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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for TBX4

Z-value: 1.03

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Transcription factors associated with TBX4

Gene Symbol Gene ID Gene Info
TBX4
ENSG00000121075.5 T-box transcription factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TBX4hg19_v2_chr17_+_59529743_595297980.372.1e-08Click!

Activity profile of TBX4 motif

Sorted Z-values of TBX4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_167453493 25.98 ENST00000295777.5
ENST00000472747.2
SERPINI1
serpin peptidase inhibitor, clade I (neuroserpin), member 1
chr11_-_5248294 21.09 ENST00000335295.4
HBB
hemoglobin, beta
chr11_+_73358594 20.20 ENST00000227214.6
ENST00000398494.4
ENST00000543085.1
PLEKHB1
pleckstrin homology domain containing, family B (evectins) member 1
chr2_-_175869936 17.35 ENST00000409900.3
CHN1
chimerin 1
chr2_-_175870085 16.35 ENST00000409156.3
CHN1
chimerin 1
chr14_+_75746781 13.57 ENST00000555347.1
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr14_+_75745477 13.06 ENST00000303562.4
ENST00000554617.1
ENST00000554212.1
ENST00000535987.1
ENST00000555242.1
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr20_+_44657845 11.11 ENST00000243964.3
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr13_-_36429763 10.41 ENST00000379893.1
DCLK1
doublecortin-like kinase 1
chr5_+_74807886 9.76 ENST00000514296.1
POLK
polymerase (DNA directed) kappa
chr6_+_39760129 8.19 ENST00000274867.4
DAAM2
dishevelled associated activator of morphogenesis 2
chr7_+_97361218 7.56 ENST00000319273.5
TAC1
tachykinin, precursor 1
chr3_-_66551397 7.40 ENST00000383703.3
LRIG1
leucine-rich repeats and immunoglobulin-like domains 1
chr2_-_157189180 7.01 ENST00000539077.1
ENST00000424077.1
ENST00000426264.1
ENST00000339562.4
ENST00000421709.1
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr7_+_97361388 6.55 ENST00000350485.4
ENST00000346867.4
TAC1
tachykinin, precursor 1
chr1_-_230561475 6.35 ENST00000391860.1
PGBD5
piggyBac transposable element derived 5
chr3_-_66551351 6.04 ENST00000273261.3
LRIG1
leucine-rich repeats and immunoglobulin-like domains 1
chr11_-_33913708 5.92 ENST00000257818.2
LMO2
LIM domain only 2 (rhombotin-like 1)
chr1_+_151584544 5.75 ENST00000458013.2
ENST00000368843.3
SNX27
sorting nexin family member 27
chr18_-_53068911 5.22 ENST00000537856.3
TCF4
transcription factor 4
chr11_-_33891362 5.16 ENST00000395833.3
LMO2
LIM domain only 2 (rhombotin-like 1)
chr4_-_186732048 5.07 ENST00000448662.2
ENST00000439049.1
ENST00000420158.1
ENST00000431808.1
ENST00000319471.9
SORBS2
sorbin and SH3 domain containing 2
chr11_-_133826852 4.78 ENST00000533871.2
ENST00000321016.8
IGSF9B
immunoglobulin superfamily, member 9B
chr2_+_103089756 4.76 ENST00000295269.4
SLC9A4
solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4
chr10_-_99531709 4.70 ENST00000266066.3
SFRP5
secreted frizzled-related protein 5
chr1_+_16062820 4.65 ENST00000294454.5
SLC25A34
solute carrier family 25, member 34
chr16_+_2588012 4.60 ENST00000354836.5
ENST00000389224.3
PDPK1
3-phosphoinositide dependent protein kinase-1
chr17_-_8066843 4.56 ENST00000404970.3
VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr9_-_75567962 4.17 ENST00000297785.3
ENST00000376939.1
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chrX_+_56259316 4.11 ENST00000468660.1
KLF8
Kruppel-like factor 8
chr11_-_129062093 4.05 ENST00000310343.9
ARHGAP32
Rho GTPase activating protein 32
chr17_-_61988556 3.87 ENST00000309894.5
ENST00000438387.2
ENST00000346606.6
ENST00000561003.1
ENST00000450719.3
ENST00000259003.10
CSHL1
chorionic somatomammotropin hormone-like 1
chr10_-_75226166 3.77 ENST00000544628.1
PPP3CB
protein phosphatase 3, catalytic subunit, beta isozyme
chr16_+_2587998 3.76 ENST00000441549.3
ENST00000268673.7
PDPK1
3-phosphoinositide dependent protein kinase-1
chr6_-_13487784 3.76 ENST00000379287.3
GFOD1
glucose-fructose oxidoreductase domain containing 1
chr17_-_26220366 3.62 ENST00000460380.2
ENST00000508862.1
ENST00000379102.3
ENST00000582441.1
LYRM9
RP1-66C13.4
LYR motif containing 9
Uncharacterized protein
chr3_-_49459865 3.40 ENST00000427987.1
AMT
aminomethyltransferase
chr4_-_102268484 3.31 ENST00000394853.4
PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr13_+_115047097 3.30 ENST00000351487.5
UPF3A
UPF3 regulator of nonsense transcripts homolog A (yeast)
chr16_+_2587965 3.28 ENST00000342085.4
ENST00000566659.1
PDPK1
3-phosphoinositide dependent protein kinase-1
chr17_-_61996160 3.28 ENST00000458650.2
ENST00000351388.4
ENST00000323322.5
GH1
growth hormone 1
chr7_-_71801980 3.25 ENST00000329008.5
CALN1
calneuron 1
chr15_-_58357932 3.15 ENST00000347587.3
ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr1_+_95582881 3.14 ENST00000370203.4
ENST00000456991.1
TMEM56
transmembrane protein 56
chr2_+_61108771 3.09 ENST00000394479.3
REL
v-rel avian reticuloendotheliosis viral oncogene homolog
chr1_+_114472481 3.02 ENST00000369555.2
HIPK1
homeodomain interacting protein kinase 1
chr20_+_44098346 3.02 ENST00000372676.3
WFDC2
WAP four-disulfide core domain 2
chr17_-_61996192 2.93 ENST00000392824.4
CSHL1
chorionic somatomammotropin hormone-like 1
chr2_-_25475120 2.89 ENST00000380746.4
ENST00000402667.1
DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr5_+_113697983 2.85 ENST00000264773.3
KCNN2
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr3_-_49459878 2.85 ENST00000546031.1
ENST00000458307.2
ENST00000430521.1
AMT
aminomethyltransferase
chr15_+_92937144 2.80 ENST00000539113.1
ENST00000555434.1
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chrX_+_69642881 2.65 ENST00000453994.2
ENST00000536730.1
ENST00000538649.1
ENST00000374382.3
GDPD2
glycerophosphodiester phosphodiesterase domain containing 2
chr14_+_21467414 2.54 ENST00000554422.1
ENST00000298681.4
SLC39A2
solute carrier family 39 (zinc transporter), member 2
chr15_-_83474806 2.51 ENST00000541889.1
ENST00000334574.8
ENST00000561368.1
FSD2
fibronectin type III and SPRY domain containing 2
chr1_+_27114589 2.48 ENST00000431541.1
ENST00000449950.2
ENST00000374145.1
PIGV
phosphatidylinositol glycan anchor biosynthesis, class V
chr9_+_140032842 2.39 ENST00000371561.3
ENST00000315048.3
GRIN1
glutamate receptor, ionotropic, N-methyl D-aspartate 1
chr5_-_34043310 2.34 ENST00000231338.7
C1QTNF3
C1q and tumor necrosis factor related protein 3
chr2_+_61108650 2.29 ENST00000295025.8
REL
v-rel avian reticuloendotheliosis viral oncogene homolog
chr12_-_90024360 2.29 ENST00000393164.2
ATP2B1
ATPase, Ca++ transporting, plasma membrane 1
chr5_+_54320078 2.28 ENST00000231009.2
GZMK
granzyme K (granzyme 3; tryptase II)
chr14_+_78870030 2.27 ENST00000553631.1
ENST00000554719.1
NRXN3
neurexin 3
chr17_-_61973929 2.20 ENST00000329882.8
ENST00000453363.3
ENST00000316193.8
CSH1
chorionic somatomammotropin hormone 1 (placental lactogen)
chr6_+_79577189 2.20 ENST00000369940.2
IRAK1BP1
interleukin-1 receptor-associated kinase 1 binding protein 1
chr6_+_32132360 2.17 ENST00000333845.6
ENST00000395512.1
ENST00000432129.1
EGFL8
EGF-like-domain, multiple 8
chr1_-_11907829 2.16 ENST00000376480.3
NPPA
natriuretic peptide A
chr5_-_60240858 2.11 ENST00000426742.2
ENST00000265038.5
ENST00000543101.1
ENST00000439176.1
ERCC8
excision repair cross-complementing rodent repair deficiency, complementation group 8
chr17_-_61996136 2.09 ENST00000342364.4
GH1
growth hormone 1
chr16_-_67965756 2.06 ENST00000571044.1
ENST00000571605.1
CTRL
chymotrypsin-like
chr20_+_44098385 2.05 ENST00000217425.5
ENST00000339946.3
WFDC2
WAP four-disulfide core domain 2
chr15_+_92937058 2.05 ENST00000268164.3
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr10_+_94833642 1.99 ENST00000224356.4
ENST00000394139.1
CYP26A1
cytochrome P450, family 26, subfamily A, polypeptide 1
chr8_+_123793633 1.88 ENST00000314393.4
ZHX2
zinc fingers and homeoboxes 2
chr5_-_114515734 1.77 ENST00000514154.1
ENST00000282369.3
TRIM36
tripartite motif containing 36
chr7_+_143013198 1.75 ENST00000343257.2
CLCN1
chloride channel, voltage-sensitive 1
chr2_-_160473114 1.70 ENST00000392783.2
BAZ2B
bromodomain adjacent to zinc finger domain, 2B
chr12_-_26278030 1.69 ENST00000242728.4
BHLHE41
basic helix-loop-helix family, member e41
chr11_-_128737259 1.67 ENST00000440599.2
ENST00000392666.1
ENST00000324036.3
KCNJ1
potassium inwardly-rectifying channel, subfamily J, member 1
chr22_-_42342733 1.65 ENST00000402420.1
CENPM
centromere protein M
chrX_+_16804544 1.56 ENST00000380122.5
ENST00000398155.4
TXLNG
taxilin gamma
chr1_+_27114418 1.55 ENST00000078527.4
PIGV
phosphatidylinositol glycan anchor biosynthesis, class V
chr1_+_114472222 1.51 ENST00000369558.1
ENST00000369561.4
HIPK1
homeodomain interacting protein kinase 1
chr1_-_1009683 1.50 ENST00000453464.2
RNF223
ring finger protein 223
chr1_+_172628154 1.47 ENST00000340030.3
ENST00000367721.2
FASLG
Fas ligand (TNF superfamily, member 6)
chr1_-_111148241 1.46 ENST00000440270.1
KCNA2
potassium voltage-gated channel, shaker-related subfamily, member 2
chr2_+_176972000 1.44 ENST00000249504.5
HOXD11
homeobox D11
chr10_+_135050908 1.41 ENST00000325980.9
VENTX
VENT homeobox
chr12_+_57853918 1.41 ENST00000532291.1
ENST00000543426.1
ENST00000228682.2
ENST00000546141.1
GLI1
GLI family zinc finger 1
chr4_-_102268628 1.38 ENST00000323055.6
ENST00000512215.1
ENST00000394854.3
PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr22_-_41215328 1.36 ENST00000434185.1
ENST00000435456.2
SLC25A17
solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17
chr1_+_114471809 1.32 ENST00000426820.2
HIPK1
homeodomain interacting protein kinase 1
chr9_-_117692697 1.28 ENST00000223795.2
TNFSF8
tumor necrosis factor (ligand) superfamily, member 8
chr9_+_71986182 1.23 ENST00000303068.7
FAM189A2
family with sequence similarity 189, member A2
chr1_+_154377669 1.15 ENST00000368485.3
ENST00000344086.4
IL6R
interleukin 6 receptor
chr8_+_103563792 1.11 ENST00000285402.3
ODF1
outer dense fiber of sperm tails 1
chr11_-_128737163 1.11 ENST00000324003.3
ENST00000392665.2
KCNJ1
potassium inwardly-rectifying channel, subfamily J, member 1
chr3_-_52443799 1.08 ENST00000470173.1
ENST00000296288.5
BAP1
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
chr4_-_186456766 1.03 ENST00000284771.6
PDLIM3
PDZ and LIM domain 3
chr4_+_160188889 1.01 ENST00000264431.4
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr1_-_226076843 1.01 ENST00000272134.5
LEFTY1
left-right determination factor 1
chr2_-_160472952 0.99 ENST00000541068.2
ENST00000355831.2
ENST00000343439.5
ENST00000392782.1
BAZ2B
bromodomain adjacent to zinc finger domain, 2B
chr2_+_11696464 0.97 ENST00000234142.5
GREB1
growth regulation by estrogen in breast cancer 1
chrX_-_11445856 0.95 ENST00000380736.1
ARHGAP6
Rho GTPase activating protein 6
chr1_+_158325684 0.93 ENST00000368162.2
CD1E
CD1e molecule
chr3_-_133748913 0.91 ENST00000310926.4
SLCO2A1
solute carrier organic anion transporter family, member 2A1
chr4_-_186456652 0.78 ENST00000284767.5
ENST00000284770.5
PDLIM3
PDZ and LIM domain 3
chr11_+_111749942 0.77 ENST00000260276.3
C11orf1
chromosome 11 open reading frame 1
chr9_-_74980113 0.77 ENST00000376962.5
ENST00000376960.4
ENST00000237937.3
ZFAND5
zinc finger, AN1-type domain 5
chr3_+_134514093 0.76 ENST00000398015.3
EPHB1
EPH receptor B1
chr13_-_52027134 0.76 ENST00000311234.4
ENST00000425000.1
ENST00000463928.1
ENST00000442263.3
ENST00000398119.2
INTS6
integrator complex subunit 6
chr7_+_27282319 0.73 ENST00000222761.3
EVX1
even-skipped homeobox 1
chr11_-_6502580 0.72 ENST00000423813.2
ENST00000396777.3
ARFIP2
ADP-ribosylation factor interacting protein 2
chr11_+_1940786 0.67 ENST00000278317.6
ENST00000381561.4
ENST00000381548.3
ENST00000360603.3
ENST00000381549.3
TNNT3
troponin T type 3 (skeletal, fast)
chr1_+_145507587 0.65 ENST00000330165.8
ENST00000369307.3
RBM8A
RNA binding motif protein 8A
chr20_+_11898507 0.65 ENST00000378226.2
BTBD3
BTB (POZ) domain containing 3
chr5_-_54281407 0.60 ENST00000381403.4
ESM1
endothelial cell-specific molecule 1
chr19_-_46526304 0.58 ENST00000008938.4
PGLYRP1
peptidoglycan recognition protein 1
chr6_-_31080336 0.58 ENST00000259870.3
C6orf15
chromosome 6 open reading frame 15
chr3_-_197024394 0.56 ENST00000434148.1
ENST00000412364.2
ENST00000436682.1
ENST00000456699.2
ENST00000392380.2
DLG1
discs, large homolog 1 (Drosophila)
chr2_-_85895295 0.55 ENST00000428225.1
ENST00000519937.2
SFTPB
surfactant protein B
chr12_-_7848364 0.53 ENST00000329913.3
GDF3
growth differentiation factor 3
chrX_+_70443050 0.48 ENST00000361726.6
GJB1
gap junction protein, beta 1, 32kDa
chr1_+_114471972 0.47 ENST00000369559.4
ENST00000369554.2
HIPK1
homeodomain interacting protein kinase 1
chr4_+_88571429 0.41 ENST00000339673.6
ENST00000282479.7
DMP1
dentin matrix acidic phosphoprotein 1
chr8_+_73449625 0.40 ENST00000523207.1
KCNB2
potassium voltage-gated channel, Shab-related subfamily, member 2
chr9_+_136399929 0.38 ENST00000393060.1
ADAMTSL2
ADAMTS-like 2
chr3_+_120626919 0.35 ENST00000273666.6
ENST00000471454.1
ENST00000472879.1
ENST00000497029.1
ENST00000492541.1
STXBP5L
syntaxin binding protein 5-like
chr1_+_26737292 0.33 ENST00000254231.4
LIN28A
lin-28 homolog A (C. elegans)
chr13_-_103053946 0.31 ENST00000376131.4
FGF14
fibroblast growth factor 14
chr2_+_62932779 0.30 ENST00000427809.1
ENST00000405482.1
ENST00000431489.1
EHBP1
EH domain binding protein 1
chr6_+_167536230 0.23 ENST00000341935.5
ENST00000349984.4
CCR6
chemokine (C-C motif) receptor 6
chr2_+_62933001 0.21 ENST00000263991.5
ENST00000354487.3
EHBP1
EH domain binding protein 1
chr5_-_74807418 0.12 ENST00000405807.4
ENST00000261415.7
COL4A3BP
collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
chr7_-_150675372 0.12 ENST00000262186.5
KCNH2
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr2_+_37458776 0.01 ENST00000002125.4
ENST00000336237.6
ENST00000431821.1
NDUFAF7
NADH dehydrogenase (ubiquinone) complex I, assembly factor 7

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
5.3 21.1 GO:0030185 nitric oxide transport(GO:0030185)
4.7 14.1 GO:2000854 positive regulation of corticosterone secretion(GO:2000854)
4.5 13.4 GO:0032474 otolith morphogenesis(GO:0032474)
3.6 29.0 GO:0001661 conditioned taste aversion(GO:0001661)
3.1 12.6 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
2.3 7.0 GO:0021538 epithalamus development(GO:0021538) habenula development(GO:0021986)
1.6 4.7 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
1.4 4.2 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
1.2 6.2 GO:0019464 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
1.2 4.7 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
1.2 11.6 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
1.0 1.0 GO:0048022 negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)
0.9 31.3 GO:0008045 motor neuron axon guidance(GO:0008045)
0.7 6.3 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.7 5.4 GO:0010536 positive regulation of activation of Janus kinase activity(GO:0010536)
0.7 2.0 GO:0016103 diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
0.7 4.6 GO:1903593 regulation of histamine secretion by mast cell(GO:1903593)
0.6 4.9 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.5 2.2 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.5 2.9 GO:0090116 C-5 methylation of cytosine(GO:0090116)
0.5 5.8 GO:0001767 establishment of lymphocyte polarity(GO:0001767)
0.5 3.8 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.5 11.2 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.5 2.3 GO:1990034 calcium ion export from cell(GO:1990034)
0.4 11.1 GO:0042789 mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.4 3.1 GO:0035799 ureter maturation(GO:0035799)
0.4 1.1 GO:0002384 hepatic immune response(GO:0002384)
0.4 1.5 GO:0021633 optic nerve structural organization(GO:0021633)
0.4 1.1 GO:0035522 monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.4 2.9 GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914)
0.4 1.4 GO:0021938 ventral midline development(GO:0007418) smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938)
0.3 9.8 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.3 5.4 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.3 4.8 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.3 2.3 GO:0035356 cellular triglyceride homeostasis(GO:0035356)
0.3 20.2 GO:0007602 phototransduction(GO:0007602)
0.3 4.8 GO:0098828 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.2 0.7 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.2 26.0 GO:0007422 peripheral nervous system development(GO:0007422)
0.2 1.8 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.2 2.6 GO:0090527 actin filament reorganization(GO:0090527)
0.2 4.0 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.2 0.6 GO:0051710 regulation of cytolysis in other organism(GO:0051710)
0.2 0.5 GO:0048859 formation of anatomical boundary(GO:0048859)
0.1 4.2 GO:0061049 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 2.3 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.1 2.5 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.1 2.2 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.1 1.7 GO:0010944 negative regulation of transcription by competitive promoter binding(GO:0010944)
0.1 0.6 GO:1903760 regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903760)
0.1 8.7 GO:0007368 determination of left/right symmetry(GO:0007368)
0.1 1.3 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.1 0.9 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.1 2.8 GO:0010107 potassium ion import(GO:0010107)
0.1 0.2 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.1 0.4 GO:0070170 regulation of tooth mineralization(GO:0070170)
0.1 1.8 GO:0007507 heart development(GO:0007507)
0.1 1.7 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.1 0.6 GO:0015868 purine nucleotide transport(GO:0015865) purine ribonucleotide transport(GO:0015868)
0.1 0.9 GO:0015732 prostaglandin transport(GO:0015732)
0.0 0.4 GO:0060481 lobar bronchus epithelium development(GO:0060481)
0.0 0.1 GO:0035621 ER to Golgi ceramide transport(GO:0035621)
0.0 0.1 GO:1902303 regulation of heart rate by hormone(GO:0003064) negative regulation of potassium ion export(GO:1902303)
0.0 0.3 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.0 0.9 GO:0051895 negative regulation of focal adhesion assembly(GO:0051895)
0.0 0.8 GO:0016180 snRNA processing(GO:0016180)
0.0 2.1 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 1.4 GO:0001658 branching involved in ureteric bud morphogenesis(GO:0001658)
0.0 1.6 GO:0030500 regulation of bone mineralization(GO:0030500)
0.0 4.0 GO:0051028 mRNA transport(GO:0051028)
0.0 4.7 GO:0006839 mitochondrial transport(GO:0006839)
0.0 6.2 GO:0048232 spermatogenesis(GO:0007283) male gamete generation(GO:0048232)
0.0 0.4 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.0 3.7 GO:0045666 positive regulation of neuron differentiation(GO:0045666)
0.0 1.9 GO:0045665 negative regulation of neuron differentiation(GO:0045665)
0.0 0.4 GO:0072661 protein targeting to plasma membrane(GO:0072661)
0.0 4.0 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
5.3 21.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
3.3 26.6 GO:0035976 AP1 complex(GO:0035976)
1.8 5.4 GO:0070195 growth hormone receptor complex(GO:0070195)
1.1 4.6 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.9 8.5 GO:0005955 calcineurin complex(GO:0005955)
0.8 5.8 GO:0071203 WASH complex(GO:0071203)
0.8 4.0 GO:0031501 mannosyltransferase complex(GO:0031501)
0.4 5.4 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.4 4.8 GO:0060077 inhibitory synapse(GO:0060077)
0.3 1.1 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.3 2.4 GO:0098839 postsynaptic density membrane(GO:0098839)
0.2 2.3 GO:0032591 dendritic spine membrane(GO:0032591)
0.2 35.7 GO:0043204 perikaryon(GO:0043204)
0.2 11.1 GO:0043198 dendritic shaft(GO:0043198)
0.2 2.9 GO:0001741 XY body(GO:0001741)
0.2 2.1 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.2 1.1 GO:0001520 outer dense fiber(GO:0001520)
0.1 4.0 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 0.8 GO:0032039 integrator complex(GO:0032039)
0.1 0.6 GO:0097013 phagocytic vesicle lumen(GO:0097013)
0.1 4.1 GO:0016235 aggresome(GO:0016235)
0.1 0.5 GO:0097208 alveolar lamellar body(GO:0097208)
0.1 0.1 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.1 2.2 GO:0042629 mast cell granule(GO:0042629)
0.1 0.6 GO:0043219 lateral loop(GO:0043219)
0.1 0.6 GO:0005614 interstitial matrix(GO:0005614)
0.1 9.0 GO:0030018 Z disc(GO:0030018)
0.1 13.4 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 2.2 GO:0031904 endosome lumen(GO:0031904)
0.0 3.3 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 2.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 14.0 GO:0030424 axon(GO:0030424)
0.0 1.4 GO:0097546 ciliary base(GO:0097546)
0.0 4.9 GO:0055037 recycling endosome(GO:0055037)
0.0 0.7 GO:0005861 troponin complex(GO:0005861)
0.0 5.2 GO:0032993 protein-DNA complex(GO:0032993)
0.0 0.5 GO:0005922 connexon complex(GO:0005922)
0.0 3.5 GO:0016605 PML body(GO:0016605)
0.0 2.3 GO:0005581 collagen trimer(GO:0005581)
0.0 1.8 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.8 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 1.5 GO:0005901 caveola(GO:0005901)
0.0 0.2 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 1.1 GO:0031519 PcG protein complex(GO:0031519)
0.0 5.1 GO:0016324 apical plasma membrane(GO:0016324)
0.0 1.7 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 2.6 GO:0030027 lamellipodium(GO:0030027)
0.0 0.7 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 6.3 GO:0005759 mitochondrial matrix(GO:0005759)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 11.6 GO:0004676 3-phosphoinositide-dependent protein kinase activity(GO:0004676)
3.5 21.1 GO:0030492 hemoglobin binding(GO:0030492)
1.8 5.4 GO:0005148 prolactin receptor binding(GO:0005148)
1.6 6.2 GO:0004047 aminomethyltransferase activity(GO:0004047)
1.3 5.1 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
1.0 11.1 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
1.0 4.0 GO:0004376 glycolipid mannosyltransferase activity(GO:0004376)
0.8 8.5 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.8 4.2 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.7 4.9 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.7 33.7 GO:0046875 ephrin receptor binding(GO:0046875)
0.7 39.4 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.7 2.6 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.6 2.9 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.5 2.9 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.5 4.8 GO:0015386 sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.5 2.8 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.4 16.3 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.4 5.2 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.4 1.1 GO:0004915 interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981)
0.4 7.0 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.3 9.8 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.3 3.1 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.3 2.4 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.2 24.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 5.1 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.2 5.8 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.2 4.7 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.2 1.0 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)
0.2 0.6 GO:0016019 peptidoglycan receptor activity(GO:0016019)
0.2 0.6 GO:0070052 collagen V binding(GO:0070052)
0.2 2.3 GO:0097109 neuroligin family protein binding(GO:0097109)
0.2 0.7 GO:0030899 calcium-dependent ATPase activity(GO:0030899)
0.2 0.8 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 4.6 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 2.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 5.4 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 0.9 GO:0030882 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.1 3.3 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.1 1.5 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.1 1.8 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 2.3 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 0.4 GO:0050436 microfibril binding(GO:0050436)
0.1 8.2 GO:0017048 Rho GTPase binding(GO:0017048)
0.1 0.9 GO:0015245 fatty acid transporter activity(GO:0015245)
0.1 2.8 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 2.0 GO:0001972 retinoic acid binding(GO:0001972)
0.1 0.6 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.1 GO:0015230 FAD transmembrane transporter activity(GO:0015230) coenzyme transporter activity(GO:0051185)
0.0 0.5 GO:0005243 gap junction channel activity(GO:0005243)
0.0 2.1 GO:0003678 DNA helicase activity(GO:0003678)
0.0 0.1 GO:0097001 ceramide binding(GO:0097001)
0.0 1.9 GO:0019905 syntaxin binding(GO:0019905)
0.0 0.5 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 1.5 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 1.8 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.2 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 1.4 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 3.1 GO:0005057 receptor signaling protein activity(GO:0005057)
0.0 5.0 GO:0005096 GTPase activator activity(GO:0005096)
0.0 15.7 GO:0004871 signal transducer activity(GO:0004871)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 26.6 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.5 33.7 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.4 11.6 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.2 13.4 PID ERBB4 PATHWAY ErbB4 signaling events
0.2 9.9 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.2 23.1 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.2 5.4 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.1 4.6 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 1.1 ST STAT3 PATHWAY STAT3 Pathway
0.1 4.0 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 23.0 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.1 4.1 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 5.2 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.8 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 2.6 PID AP1 PATHWAY AP-1 transcription factor network
0.0 1.6 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 2.3 PID CMYB PATHWAY C-MYB transcription factor network
0.0 1.7 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.9 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.6 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 2.9 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.0 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 26.6 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.5 4.2 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.4 11.6 REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.3 7.6 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.3 4.6 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.2 4.9 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.2 34.6 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.2 2.4 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.2 4.0 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.2 2.5 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.1 21.1 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 7.9 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 15.9 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 5.2 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 2.8 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.1 1.1 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.1 14.3 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 4.8 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.1 1.7 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 2.2 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 5.5 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 5.3 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
0.1 1.5 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.9 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 1.0 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 4.9 REACTOME SIGNALING BY EGFR IN CANCER Genes involved in Signaling by EGFR in Cancer
0.0 2.0 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.5 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 4.0 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.0 0.6 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors