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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for TBX15_MGA
Z-value: 0.62
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Transcription factors associated with TBX15_MGA
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MGA | hg19_v2_chr15_+_41952591_41952672 | -0.02 | 8.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TBX15_MGA
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.6 | 47.1 | GO:0035826 | rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680) |
| 3.6 | 43.5 | GO:0035437 | maintenance of protein localization in endoplasmic reticulum(GO:0035437) |
| 0.1 | 33.1 | GO:0043687 | post-translational protein modification(GO:0043687) |
| 8.2 | 32.7 | GO:0006780 | uroporphyrinogen III biosynthetic process(GO:0006780) uroporphyrinogen III metabolic process(GO:0046502) |
| 1.8 | 31.8 | GO:0000920 | cell separation after cytokinesis(GO:0000920) |
| 5.2 | 31.2 | GO:1902766 | skeletal muscle satellite cell migration(GO:1902766) |
| 2.6 | 26.1 | GO:0070973 | protein localization to endoplasmic reticulum exit site(GO:0070973) |
| 0.4 | 25.8 | GO:0007566 | embryo implantation(GO:0007566) |
| 1.1 | 25.4 | GO:0034315 | regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315) |
| 5.0 | 24.9 | GO:1903588 | negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 68.7 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 4.1 | 49.8 | GO:0097487 | multivesicular body, internal vesicle(GO:0097487) |
| 0.0 | 43.8 | GO:0005794 | Golgi apparatus(GO:0005794) |
| 0.9 | 31.2 | GO:0032420 | stereocilium(GO:0032420) |
| 0.8 | 30.8 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 1.3 | 25.6 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 1.6 | 23.6 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.1 | 23.4 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.4 | 23.2 | GO:0005871 | kinesin complex(GO:0005871) |
| 1.4 | 19.8 | GO:0030663 | COPI-coated vesicle membrane(GO:0030663) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 46.5 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.2 | 46.2 | GO:0008201 | heparin binding(GO:0008201) |
| 8.8 | 35.2 | GO:0005046 | KDEL sequence binding(GO:0005046) |
| 10.9 | 32.7 | GO:0004775 | succinate-CoA ligase (ADP-forming) activity(GO:0004775) |
| 0.2 | 30.7 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 0.2 | 28.8 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.6 | 26.5 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.3 | 23.2 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 1.4 | 20.2 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.7 | 19.8 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 48.8 | PID AURORA B PATHWAY | Aurora B signaling |
| 1.2 | 41.5 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 1.3 | 32.7 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.1 | 32.6 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.3 | 31.1 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.2 | 24.9 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.6 | 24.3 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.3 | 21.2 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.4 | 20.2 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.3 | 17.8 | PID PLK1 PATHWAY | PLK1 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 70.1 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.9 | 38.3 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 1.4 | 32.7 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.7 | 28.4 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.3 | 27.2 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 1.9 | 26.2 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.9 | 23.2 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.7 | 18.4 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 1.0 | 18.0 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 2.2 | 17.4 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |