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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for TBX5
Z-value: 1.45
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Transcription factors associated with TBX5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TBX5 | hg19_v2_chr12_-_114841703_114841726 | 0.47 | 1.2e-13 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TBX5
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.4 | 51.4 | GO:0001661 | conditioned taste aversion(GO:0001661) |
| 0.1 | 46.1 | GO:0051056 | regulation of small GTPase mediated signal transduction(GO:0051056) |
| 4.3 | 42.8 | GO:1990416 | cellular response to brain-derived neurotrophic factor stimulus(GO:1990416) |
| 8.9 | 35.7 | GO:0030185 | nitric oxide transport(GO:0030185) |
| 2.5 | 34.9 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
| 4.4 | 31.0 | GO:2000503 | positive regulation of natural killer cell chemotaxis(GO:2000503) |
| 1.2 | 27.6 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.7 | 25.2 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 1.2 | 23.8 | GO:0006853 | carnitine shuttle(GO:0006853) |
| 0.2 | 21.8 | GO:0007422 | peripheral nervous system development(GO:0007422) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 64.0 | GO:0043204 | perikaryon(GO:0043204) |
| 6.1 | 48.5 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.0 | 41.9 | GO:0016021 | integral component of membrane(GO:0016021) |
| 7.7 | 30.9 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.1 | 25.4 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.1 | 19.4 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 19.1 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.1 | 18.4 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.1 | 17.9 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.1 | 17.2 | GO:0005802 | trans-Golgi network(GO:0005802) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 48.5 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.1 | 45.5 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 14.3 | 42.8 | GO:0004676 | 3-phosphoinositide-dependent protein kinase activity(GO:0004676) |
| 5.1 | 30.9 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 1.5 | 27.6 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.6 | 27.4 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.2 | 27.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 4.8 | 23.8 | GO:0004095 | carnitine O-palmitoyltransferase activity(GO:0004095) |
| 3.3 | 23.4 | GO:0031726 | CCR1 chemokine receptor binding(GO:0031726) |
| 0.1 | 20.4 | GO:0003823 | antigen binding(GO:0003823) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 76.2 | SIG IL4RECEPTOR IN B LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 0.1 | 49.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 2.2 | 48.5 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.3 | 32.7 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.5 | 30.2 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.3 | 19.3 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.3 | 19.3 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 15.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.4 | 12.8 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.5 | 12.1 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 66.5 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 2.4 | 48.5 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 1.3 | 42.8 | REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA | Genes involved in G beta:gamma signalling through PI3Kgamma |
| 0.4 | 27.4 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.2 | 26.4 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.8 | 23.8 | REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 0.2 | 17.4 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.7 | 16.7 | REACTOME PLATELET SENSITIZATION BY LDL | Genes involved in Platelet sensitization by LDL |
| 0.2 | 15.9 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.2 | 15.7 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |