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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for T
Z-value: 0.67
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Transcription factors associated with T
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| T | hg19_v2_chr6_-_166582107_166582188 | -0.43 | 3.6e-11 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of T
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.6 | 47.2 | GO:0019388 | galactose catabolic process(GO:0019388) |
| 0.4 | 40.1 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 4.6 | 23.0 | GO:1904844 | response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845) |
| 2.5 | 22.4 | GO:0060235 | lens induction in camera-type eye(GO:0060235) |
| 1.0 | 20.3 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 6.4 | 19.2 | GO:0032687 | negative regulation of interferon-alpha production(GO:0032687) |
| 0.2 | 18.8 | GO:0036498 | IRE1-mediated unfolded protein response(GO:0036498) |
| 2.0 | 18.3 | GO:0045716 | positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716) |
| 1.6 | 16.1 | GO:0035845 | photoreceptor cell outer segment organization(GO:0035845) |
| 5.1 | 15.2 | GO:0046098 | hypoxanthine salvage(GO:0043103) guanine metabolic process(GO:0046098) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 47.5 | GO:0070062 | extracellular exosome(GO:0070062) |
| 1.2 | 25.2 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.0 | 24.3 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 1.4 | 23.0 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.2 | 22.1 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.3 | 21.8 | GO:0005811 | lipid particle(GO:0005811) |
| 1.4 | 20.3 | GO:0008290 | F-actin capping protein complex(GO:0008290) Flemming body(GO:0090543) |
| 0.1 | 19.3 | GO:0005938 | cell cortex(GO:0005938) |
| 2.7 | 18.8 | GO:0005785 | signal recognition particle receptor complex(GO:0005785) |
| 0.1 | 16.8 | GO:0016605 | PML body(GO:0016605) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 15.7 | 47.2 | GO:0003978 | UDP-N-acetylglucosamine 4-epimerase activity(GO:0003974) UDP-glucose 4-epimerase activity(GO:0003978) |
| 0.1 | 31.4 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.1 | 29.4 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 1.2 | 25.2 | GO:0070628 | proteasome binding(GO:0070628) |
| 1.2 | 23.0 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 6.3 | 18.8 | GO:0005047 | signal recognition particle binding(GO:0005047) |
| 3.2 | 16.1 | GO:0002046 | opsin binding(GO:0002046) |
| 0.5 | 14.9 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.1 | 12.4 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.3 | 11.6 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 23.0 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.1 | 13.6 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.1 | 12.5 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.3 | 9.5 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.1 | 9.0 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.2 | 8.9 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 6.1 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 5.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 5.3 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 5.3 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 63.1 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 0.1 | 47.2 | REACTOME METABOLISM OF CARBOHYDRATES | Genes involved in Metabolism of carbohydrates |
| 0.3 | 18.8 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.2 | 16.3 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.6 | 15.2 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.7 | 11.3 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.5 | 11.2 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 1.2 | 9.7 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.3 | 9.5 | REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |
| 0.2 | 9.3 | REACTOME MRNA 3 END PROCESSING | Genes involved in mRNA 3'-end processing |