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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for SREBF2

Z-value: 0.26

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Transcription factors associated with SREBF2

Gene Symbol Gene ID Gene Info
SREBF2
ENSG00000198911.7 sterol regulatory element binding transcription factor 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SREBF2hg19_v2_chr22_+_42229100_42229146-0.018.5e-01Click!

Activity profile of SREBF2 motif

Sorted Z-values of SREBF2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_74959978 10.78 ENST00000541064.1
NPC2
Niemann-Pick disease, type C2
chr14_-_74960030 10.18 ENST00000553490.1
ENST00000557510.1
NPC2
Niemann-Pick disease, type C2
chr2_-_56150184 10.11 ENST00000394554.1
EFEMP1
EGF containing fibulin-like extracellular matrix protein 1
chr14_-_74959994 9.35 ENST00000238633.2
ENST00000434013.2
NPC2
Niemann-Pick disease, type C2
chr6_-_53213780 9.31 ENST00000304434.6
ENST00000370918.4
ELOVL5
ELOVL fatty acid elongase 5
chr17_-_40075197 9.12 ENST00000590770.1
ENST00000590151.1
ACLY
ATP citrate lyase
chr17_-_15168624 8.99 ENST00000312280.3
ENST00000494511.1
ENST00000580584.1
PMP22
peripheral myelin protein 22
chr2_+_27435734 8.45 ENST00000419744.1
ATRAID
all-trans retinoic acid-induced differentiation factor
chr17_-_40075219 7.83 ENST00000537919.1
ENST00000352035.2
ENST00000353196.1
ENST00000393896.2
ACLY
ATP citrate lyase
chr12_-_91505608 7.75 ENST00000266718.4
LUM
lumican
chr5_-_39425068 7.42 ENST00000515700.1
ENST00000339788.6
DAB2
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr6_+_151561085 7.36 ENST00000402676.2
AKAP12
A kinase (PRKA) anchor protein 12
chr12_-_53343602 7.29 ENST00000546897.1
ENST00000552551.1
KRT8
keratin 8
chr18_-_21166841 7.07 ENST00000269228.5
NPC1
Niemann-Pick disease, type C1
chr8_+_26435359 6.81 ENST00000311151.5
DPYSL2
dihydropyrimidinase-like 2
chr10_-_74856608 6.72 ENST00000307116.2
ENST00000373008.2
ENST00000412021.2
ENST00000394890.2
ENST00000263556.3
ENST00000440381.1
P4HA1
prolyl 4-hydroxylase, alpha polypeptide I
chr19_-_11308190 5.96 ENST00000586659.1
ENST00000592903.1
ENST00000589359.1
ENST00000588724.1
ENST00000432929.2
KANK2
KN motif and ankyrin repeat domains 2
chr6_-_31926208 5.63 ENST00000454913.1
ENST00000436289.2
NELFE
negative elongation factor complex member E
chr5_-_149535421 5.47 ENST00000261799.4
PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr9_+_131452239 4.75 ENST00000372688.4
ENST00000372686.5
SET
SET nuclear oncogene
chr14_+_56046990 4.62 ENST00000438792.2
ENST00000395314.3
ENST00000395308.1
KTN1
kinectin 1 (kinesin receptor)
chr3_+_5020801 4.26 ENST00000256495.3
BHLHE40
basic helix-loop-helix family, member e40
chr1_-_155232221 4.11 ENST00000355379.3
SCAMP3
secretory carrier membrane protein 3
chr17_+_73257945 4.09 ENST00000579002.1
MRPS7
mitochondrial ribosomal protein S7
chr17_+_73257742 3.92 ENST00000579761.1
ENST00000245539.6
MRPS7
mitochondrial ribosomal protein S7
chr9_+_131451480 3.84 ENST00000322030.8
SET
SET nuclear oncogene
chr14_+_56046914 3.60 ENST00000413890.2
ENST00000395309.3
ENST00000554567.1
ENST00000555498.1
KTN1
kinectin 1 (kinesin receptor)
chr1_-_155232047 3.60 ENST00000302631.3
SCAMP3
secretory carrier membrane protein 3
chr10_-_3827417 3.37 ENST00000497571.1
ENST00000542957.1
KLF6
Kruppel-like factor 6
chr1_+_39796810 3.30 ENST00000289893.4
MACF1
microtubule-actin crosslinking factor 1
chr6_-_52860171 3.08 ENST00000370963.4
GSTA4
glutathione S-transferase alpha 4
chr11_+_2923423 2.96 ENST00000312221.5
SLC22A18
solute carrier family 22, member 18
chr11_+_2923499 2.91 ENST00000449793.2
SLC22A18
solute carrier family 22, member 18
chr11_+_2923619 2.59 ENST00000380574.1
SLC22A18
solute carrier family 22, member 18
chr3_-_98620500 2.40 ENST00000326840.6
DCBLD2
discoidin, CUB and LCCL domain containing 2
chr4_+_75230853 2.39 ENST00000244869.2
EREG
epiregulin
chr19_+_11200038 2.30 ENST00000558518.1
ENST00000557933.1
ENST00000455727.2
ENST00000535915.1
ENST00000545707.1
ENST00000558013.1
LDLR
low density lipoprotein receptor
chr2_+_232573222 2.27 ENST00000341369.7
ENST00000409683.1
PTMA
prothymosin, alpha
chr6_-_52859968 1.90 ENST00000370959.1
GSTA4
glutathione S-transferase alpha 4
chr17_-_56065484 1.72 ENST00000581208.1
VEZF1
vascular endothelial zinc finger 1
chr3_+_160117418 1.55 ENST00000465903.1
ENST00000485645.1
ENST00000360111.2
ENST00000472991.1
ENST00000467468.1
ENST00000469762.1
ENST00000489573.1
ENST00000462787.1
ENST00000490207.1
ENST00000485867.1
SMC4
structural maintenance of chromosomes 4
chr5_-_43313574 1.47 ENST00000325110.6
ENST00000433297.2
HMGCS1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr4_-_54930790 1.45 ENST00000263921.3
CHIC2
cysteine-rich hydrophobic domain 2
chr2_+_232573208 1.37 ENST00000409115.3
PTMA
prothymosin, alpha
chr19_-_55791058 1.32 ENST00000587959.1
ENST00000585927.1
ENST00000587922.1
ENST00000585698.1
HSPBP1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr2_+_232572361 1.22 ENST00000409321.1
PTMA
prothymosin, alpha
chr6_-_32152020 1.10 ENST00000375055.2
AGER
advanced glycosylation end product-specific receptor
chr6_-_32152064 1.06 ENST00000375076.4
ENST00000375070.3
AGER
advanced glycosylation end product-specific receptor
chr9_+_100745615 1.01 ENST00000339399.4
ANP32B
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr6_-_32151999 0.95 ENST00000375069.3
ENST00000538695.1
ENST00000438221.2
ENST00000375065.5
ENST00000450110.1
ENST00000375067.3
ENST00000375056.2
AGER
advanced glycosylation end product-specific receptor
chr16_+_31225337 0.79 ENST00000322122.3
TRIM72
tripartite motif containing 72
chr15_+_33010175 0.75 ENST00000300177.4
ENST00000560677.1
ENST00000560830.1
GREM1
gremlin 1, DAN family BMP antagonist
chr1_+_206643806 0.69 ENST00000537984.1
IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr13_+_24844819 0.54 ENST00000399949.2
SPATA13
spermatogenesis associated 13
chr10_-_116444371 0.41 ENST00000533213.2
ENST00000369252.4
ABLIM1
actin binding LIM protein 1
chr8_-_17579726 0.40 ENST00000381861.3
MTUS1
microtubule associated tumor suppressor 1
chr1_-_42384343 0.38 ENST00000372584.1
HIVEP3
human immunodeficiency virus type I enhancer binding protein 3
chr2_-_219925189 0.33 ENST00000295731.6
IHH
indian hedgehog
chr15_-_73076030 0.24 ENST00000311669.8
ADPGK
ADP-dependent glucokinase
chr19_-_18392422 0.01 ENST00000252818.3
JUND
jun D proto-oncogene

Network of associatons between targets according to the STRING database.

First level regulatory network of SREBF2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
7.6 30.3 GO:0019747 regulation of isoprenoid metabolic process(GO:0019747)
2.0 6.0 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
1.9 7.4 GO:0035026 leading edge cell differentiation(GO:0035026)
1.8 5.5 GO:0060437 lung growth(GO:0060437) metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
1.5 9.0 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
1.1 10.1 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
1.1 16.9 GO:0006107 oxaloacetate metabolic process(GO:0006107)
1.1 8.5 GO:0046618 drug export(GO:0046618)
1.0 3.1 GO:1904596 regulation of connective tissue replacement involved in inflammatory response wound healing(GO:1904596) negative regulation of connective tissue replacement involved in inflammatory response wound healing(GO:1904597) regulation of advanced glycation end-product receptor activity(GO:1904603) negative regulation of advanced glycation end-product receptor activity(GO:1904604) negative regulation of connective tissue replacement(GO:1905204)
1.0 7.7 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.9 7.1 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.8 6.7 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.8 2.4 GO:0042700 luteinizing hormone signaling pathway(GO:0042700)
0.8 2.3 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.5 7.3 GO:0051599 response to hydrostatic pressure(GO:0051599)
0.5 7.4 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.4 9.0 GO:0032060 bleb assembly(GO:0032060)
0.4 9.2 GO:0033689 negative regulation of osteoblast proliferation(GO:0033689)
0.4 5.6 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.3 8.6 GO:0006337 nucleosome disassembly(GO:0006337)
0.3 8.0 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.2 1.5 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.2 4.3 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.1 5.0 GO:1901687 glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
0.1 1.5 GO:0009642 response to light intensity(GO:0009642)
0.1 12.5 GO:0006892 post-Golgi vesicle-mediated transport(GO:0006892)
0.1 0.3 GO:0048073 regulation of eye pigmentation(GO:0048073)
0.1 0.8 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.1 6.8 GO:0030516 regulation of axon extension(GO:0030516)
0.0 1.0 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 0.7 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 1.7 GO:0001885 endothelial cell development(GO:0001885)
0.0 2.9 GO:0030183 B cell differentiation(GO:0030183)
0.0 8.2 GO:0043687 post-translational protein modification(GO:0043687)
0.0 1.3 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.0 2.4 GO:0030308 negative regulation of cell growth(GO:0030308)
0.0 0.9 GO:0030032 lamellipodium assembly(GO:0030032)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 9.0 GO:0097447 dendritic tree(GO:0097447)
2.2 6.7 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
1.1 5.6 GO:0032021 NELF complex(GO:0032021)
0.8 7.4 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.6 6.9 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.4 47.3 GO:0035578 azurophil granule lumen(GO:0035578)
0.3 9.0 GO:0043218 compact myelin(GO:0043218)
0.3 8.0 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.3 7.3 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.2 2.3 GO:0097443 sorting endosome(GO:0097443)
0.2 1.5 GO:0000796 condensin complex(GO:0000796)
0.1 8.6 GO:0005811 lipid particle(GO:0005811)
0.0 6.1 GO:0031902 late endosome membrane(GO:0031902)
0.0 5.5 GO:0043202 lysosomal lumen(GO:0043202)
0.0 6.0 GO:0001650 fibrillar center(GO:0001650)
0.0 8.2 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 10.4 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 16.2 GO:0005635 nuclear envelope(GO:0005635)
0.0 1.4 GO:0005798 Golgi-associated vesicle(GO:0005798)
0.0 2.7 GO:0032587 ruffle membrane(GO:0032587)
0.0 4.4 GO:0005938 cell cortex(GO:0005938)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 18.4 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
2.3 6.8 GO:0004157 dihydropyrimidinase activity(GO:0004157)
2.0 10.1 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
1.8 5.5 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
1.7 8.5 GO:0015307 drug:proton antiporter activity(GO:0015307)
1.5 9.0 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
1.3 6.7 GO:0019798 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
1.0 3.1 GO:1904599 advanced glycation end-product binding(GO:1904599)
0.7 37.4 GO:0015485 cholesterol binding(GO:0015485)
0.5 4.3 GO:0043426 MRF binding(GO:0043426)
0.5 7.4 GO:0008179 adenylate cyclase binding(GO:0008179)
0.3 7.4 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.3 2.3 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.2 0.7 GO:0036435 K48-linked polyubiquitin binding(GO:0036435)
0.2 8.6 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 8.2 GO:0019894 kinesin binding(GO:0019894)
0.1 8.0 GO:0019843 rRNA binding(GO:0019843)
0.1 0.8 GO:0016015 morphogen activity(GO:0016015)
0.1 5.0 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 7.3 GO:0097110 scaffold protein binding(GO:0097110)
0.1 7.7 GO:0005518 collagen binding(GO:0005518)
0.1 0.3 GO:0005113 patched binding(GO:0005113)
0.0 2.4 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.8 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 7.7 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 1.0 GO:0070063 RNA polymerase binding(GO:0070063)
0.0 3.3 GO:0051015 actin filament binding(GO:0051015)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.3 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.2 5.5 PID S1P S1P1 PATHWAY S1P1 pathway
0.1 7.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 7.3 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 2.9 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.1 9.0 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.1 8.6 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 7.4 PID TGFBR PATHWAY TGF-beta receptor signaling
0.1 1.6 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 3.1 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 10.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 6.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.5 PID AURORA B PATHWAY Aurora B signaling
0.0 1.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.8 PID BMP PATHWAY BMP receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 26.0 REACTOME FATTY ACYL COA BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.4 7.7 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.4 7.4 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.4 8.5 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.2 6.8 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 5.0 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 2.3 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 3.1 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.1 4.3 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 1.5 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.6 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 0.7 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 5.5 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 0.4 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling