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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for TFAP2B
Z-value: 0.50
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Transcription factors associated with TFAP2B
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TFAP2B | hg19_v2_chr6_+_50786414_50786439 | 0.33 | 6.3e-07 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TFAP2B
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 48.4 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 0.3 | 36.4 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 8.0 | 31.9 | GO:0071461 | cellular response to redox state(GO:0071461) |
| 2.1 | 28.9 | GO:2001199 | negative regulation of dendritic cell differentiation(GO:2001199) |
| 4.3 | 21.4 | GO:0019464 | glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464) |
| 1.3 | 18.8 | GO:0043653 | mitochondrial fragmentation involved in apoptotic process(GO:0043653) |
| 0.2 | 16.7 | GO:0006968 | cellular defense response(GO:0006968) |
| 1.0 | 15.7 | GO:0050862 | positive regulation of T cell receptor signaling pathway(GO:0050862) |
| 0.8 | 14.8 | GO:0051255 | spindle midzone assembly(GO:0051255) |
| 0.5 | 13.8 | GO:0030947 | regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030947) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 69.7 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.4 | 55.6 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.5 | 50.8 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 20.2 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 2.1 | 19.0 | GO:0044194 | cytolytic granule(GO:0044194) |
| 6.3 | 18.8 | GO:0044609 | DBIRD complex(GO:0044609) |
| 0.0 | 17.0 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.6 | 14.9 | GO:0000242 | pericentriolar material(GO:0000242) |
| 2.1 | 14.6 | GO:0030061 | mitochondrial crista(GO:0030061) |
| 0.1 | 13.5 | GO:0005796 | Golgi lumen(GO:0005796) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 44.4 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.2 | 36.8 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 3.2 | 31.9 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 5.3 | 21.4 | GO:0004047 | aminomethyltransferase activity(GO:0004047) |
| 0.2 | 20.7 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.4 | 20.1 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 1.2 | 16.3 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 2.6 | 15.7 | GO:0042610 | CD8 receptor binding(GO:0042610) |
| 0.5 | 13.7 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.8 | 13.5 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 49.4 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.5 | 40.3 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.3 | 29.6 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.5 | 21.1 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 2.1 | 16.7 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.3 | 14.6 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
| 0.1 | 13.3 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 12.2 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.2 | 10.2 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.2 | 9.8 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 71.1 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 1.2 | 51.2 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.3 | 50.2 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 1.7 | 31.6 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.2 | 21.1 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.6 | 11.7 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.1 | 11.4 | REACTOME G ALPHA Q SIGNALLING EVENTS | Genes involved in G alpha (q) signalling events |
| 0.6 | 10.8 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.9 | 10.7 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.2 | 10.1 | REACTOME GLUCAGON TYPE LIGAND RECEPTORS | Genes involved in Glucagon-type ligand receptors |