ISMARA results: TCF7L2

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for TCF7L2

Z-value: 0.64

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Transcription factors associated with TCF7L2

Gene Symbol	Gene ID	Gene Info
TCF7L2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000148737.11	transcription factor 7 like 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TCF7L2	hg19_v2_chr10_+_114709999_114710031	0.46	6.4e-13	Click!

Activity profile of TCF7L2 motif

Sorted Z-values of TCF7L2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_+_69455855 Show fit	21.60	ENST00000227507.2 ENST00000536559.1	CCND1 Ensembl NCBI GeneCards UniProt NextProt Show fit	cyclin D1
chr5_-_16936340 Show fit	17.13	ENST00000507288.1 ENST00000513610.1	MYO10 Ensembl NCBI GeneCards UniProt NextProt Show fit	myosin X
chr11_+_114128522 Show fit	16.30	ENST00000535401.1	NNMT Ensembl NCBI GeneCards UniProt NextProt Show fit	nicotinamide N-methyltransferase
chr17_-_40169659 Show fit	12.31	ENST00000457167.4	DNAJC7 Ensembl NCBI GeneCards UniProt NextProt Show fit	DnaJ (Hsp40) homolog, subfamily C, member 7
chrX_-_10588459 Show fit	11.46	ENST00000380782.2	MID1 Ensembl NCBI GeneCards UniProt NextProt Show fit	midline 1 (Opitz/BBB syndrome)
chrX_-_10588595 Show fit	10.63	ENST00000423614.1 ENST00000317552.4	MID1 Ensembl NCBI GeneCards UniProt NextProt Show fit	midline 1 (Opitz/BBB syndrome)
chr13_+_76334795 Show fit	10.48	ENST00000526202.1 ENST00000465261.2	LMO7 Ensembl NCBI GeneCards UniProt NextProt Show fit	LIM domain 7
chr10_+_54074033 Show fit	10.44	ENST00000373970.3	DKK1 Ensembl NCBI GeneCards UniProt NextProt Show fit	dickkopf WNT signaling pathway inhibitor 1
chr3_-_134093275 Show fit	10.38	ENST00000513145.1 ENST00000422605.2	AMOTL2 Ensembl NCBI GeneCards UniProt NextProt Show fit	angiomotin like 2
chr13_+_76334567 Show fit	9.85	ENST00000321797.8	LMO7 Ensembl NCBI GeneCards UniProt NextProt Show fit	LIM domain 7

Showing 1 to 10 of 158 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF7L2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	22.1	GO:0035372	protein localization to microtubule(GO:0035372)
0.3	21.9	GO:0051489	regulation of filopodium assembly(GO:0051489)
2.2	21.6	GO:0070141	response to UV-A(GO:0070141)
0.0	19.6	GO:0043687	post-translational protein modification(GO:0043687)
0.4	18.0	GO:0035329	hippo signaling(GO:0035329)
5.7	17.2	GO:0030474	spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
1.4	16.3	GO:0034356	NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
2.5	15.3	GO:0010909	regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
3.4	13.7	GO:0031179	peptide amidation(GO:0001519) protein amidation(GO:0018032) peptide modification(GO:0031179)
0.3	13.1	GO:0036075	endochondral ossification(GO:0001958) replacement ossification(GO:0036075)

Showing 1 to 10 of 83 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	27.1	GO:0005881	cytoplasmic microtubule(GO:0005881)
0.4	25.2	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
1.1	21.9	GO:0032433	filopodium tip(GO:0032433)
0.1	18.1	GO:0005923	bicellular tight junction(GO:0005923)
0.1	17.7	GO:0000151	ubiquitin ligase complex(GO:0000151)
5.7	17.2	GO:0070762	nuclear pore transmembrane ring(GO:0070762)
2.5	15.3	GO:0070369	beta-catenin-TCF7L2 complex(GO:0070369)
3.3	13.1	GO:0030936	collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
0.2	11.7	GO:0045271	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.3	11.2	GO:0031258	lamellipodium membrane(GO:0031258)

Showing 1 to 10 of 48 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.4	21.9	GO:0060002	plus-end directed microfilament motor activity(GO:0060002)
0.2	21.7	GO:0051219	phosphoprotein binding(GO:0051219)
0.7	21.6	GO:0070064	proline-rich region binding(GO:0070064)
0.6	17.2	GO:0017056	structural constituent of nuclear pore(GO:0017056)
4.1	16.3	GO:0030760	nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
3.4	13.7	GO:0004504	peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.7	13.4	GO:0045295	gamma-catenin binding(GO:0045295)
0.1	13.1	GO:0008201	heparin binding(GO:0008201)
0.0	12.7	GO:0003714	transcription corepressor activity(GO:0003714)
0.4	12.3	GO:0001671	ATPase activator activity(GO:0001671)

Showing 1 to 10 of 68 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	21.9	PID NETRIN PATHWAY	Netrin-mediated signaling events
1.2	21.6	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.1	19.3	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.1	15.1	PID AP1 PATHWAY	AP-1 transcription factor network
0.3	13.1	NABA COLLAGENS	Genes encoding collagen proteins
0.5	11.2	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.3	10.4	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.2	10.1	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.3	10.0	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.2	9.2	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport

Showing 1 to 10 of 23 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	28.6	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.3	21.9	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
0.9	21.6	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.2	16.6	REACTOME PHASE II CONJUGATION	Genes involved in Phase II conjugation
0.2	13.1	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	9.5	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
0.5	9.2	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.3	8.6	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.1	6.0	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.2	5.3	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade

Showing 1 to 10 of 29 entries

Results for TCF7L2

Z-value: 0.64

Motif logo

Transcription factors associated with TCF7L2

Activity-expression correlation:

Activity profile of TCF7L2 motif

Sorted Z-values of TCF7L2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF7L2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: