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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for TBX21_TBR1
Z-value: 0.98
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Transcription factors associated with TBX21_TBR1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TBX21 | hg19_v2_chr17_+_45810594_45810610 | 0.56 | 4.9e-19 | Click! |
| TBR1 | hg19_v2_chr2_+_162272605_162272753 | 0.47 | 4.1e-13 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TBX21_TBR1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.7 | 29.9 | GO:2000766 | negative regulation of cytoplasmic translation(GO:2000766) |
| 3.4 | 27.5 | GO:0001661 | conditioned taste aversion(GO:0001661) |
| 6.8 | 27.1 | GO:0002904 | positive regulation of B cell apoptotic process(GO:0002904) |
| 0.7 | 25.1 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 0.3 | 21.4 | GO:0007602 | phototransduction(GO:0007602) |
| 1.1 | 20.6 | GO:0010457 | centriole-centriole cohesion(GO:0010457) |
| 0.1 | 19.7 | GO:0046718 | viral entry into host cell(GO:0046718) |
| 2.6 | 18.3 | GO:1903818 | positive regulation of voltage-gated potassium channel activity(GO:1903818) |
| 0.9 | 17.6 | GO:0030277 | maintenance of gastrointestinal epithelium(GO:0030277) |
| 5.8 | 17.5 | GO:0032474 | otolith morphogenesis(GO:0032474) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 30.9 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.2 | 25.5 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 3.2 | 25.4 | GO:0035976 | AP1 complex(GO:0035976) |
| 1.2 | 22.8 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.3 | 18.2 | GO:0030286 | dynein complex(GO:0030286) |
| 0.1 | 17.7 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 16.6 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.2 | 16.5 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 16.5 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 12.7 | GO:0005814 | centriole(GO:0005814) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 39.7 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.7 | 36.8 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 1.9 | 29.9 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 6.8 | 27.3 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
| 0.6 | 26.7 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.2 | 24.0 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.2 | 21.4 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.9 | 18.2 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 5.9 | 17.8 | GO:0050528 | acyloxyacyl hydrolase activity(GO:0050528) |
| 0.1 | 16.0 | GO:0003823 | antigen binding(GO:0003823) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 32.5 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.4 | 28.9 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.2 | 28.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 28.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.4 | 27.6 | PID FGF PATHWAY | FGF signaling pathway |
| 1.2 | 25.4 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.4 | 25.1 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.2 | 19.0 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.5 | 16.2 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.6 | 14.1 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 44.2 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 1.3 | 26.5 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.4 | 20.0 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.5 | 19.2 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.2 | 18.5 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.1 | 18.1 | REACTOME SIGNALING BY EGFR IN CANCER | Genes involved in Signaling by EGFR in Cancer |
| 0.2 | 16.0 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.8 | 15.6 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.6 | 15.3 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.2 | 14.6 | REACTOME CIRCADIAN CLOCK | Genes involved in Circadian Clock |