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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for STAT5A
Z-value: 0.40
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Transcription factors associated with STAT5A
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| STAT5A | hg19_v2_chr17_+_40440481_40440561 | 0.45 | 4.6e-12 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_15103621 Show fit | 21.42 |
ENST00000536592.1
|
Rho GDP dissociation inhibitor (GDI) beta |
|
| chr3_-_50649192 Show fit | 20.59 |
ENST00000443053.2
ENST00000348721.3 |
cytokine inducible SH2-containing protein |
|
| chr3_+_50649302 Show fit | 19.98 |
ENST00000446044.1
|
mitogen-activated protein kinase-activated protein kinase 3 |
|
| chr6_+_32605195 Show fit | 19.32 |
ENST00000374949.2
|
major histocompatibility complex, class II, DQ alpha 1 |
|
| chr2_-_89292422 Show fit | 18.05 |
ENST00000495489.1
|
immunoglobulin kappa variable 1-8 |
|
| chr6_+_32407619 Show fit | 16.62 |
ENST00000395388.2
ENST00000374982.5 |
major histocompatibility complex, class II, DR alpha |
|
| chr1_-_36937075 Show fit | 16.34 |
ENST00000464465.2
|
colony stimulating factor 3 receptor (granulocyte) |
|
| chr19_+_42724423 Show fit | 16.25 |
ENST00000301215.3
ENST00000597945.1 |
zinc finger protein 526 |
|
| chr2_-_89399845 Show fit | 14.00 |
ENST00000479981.1
|
immunoglobulin kappa variable 1-16 |
|
| chr6_+_33048222 Show fit | 13.89 |
ENST00000428835.1
|
major histocompatibility complex, class II, DP beta 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of STAT5A
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 85.9 | GO:0002433 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096) |
| 0.6 | 84.0 | GO:0060333 | interferon-gamma-mediated signaling pathway(GO:0060333) |
| 11.6 | 46.4 | GO:0071461 | cellular response to redox state(GO:0071461) |
| 0.7 | 29.9 | GO:0045824 | negative regulation of innate immune response(GO:0045824) |
| 1.3 | 28.2 | GO:0097186 | amelogenesis(GO:0097186) |
| 0.7 | 25.6 | GO:1900077 | negative regulation of cellular response to insulin stimulus(GO:1900077) |
| 2.5 | 20.0 | GO:0044351 | macropinocytosis(GO:0044351) |
| 0.3 | 19.5 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 3.9 | 19.3 | GO:0014738 | regulation of muscle hyperplasia(GO:0014738) |
| 3.9 | 19.3 | GO:0002378 | immunoglobulin biosynthetic process(GO:0002378) negative regulation of glucose import in response to insulin stimulus(GO:2001274) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 103.6 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 3.3 | 70.1 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 38.8 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 33.5 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.5 | 28.9 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.2 | 27.0 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 1.0 | 19.3 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.3 | 19.2 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
| 2.4 | 19.0 | GO:0032010 | phagolysosome(GO:0032010) |
| 0.2 | 18.4 | GO:0070821 | tertiary granule membrane(GO:0070821) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 68.8 | GO:0003823 | antigen binding(GO:0003823) |
| 4.0 | 56.2 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 4.6 | 46.4 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 2.4 | 43.0 | GO:0019864 | IgG binding(GO:0019864) |
| 0.3 | 39.9 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 0.2 | 36.9 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.4 | 32.5 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 0.0 | 30.5 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.1 | 29.2 | GO:0000982 | transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982) |
| 7.1 | 28.2 | GO:0051916 | granulocyte colony-stimulating factor binding(GO:0051916) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 73.0 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.6 | 31.7 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.6 | 31.7 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.5 | 27.2 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 1.9 | 26.4 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
| 0.8 | 25.4 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.4 | 23.4 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.5 | 22.4 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.7 | 21.2 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.7 | 17.6 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 75.6 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 1.1 | 50.7 | REACTOME GROWTH HORMONE RECEPTOR SIGNALING | Genes involved in Growth hormone receptor signaling |
| 2.0 | 44.9 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.3 | 43.4 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 1.3 | 34.1 | REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION | Genes involved in activated TAK1 mediates p38 MAPK activation |
| 0.3 | 32.1 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.6 | 31.5 | REACTOME GPVI MEDIATED ACTIVATION CASCADE | Genes involved in GPVI-mediated activation cascade |
| 0.7 | 30.8 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.1 | 25.4 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 1.1 | 19.3 | REACTOME DEFENSINS | Genes involved in Defensins |