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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for TBX20

Z-value: 0.40

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Transcription factors associated with TBX20

Gene Symbol Gene ID Gene Info
TBX20
ENSG00000164532.10 T-box transcription factor 20

Activity profile of TBX20 motif

Sorted Z-values of TBX20 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_+_57662419 45.97 ENST00000388812.4
ENST00000538815.1
ENST00000456916.1
ENST00000567154.1
ENST00000388813.5
ENST00000562558.1
ENST00000566271.2
GPR56
G protein-coupled receptor 56
chr6_-_2842087 11.62 ENST00000537185.1
SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr6_-_2842219 8.15 ENST00000380739.5
SERPINB1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr17_-_3599327 8.10 ENST00000551178.1
ENST00000552276.1
ENST00000547178.1
P2RX5
purinergic receptor P2X, ligand-gated ion channel, 5
chr3_-_131221790 7.54 ENST00000512877.1
ENST00000264995.3
ENST00000511168.1
ENST00000425847.2
MRPL3
mitochondrial ribosomal protein L3
chr17_-_3599492 7.44 ENST00000435558.1
ENST00000345901.3
P2RX5
purinergic receptor P2X, ligand-gated ion channel, 5
chrX_-_100872911 6.18 ENST00000361910.4
ENST00000539247.1
ENST00000538627.1
ARMCX6
armadillo repeat containing, X-linked 6
chr7_-_139763521 6.15 ENST00000263549.3
PARP12
poly (ADP-ribose) polymerase family, member 12
chr17_-_3599696 5.99 ENST00000225328.5
P2RX5
purinergic receptor P2X, ligand-gated ion channel, 5
chr1_+_43824669 4.82 ENST00000372462.1
CDC20
cell division cycle 20
chr2_-_219134343 4.64 ENST00000447885.1
ENST00000420660.1
AAMP
angio-associated, migratory cell protein
chr19_-_4540486 4.60 ENST00000306390.6
LRG1
leucine-rich alpha-2-glycoprotein 1
chr5_+_135394840 4.14 ENST00000503087.1
TGFBI
transforming growth factor, beta-induced, 68kDa
chr6_-_90062543 3.97 ENST00000435041.2
UBE2J1
ubiquitin-conjugating enzyme E2, J1
chr17_-_7080227 3.95 ENST00000574330.1
ASGR1
asialoglycoprotein receptor 1
chr2_-_219134822 3.90 ENST00000444053.1
ENST00000248450.4
AAMP
angio-associated, migratory cell protein
chr2_+_207630081 3.82 ENST00000236980.6
ENST00000418289.1
ENST00000402774.3
ENST00000403094.3
FASTKD2
FAST kinase domains 2
chr1_-_11118896 3.69 ENST00000465788.1
SRM
spermidine synthase
chr11_-_14358620 3.69 ENST00000531421.1
RRAS2
related RAS viral (r-ras) oncogene homolog 2
chr2_+_64068074 3.43 ENST00000394417.2
ENST00000484142.1
ENST00000482668.1
ENST00000467648.2
UGP2
UDP-glucose pyrophosphorylase 2
chr3_+_142315225 3.39 ENST00000457734.2
ENST00000483373.1
ENST00000475296.1
ENST00000495744.1
ENST00000476044.1
ENST00000461644.1
PLS1
plastin 1
chr12_-_56123444 2.81 ENST00000546457.1
ENST00000549117.1
CD63
CD63 molecule
chr16_+_31044812 2.80 ENST00000313843.3
STX4
syntaxin 4
chr1_-_154909329 2.24 ENST00000368467.3
PMVK
phosphomevalonate kinase
chr15_-_22448819 2.07 ENST00000604066.1
IGHV1OR15-1
immunoglobulin heavy variable 1/OR15-1 (non-functional)
chr10_+_114135004 2.03 ENST00000393081.1
ACSL5
acyl-CoA synthetase long-chain family member 5
chr14_-_106453155 1.96 ENST00000390594.2
IGHV1-2
immunoglobulin heavy variable 1-2
chr1_-_17380630 1.89 ENST00000375499.3
SDHB
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
chr1_-_158300747 1.68 ENST00000451207.1
CD1B
CD1b molecule
chr2_+_61108650 1.65 ENST00000295025.8
REL
v-rel avian reticuloendotheliosis viral oncogene homolog
chr1_+_87797351 1.64 ENST00000370542.1
LMO4
LIM domain only 4
chr12_+_15475331 1.58 ENST00000281171.4
PTPRO
protein tyrosine phosphatase, receptor type, O
chr8_+_27182862 1.28 ENST00000521164.1
ENST00000346049.5
PTK2B
protein tyrosine kinase 2 beta
chr8_+_27183033 1.21 ENST00000420218.2
PTK2B
protein tyrosine kinase 2 beta
chr12_+_15475462 1.16 ENST00000543886.1
ENST00000348962.2
PTPRO
protein tyrosine phosphatase, receptor type, O
chr5_+_133861339 1.05 ENST00000282605.4
ENST00000361895.2
ENST00000402835.1
PHF15
jade family PHD finger 2
chr4_-_26492076 1.01 ENST00000295589.3
CCKAR
cholecystokinin A receptor
chr10_+_114135952 0.99 ENST00000356116.1
ENST00000433418.1
ENST00000354273.4
ACSL5
acyl-CoA synthetase long-chain family member 5
chr12_-_121477039 0.90 ENST00000257570.5
OASL
2'-5'-oligoadenylate synthetase-like
chr22_+_38219389 0.88 ENST00000249041.2
GALR3
galanin receptor 3
chr1_+_147013182 0.86 ENST00000234739.3
BCL9
B-cell CLL/lymphoma 9
chr12_-_121476750 0.81 ENST00000543677.1
OASL
2'-5'-oligoadenylate synthetase-like
chr12_-_121476959 0.80 ENST00000339275.5
OASL
2'-5'-oligoadenylate synthetase-like
chr2_+_61108771 0.73 ENST00000394479.3
REL
v-rel avian reticuloendotheliosis viral oncogene homolog
chr14_+_77228532 0.67 ENST00000167106.4
ENST00000554237.1
VASH1
vasohibin 1
chr15_-_38519066 0.61 ENST00000561320.1
ENST00000561161.1
RP11-346D14.1
RP11-346D14.1
chrX_+_78200913 0.43 ENST00000171757.2
P2RY10
purinergic receptor P2Y, G-protein coupled, 10
chrX_+_78200829 0.39 ENST00000544091.1
P2RY10
purinergic receptor P2Y, G-protein coupled, 10
chr15_-_74504560 0.37 ENST00000449139.2
STRA6
stimulated by retinoic acid 6
chr15_-_74504597 0.29 ENST00000416286.3
STRA6
stimulated by retinoic acid 6
chr1_+_162760513 0.21 ENST00000367915.1
ENST00000367917.3
ENST00000254521.3
ENST00000367913.1
HSD17B7
hydroxysteroid (17-beta) dehydrogenase 7
chr22_-_46283597 0.11 ENST00000451118.1
WI2-85898F10.1
WI2-85898F10.1

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX20

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.8 GO:1902568 positive regulation of eosinophil degranulation(GO:0043311) positive regulation of eosinophil activation(GO:1902568)
0.9 2.7 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.8 3.8 GO:1902775 mitochondrial ribosome assembly(GO:0061668) mitochondrial large ribosomal subunit assembly(GO:1902775)
0.7 2.2 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.7 22.4 GO:0035590 purinergic nucleotide receptor signaling pathway(GO:0035590)
0.7 3.4 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.7 3.4 GO:1902896 terminal web assembly(GO:1902896)
0.6 2.5 GO:2000538 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.6 4.0 GO:0070862 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.5 3.7 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.3 4.8 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.2 0.7 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
0.2 2.8 GO:2000680 rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680)
0.1 1.7 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.1 2.4 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.1 4.6 GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.1 1.6 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.1 1.9 GO:0006105 succinate metabolic process(GO:0006105)
0.1 0.7 GO:0061143 alveolar primary septum development(GO:0061143)
0.1 3.0 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.1 8.5 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.1 7.5 GO:0070125 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.1 4.0 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.1 19.8 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 2.5 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 2.1 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 3.2 GO:0002062 chondrocyte differentiation(GO:0002062)
0.0 0.9 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.0 0.9 GO:0043403 skeletal muscle tissue regeneration(GO:0043403)
0.0 3.7 GO:0001649 osteoblast differentiation(GO:0001649)
0.0 0.2 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 2.0 GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 21.5 GO:0044453 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.6 3.4 GO:1990357 terminal web(GO:1990357)
0.5 1.9 GO:0045283 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.3 2.8 GO:0000322 storage vacuole(GO:0000322)
0.3 8.5 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.2 2.8 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.2 2.4 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.2 7.5 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.2 2.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.2 4.8 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 3.8 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 4.6 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 19.8 GO:0034774 secretory granule lumen(GO:0034774)
0.0 2.1 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 4.1 GO:0005604 basement membrane(GO:0005604)
0.0 2.7 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 3.0 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.9 GO:0005801 cis-Golgi network(GO:0005801)
0.0 2.2 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 21.5 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
1.2 3.7 GO:0004766 spermidine synthase activity(GO:0004766)
1.1 3.4 GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748)
1.0 1.0 GO:0004951 cholecystokinin receptor activity(GO:0004951)
0.8 2.5 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.8 4.8 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.7 2.8 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.6 1.9 GO:0051538 succinate dehydrogenase (ubiquinone) activity(GO:0008177) 3 iron, 4 sulfur cluster binding(GO:0051538)
0.5 4.0 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.3 2.5 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.2 0.9 GO:0004966 galanin receptor activity(GO:0004966)
0.2 6.2 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.2 19.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 1.7 GO:0030884 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.2 3.0 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.1 2.7 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1 4.0 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 0.2 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.1 4.6 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.1 8.5 GO:0051082 unfolded protein binding(GO:0051082)
0.1 4.1 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 3.8 GO:0019843 rRNA binding(GO:0019843)
0.0 2.4 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.8 GO:0001614 purinergic nucleotide receptor activity(GO:0001614) nucleotide receptor activity(GO:0016502)
0.0 7.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 2.1 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 2.2 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.0 3.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.7 GO:0051183 vitamin transporter activity(GO:0051183)
0.0 1.6 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 2.0 GO:0003823 antigen binding(GO:0003823)
0.0 3.7 GO:0003924 GTPase activity(GO:0003924)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.1 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 2.8 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 2.5 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1 18.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 4.8 PID PLK1 PATHWAY PLK1 signaling events
0.1 2.4 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 2.7 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.6 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 4.6 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.8 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1 3.7 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.1 3.0 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 3.4 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 2.8 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 2.5 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 1.9 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 2.5 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 4.1 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.8 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 2.5 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 2.4 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
0.0 4.0 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 2.8 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+