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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for STAT5B
Z-value: 0.78
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Transcription factors associated with STAT5B
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| STAT5B | hg19_v2_chr17_-_40428359_40428462 | -0.00 | 9.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of STAT5B
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 466.9 | GO:0006351 | transcription, DNA-templated(GO:0006351) |
| 2.1 | 27.8 | GO:0031573 | intra-S DNA damage checkpoint(GO:0031573) |
| 1.5 | 19.9 | GO:0097034 | mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034) |
| 0.3 | 19.6 | GO:0035306 | positive regulation of dephosphorylation(GO:0035306) positive regulation of protein dephosphorylation(GO:0035307) |
| 0.2 | 18.0 | GO:0009301 | snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795) |
| 0.3 | 14.5 | GO:0070830 | bicellular tight junction assembly(GO:0070830) |
| 0.6 | 12.7 | GO:0009312 | oligosaccharide biosynthetic process(GO:0009312) |
| 1.0 | 12.5 | GO:0048096 | chromatin-mediated maintenance of transcription(GO:0048096) |
| 0.5 | 11.8 | GO:0003215 | cardiac right ventricle morphogenesis(GO:0003215) |
| 0.4 | 11.3 | GO:0071168 | protein localization to chromatin(GO:0071168) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 283.3 | GO:0005634 | nucleus(GO:0005634) |
| 1.7 | 19.9 | GO:0005744 | mitochondrial inner membrane presequence translocase complex(GO:0005744) |
| 1.4 | 18.3 | GO:0001741 | XY body(GO:0001741) |
| 2.5 | 17.4 | GO:0097165 | nuclear stress granule(GO:0097165) |
| 0.2 | 15.2 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.4 | 14.5 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.8 | 10.7 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.1 | 10.7 | GO:0035097 | histone methyltransferase complex(GO:0035097) |
| 0.1 | 10.5 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 3.3 | 10.0 | GO:0005879 | axonemal microtubule(GO:0005879) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 322.5 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.1 | 183.8 | GO:0003677 | DNA binding(GO:0003677) |
| 0.1 | 21.4 | GO:0016746 | transferase activity, transferring acyl groups(GO:0016746) |
| 0.0 | 17.1 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.7 | 14.5 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.7 | 12.5 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
| 4.0 | 12.1 | GO:0047273 | galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity(GO:0047273) |
| 0.1 | 11.8 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 2.3 | 11.3 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.5 | 11.2 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 16.3 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.2 | 14.5 | PID ER NONGENOMIC PATHWAY | Plasma membrane estrogen receptor signaling |
| 0.1 | 11.8 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.2 | 7.7 | ST ADRENERGIC | Adrenergic Pathway |
| 0.1 | 7.0 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 5.3 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.1 | 5.1 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.0 | 4.9 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 3.8 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.1 | 3.7 | PID CXCR3 PATHWAY | CXCR3-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 287.0 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.2 | 14.7 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 11.7 | REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES | Genes involved in Recruitment of mitotic centrosome proteins and complexes |
| 0.2 | 11.3 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.7 | 10.7 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.2 | 10.5 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.1 | 9.3 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.6 | 7.8 | REACTOME ANDROGEN BIOSYNTHESIS | Genes involved in Androgen biosynthesis |
| 0.8 | 7.5 | REACTOME BETA DEFENSINS | Genes involved in Beta defensins |
| 0.2 | 7.2 | REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter |