.5 46.9 GO:0035578 azurophil granule lumen(GO:0035578)
0.5 3.2 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.4 24.9 GO:0000786 nucleosome(GO:0000786)
0.4 1.3 GO:0002945 cyclin K-CDK13 complex(GO:0002945)
0.4 2.5 GO:1990130 Iml1 complex(GO:1990130)
0.4 118.3 GO:0009897 external side of plasma membrane(GO:0009897)
0.4 29.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.4 56.5 GO:0101002 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.4 8.4 GO:0042627 chylomicron(GO:0042627)
0.4 12.3 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.4 0.4 GO:0005953 CAAX-protein geranylgeranyltransferase complex(GO:0005953)
0.4 8.8 GO:0034451 centriolar satellite(GO:0034451)
0.4 20.6 GO:0031201 SNARE complex(GO:0031201)
0.3 4.0 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545) nuclear transcriptional repressor complex(GO:0090568)
0.3 9.3 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.3 9.2 GO:0000781 chromosome, telomeric region(GO:0000781)
0.3 3.7 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.3 1.3 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.3 0.8 GO:0035189 Rb-E2F complex(GO:0035189)
0.2 1.7 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.2 5.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 6.7 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.2 11.6 GO:0005801 cis-Golgi network(GO:0005801)
0.2 7.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.2 4.0 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.2 7.8 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.2 1.6 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.2 5.0 GO:0005921 gap junction(GO:0005921)
0.2 0.8 GO:0030914 STAGA complex(GO:0030914)
0.2 1.3 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.2 1.2 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.2 33.0 GO:0098802 plasma membrane receptor complex(GO:0098802)
0.2 2.6 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.2 1.0 GO:0043196 varicosity(GO:0043196)
0.2 1.4 GO:0035102 PRC1 complex(GO:0035102)
0.2 6.2 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.2 6.1 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.2 295.3 GO:0005887 integral component of plasma membrane(GO:0005887)
0.2 10.1 GO:0031902 late endosome membrane(GO:0031902)
0.2 8.4 GO:0001750 photoreceptor outer segment(GO:0001750)
0.2 20.7 GO:0031901 early endosome membrane(GO:0031901)
0.2 12.6 GO:0043679 axon terminus(GO:0043679)
0.2 13.2 GO:0010008 endosome membrane(GO:0010008)
0.2 1.5 GO:0032039 integrator complex(GO:0032039)
0.2 3.1 GO:0035580 specific granule lumen(GO:0035580)
0.2 10.9 GO:0005905 clathrin-coated pit(GO:0005905)
0.2 0.8 GO:1990131 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.2 20.4 GO:0030139 endocytic vesicle(GO:0030139)
0.2 56.5 GO:0000790 nuclear chromatin(GO:0000790)
0.1 7.9 GO:0072686 mitotic spindle(GO:0072686)
0.1 23.2 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 1.4 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.1 7.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 0.4 GO:0000799 nuclear condensin complex(GO:0000799)
0.1 8.5 GO:0015030 Cajal body(GO:0015030)
0.1 12.0 GO:0005814 centriole(GO:0005814)
0.1 2.2 GO:0042383 sarcolemma(GO:0042383)
0.1 11.3 GO:0032587 ruffle membrane(GO:0032587)
0.1 8.0 GO:0043202 lysosomal lumen(GO:0043202)
0.1 3.4 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 13.1 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 1.0 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 2.1 GO:0051233 spindle midzone(GO:0051233)
0.1 9.7 GO:0030667 secretory granule membrane(GO:0030667)
0.1 2.4 GO:0005861 troponin complex(GO:0005861)
0.1 10.2 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.1 6.1 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 3.6 GO:0005802 trans-Golgi network(GO:0005802)
0.1 1.0 GO:0005685 U1 snRNP(GO:0005685)
0.1 2.1 GO:0032040 small-subunit processome(GO:0032040)
0.1 12.3 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.1 2.2 GO:0005819 spindle(GO:0005819)
0.1 0.2 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 10.6 GO:0044454 nuclear chromosome part(GO:0044454)
0.1 0.4 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 1.4 GO:0070069 cytochrome complex(GO:0070069)
0.0 2.8 GO:0030175 filopodium(GO:0030175)
0.0 5.1 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 1.4 GO:0097546 ciliary base(GO:0097546)
0.0 4.9 GO:0030133 transport vesicle(GO:0030133)
0.0 4.1 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.8 GO:0032982 myosin filament(GO:0032982)
0.0 7.0 GO:0031965 nuclear membrane(GO:0031965)
0.0 12.9 GO:0000139 Golgi membrane(GO:0000139)
0.0 2.3 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 0.3 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.3 GO:0005903 brush border(GO:0005903)
0.0 2.3 GO:0072562 blood microparticle(GO:0072562)
0.0 1.6 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 5.9 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.1 GO:0032797 SMN complex(GO:0032797)
0.0 3.3 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.3 GO:0031226 intrinsic component of plasma membrane(GO:0031226)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
13.5 40.6 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
12.9 128.9 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
12.2 36.7 GO:0004914 interleukin-5 receptor activity(GO:0004914)
10.9 108.8 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
10.6 42.2 GO:0030107 HLA-A specific inhibitory MHC class I receptor activity(GO:0030107)
8.8 61.6 GO:0030369 ICAM-3 receptor activity(GO:0030369)
7.7 23.2 GO:0016019 peptidoglycan receptor activity(GO:0016019)
7.2 21.6 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
7.0 28.0 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
6.8 75.0 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
6.8 20.3 GO:0004819 glutamine-tRNA ligase activity(GO:0004819)
6.2 18.5 GO:0045322 unmethylated CpG binding(GO:0045322)
5.8 17.4 GO:0022897 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
5.5 16.4 GO:0003826 alpha-ketoacid dehydrogenase activity(GO:0003826) 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity(GO:0003863)
5.3 21.3 GO:0032396 inhibitory MHC class I receptor activity(GO:0032396)
5.2 15.6 GO:0017108 5'-flap endonuclease activity(GO:0017108)
5.2 15.5 GO:0001069 regulatory region RNA binding(GO:0001069)
5.1 20.6 GO:0019770 IgG receptor activity(GO:0019770)
4.9 14.8 GO:0090556 apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
4.0 76.8 GO:0015923 mannosidase activity(GO:0015923)
4.0 20.0 GO:0017159 pantetheine hydrolase activity(GO:0017159)
4.0 15.9 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
3.9 35.3 GO:0043426 MRF binding(GO:0043426)
3.8 19.2 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
3.8 64.9 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
3.7 66.8 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
3.4 55.2 GO:0032036 myosin heavy chain binding(GO:0032036)
3.4 20.7 GO:0001851 complement component C3b binding(GO:0001851)
3.4 48.2 GO:0019864 IgG binding(GO:0019864)
3.1 25.1 GO:0071933 Arp2/3 complex binding(GO:0071933)
3.1 40.6 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
2.9 17.5 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
2.9 77.8 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
2.8 28.4 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
2.7 30.1 GO:0005049 nuclear export signal receptor activity(GO:0005049)
2.7 51.6 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
2.5 15.3 GO:0004522 ribonuclease A activity(GO:0004522)
2.5 17.3 GO:0005353 fructose transmembrane transporter activity(GO:0005353)
2.5 12.3 GO:0047820 D-glutamate cyclase activity(GO:0047820)
2.4 4.8 GO:0004832 valine-tRNA ligase activity(GO:0004832)
2.4 14.3 GO:0035800 deubiquitinase activator activity(GO:0035800)
2.2 17.9 GO:0005497 androgen binding(GO:0005497)
2.1 6.3 GO:0001181 transcription factor activity, core RNA polymerase I binding(GO:0001181)
2.1 8.4 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
2.0 32.7 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
2.0 15.9 GO:1990405 protein antigen binding(GO:1990405)
1.8 5.5 GO:0004730 pseudouridylate synthase activity(GO:0004730)
1.8 5.4 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
1.8 51.3 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
1.7 18.5 GO:0051434 BH3 domain binding(GO:0051434)
1.7 21.8 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
1.6 6.3 GO:0070735 protein-glycine ligase activity(GO:0070735)
1.5 6.1 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
1.5 17.8 GO:0089720 caspase binding(GO:0089720)
1.5 13.3 GO:0051400 BH domain binding(GO:0051400)
1.4 11.6 GO:0034235 GPI anchor binding(GO:0034235)
1.4 5.7 GO:0004594 pantothenate kinase activity(GO:0004594)
1.4 5.6 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
1.4 5.5 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
1.4 6.8 GO:0071208 histone pre-mRNA DCP binding(GO:0071208)
1.3 14.8 GO:0004875 complement receptor activity(GO:0004875)
1.3 39.4 GO:0023026 MHC class II protein complex binding(GO:0023026)
1.3 7.9 GO:0050681 steroid hormone receptor binding(GO:0035258) androgen receptor binding(GO:0050681)
1.3 6.5 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
1.3 5.1 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262) ribosylnicotinate kinase activity(GO:0061769)
1.3 10.2 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
1.3 1.3 GO:0036435 K48-linked polyubiquitin binding(GO:0036435)
1.2 21.0 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
1.2 3.7 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
1.1 15.7 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
1.1 18.2 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
1.1 7.5 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
1.1 5.3 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
1.1 7.4 GO:0004920 interleukin-10 receptor activity(GO:0004920)
1.0 11.2 GO:0022820 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
1.0 3.0 GO:0015361 low-affinity sodium:dicarboxylate symporter activity(GO:0015361)
0.9 19.8 GO:0070300 phosphatidic acid binding(GO:0070300)
0.9 21.6 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.9 1.9 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.9 17.5 GO:0050786 RAGE receptor binding(GO:0050786)
0.9 91.5 GO:0030295 protein kinase activator activity(GO:0030295)
0.9 15.7 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.9 16.2 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.8 29.5 GO:0043236 laminin binding(GO:0043236)
0.8 7.3 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.8 7.1 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor(GO:0050664)
0.8 6.3 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.8 12.4 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.7 2.2 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.7 5.7 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.7 9.9 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.7 16.9 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.7 2.1 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)
0.7 9.2 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.6 5.1 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.6 10.0 GO:0051787 misfolded protein binding(GO:0051787)
0.6 4.3 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.6 3.5 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.6 7.6 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.6 2.3 GO:0019863 IgE binding(GO:0019863)
0.6 2.3 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.6 7.3 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.6 2.8 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.5 3.3 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.5 1.1 GO:0004947 bradykinin receptor activity(GO:0004947)
0.5 1.1 GO:0042954 lipoprotein transporter activity(GO:0042954)
0.5 1.1 GO:0010858 calcium-dependent protein kinase regulator activity(GO:0010858)
0.5 38.9 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.5 3.1 GO:0051011 microtubule minus-end binding(GO:0051011)
0.5 3.0 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.5 12.4 GO:0004383 guanylate cyclase activity(GO:0004383)
0.5 4.5 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.5 10.4 GO:0042609 CD4 receptor binding(GO:0042609)
0.5 2.0 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.5 37.9 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.5 1.4 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.5 16.6 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.5 2.8 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.5 78.8 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.5 28.8 GO:0019843 rRNA binding(GO:0019843)
0.4 16.8 GO:0005484 SNAP receptor activity(GO:0005484)
0.4 5.1 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.4 6.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.4 5.3 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.4 2.3 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.4 18.7 GO:0005044 scavenger receptor activity(GO:0005044)
0.4 4.0 GO:0004438 phosphatidylinositol-3-phosphatase activity(GO:0004438) phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) phosphatidylinositol monophosphate phosphatase activity(GO:0052744)
0.4 9.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.3 2.6 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.3 16.2 GO:0017080 sodium channel regulator activity(GO:0017080)
0.3 10.7 GO:0031593 polyubiquitin binding(GO:0031593)
0.3 3.1 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.3 5.4 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.3 4.8 GO:0005537 mannose binding(GO:0005537)
0.3 6.0 GO:0005123 death receptor binding(GO:0005123)
0.3 3.2 GO:0008179 adenylate cyclase binding(GO:0008179)
0.3 12.5 GO:0016279 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.3 4.5 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.3 15.8 GO:0035064 methylated histone binding(GO:0035064)
0.3 5.2 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.3 6.2 GO:0070403 NAD+ binding(GO:0070403)
0.3 0.5 GO:0004040 amidase activity(GO:0004040)
0.2 7.7 GO:0043015 gamma-tubulin binding(GO:0043015)
0.2 1.9 GO:0004064 arylesterase activity(GO:0004064)
0.2 7.1 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.2 4.0 GO:0008494 translation activator activity(GO:0008494)
0.2 2.7 GO:0043422 protein kinase B binding(GO:0043422)
0.2 9.9 GO:0001784 phosphotyrosine binding(GO:0001784)
0.2 42.4 GO:0003823 antigen binding(GO:0003823)
0.2 2.8 GO:0035613 RNA stem-loop binding(GO:0035613)
0.2 1.3 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.2 1.5 GO:0005534 galactose binding(GO:0005534)
0.2 1.0 GO:0004883 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.2 27.2 GO:0005178 integrin binding(GO:0005178)
0.2 3.0 GO:0019992 diacylglycerol binding(GO:0019992)
0.2 4.3 GO:0071889 14-3-3 protein binding(GO:0071889)
0.2 4.2 GO:0071949 FAD binding(GO:0071949)
0.2 1.9 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.2 2.4 GO:0031014 troponin T binding(GO:0031014)
0.2 3.4 GO:0001055 RNA polymerase II activity(GO:0001055)
0.2 3.1 GO:0097602 cullin family protein binding(GO:0097602)
0.2 2.2 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.2 3.5 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 3.5 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 43.5 GO:0005096 GTPase activator activity(GO:0005096)
0.1 2.8 GO:0032452 histone demethylase activity(GO:0032452)
0.1 3.5 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 3.2 GO:0036442 hydrogen-exporting ATPase activity(GO:0036442) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 0.5 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.1 1.9 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 0.8 GO:0008469 histone-arginine N-methyltransferase activity(GO:0008469) protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.1 3.7 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 6.7 GO:0019894 kinesin binding(GO:0019894)
0.1 2.4 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 3.4 GO:0003785 actin monomer binding(GO:0003785)
0.1 1.2 GO:0097016 L27 domain binding(GO:0097016)
0.1 3.4 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 0.9 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.1 1.0 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.1 1.5 GO:0016018 cyclosporin A binding(GO:0016018)
0.1 23.6 GO:0051015 actin filament binding(GO:0051015)
0.1 0.7 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439) inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.1 0.3 GO:0015234 thiamine transmembrane transporter activity(GO:0015234) thiamine uptake transmembrane transporter activity(GO:0015403) azole transmembrane transporter activity(GO:1901474)
0.1 20.0 GO:0005516 calmodulin binding(GO:0005516)
0.1 0.9 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.1 2.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 1.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 1.9 GO:0030331 estrogen receptor binding(GO:0030331)
0.1 5.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 0.8 GO:0050321 tau-protein kinase activity(GO:0050321)
0.1 0.3 GO:0003958 NADPH-hemoprotein reductase activity(GO:0003958)
0.1 10.2 GO:0001047 core promoter binding(GO:0001047)
0.1 4.3 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.1 2.5 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 2.2 GO:0043394 proteoglycan binding(GO:0043394)
0.1 1.1 GO:0099604 calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.1 14.5 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 12.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 4.8 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 3.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 3.6 GO:0042826 histone deacetylase binding(GO:0042826)
0.1 0.4 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.1 0.9 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.1 5.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 6.8 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds(GO:0016810)
0.1 1.8 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.1 3.3 GO:0000149 SNARE binding(GO:0000149)
0.1 1.9 GO:0030276 clathrin binding(GO:0030276)
0.1 3.1 GO:0004536 deoxyribonuclease activity(GO:0004536)
0.1 9.2 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) RNA polymerase II regulatory region DNA binding(GO:0001012)
0.1 1.8 GO:0005109 frizzled binding(GO:0005109)
0.1 3.6 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 1.3 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 17.4 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.2 GO:0001016 transcription factor activity, RNA polymerase III transcription factor binding(GO:0001007) RNA polymerase III regulatory region DNA binding(GO:0001016)
0.0 1.4 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.2 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 4.8 GO:0003690 double-stranded DNA binding(GO:0003690)
0.0 6.6 GO:0008083 growth factor activity(GO:0008083)
0.0 0.4 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 2.3 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 16.4 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 1.3 GO:0030332 cyclin binding(GO:0030332)
0.0 0.8 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.0 0.1 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.0 6.8 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 1.0 GO:0005518 collagen binding(GO:0005518)
0.0 0.5 GO:0008009 chemokine activity(GO:0008009)
0.0 0.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.3 GO:0051393 alpha-actinin binding(GO:0051393)
0.0 0.6 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 0.4 GO:0019840 isoprenoid binding(GO:0019840)
0.0 0.4 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 199.0 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
2.7 32.0 PID IL5 PATHWAY IL5-mediated signaling events
2.5 199.4 PID RAC1 PATHWAY RAC1 signaling pathway
2.4 288.2 PID BCR 5PATHWAY BCR signaling pathway
2.0 142.6 PID RHOA REG PATHWAY Regulation of RhoA activity
1.4 54.2 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
1.2 69.6 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
1.1 34.1 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
1.0 25.2 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
1.0 27.2 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
1.0 29.1 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.8 7.8 PID EPO PATHWAY EPO signaling pathway
0.7 15.9 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.6 19.0 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.5 71.4 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.5 26.0 PID IL12 2PATHWAY IL12-mediated signaling events
0.5 8.5 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.5 18.2 PID IL6 7 PATHWAY IL6-mediated signaling events
0.4 11.6 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway
0.3 27.5 PID AR PATHWAY Coregulation of Androgen receptor activity
0.3 13.7 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.3 3.0 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.3 5.4 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.3 6.4 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.3 24.8 PID CMYB PATHWAY C-MYB transcription factor network
0.2 4.8 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.2 10.2 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.2 3.0 PID IGF1 PATHWAY IGF1 pathway
0.2 7.8 PID IL4 2PATHWAY IL4-mediated signaling events
0.2 6.9 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.2 7.4 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.2 2.5 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.2 5.7 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.2 7.1 PID MTOR 4PATHWAY mTOR signaling pathway
0.1 2.3 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.1 3.0 PID RAS PATHWAY Regulation of Ras family activation
0.1 1.9 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.1 0.9 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 4.0 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.1 9.1 PID P53 REGULATION PATHWAY p53 pathway
0.1 21.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.0 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.1 3.3 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 39.3 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.1 2.4 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.1 4.0 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.1 3.9 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.1 4.0 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.1 1.3 PID EPHB FWD PATHWAY EPHB forward signaling
0.1 2.9 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.1 1.2 PID INSULIN PATHWAY Insulin Pathway
0.1 1.5 PID ALK1 PATHWAY ALK1 signaling events
0.1 1.5 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 1.1 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 0.7 PID BARD1 PATHWAY BARD1 signaling events
0.0 1.2 PID NOTCH PATHWAY Notch signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
9.8 29.5 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
3.9 51.2 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
3.9 121.2 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
3.4 147.4 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
3.2 279.2 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
2.7 51.1 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
2.4 120.3 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
2.1 25.3 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
1.7 70.9 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
1.3 81.6 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
1.2 14.8 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
1.1 36.7 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.9 162.4 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.9 7.1 REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.9 3.4 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.8 23.8 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.8 17.3 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.8 17.3 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.8 29.9 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.7 17.1 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.7 14.8 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.7 17.4 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.7 12.3 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.7 7.2 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.7 12.4 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.6 7.8 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.6 46.5 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.6 16.4 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.6 14.8 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.6 45.8 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.5 85.4 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.5 23.5 REACTOME MYOGENESIS Genes involved in Myogenesis
0.4 7.1 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.4 5.0 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.4 5.9 REACTOME ARMS MEDIATED ACTIVATION Genes involved in ARMS-mediated activation
0.3 6.2 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.3 7.3 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.3 10.3 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.3 3.2 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.3 4.4 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.3 8.6 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.3 6.0 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.3 3.9 REACTOME SIGNALING BY NOTCH4 Genes involved in Signaling by NOTCH4
0.3 3.0 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.3 11.7 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.3 4.5 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.2 2.2 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.2 3.7 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.2 3.6 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.2 3.1 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.2 3.4 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.2 14.4 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.1 1.9 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 2.4 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.1 6.2 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.1 1.0 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 2.9 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 3.4 REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.1 3.8 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 5.5 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.1 2.6 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.1 3.2 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.1 4.0 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 1.8 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.1 1.6 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 7.9 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.1 0.7 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 11.5 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 1.7 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 2.4 REACTOME CIRCADIAN CLOCK Genes involved in Circadian Clock
0.1 2.1 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 6.7 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 5.1 REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.0 0.7 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 2.1 REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.0 3.9 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.6 REACTOME SIGNALING BY SCF KIT Genes involved in Signaling by SCF-KIT
0.0 0.5 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.8 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels