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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for TBX1
Z-value: 0.81
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Transcription factors associated with TBX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TBX1 | hg19_v2_chr22_+_19744226_19744226 | 0.36 | 3.3e-08 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TBX1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 43.6 | GO:0097242 | beta-amyloid clearance(GO:0097242) |
| 0.6 | 38.9 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 1.1 | 29.5 | GO:1904659 | hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659) |
| 0.3 | 28.7 | GO:0050776 | regulation of immune response(GO:0050776) |
| 1.0 | 24.8 | GO:0035338 | long-chain fatty-acyl-CoA biosynthetic process(GO:0035338) |
| 7.4 | 22.1 | GO:0002522 | leukocyte migration involved in immune response(GO:0002522) |
| 2.2 | 21.7 | GO:1990416 | cellular response to brain-derived neurotrophic factor stimulus(GO:1990416) |
| 0.2 | 21.1 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 4.1 | 20.3 | GO:2001187 | positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187) |
| 2.0 | 20.3 | GO:0060267 | positive regulation of respiratory burst(GO:0060267) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 48.9 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 8.1 | 40.5 | GO:0034688 | integrin alphaM-beta2 complex(GO:0034688) |
| 0.8 | 39.2 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 38.4 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 34.7 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
| 0.3 | 30.1 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.1 | 26.9 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.2 | 25.2 | GO:0043204 | perikaryon(GO:0043204) |
| 0.2 | 25.0 | GO:0034705 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 0.3 | 23.4 | GO:0035580 | specific granule lumen(GO:0035580) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 83.3 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.3 | 68.8 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 1.1 | 57.5 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 4.0 | 40.5 | GO:0001851 | complement component C3b binding(GO:0001851) |
| 0.1 | 34.4 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 2.2 | 31.2 | GO:0055056 | D-glucose transmembrane transporter activity(GO:0055056) |
| 0.4 | 25.4 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 8.2 | 24.6 | GO:0004676 | 3-phosphoinositide-dependent protein kinase activity(GO:0004676) |
| 1.3 | 23.2 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 0.4 | 22.9 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 59.8 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 1.4 | 57.6 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.5 | 44.1 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.2 | 42.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 29.7 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 0.5 | 28.4 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.3 | 27.2 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.2 | 26.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.4 | 22.7 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.2 | 21.8 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 137.5 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.8 | 61.9 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.9 | 56.2 | REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING | Genes involved in Integrin alphaIIb beta3 signaling |
| 0.4 | 31.8 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.5 | 29.5 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 1.2 | 24.8 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.2 | 24.7 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.9 | 19.8 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.4 | 19.4 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.9 | 17.2 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |