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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for TCF21

Z-value: 0.72

Motif logo

Transcription factors associated with TCF21

Gene Symbol Gene ID Gene Info
ENSG00000118526.6 transcription factor 21

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TCF21hg19_v2_chr6_+_134210243_134210276-0.063.8e-01Click!

Activity profile of TCF21 motif

Sorted Z-values of TCF21 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_79805146 19.62 ENST00000415593.1
prolyl 4-hydroxylase, beta polypeptide
chrX_+_48432892 18.43 ENST00000376759.3
ENST00000430348.2
RNA binding motif (RNP1, RRM) protein 3
chr5_+_68462837 18.18 ENST00000256442.5
cyclin B1
chr3_-_81792780 17.73 ENST00000489715.1
glucan (1,4-alpha-), branching enzyme 1
chrX_+_69509927 17.20 ENST00000374403.3
kinesin family member 4A
chr8_-_71519889 17.09 ENST00000521425.1
translocation associated membrane protein 1
chr5_+_68462944 16.96 ENST00000506572.1
cyclin B1
chr5_+_68463043 16.40 ENST00000508407.1
ENST00000505500.1
cyclin B1
chr19_+_16186903 15.76 ENST00000588507.1
tropomyosin 4
chr5_-_95158644 15.17 ENST00000237858.6
glutaredoxin (thioltransferase)
chr8_-_55014415 13.80 ENST00000522007.1
ENST00000521898.1
ENST00000518546.1
ENST00000316963.3
lysophospholipase I
chr20_-_52210368 13.26 ENST00000371471.2
zinc finger protein 217
chr5_+_135364584 12.94 ENST00000442011.2
ENST00000305126.8
transforming growth factor, beta-induced, 68kDa
chr1_-_94374946 12.54 ENST00000370238.3
glutamate-cysteine ligase, modifier subunit
chr12_+_122326662 12.16 ENST00000261817.2
ENST00000538613.1
ENST00000542602.1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
chr22_+_40742512 12.07 ENST00000454266.2
ENST00000342312.6
adenylosuccinate lyase
chr3_-_182833863 11.61 ENST00000492597.1
methylcrotonoyl-CoA carboxylase 1 (alpha)
chr1_-_150669500 11.55 ENST00000271732.3
golgi phosphoprotein 3-like
chr12_-_50677255 11.00 ENST00000551691.1
ENST00000394943.3
ENST00000341247.4
LIM domain and actin binding 1
chr22_+_38071615 10.95 ENST00000215909.5
lectin, galactoside-binding, soluble, 1
chr7_-_99698338 10.83 ENST00000354230.3
ENST00000425308.1
minichromosome maintenance complex component 7
chr11_+_74660278 10.75 ENST00000263672.6
ENST00000530257.1
ENST00000526361.1
ENST00000532972.1
signal peptidase complex subunit 2 homolog (S. cerevisiae)
chr18_+_3247779 10.53 ENST00000578611.1
ENST00000583449.1
myosin, light chain 12A, regulatory, non-sarcomeric
chr19_+_16187085 10.49 ENST00000300933.4
tropomyosin 4
chrX_-_16887963 10.37 ENST00000380084.4
retinoblastoma binding protein 7
chr12_-_10875831 10.36 ENST00000279550.7
ENST00000228251.4
Y box binding protein 3
chr11_+_32112431 10.05 ENST00000054950.3
reticulocalbin 1, EF-hand calcium binding domain
chr2_-_106054952 9.99 ENST00000336660.5
ENST00000393352.3
ENST00000607522.1
four and a half LIM domains 2
chr20_+_30327063 9.78 ENST00000300403.6
ENST00000340513.4
TPX2, microtubule-associated
chr11_+_58910201 9.72 ENST00000528737.1
family with sequence similarity 111, member A
chr12_+_50144381 9.60 ENST00000552370.1
transmembrane BAX inhibitor motif containing 6
chr11_+_58910295 9.50 ENST00000420244.1
family with sequence similarity 111, member A
chr17_+_34848049 9.50 ENST00000588902.1
ENST00000591067.1
zinc finger, HIT-type containing 3
chr16_-_9030515 9.39 ENST00000535863.1
ENST00000381886.4
ubiquitin specific peptidase 7 (herpes virus-associated)
chr15_+_65843130 9.23 ENST00000569894.1
protein tyrosine phosphatase-like A domain containing 1
chr7_-_132766818 9.19 ENST00000262570.5
coiled-coil-helix-coiled-coil-helix domain containing 3
chr11_-_88070920 9.13 ENST00000524463.1
ENST00000227266.5
cathepsin C
chr17_-_43025005 8.90 ENST00000587309.1
ENST00000593135.1
ENST00000339151.4
kinesin family member 18B
chr7_-_132766800 8.67 ENST00000542753.1
ENST00000448878.1
coiled-coil-helix-coiled-coil-helix domain containing 3
chr11_-_82997371 8.66 ENST00000525503.1
coiled-coil domain containing 90B
chr11_+_125496619 8.57 ENST00000532669.1
ENST00000278916.3
checkpoint kinase 1
chr1_-_9129895 8.50 ENST00000473209.1
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr6_-_31697255 8.33 ENST00000436437.1
dimethylarginine dimethylaminohydrolase 2
chr15_+_63340734 8.30 ENST00000560959.1
tropomyosin 1 (alpha)
chr5_-_98262240 8.30 ENST00000284049.3
chromodomain helicase DNA binding protein 1
chr2_-_17981462 8.26 ENST00000402989.1
ENST00000428868.1
structural maintenance of chromosomes 6
chr15_+_63340858 8.10 ENST00000560615.1
tropomyosin 1 (alpha)
chr22_-_36924944 7.87 ENST00000405442.1
ENST00000402116.1
eukaryotic translation initiation factor 3, subunit D
chr11_-_67169253 7.80 ENST00000527663.1
ENST00000312989.7
protein phosphatase 1, catalytic subunit, alpha isozyme
chr15_+_63796779 7.76 ENST00000561442.1
ENST00000560070.1
ENST00000540797.1
ENST00000380324.3
ENST00000268049.7
ENST00000536001.1
ENST00000539772.1
ubiquitin specific peptidase 3
chr11_+_125496400 7.76 ENST00000524737.1
checkpoint kinase 1
chr17_+_45286387 7.75 ENST00000572316.1
ENST00000354968.1
ENST00000576874.1
ENST00000536623.2
myosin, light chain 4, alkali; atrial, embryonic
chr13_+_37574678 7.69 ENST00000389704.3
exosome component 8
chr4_-_140223670 7.56 ENST00000394228.1
ENST00000539387.1
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
chr16_-_31105870 7.46 ENST00000394971.3
vitamin K epoxide reductase complex, subunit 1
chr17_+_6347729 7.45 ENST00000572447.1
family with sequence similarity 64, member A
chr12_-_6960407 7.42 ENST00000540683.1
ENST00000229265.6
ENST00000535406.1
ENST00000422785.3
cell division cycle associated 3
chr15_+_63340647 7.38 ENST00000404484.4
tropomyosin 1 (alpha)
chr22_+_44351301 7.26 ENST00000350028.4
SAMM50 sorting and assembly machinery component
chr16_-_46655538 7.23 ENST00000303383.3
SHC SH2-domain binding protein 1
chr2_-_234763147 7.21 ENST00000411486.2
ENST00000432087.1
ENST00000441687.1
ENST00000414924.1
Holliday junction recognition protein
chr18_+_3448455 7.20 ENST00000549780.1
TGFB-induced factor homeobox 1
chr18_+_158513 7.16 ENST00000400266.3
ENST00000580410.1
ENST00000383589.2
ENST00000261601.7
ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
chr17_+_6347761 7.13 ENST00000250056.8
ENST00000571373.1
ENST00000570337.2
ENST00000572595.2
ENST00000576056.1
family with sequence similarity 64, member A
chr3_+_23959185 7.02 ENST00000354811.5
ribosomal protein L15
chrX_-_107334750 7.01 ENST00000340200.5
ENST00000372296.1
ENST00000372295.1
ENST00000361815.5
proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
chr5_-_179050066 6.94 ENST00000329433.6
ENST00000510411.1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr13_-_41635512 6.93 ENST00000405737.2
E74-like factor 1 (ets domain transcription factor)
chrX_-_107334790 6.92 ENST00000217958.3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
chr7_-_6523755 6.80 ENST00000436575.1
ENST00000258739.4
diacylglycerol lipase, beta
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
chr15_+_89787180 6.68 ENST00000300027.8
ENST00000310775.7
ENST00000567891.1
ENST00000564920.1
ENST00000565255.1
ENST00000567996.1
ENST00000451393.2
ENST00000563250.1
Fanconi anemia, complementation group I
chr3_+_197677379 6.59 ENST00000442341.1
ribosomal protein L35a
chr20_-_52790055 6.51 ENST00000395955.3
cytochrome P450, family 24, subfamily A, polypeptide 1
chr2_-_3595547 6.46 ENST00000438485.1
Uncharacterized protein
chr4_+_37892682 6.34 ENST00000508802.1
ENST00000261439.4
ENST00000402522.1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr11_-_82997420 6.22 ENST00000455220.2
ENST00000529689.1
coiled-coil domain containing 90B
chr15_+_63340553 6.14 ENST00000334895.5
tropomyosin 1 (alpha)
chr19_-_4867665 6.13 ENST00000592528.1
ENST00000589494.1
ENST00000585479.1
ENST00000221957.4
perilipin 3
chr15_-_72523924 6.07 ENST00000566809.1
ENST00000567087.1
ENST00000569050.1
ENST00000568883.1
pyruvate kinase, muscle
chr3_+_52245458 6.00 ENST00000459884.1
aminolevulinate, delta-, synthase 1
chr6_-_31697563 5.97 ENST00000375789.2
ENST00000416410.1
dimethylarginine dimethylaminohydrolase 2
chr11_-_82997013 5.83 ENST00000529073.1
ENST00000529611.1
coiled-coil domain containing 90B
chr8_+_33342268 5.82 ENST00000360128.6
MAK16 homolog (S. cerevisiae)
chr6_+_30585486 5.67 ENST00000259873.4
ENST00000506373.2
mitochondrial ribosomal protein S18B
chr22_+_44351419 5.66 ENST00000396202.3
SAMM50 sorting and assembly machinery component
chr17_+_45286706 5.63 ENST00000393450.1
ENST00000572303.1
myosin, light chain 4, alkali; atrial, embryonic
chr2_-_191115229 5.59 ENST00000409820.2
ENST00000410045.1
3-hydroxyisobutyryl-CoA hydrolase
chr11_-_104827425 5.54 ENST00000393150.3
caspase 4, apoptosis-related cysteine peptidase
chr11_+_125496124 5.54 ENST00000533778.2
ENST00000534070.1
checkpoint kinase 1
chr15_+_63340775 5.53 ENST00000559281.1
ENST00000317516.7
tropomyosin 1 (alpha)
chr2_+_231280908 5.53 ENST00000427101.2
ENST00000432979.1
SP100 nuclear antigen
chr17_-_7297833 5.48 ENST00000571802.1
ENST00000576201.1
ENST00000573213.1
ENST00000324822.11
TMEM256-PLSCR3 readthrough (NMD candidate)
chr11_+_64948665 5.47 ENST00000533820.1
calpain 1, (mu/I) large subunit
chr20_-_54967187 5.38 ENST00000422322.1
ENST00000371356.2
ENST00000451915.1
ENST00000347343.2
ENST00000395911.1
ENST00000395907.1
ENST00000441357.1
ENST00000456249.1
ENST00000420474.1
ENST00000395909.4
ENST00000395914.1
ENST00000312783.6
ENST00000395915.3
ENST00000395913.3
aurora kinase A
chr1_+_212738676 5.37 ENST00000366981.4
ENST00000366987.2
activating transcription factor 3
chr16_+_56970567 5.33 ENST00000563911.1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr22_-_50964558 5.31 ENST00000535425.1
ENST00000439934.1
SCO2 cytochrome c oxidase assembly protein
chr18_+_55888767 5.26 ENST00000431212.2
ENST00000586268.1
ENST00000587190.1
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr1_-_39339777 5.25 ENST00000397572.2
MYC binding protein
chr6_-_28891709 5.24 ENST00000377194.3
ENST00000377199.3
tripartite motif containing 27
chr2_+_192110199 5.16 ENST00000304164.4
myosin IB
chr7_-_41742697 4.97 ENST00000242208.4
inhibin, beta A
chr11_-_503521 4.93 ENST00000534797.1
ribonuclease/angiogenin inhibitor 1
chr1_+_79115503 4.87 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
interferon-induced protein 44
chr8_-_117886955 4.82 ENST00000297338.2
RAD21 homolog (S. pombe)
chr1_+_155107820 4.77 ENST00000484157.1
solute carrier family 50 (sugar efflux transporter), member 1
chr20_-_43133491 4.74 ENST00000411544.1
serine incorporator 3
chr1_-_202927490 4.74 ENST00000340990.5
adiponectin receptor 1
chr3_+_141106643 4.70 ENST00000514251.1
zinc finger and BTB domain containing 38
chr3_+_49058444 4.69 ENST00000326925.6
ENST00000395458.2
NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
chr11_-_1643368 4.68 ENST00000399682.1
keratin associated protein 5-4
chr20_-_61847586 4.65 ENST00000370339.3
YTH domain family, member 1
chr14_-_50154921 4.58 ENST00000553805.2
ENST00000554396.1
ENST00000216367.5
ENST00000539565.2
polymerase (DNA directed), epsilon 2, accessory subunit
chr16_-_31106048 4.48 ENST00000300851.6
vitamin K epoxide reductase complex, subunit 1
chr19_-_43702231 4.44 ENST00000597374.1
ENST00000599371.1
pregnancy specific beta-1-glycoprotein 4
chr5_+_95066823 4.37 ENST00000506817.1
ENST00000379982.3
Rho-related BTB domain containing 3
chrX_+_148622138 4.33 ENST00000450602.2
ENST00000441248.1
chromosome X open reading frame 40A
chr21_-_33651324 4.31 ENST00000290130.3
MIS18 kinetochore protein A
chr17_-_77813186 4.21 ENST00000448310.1
ENST00000269397.4
chromobox homolog 4
chr11_-_87908600 4.09 ENST00000531138.1
ENST00000526372.1
ENST00000243662.6
RAB38, member RAS oncogene family
chr16_-_31106211 4.08 ENST00000532364.1
ENST00000529564.1
ENST00000319788.7
ENST00000354895.4
ENST00000394975.2
Uncharacterized protein
vitamin K epoxide reductase complex, subunit 1
chr11_-_111957451 4.07 ENST00000504148.2
ENST00000541231.1
translocase of inner mitochondrial membrane 8 homolog B (yeast)
chr11_-_62341445 4.02 ENST00000329251.4
eukaryotic translation elongation factor 1 gamma
chr1_+_148739443 3.98 ENST00000417839.1
neuroblastoma breakpoint family, member 16
chr1_-_167522982 3.95 ENST00000370509.4
cellular repressor of E1A-stimulated genes 1
chr2_+_181845298 3.91 ENST00000410062.4
ubiquitin-conjugating enzyme E2E 3
chr3_+_135969148 3.86 ENST00000251654.4
ENST00000490504.1
ENST00000483687.1
ENST00000468777.1
ENST00000462637.1
ENST00000466072.1
ENST00000482086.1
ENST00000471595.1
ENST00000469217.1
ENST00000465423.1
ENST00000478469.1
propionyl CoA carboxylase, beta polypeptide
chr16_+_71929397 3.78 ENST00000537613.1
ENST00000424485.2
ENST00000606369.1
ENST00000329908.8
ENST00000538850.1
ENST00000541918.1
ENST00000534994.1
ENST00000378798.5
ENST00000539186.1
increased sodium tolerance 1 homolog (yeast)
chr1_-_206785898 3.77 ENST00000271764.2
eukaryotic translation initiation factor 2D
chr20_+_44044717 3.77 ENST00000279036.6
ENST00000279035.9
ENST00000372689.5
ENST00000545755.1
ENST00000341555.5
ENST00000535404.1
ENST00000543458.2
ENST00000432270.1
phosphatidylinositol glycan anchor biosynthesis, class T
chr11_+_111957497 3.71 ENST00000375549.3
ENST00000528182.1
ENST00000528048.1
ENST00000528021.1
ENST00000526592.1
ENST00000525291.1
succinate dehydrogenase complex, subunit D, integral membrane protein
chr1_-_206785789 3.68 ENST00000437518.1
ENST00000367114.3
eukaryotic translation initiation factor 2D
chr4_+_146403912 3.62 ENST00000507367.1
ENST00000394092.2
ENST00000515385.1
SMAD family member 1
chr18_+_21529811 3.58 ENST00000588004.1
laminin, alpha 3
chr2_-_158345462 3.57 ENST00000439355.1
ENST00000540637.1
cytohesin 1 interacting protein
chr1_-_9129631 3.57 ENST00000377414.3
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr22_+_23264766 3.54 ENST00000390331.2
immunoglobulin lambda constant 7
chr10_-_51130715 3.48 ENST00000402038.3
poly (ADP-ribose) glycohydrolase
chr11_+_64002292 3.45 ENST00000426086.2
vascular endothelial growth factor B
chr1_+_144811943 3.38 ENST00000281815.8
neuroblastoma breakpoint family, member 9
chr12_-_14133053 3.38 ENST00000609686.1
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
chr3_+_49059038 3.36 ENST00000451378.2
NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
chrX_+_148622513 3.33 ENST00000393985.3
ENST00000423421.1
ENST00000423540.2
ENST00000434353.2
ENST00000514208.1
chromosome X open reading frame 40A
chr9_+_34646624 3.31 ENST00000450095.2
ENST00000556278.1
galactose-1-phosphate uridylyltransferase
Uncharacterized protein
chr6_+_143772060 3.27 ENST00000367591.4
peroxisomal biogenesis factor 3
chr8_-_41522719 3.17 ENST00000335651.6
ankyrin 1, erythrocytic
chr6_-_2842219 3.14 ENST00000380739.5
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr9_+_131133598 3.11 ENST00000372853.4
ENST00000452446.1
ENST00000372850.1
ENST00000372847.1
ubiquitin related modifier 1
chr1_-_21113105 3.10 ENST00000375000.1
ENST00000419490.1
ENST00000414993.1
ENST00000443615.1
ENST00000312239.5
heterochromatin protein 1, binding protein 3
chr11_+_7597639 3.06 ENST00000533792.1
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chrX_-_102942961 3.04 ENST00000434230.1
ENST00000418819.1
ENST00000360458.1
mortality factor 4 like 2
chr8_-_82633476 2.94 ENST00000518419.1
ENST00000517588.1
ENST00000521895.1
ENST00000520076.1
ENST00000519523.1
ENST00000522520.1
ENST00000521287.1
ENST00000523096.1
ENST00000220669.5
ENST00000517450.1
zinc finger, AN1-type domain 1
chr7_-_76255444 2.92 ENST00000454397.1
POM121 and ZP3 fusion
chr11_-_615570 2.90 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
interferon regulatory factor 7
chr6_+_26458152 2.87 ENST00000312541.5
butyrophilin, subfamily 2, member A1
chr10_-_12084770 2.84 ENST00000357604.5
UPF2 regulator of nonsense transcripts homolog (yeast)
chr4_+_47487285 2.82 ENST00000273859.3
ENST00000504445.1
ATPase, class V, type 10D
chr22_+_39052632 2.80 ENST00000411557.1
ENST00000396811.2
ENST00000216029.3
ENST00000416285.1
chibby homolog 1 (Drosophila)
chr1_-_204135450 2.77 ENST00000272190.8
ENST00000367195.2
renin
chr2_+_68384976 2.77 ENST00000263657.2
partner of NOB1 homolog (S. cerevisiae)
chr2_-_152590946 2.76 ENST00000172853.10
nebulin
chr11_+_34127142 2.75 ENST00000257829.3
ENST00000531159.2
N-acetyltransferase 10 (GCN5-related)
chr9_+_118950325 2.72 ENST00000534838.1
pregnancy-associated plasma protein A, pappalysin 1
chr4_-_4543700 2.69 ENST00000505286.1
ENST00000306200.2
syntaxin 18
chr17_-_26989136 2.69 ENST00000247020.4
stromal cell-derived factor 2
chr16_+_30383613 2.60 ENST00000568749.1
myosin light chain, phosphorylatable, fast skeletal muscle
chr13_+_41635617 2.60 ENST00000542082.1
WW domain binding protein 4
chr17_-_7145106 2.57 ENST00000577035.1
GABA(A) receptor-associated protein
chr1_+_144151520 2.44 ENST00000369372.4
neuroblastoma breakpoint family, member 8
chr15_-_42749711 2.41 ENST00000565611.1
ENST00000263805.4
ENST00000565948.1
zinc finger protein 106
chr1_+_46049706 2.40 ENST00000527470.1
ENST00000525515.1
ENST00000537798.1
ENST00000402363.3
ENST00000528238.1
ENST00000350030.3
ENST00000470768.1
ENST00000372052.4
ENST00000351223.3
nuclear autoantigenic sperm protein (histone-binding)
chr4_+_37962018 2.28 ENST00000504686.1
pituitary tumor-transforming 2
chr17_-_7145475 2.23 ENST00000571129.1
ENST00000571253.1
ENST00000573928.1
GABA(A) receptor-associated protein
chr11_+_71498552 2.19 ENST00000346333.6
ENST00000359244.4
ENST00000426628.2
family with sequence similarity 86, member C1
chr15_+_57998923 2.17 ENST00000380557.4
polymerase (RNA) II (DNA directed) polypeptide M
chr2_+_219264466 2.14 ENST00000273062.2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr16_-_31439735 2.14 ENST00000287490.4
cytochrome c oxidase subunit VIa polypeptide 2
chr17_+_4736627 2.14 ENST00000355280.6
ENST00000347992.7
misshapen-like kinase 1
chr5_-_140700322 2.13 ENST00000313368.5
TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa
chr1_-_45476944 2.12 ENST00000372172.4
HECT domain containing E3 ubiquitin protein ligase 3
chr2_+_232575128 2.07 ENST00000412128.1
prothymosin, alpha
chr12_+_56473628 2.05 ENST00000549282.1
ENST00000549061.1
ENST00000267101.3
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
chr9_+_34646651 2.02 ENST00000378842.3
galactose-1-phosphate uridylyltransferase
chr19_-_41903161 1.97 ENST00000602129.1
ENST00000593771.1
ENST00000596905.1
ENST00000221233.4
exosome component 5
chr19_+_48216600 1.97 ENST00000263277.3
ENST00000538399.1
EH-domain containing 2
chr12_+_57828521 1.90 ENST00000309668.2
inhibin, beta C
chr14_-_23288930 1.90 ENST00000554517.1
ENST00000285850.7
ENST00000397529.2
ENST00000555702.1
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr7_-_128045984 1.88 ENST00000470772.1
ENST00000480861.1
ENST00000496200.1
IMP (inosine 5'-monophosphate) dehydrogenase 1
chr7_-_25164868 1.86 ENST00000409409.1
ENST00000409764.1
ENST00000413447.1
cytochrome c, somatic
chr2_+_61244697 1.86 ENST00000401576.1
ENST00000295030.5
ENST00000414712.2
peroxisomal biogenesis factor 13
chr6_+_150070857 1.85 ENST00000544496.1
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr9_+_125137565 1.82 ENST00000373698.5
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr4_-_89152474 1.78 ENST00000515655.1
ATP-binding cassette, sub-family G (WHITE), member 2
chr7_+_99102573 1.76 ENST00000394170.2
zinc finger with KRAB and SCAN domains 5
chrX_+_9431324 1.74 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
transducin (beta)-like 1X-linked
chr15_+_57998821 1.73 ENST00000299638.3
polymerase (RNA) II (DNA directed) polypeptide M
chr1_+_25870070 1.71 ENST00000374338.4
low density lipoprotein receptor adaptor protein 1
chr18_-_77748527 1.70 ENST00000591711.1
ENST00000588162.1
ENST00000269601.5
thioredoxin-like 4A
chr6_+_46761118 1.67 ENST00000230588.4
meprin A, alpha (PABA peptide hydrolase)
chr19_+_11546093 1.66 ENST00000591462.1
protein kinase C substrate 80K-H

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF21

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
17.2 51.5 GO:0031660 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662) response to DDT(GO:0046680) histone H3-S10 phosphorylation involved in chromosome condensation(GO:2000775)
5.2 26.1 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
4.5 35.9 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
4.0 12.1 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
3.6 21.9 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
3.1 12.5 GO:1904386 response to thyroxine(GO:0097068) response to L-phenylalanine derivative(GO:1904386)
3.1 30.6 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
2.8 13.8 GO:0002084 protein depalmitoylation(GO:0002084) negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
2.6 7.9 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732)
2.4 7.2 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
2.4 4.8 GO:1901656 glycoside transport(GO:1901656)
2.3 9.4 GO:0035616 maintenance of DNA methylation(GO:0010216) histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
2.2 6.5 GO:0042369 vitamin D catabolic process(GO:0042369)
2.1 10.4 GO:0010286 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
2.0 10.0 GO:0055011 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
2.0 7.8 GO:0036496 regulation of translational initiation by eIF2 alpha dephosphorylation(GO:0036496)
1.9 7.7 GO:0034476 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
1.8 5.4 GO:1900195 spindle assembly involved in female meiosis I(GO:0007057) positive regulation of oocyte maturation(GO:1900195)
1.8 5.4 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
1.8 5.3 GO:0006258 UDP-glucose catabolic process(GO:0006258) galactose catabolic process via UDP-galactose(GO:0033499)
1.7 12.2 GO:0098704 fructose transport(GO:0015755) fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539)
1.7 6.8 GO:1902044 regulation of Fas signaling pathway(GO:1902044)
1.7 5.0 GO:0060278 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
1.6 16.0 GO:0042373 vitamin K metabolic process(GO:0042373)
1.6 9.6 GO:1904721 regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) negative regulation of ribonuclease activity(GO:0060701) negative regulation of endoribonuclease activity(GO:0060702) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
1.3 3.9 GO:0051685 maintenance of ER location(GO:0051685)
1.3 10.4 GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
1.3 11.6 GO:0006552 leucine catabolic process(GO:0006552)
1.3 3.9 GO:0019626 short-chain fatty acid catabolic process(GO:0019626)
1.2 3.7 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
1.2 12.9 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
1.1 17.2 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
1.1 5.6 GO:0006574 valine catabolic process(GO:0006574)
1.1 10.8 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
1.0 5.2 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
1.0 3.1 GO:0034227 tRNA thio-modification(GO:0034227)
1.0 6.1 GO:0042866 pyruvate biosynthetic process(GO:0042866)
1.0 4.8 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.9 7.4 GO:0032790 ribosome disassembly(GO:0032790)
0.9 8.3 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.9 2.7 GO:0002101 tRNA wobble cytosine modification(GO:0002101)
0.9 14.3 GO:0006527 arginine catabolic process(GO:0006527)
0.8 15.2 GO:0045838 positive regulation of membrane potential(GO:0045838)
0.7 18.3 GO:0008053 mitochondrial fusion(GO:0008053)
0.7 2.8 GO:0007525 somatic muscle development(GO:0007525)
0.7 3.4 GO:2000110 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) negative regulation of macrophage apoptotic process(GO:2000110)
0.7 4.7 GO:0009597 detection of virus(GO:0009597)
0.7 2.0 GO:0071051 polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.7 2.0 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
0.6 1.9 GO:0000821 regulation of arginine metabolic process(GO:0000821)
0.6 3.8 GO:0009838 abscission(GO:0009838)
0.6 3.8 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.6 1.9 GO:0060152 peroxisome localization(GO:0060151) microtubule-based peroxisome localization(GO:0060152)
0.6 6.8 GO:0006621 protein retention in ER lumen(GO:0006621)
0.6 5.5 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.6 4.7 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.6 4.1 GO:1903232 melanosome assembly(GO:1903232)
0.6 40.7 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.5 3.3 GO:0016557 peroxisome membrane biogenesis(GO:0016557)
0.5 5.3 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.5 10.8 GO:0006465 signal peptide processing(GO:0006465)
0.5 2.9 GO:0035803 egg coat formation(GO:0035803)
0.5 2.4 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.5 1.4 GO:0032289 central nervous system myelin formation(GO:0032289) detection of bacterial lipoprotein(GO:0042494) detection of triacyl bacterial lipopeptide(GO:0042495) detection of bacterial lipopeptide(GO:0070340)
0.5 2.8 GO:0002018 renin-angiotensin regulation of aldosterone production(GO:0002018)
0.5 6.0 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
0.5 5.5 GO:0060056 mammary gland involution(GO:0060056)
0.5 3.6 GO:0002051 osteoblast fate commitment(GO:0002051)
0.4 2.7 GO:1902953 positive regulation of ER to Golgi vesicle-mediated transport(GO:1902953)
0.4 1.7 GO:0090118 receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport(GO:0090118)
0.4 11.5 GO:0061641 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.4 3.5 GO:0060754 positive regulation of mast cell chemotaxis(GO:0060754)
0.4 1.5 GO:1901804 beta-glucoside metabolic process(GO:1901804) beta-glucoside catabolic process(GO:1901805) positive regulation of neuronal action potential(GO:1904457)
0.3 2.4 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.3 7.8 GO:0016578 histone deubiquitination(GO:0016578)
0.3 1.9 GO:0006177 GMP biosynthetic process(GO:0006177)
0.3 1.5 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.3 6.9 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.3 5.3 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.3 2.6 GO:0030091 protein repair(GO:0030091)
0.3 4.8 GO:0043562 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.3 0.6 GO:0002874 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.3 6.7 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.3 4.6 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.2 4.4 GO:0007565 female pregnancy(GO:0007565)
0.2 2.7 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.2 3.4 GO:0046415 urate metabolic process(GO:0046415)
0.2 9.8 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.2 4.5 GO:0045199 maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.2 0.7 GO:2000661 positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
0.2 0.5 GO:0070827 chromatin maintenance(GO:0070827)
0.2 4.9 GO:0043923 positive regulation by host of viral transcription(GO:0043923)
0.2 15.8 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.2 17.9 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.2 2.1 GO:0015846 polyamine transport(GO:0015846)
0.2 1.0 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.2 11.0 GO:0031529 ruffle organization(GO:0031529)
0.2 15.6 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.2 2.4 GO:0048194 Golgi vesicle budding(GO:0048194)
0.2 30.7 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
0.2 4.0 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.2 4.1 GO:0072321 chaperone-mediated protein transport(GO:0072321)
0.2 0.4 GO:2000321 positive regulation of T-helper 17 cell differentiation(GO:2000321)
0.2 3.1 GO:0070828 heterochromatin organization(GO:0070828)
0.2 1.4 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
0.2 1.4 GO:0002326 B cell lineage commitment(GO:0002326) immunoglobulin V(D)J recombination(GO:0033152)
0.2 1.2 GO:0034127 regulation of MyD88-independent toll-like receptor signaling pathway(GO:0034127) negative regulation of MyD88-independent toll-like receptor signaling pathway(GO:0034128) positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.2 8.6 GO:0001913 T cell mediated cytotoxicity(GO:0001913)
0.2 0.8 GO:0090650 renal water absorption(GO:0070295) response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)
0.1 4.6 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.1 1.6 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.1 2.7 GO:0032354 response to follicle-stimulating hormone(GO:0032354)
0.1 2.4 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.1 1.3 GO:0070166 enamel mineralization(GO:0070166)
0.1 1.6 GO:0048298 positive regulation of isotype switching to IgA isotypes(GO:0048298)
0.1 3.6 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 10.9 GO:0070527 platelet aggregation(GO:0070527)
0.1 1.4 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 2.6 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.1 0.7 GO:0032057 negative regulation of translational initiation in response to stress(GO:0032057)
0.1 3.0 GO:0043968 histone H2A acetylation(GO:0043968)
0.1 1.3 GO:1904706 negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.1 15.4 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.1 1.8 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.1 5.0 GO:0007019 microtubule depolymerization(GO:0007019)
0.1 0.5 GO:0051122 hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.1 2.1 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.1 2.0 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.1 3.9 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.1 0.9 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.1 0.9 GO:0006600 creatine metabolic process(GO:0006600)
0.1 0.2 GO:0010041 response to iron(III) ion(GO:0010041)
0.1 0.8 GO:0006707 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.1 0.2 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.1 9.0 GO:0045727 positive regulation of translation(GO:0045727)
0.1 3.4 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1 5.7 GO:0070125 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.1 0.3 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
0.1 0.6 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.1 1.3 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.1 2.2 GO:0032259 methylation(GO:0032259)
0.1 2.3 GO:2000816 negative regulation of mitotic sister chromatid separation(GO:2000816)
0.1 0.9 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.1 1.7 GO:0006491 N-glycan processing(GO:0006491)
0.1 2.6 GO:0016925 protein sumoylation(GO:0016925)
0.1 4.4 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.1 2.8 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.1 1.0 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.1 2.0 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.3 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 6.5 GO:0031424 keratinization(GO:0031424)
0.0 4.0 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.3 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.0 0.4 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.0 2.1 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0 1.2 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.6 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 1.6 GO:0030308 negative regulation of cell growth(GO:0030308)
0.0 3.6 GO:0050853 B cell receptor signaling pathway(GO:0050853)
0.0 2.8 GO:0006402 mRNA catabolic process(GO:0006402)
0.0 0.3 GO:1902916 positive regulation of protein polyubiquitination(GO:1902916)
0.0 0.7 GO:0090083 regulation of inclusion body assembly(GO:0090083)
0.0 1.4 GO:0033146 regulation of intracellular estrogen receptor signaling pathway(GO:0033146)
0.0 1.7 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 1.1 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.1 GO:0046886 positive regulation of hormone biosynthetic process(GO:0046886)
0.0 0.2 GO:0015074 DNA integration(GO:0015074)
0.0 3.4 GO:0006364 rRNA processing(GO:0006364)
0.0 0.2 GO:0002414 immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.0 0.6 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.0 1.7 GO:0016575 histone deacetylation(GO:0016575)
0.0 0.4 GO:0001569 patterning of blood vessels(GO:0001569)
0.0 0.4 GO:0060259 regulation of feeding behavior(GO:0060259)
0.0 0.8 GO:0048704 embryonic skeletal system morphogenesis(GO:0048704)
0.0 0.8 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.0 1.3 GO:0055007 cardiac muscle cell differentiation(GO:0055007)
0.0 3.7 GO:0007601 visual perception(GO:0007601)
0.0 0.8 GO:0001525 angiogenesis(GO:0001525)
0.0 7.7 GO:0043312 neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0 0.1 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0 0.4 GO:0043967 histone H4 acetylation(GO:0043967)
0.0 0.6 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
10.3 51.5 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
6.5 19.6 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
3.3 62.2 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
2.6 17.9 GO:0061617 MICOS complex(GO:0061617)
2.3 11.6 GO:1905202 3-methylcrotonyl-CoA carboxylase complex, mitochondrial(GO:0002169) methylcrotonoyl-CoA carboxylase complex(GO:1905202)
2.1 8.3 GO:0030915 Smc5-Smc6 complex(GO:0030915)
1.8 5.4 GO:1990622 CHOP-ATF3 complex(GO:1990622)
1.7 5.0 GO:0043512 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
1.5 10.8 GO:0005787 signal peptidase complex(GO:0005787)
1.4 26.1 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
1.3 3.8 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
1.2 13.3 GO:0098799 outer mitochondrial membrane protein complex(GO:0098799)
1.2 4.8 GO:0000798 nuclear cohesin complex(GO:0000798)
1.1 8.9 GO:0005818 astral microtubule(GO:0000235) aster(GO:0005818)
1.0 6.8 GO:0030870 Mre11 complex(GO:0030870)
0.9 3.7 GO:0045273 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.9 5.5 GO:0072557 IPAF inflammasome complex(GO:0072557)
0.9 4.6 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.9 5.3 GO:1990037 Lewy body core(GO:1990037)
0.9 9.7 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.9 7.9 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.8 10.8 GO:0042555 MCM complex(GO:0042555)
0.8 4.9 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.8 4.1 GO:0031905 early endosome lumen(GO:0031905)
0.8 7.8 GO:0042587 glycogen granule(GO:0042587) PTW/PP1 phosphatase complex(GO:0072357)
0.8 7.8 GO:0070938 contractile ring(GO:0070938)
0.7 5.4 GO:0032133 chromosome passenger complex(GO:0032133)
0.5 4.1 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.5 1.4 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
0.4 3.6 GO:0005610 laminin-5 complex(GO:0005610)
0.4 10.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.3 19.2 GO:0045171 intercellular bridge(GO:0045171)
0.3 30.4 GO:0016459 myosin complex(GO:0016459)
0.3 4.2 GO:0035102 PRC1 complex(GO:0035102)
0.3 3.8 GO:0090543 Flemming body(GO:0090543)
0.3 1.1 GO:0036449 microtubule minus-end(GO:0036449)
0.3 21.9 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.3 4.8 GO:0097225 sperm midpiece(GO:0097225)
0.2 1.7 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.2 2.6 GO:0043203 axon hillock(GO:0043203)
0.2 5.7 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.2 3.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.2 13.2 GO:0005844 polysome(GO:0005844)
0.2 2.1 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.2 4.5 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.2 32.0 GO:0015934 large ribosomal subunit(GO:0015934)
0.2 5.1 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.2 30.6 GO:0001650 fibrillar center(GO:0001650)
0.2 15.0 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 11.0 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.2 3.6 GO:0071141 SMAD protein complex(GO:0071141)
0.2 2.1 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 15.8 GO:0035578 azurophil granule lumen(GO:0035578)
0.1 7.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 0.6 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.1 7.6 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 5.1 GO:0045095 keratin filament(GO:0045095)
0.1 3.0 GO:0035267 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.1 0.7 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.1 12.2 GO:0035579 specific granule membrane(GO:0035579)
0.1 7.2 GO:0000502 proteasome complex(GO:0000502)
0.1 2.7 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 5.3 GO:0005771 multivesicular body(GO:0005771)
0.1 8.8 GO:0005604 basement membrane(GO:0005604)
0.1 1.7 GO:0005682 U5 snRNP(GO:0005682)
0.1 0.4 GO:0072559 NLRP3 inflammasome complex(GO:0072559)
0.1 1.6 GO:0071564 npBAF complex(GO:0071564)
0.1 4.3 GO:0005801 cis-Golgi network(GO:0005801)
0.1 3.6 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 8.0 GO:0016605 PML body(GO:0016605)
0.1 0.3 GO:0070081 clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.1 11.5 GO:1904813 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.1 1.2 GO:0097342 ripoptosome(GO:0097342)
0.1 1.6 GO:0030990 intraciliary transport particle(GO:0030990)
0.1 19.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 1.9 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.4 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 2.7 GO:0031201 SNARE complex(GO:0031201)
0.0 3.4 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 5.2 GO:0072562 blood microparticle(GO:0072562)
0.0 0.9 GO:0035371 microtubule plus-end(GO:0035371)
0.0 3.5 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 1.0 GO:0005861 troponin complex(GO:0005861)
0.0 22.8 GO:0031966 mitochondrial membrane(GO:0031966)
0.0 3.4 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 1.0 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.4 GO:0043194 axon initial segment(GO:0043194)
0.0 3.9 GO:0016591 DNA-directed RNA polymerase II, holoenzyme(GO:0016591)
0.0 2.0 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 2.6 GO:0030496 midbody(GO:0030496)
0.0 0.5 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 7.2 GO:0016607 nuclear speck(GO:0016607)
0.0 18.1 GO:0005739 mitochondrion(GO:0005739)
0.0 16.3 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 0.8 GO:0005811 lipid particle(GO:0005811)
0.0 4.5 GO:0005925 focal adhesion(GO:0005925)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
7.4 51.5 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
4.0 16.0 GO:0016900 oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor(GO:0016900) vitamin-K-epoxide reductase (warfarin-sensitive) activity(GO:0047057)
3.9 19.6 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
3.6 10.9 GO:0048030 disaccharide binding(GO:0048030)
3.6 21.9 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
3.3 13.4 GO:0032038 myosin II heavy chain binding(GO:0032038)
2.9 14.3 GO:0016403 dimethylargininase activity(GO:0016403)
2.4 7.2 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
2.3 11.6 GO:0004485 methylcrotonoyl-CoA carboxylase activity(GO:0004485)
2.0 6.0 GO:0003870 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
2.0 9.8 GO:0061676 importin-alpha family protein binding(GO:0061676)
1.7 12.2 GO:0005353 fructose transmembrane transporter activity(GO:0005353)
1.7 13.8 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
1.7 6.8 GO:0005046 KDEL sequence binding(GO:0005046)
1.7 5.0 GO:0070699 type II activin receptor binding(GO:0070699)
1.6 9.6 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
1.5 6.1 GO:0004743 pyruvate kinase activity(GO:0004743)
1.5 15.2 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
1.5 12.1 GO:0016842 amidine-lyase activity(GO:0016842)
1.3 6.7 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
1.3 3.8 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
1.2 3.7 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
1.2 4.9 GO:0008428 ribonuclease inhibitor activity(GO:0008428)
1.0 4.1 GO:0035651 AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651)
0.9 2.6 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.8 6.8 GO:0070087 chromo shadow domain binding(GO:0070087)
0.7 67.6 GO:0008307 structural constituent of muscle(GO:0008307)
0.7 5.3 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.6 3.9 GO:0016421 CoA carboxylase activity(GO:0016421)
0.6 1.9 GO:0045155 electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity(GO:0045155)
0.6 5.4 GO:0035174 histone serine kinase activity(GO:0035174)
0.6 3.5 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.6 12.8 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.6 17.2 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.5 2.1 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
0.5 5.3 GO:0070569 uridylyltransferase activity(GO:0070569)
0.5 5.3 GO:0004645 phosphorylase activity(GO:0004645)
0.5 1.9 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.5 1.4 GO:0070644 vitamin D response element binding(GO:0070644)
0.5 1.8 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.4 2.7 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.4 9.1 GO:0031404 chloride ion binding(GO:0031404)
0.4 19.1 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.4 2.1 GO:0008420 CTD phosphatase activity(GO:0008420)
0.4 5.5 GO:0050700 CARD domain binding(GO:0050700)
0.4 3.4 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.4 10.8 GO:0070410 co-SMAD binding(GO:0070410)
0.4 1.5 GO:0004348 glucosylceramidase activity(GO:0004348)
0.4 7.9 GO:0000339 RNA cap binding(GO:0000339)
0.4 4.6 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.4 8.2 GO:0008266 poly(U) RNA binding(GO:0008266)
0.3 2.9 GO:0032190 acrosin binding(GO:0032190)
0.3 1.3 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.3 5.5 GO:0016289 CoA hydrolase activity(GO:0016289)
0.3 7.8 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.3 11.0 GO:0003785 actin monomer binding(GO:0003785)
0.3 9.4 GO:0070182 DNA polymerase binding(GO:0070182)
0.3 1.0 GO:0030899 calcium-dependent ATPase activity(GO:0030899)
0.3 2.0 GO:0038132 neuregulin binding(GO:0038132)
0.2 4.7 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.2 4.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.2 9.7 GO:0004532 exoribonuclease activity(GO:0004532)
0.2 4.2 GO:0032183 SUMO binding(GO:0032183)
0.2 4.8 GO:0050811 GABA receptor binding(GO:0050811)
0.2 1.8 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.2 21.3 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.2 1.6 GO:0015321 sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.2 2.4 GO:0015194 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.2 1.6 GO:0045504 dynein heavy chain binding(GO:0045504)
0.2 10.4 GO:0004407 histone deacetylase activity(GO:0004407)
0.2 0.8 GO:0015254 glycerol channel activity(GO:0015254)
0.2 1.4 GO:0016790 thiolester hydrolase activity(GO:0016790)
0.2 13.3 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 4.7 GO:0008327 methyl-CpG binding(GO:0008327)
0.2 3.1 GO:0016783 sulfurtransferase activity(GO:0016783)
0.2 15.1 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.2 1.9 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.2 0.9 GO:0004111 creatine kinase activity(GO:0004111)
0.2 0.7 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
0.2 3.9 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.2 0.9 GO:0016402 pristanoyl-CoA oxidase activity(GO:0016402)
0.2 5.5 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.2 1.8 GO:0042834 peptidoglycan binding(GO:0042834)
0.2 7.5 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.2 4.6 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.2 8.2 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 13.8 GO:0032947 protein complex scaffold(GO:0032947)
0.1 7.6 GO:0042169 SH2 domain binding(GO:0042169)
0.1 7.6 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.5 GO:0004052 arachidonate 12-lipoxygenase activity(GO:0004052)
0.1 4.8 GO:0051119 sugar transmembrane transporter activity(GO:0051119)
0.1 2.8 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 19.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 1.2 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1 2.1 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.1 2.4 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.1 0.6 GO:0004090 carbonyl reductase (NADPH) activity(GO:0004090)
0.1 4.9 GO:0000049 tRNA binding(GO:0000049)
0.1 0.6 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.1 4.4 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.1 10.4 GO:0017048 Rho GTPase binding(GO:0017048)
0.1 4.2 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 0.3 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
0.1 0.4 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
0.1 2.8 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 1.0 GO:0008565 protein transporter activity(GO:0008565)
0.1 1.5 GO:0070064 proline-rich region binding(GO:0070064)
0.1 4.0 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 3.6 GO:0031491 nucleosome binding(GO:0031491)
0.1 0.9 GO:0033038 bitter taste receptor activity(GO:0033038)
0.1 3.9 GO:0034062 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.1 2.7 GO:0051879 Hsp90 protein binding(GO:0051879)
0.1 3.8 GO:0050681 androgen receptor binding(GO:0050681)
0.1 0.6 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.1 3.6 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 2.7 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 12.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 3.9 GO:0044325 ion channel binding(GO:0044325)
0.1 1.7 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.3 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 3.4 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 1.5 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.1 GO:0004874 aryl hydrocarbon receptor activity(GO:0004874)
0.0 0.2 GO:0019770 IgG receptor activity(GO:0019770)
0.0 1.6 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.4 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.4 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 2.1 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 0.8 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.0 2.4 GO:0019905 syntaxin binding(GO:0019905)
0.0 0.8 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.6 GO:0030515 snoRNA binding(GO:0030515)
0.0 1.0 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 8.5 GO:0008134 transcription factor binding(GO:0008134)
0.0 0.4 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.4 GO:0050780 dopamine receptor binding(GO:0050780)
0.0 0.5 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.8 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 2.2 GO:0008168 methyltransferase activity(GO:0008168)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 21.9 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
1.1 66.7 PID PLK1 PATHWAY PLK1 signaling events
0.4 16.4 PID ALK1 PATHWAY ALK1 signaling events
0.3 10.0 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.2 12.9 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.2 4.1 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 6.7 PID FANCONI PATHWAY Fanconi anemia pathway
0.2 28.3 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.2 3.5 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.2 3.6 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.2 6.8 PID NCADHERIN PATHWAY N-cadherin signaling events
0.2 6.9 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.1 18.5 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.1 9.4 PID FOXO PATHWAY FoxO family signaling
0.1 5.5 PID ATR PATHWAY ATR signaling pathway
0.1 2.7 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 4.2 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.1 2.1 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 10.9 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 3.4 PID REELIN PATHWAY Reelin signaling pathway
0.1 6.4 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 5.3 PID TGFBR PATHWAY TGF-beta receptor signaling
0.1 2.6 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 5.9 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.1 7.4 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 4.2 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 2.0 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 5.8 PID CMYB PATHWAY C-MYB transcription factor network
0.1 1.9 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.1 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 1.3 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.4 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 0.9 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 2.1 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.2 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.3 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 1.7 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.7 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 0.7 ST P38 MAPK PATHWAY p38 MAPK Pathway
0.0 2.9 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.8 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 73.4 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
1.1 78.3 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
1.1 9.7 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
1.1 16.0 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
1.0 21.3 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.8 14.0 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.7 10.8 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.7 17.2 REACTOME KINESINS Genes involved in Kinesins
0.6 17.2 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.6 10.8 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.6 12.2 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.5 6.9 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.4 15.2 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.4 10.7 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.4 13.8 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.4 12.5 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.4 26.1 REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT Genes involved in p53-Independent G1/S DNA damage checkpoint
0.4 21.9 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.3 7.8 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.3 4.6 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.3 17.0 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.3 4.6 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.3 3.4 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.2 12.3 REACTOME AMYLOIDS Genes involved in Amyloids
0.2 6.0 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.2 3.9 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.2 3.7 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.2 3.5 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.2 1.8 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.2 6.2 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.2 43.3 REACTOME TRANSLATION Genes involved in Translation
0.2 5.7 REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.2 3.3 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.2 7.2 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 16.3 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.1 4.9 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 1.4 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.1 2.7 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 9.4 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 3.8 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.1 5.5 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.1 1.7 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 10.8 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.1 12.2 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 2.8 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.1 4.8 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.1 2.0 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 6.8 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.1 2.3 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 1.5 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 8.3 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.4 REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR Genes involved in Thromboxane signalling through TP receptor
0.0 1.6 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.0 1.1 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 1.5 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.8 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 3.6 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 1.4 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.9 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.3 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 1.2 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 1.9 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.1 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.8 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0 0.9 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes