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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for SREBF2
Z-value: 0.26
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Transcription factors associated with SREBF2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SREBF2 | hg19_v2_chr22_+_42229100_42229146 | -0.01 | 8.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SREBF2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.6 | 30.3 | GO:0019747 | regulation of isoprenoid metabolic process(GO:0019747) |
| 1.1 | 16.9 | GO:0006107 | oxaloacetate metabolic process(GO:0006107) |
| 0.1 | 12.5 | GO:0006892 | post-Golgi vesicle-mediated transport(GO:0006892) |
| 1.1 | 10.1 | GO:0048050 | post-embryonic eye morphogenesis(GO:0048050) |
| 0.4 | 9.2 | GO:0033689 | negative regulation of osteoblast proliferation(GO:0033689) |
| 1.5 | 9.0 | GO:0019368 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 0.4 | 9.0 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.3 | 8.6 | GO:0006337 | nucleosome disassembly(GO:0006337) |
| 1.1 | 8.5 | GO:0046618 | drug export(GO:0046618) |
| 0.0 | 8.2 | GO:0043687 | post-translational protein modification(GO:0043687) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 47.3 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.0 | 16.2 | GO:0005635 | nuclear envelope(GO:0005635) |
| 0.0 | 10.4 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 3.0 | 9.0 | GO:0097447 | dendritic tree(GO:0097447) |
| 0.3 | 9.0 | GO:0043218 | compact myelin(GO:0043218) |
| 0.1 | 8.6 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 8.2 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.3 | 8.0 | GO:0005763 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.8 | 7.4 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.3 | 7.3 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 37.4 | GO:0015485 | cholesterol binding(GO:0015485) |
| 3.7 | 18.4 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
| 2.0 | 10.1 | GO:0005006 | epidermal growth factor-activated receptor activity(GO:0005006) |
| 1.5 | 9.0 | GO:0102338 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 0.2 | 8.6 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 1.7 | 8.5 | GO:0015307 | drug:proton antiporter activity(GO:0015307) |
| 0.1 | 8.2 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.1 | 8.0 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.1 | 7.7 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 7.7 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 9.0 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.1 | 8.6 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 7.7 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 7.4 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 7.3 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 6.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 5.5 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.2 | 4.3 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 3.1 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 26.0 | REACTOME FATTY ACYL COA BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |
| 0.4 | 8.5 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.4 | 7.7 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.4 | 7.4 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.2 | 6.8 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.0 | 5.5 | REACTOME DOWNSTREAM SIGNAL TRANSDUCTION | Genes involved in Downstream signal transduction |
| 0.1 | 5.0 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 4.3 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.1 | 3.1 | REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.1 | 2.3 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |