Project
GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for TFAP2C
Z-value: 0.84
Motif logo
Transcription factors associated with TFAP2C
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TFAP2C | hg19_v2_chr20_+_55204351_55204377 | -0.29 | 1.9e-05 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr21_-_46348694 Show fit | 24.84 |
ENST00000355153.4
ENST00000397850.2 |
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) |
|
| chrX_+_153237740 Show fit | 23.84 |
ENST00000369982.4
|
transmembrane protein 187 |
|
| chr15_+_91427691 Show fit | 21.33 |
ENST00000559355.1
ENST00000394302.1 |
feline sarcoma oncogene |
|
| chr18_+_77439775 Show fit | 17.94 |
ENST00000299543.7
ENST00000075430.7 |
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 |
|
| chr14_+_102027688 Show fit | 17.31 |
ENST00000510508.4
ENST00000359323.3 |
deiodinase, iodothyronine, type III |
|
| chr15_-_64338521 Show fit | 17.07 |
ENST00000457488.1
ENST00000558069.1 |
death-associated protein kinase 2 |
|
| chr16_+_222846 Show fit | 17.01 |
ENST00000251595.6
ENST00000397806.1 |
hemoglobin, alpha 2 |
|
| chr15_+_44580955 Show fit | 16.97 |
ENST00000345795.2
ENST00000360824.3 |
cancer susceptibility candidate 4 |
|
| chr15_+_44580899 Show fit | 15.74 |
ENST00000559222.1
ENST00000299957.6 |
cancer susceptibility candidate 4 |
|
| chr6_+_33043703 Show fit | 15.65 |
ENST00000418931.2
ENST00000535465.1 |
major histocompatibility complex, class II, DP beta 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of TFAP2C
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 93.5 | GO:0043547 | positive regulation of GTPase activity(GO:0043547) |
| 0.7 | 47.6 | GO:0050672 | negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672) |
| 2.3 | 43.6 | GO:0002523 | leukocyte migration involved in inflammatory response(GO:0002523) |
| 0.4 | 42.3 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 1.9 | 31.8 | GO:2000251 | positive regulation of actin cytoskeleton reorganization(GO:2000251) |
| 3.1 | 31.2 | GO:0060052 | neurofilament cytoskeleton organization(GO:0060052) |
| 1.5 | 26.6 | GO:0097320 | membrane tubulation(GO:0097320) |
| 0.6 | 26.1 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 4.3 | 25.5 | GO:0052565 | response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565) |
| 0.9 | 25.4 | GO:0045730 | respiratory burst(GO:0045730) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 284.2 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.7 | 70.0 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 0.4 | 57.2 | GO:0032587 | ruffle membrane(GO:0032587) |
| 1.9 | 47.6 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.3 | 46.5 | GO:0030136 | clathrin-coated vesicle(GO:0030136) |
| 0.3 | 42.1 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 1.8 | 35.1 | GO:0001891 | phagocytic cup(GO:0001891) |
| 6.7 | 33.5 | GO:0034688 | integrin alphaM-beta2 complex(GO:0034688) |
| 0.4 | 33.2 | GO:0005796 | Golgi lumen(GO:0005796) |
| 1.1 | 31.9 | GO:0044298 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 252.1 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.8 | 78.7 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.2 | 68.0 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 1.2 | 66.9 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.2 | 59.1 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.5 | 59.0 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.5 | 51.0 | GO:0003707 | steroid hormone receptor activity(GO:0003707) |
| 1.9 | 47.6 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.3 | 41.9 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 1.6 | 35.6 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 64.5 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.2 | 61.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.3 | 45.7 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 1.1 | 44.7 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.8 | 41.5 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.2 | 41.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 1.2 | 28.2 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.4 | 25.6 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.6 | 24.4 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.3 | 24.1 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 78.6 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.6 | 53.8 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.3 | 50.9 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 1.0 | 50.3 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.9 | 46.9 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.9 | 37.3 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 1.8 | 36.4 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 1.6 | 33.4 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.8 | 32.7 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.9 | 30.3 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |