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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for STAT1_STAT3_BCL6
Z-value: 0.50
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Transcription factors associated with STAT1_STAT3_BCL6
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000115415.14 | signal transducer and activator of transcription 1 | |
| ENSG00000168610.10 | signal transducer and activator of transcription 3 | |
| ENSG00000113916.13 | BCL6 transcription repressor |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| STAT1 | hg19_v2_chr2_-_191878874_191878976 | -0.42 | 7.6e-11 | Click! |
| BCL6 | hg19_v2_chr3_-_187454281_187454357 | 0.29 | 1.3e-05 | Click! |
| STAT3 | hg19_v2_chr17_-_40540377_40540481 | -0.14 | 3.4e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of STAT1_STAT3_BCL6
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 21.5 | 128.8 | GO:1902998 | macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 23.4 | 70.3 | GO:0071140 | resolution of recombination intermediates(GO:0071139) resolution of mitotic recombination intermediates(GO:0071140) |
| 13.9 | 41.8 | GO:1903410 | lysine import(GO:0034226) L-lysine import(GO:0061461) L-lysine import into cell(GO:1903410) |
| 6.5 | 39.1 | GO:0090131 | mesenchyme migration(GO:0090131) |
| 2.6 | 39.0 | GO:0034638 | phosphatidylcholine catabolic process(GO:0034638) |
| 12.9 | 38.8 | GO:1901624 | negative regulation of lymphocyte chemotaxis(GO:1901624) |
| 0.6 | 38.4 | GO:0090502 | RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502) |
| 2.8 | 33.1 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 1.9 | 30.8 | GO:0017187 | peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214) |
| 1.7 | 29.8 | GO:0007021 | tubulin complex assembly(GO:0007021) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.1 | 137.7 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.2 | 114.1 | GO:0005813 | centrosome(GO:0005813) |
| 0.5 | 53.4 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 3.5 | 53.0 | GO:0030478 | actin cap(GO:0030478) |
| 0.0 | 50.3 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.3 | 46.0 | GO:0072562 | blood microparticle(GO:0072562) |
| 9.8 | 39.1 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 2.3 | 39.1 | GO:0043194 | axon initial segment(GO:0043194) |
| 2.4 | 33.1 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.1 | 30.6 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.4 | 128.8 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 8.8 | 70.3 | GO:0008821 | crossover junction endodeoxyribonuclease activity(GO:0008821) |
| 16.1 | 48.3 | GO:0031727 | CCR2 chemokine receptor binding(GO:0031727) |
| 0.5 | 45.4 | GO:0005518 | collagen binding(GO:0005518) |
| 0.1 | 42.8 | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981) |
| 2.5 | 41.8 | GO:0031702 | type 1 angiotensin receptor binding(GO:0031702) |
| 13.8 | 41.3 | GO:0098519 | nucleotide phosphatase activity, acting on free nucleotides(GO:0098519) |
| 1.5 | 41.3 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 8.9 | 35.6 | GO:0047391 | alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391) |
| 5.6 | 33.6 | GO:0004522 | ribonuclease A activity(GO:0004522) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 101.0 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 1.1 | 75.7 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.3 | 74.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.4 | 63.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.8 | 54.6 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 1.2 | 41.4 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.8 | 41.0 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.6 | 39.6 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 30.1 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 0.8 | 20.9 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 142.7 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 1.7 | 107.6 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.3 | 62.7 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.4 | 53.9 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 2.7 | 43.9 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.6 | 35.3 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |
| 1.1 | 35.0 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |
| 1.0 | 34.9 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 1.2 | 33.1 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 2.2 | 24.3 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |