ISMARA results: STAT6

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for STAT6

Z-value: 0.23

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Transcription factors associated with STAT6

Gene Symbol	Gene ID	Gene Info
STAT6 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000166888.6	signal transducer and activator of transcription 6

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
STAT6	hg19_v2_chr12_-_57505121_57505216	0.28	3.5e-05	Click!

Activity profile of STAT6 motif

Sorted Z-values of STAT6 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr16_+_30075463 Show fit	13.49	ENST00000562168.1 ENST00000569545.1	ALDOA Ensembl NCBI GeneCards UniProt NextProt Show fit	aldolase A, fructose-bisphosphate
chr16_+_30075595 Show fit	13.14	ENST00000563060.2	ALDOA Ensembl NCBI GeneCards UniProt NextProt Show fit	aldolase A, fructose-bisphosphate
chr16_+_30075783 Show fit	12.44	ENST00000412304.2	ALDOA Ensembl NCBI GeneCards UniProt NextProt Show fit	aldolase A, fructose-bisphosphate
chr14_-_69446034 Show fit	12.40	ENST00000193403.6	ACTN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	actinin, alpha 1
chr11_-_14379997 Show fit	11.32	ENST00000526063.1 ENST00000532814.1	RRAS2 Ensembl NCBI GeneCards UniProt NextProt Show fit	related RAS viral (r-ras) oncogene homolog 2
chr5_+_102201722 Show fit	9.94	ENST00000274392.9 ENST00000455264.2	PAM Ensembl NCBI GeneCards UniProt NextProt Show fit	peptidylglycine alpha-amidating monooxygenase
chr1_-_68299130 Show fit	9.69	ENST00000370982.3	GNG12 Ensembl NCBI GeneCards UniProt NextProt Show fit	guanine nucleotide binding protein (G protein), gamma 12
chr5_+_74011328 Show fit	7.59	ENST00000513336.1	HEXB Ensembl NCBI GeneCards UniProt NextProt Show fit	hexosaminidase B (beta polypeptide)
chr1_-_209824643 Show fit	6.27	ENST00000391911.1 ENST00000415782.1	LAMB3 Ensembl NCBI GeneCards UniProt NextProt Show fit	laminin, beta 3
chr1_-_108735440 Show fit	5.90	ENST00000370041.4	SLC25A24 Ensembl NCBI GeneCards UniProt NextProt Show fit	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24

Showing 1 to 10 of 149 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of STAT6

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.2	39.1	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.3	14.8	GO:0043268	positive regulation of potassium ion transport(GO:0043268)
0.8	12.4	GO:0051639	actin filament network formation(GO:0051639)
0.9	11.2	GO:0048298	positive regulation of isotype switching to IgA isotypes(GO:0048298)
2.6	10.3	GO:0031179	peptide amidation(GO:0001519) protein amidation(GO:0018032) peptide modification(GO:0031179)
0.2	9.7	GO:0071377	cellular response to glucagon stimulus(GO:0071377)
0.1	9.4	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479)
1.0	8.8	GO:0030091	protein repair(GO:0030091)
0.0	8.0	GO:0030335	positive regulation of cell migration(GO:0030335)
1.5	7.6	GO:0007619	courtship behavior(GO:0007619)

Showing 1 to 10 of 85 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	39.1	GO:0031430	M band(GO:0031430)
0.1	35.3	GO:0005925	focal adhesion(GO:0005925)
0.1	16.7	GO:0043202	lysosomal lumen(GO:0043202)
0.8	12.4	GO:0005916	fascia adherens(GO:0005916)
0.2	9.7	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.0	8.7	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.1	8.6	GO:0043204	perikaryon(GO:0043204)
0.0	8.0	GO:0016323	basolateral plasma membrane(GO:0016323)
0.8	6.3	GO:0005610	laminin-5 complex(GO:0005610)
0.1	5.8	GO:0000777	condensed chromosome kinetochore(GO:0000777)

Showing 1 to 10 of 44 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.6	39.1	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.1	14.8	GO:0044325	ion channel binding(GO:0044325)
0.5	12.4	GO:0017166	vinculin binding(GO:0017166)
2.6	10.3	GO:0004598	peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.8	9.7	GO:0042301	phosphate ion binding(GO:0042301)
0.2	9.6	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
1.8	8.8	GO:0008113	peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0	8.6	GO:0003924	GTPase activity(GO:0003924)
0.9	7.6	GO:0004563	beta-N-acetylhexosaminidase activity(GO:0004563)
0.6	6.2	GO:0015174	basic amino acid transmembrane transporter activity(GO:0015174)

Showing 1 to 10 of 74 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	39.4	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.1	21.9	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.3	14.8	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.3	6.3	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.2	6.2	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1	6.1	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.1	5.1	PID ILK PATHWAY	Integrin-linked kinase signaling
0.1	5.0	NABA COLLAGENS	Genes encoding collagen proteins
0.1	4.8	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.1	4.7	PID NETRIN PATHWAY	Netrin-mediated signaling events

Showing 1 to 10 of 23 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	39.1	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.6	17.5	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.7	11.9	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.1	11.2	REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.4	9.7	REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA	Genes involved in G beta:gamma signalling through PLC beta
0.1	9.4	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.2	6.2	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.1	5.9	REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	Genes involved in Antiviral mechanism by IFN-stimulated genes
0.2	5.6	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.1	5.1	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase

Showing 1 to 10 of 38 entries

Results for STAT6

Z-value: 0.23

Motif logo

Transcription factors associated with STAT6

Activity-expression correlation:

Activity profile of STAT6 motif

Sorted Z-values of STAT6 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of STAT6

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: