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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for TFAP2E

Z-value: 1.06

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Transcription factors associated with TFAP2E

Gene Symbol Gene ID Gene Info
TFAP2E
ENSG00000116819.6 transcription factor AP-2 epsilon

Activity profile of TFAP2E motif

Sorted Z-values of TFAP2E motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_+_56623433 23.44 ENST00000570176.1
MT3
metallothionein 3
chr17_-_42992856 23.01 ENST00000588316.1
ENST00000435360.2
ENST00000586793.1
ENST00000588735.1
ENST00000588037.1
ENST00000592320.1
ENST00000253408.5
GFAP
glial fibrillary acidic protein
chr11_+_82612740 22.18 ENST00000524921.1
ENST00000528759.1
ENST00000525361.1
ENST00000430323.2
ENST00000533655.1
ENST00000532764.1
ENST00000532589.1
ENST00000525388.1
C11orf82
chromosome 11 open reading frame 82
chr12_+_53773944 20.48 ENST00000551969.1
ENST00000327443.4
SP1
Sp1 transcription factor
chr1_-_11866034 16.08 ENST00000376590.3
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr1_-_11865982 15.86 ENST00000418034.1
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr5_-_115152651 15.38 ENST00000250535.4
CDO1
cysteine dioxygenase type 1
chr2_-_177502254 13.20 ENST00000339037.3
AC017048.3
long intergenic non-protein coding RNA 1116
chr15_+_23810853 13.12 ENST00000568252.1
MKRN3
makorin ring finger protein 3
chr14_+_24837226 12.20 ENST00000554050.1
ENST00000554903.1
ENST00000554779.1
ENST00000250373.4
ENST00000553708.1
NFATC4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
chr1_+_9599540 11.91 ENST00000302692.6
SLC25A33
solute carrier family 25 (pyrimidine nucleotide carrier), member 33
chr6_+_7108210 10.85 ENST00000467782.1
ENST00000334984.6
ENST00000349384.6
RREB1
ras responsive element binding protein 1
chr3_+_49591881 10.14 ENST00000296452.4
BSN
bassoon presynaptic cytomatrix protein
chr1_+_9005917 9.94 ENST00000549778.1
ENST00000480186.3
ENST00000377443.2
ENST00000377436.3
ENST00000377442.2
CA6
carbonic anhydrase VI
chrX_+_152990302 9.42 ENST00000218104.3
ABCD1
ATP-binding cassette, sub-family D (ALD), member 1
chr4_-_82393009 9.10 ENST00000436139.2
RASGEF1B
RasGEF domain family, member 1B
chr17_+_3627185 8.84 ENST00000325418.4
GSG2
germ cell associated 2 (haspin)
chr15_+_27112058 8.81 ENST00000355395.5
GABRA5
gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr3_+_4535155 8.76 ENST00000544951.1
ITPR1
inositol 1,4,5-trisphosphate receptor, type 1
chr11_-_47870091 8.65 ENST00000526870.1
NUP160
nucleoporin 160kDa
chr12_+_53443963 8.59 ENST00000546602.1
ENST00000552570.1
ENST00000549700.1
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr15_+_27112251 8.22 ENST00000400081.3
GABRA5
gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr7_-_140624499 7.92 ENST00000288602.6
BRAF
v-raf murine sarcoma viral oncogene homolog B
chr15_+_27112380 7.91 ENST00000554596.1
GABRA5
gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr6_+_7107830 7.43 ENST00000379933.3
RREB1
ras responsive element binding protein 1
chr15_-_65503801 7.36 ENST00000261883.4
CILP
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
chr15_+_27112194 7.36 ENST00000555182.1
GABRA5
gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr15_+_27112296 6.99 ENST00000554038.1
GABRA5
gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr10_+_99894399 6.95 ENST00000298999.3
ENST00000314594.5
R3HCC1L
R3H domain and coiled-coil containing 1-like
chr19_-_11039188 6.93 ENST00000588347.1
YIPF2
Yip1 domain family, member 2
chr2_+_239335449 6.74 ENST00000264607.4
ASB1
ankyrin repeat and SOCS box containing 1
chr10_+_99894380 6.73 ENST00000370584.3
R3HCC1L
R3H domain and coiled-coil containing 1-like
chr12_+_75784850 6.57 ENST00000550916.1
ENST00000435775.1
ENST00000378689.2
ENST00000378692.3
ENST00000320460.4
ENST00000547164.1
GLIPR1L2
GLI pathogenesis-related 1 like 2
chr17_-_47755338 6.51 ENST00000508805.1
ENST00000515508.2
ENST00000451526.2
ENST00000507970.1
SPOP
speckle-type POZ protein
chr19_-_46389359 6.45 ENST00000302165.3
IRF2BP1
interferon regulatory factor 2 binding protein 1
chr17_+_29158962 6.43 ENST00000321990.4
ATAD5
ATPase family, AAA domain containing 5
chr20_+_58508817 6.23 ENST00000358293.3
FAM217B
family with sequence similarity 217, member B
chr10_-_112678976 5.93 ENST00000448814.1
BBIP1
BBSome interacting protein 1
chr1_-_11865351 5.63 ENST00000413656.1
ENST00000376585.1
ENST00000423400.1
ENST00000431243.1
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr19_+_4969116 5.19 ENST00000588337.1
ENST00000159111.4
ENST00000381759.4
KDM4B
lysine (K)-specific demethylase 4B
chr13_-_27334879 5.17 ENST00000405846.3
GPR12
G protein-coupled receptor 12
chr19_+_36195429 5.16 ENST00000392197.2
ZBTB32
zinc finger and BTB domain containing 32
chr11_-_47870019 5.09 ENST00000378460.2
NUP160
nucleoporin 160kDa
chr3_+_4535025 5.02 ENST00000302640.8
ENST00000354582.6
ENST00000423119.2
ENST00000357086.4
ENST00000456211.2
ITPR1
inositol 1,4,5-trisphosphate receptor, type 1
chr4_-_85419603 4.84 ENST00000295886.4
NKX6-1
NK6 homeobox 1
chr11_+_116700614 4.73 ENST00000375345.1
APOC3
apolipoprotein C-III
chr19_+_36195467 4.71 ENST00000426659.2
ZBTB32
zinc finger and BTB domain containing 32
chr1_+_35225339 4.65 ENST00000339480.1
GJB4
gap junction protein, beta 4, 30.3kDa
chr11_+_116700600 4.52 ENST00000227667.3
APOC3
apolipoprotein C-III
chr3_+_155860751 4.35 ENST00000471742.1
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr1_+_17634689 4.22 ENST00000375453.1
ENST00000375448.4
PADI4
peptidyl arginine deiminase, type IV
chr10_-_98273668 4.09 ENST00000357947.3
TLL2
tolloid-like 2
chr9_-_21077939 4.07 ENST00000380232.2
IFNB1
interferon, beta 1, fibroblast
chrX_+_128872998 3.99 ENST00000371106.3
XPNPEP2
X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
chr3_+_51428704 3.85 ENST00000323686.4
RBM15B
RNA binding motif protein 15B
chr20_-_13619550 3.80 ENST00000455532.1
ENST00000544472.1
ENST00000539805.1
ENST00000337743.4
TASP1
taspase, threonine aspartase, 1
chr2_-_45236540 3.79 ENST00000303077.6
SIX2
SIX homeobox 2
chr19_-_43969796 3.65 ENST00000244333.3
LYPD3
LY6/PLAUR domain containing 3
chr9_-_34662651 3.63 ENST00000259631.4
CCL27
chemokine (C-C motif) ligand 27
chr11_-_113345995 3.62 ENST00000355319.2
ENST00000542616.1
DRD2
dopamine receptor D2
chr20_+_55205825 3.54 ENST00000544508.1
TFAP2C
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
chr5_+_133984462 3.54 ENST00000398844.2
ENST00000322887.4
SEC24A
SEC24 family member A
chr12_+_57984965 3.51 ENST00000540759.2
ENST00000551772.1
ENST00000550465.1
ENST00000354947.5
PIP4K2C
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
chr8_+_17780483 3.49 ENST00000517730.1
ENST00000518537.1
ENST00000523055.1
ENST00000519253.1
PCM1
pericentriolar material 1
chr17_-_39769005 3.32 ENST00000301653.4
ENST00000593067.1
KRT16
keratin 16
chr17_+_72428218 3.30 ENST00000392628.2
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr11_-_35440796 3.20 ENST00000278379.3
SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr6_+_37787262 3.01 ENST00000287218.4
ZFAND3
zinc finger, AN1-type domain 3
chr19_-_39264072 3.01 ENST00000599035.1
ENST00000378626.4
LGALS7
lectin, galactoside-binding, soluble, 7
chr3_+_52813932 3.00 ENST00000537050.1
ITIH1
inter-alpha-trypsin inhibitor heavy chain 1
chr19_-_11039261 2.97 ENST00000590329.1
ENST00000587943.1
ENST00000585858.1
ENST00000586748.1
ENST00000586575.1
ENST00000253031.2
YIPF2
Yip1 domain family, member 2
chr1_+_17248418 2.85 ENST00000375541.5
CROCC
ciliary rootlet coiled-coil, rootletin
chr1_-_201346761 2.76 ENST00000455702.1
ENST00000422165.1
ENST00000367318.5
ENST00000367320.2
ENST00000438742.1
ENST00000412633.1
ENST00000458432.2
ENST00000421663.2
ENST00000367322.1
ENST00000509001.1
TNNT2
troponin T type 2 (cardiac)
chr19_+_45504688 2.73 ENST00000221452.8
ENST00000540120.1
ENST00000505236.1
RELB
v-rel avian reticuloendotheliosis viral oncogene homolog B
chr11_-_118305921 2.65 ENST00000532619.1
RP11-770J1.4
RP11-770J1.4
chr11_-_66056478 2.62 ENST00000431556.2
ENST00000528575.1
YIF1A
Yip1 interacting factor homolog A (S. cerevisiae)
chr14_+_21214039 2.57 ENST00000326842.2
EDDM3A
epididymal protein 3A
chr12_+_72666407 2.52 ENST00000261180.4
TRHDE
thyrotropin-releasing hormone degrading enzyme
chr17_-_31620006 2.43 ENST00000225823.2
ASIC2
acid-sensing (proton-gated) ion channel 2
chr3_-_48130314 2.35 ENST00000439356.1
ENST00000395734.3
ENST00000426837.2
MAP4
microtubule-associated protein 4
chr11_-_35441524 2.19 ENST00000395750.1
ENST00000449068.1
SLC1A2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr11_-_47869865 2.16 ENST00000530326.1
ENST00000532747.1
NUP160
nucleoporin 160kDa
chr2_+_38893047 2.16 ENST00000272252.5
GALM
galactose mutarotase (aldose 1-epimerase)
chr22_+_29601840 2.07 ENST00000334018.6
ENST00000429226.1
ENST00000404755.3
ENST00000404820.3
ENST00000430127.1
EMID1
EMI domain containing 1
chr3_-_48632593 1.98 ENST00000454817.1
ENST00000328333.8
COL7A1
collagen, type VII, alpha 1
chr9_+_19230433 1.93 ENST00000434457.2
ENST00000602925.1
DENND4C
DENN/MADD domain containing 4C
chr11_+_118478313 1.89 ENST00000356063.5
PHLDB1
pleckstrin homology-like domain, family B, member 1
chr5_-_151304337 1.80 ENST00000455880.2
ENST00000545569.1
ENST00000274576.4
GLRA1
glycine receptor, alpha 1
chr9_+_35605274 1.79 ENST00000336395.5
TESK1
testis-specific kinase 1
chrX_+_152783131 1.75 ENST00000349466.2
ENST00000370186.1
ATP2B3
ATPase, Ca++ transporting, plasma membrane 3
chr2_+_241375069 1.75 ENST00000264039.2
GPC1
glypican 1
chr2_+_233243233 1.70 ENST00000392027.2
ALPP
alkaline phosphatase, placental
chr2_+_74741569 1.69 ENST00000233638.7
TLX2
T-cell leukemia homeobox 2
chr16_+_69600058 1.69 ENST00000393742.2
NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr6_+_99282570 1.46 ENST00000328345.5
POU3F2
POU class 3 homeobox 2
chr2_-_241831424 1.44 ENST00000402775.2
ENST00000307486.8
C2orf54
chromosome 2 open reading frame 54
chr4_-_101439242 1.41 ENST00000296420.4
EMCN
endomucin
chr16_+_69599899 1.39 ENST00000567239.1
NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr3_+_110790590 1.38 ENST00000485303.1
PVRL3
poliovirus receptor-related 3
chr3_-_136471204 1.17 ENST00000480733.1
ENST00000383202.2
ENST00000236698.5
ENST00000434713.2
STAG1
stromal antigen 1
chr6_+_13272904 1.12 ENST00000379335.3
ENST00000379329.1
PHACTR1
phosphatase and actin regulator 1
chr14_-_25519317 0.94 ENST00000323944.5
STXBP6
syntaxin binding protein 6 (amisyn)
chr6_+_292051 0.89 ENST00000344450.5
DUSP22
dual specificity phosphatase 22
chrX_+_115567767 0.86 ENST00000371900.4
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr11_-_82612727 0.82 ENST00000531128.1
ENST00000535099.1
ENST00000527444.1
PRCP
prolylcarboxypeptidase (angiotensinase C)
chr19_+_50936142 0.76 ENST00000357701.5
MYBPC2
myosin binding protein C, fast type
chr12_-_48213568 0.73 ENST00000080059.7
ENST00000354334.3
ENST00000430670.1
ENST00000552960.1
ENST00000440293.1
HDAC7
histone deacetylase 7
chr22_+_31608219 0.43 ENST00000406516.1
ENST00000444929.2
ENST00000331728.4
LIMK2
LIM domain kinase 2
chr17_+_37824411 0.43 ENST00000269582.2
PNMT
phenylethanolamine N-methyltransferase
chr8_+_17780346 0.34 ENST00000325083.8
PCM1
pericentriolar material 1
chr17_+_37824700 0.32 ENST00000581428.1
PNMT
phenylethanolamine N-methyltransferase
chr17_+_37824217 0.24 ENST00000394246.1
PNMT
phenylethanolamine N-methyltransferase
chr1_-_154531095 0.14 ENST00000292211.4
UBE2Q1
ubiquitin-conjugating enzyme E2Q family member 1
chr9_+_136501478 0.11 ENST00000393056.2
ENST00000263611.2
DBH
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
chr19_+_49458107 0.02 ENST00000539787.1
ENST00000345358.7
ENST00000391871.3
ENST00000415969.2
ENST00000354470.3
ENST00000506183.1
ENST00000293288.8
BAX
BCL2-associated X protein

Network of associatons between targets according to the STRING database.

First level regulatory network of TFAP2E

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
7.8 23.4 GO:0097212 cadmium ion homeostasis(GO:0055073) lysosomal membrane organization(GO:0097212) negative regulation of hydrogen peroxide catabolic process(GO:2000296) regulation of oxygen metabolic process(GO:2000374)
7.5 37.6 GO:0033274 response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)
4.1 16.4 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
4.0 11.9 GO:0006864 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
3.8 15.4 GO:0042412 taurine biosynthetic process(GO:0042412)
3.4 13.8 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
3.4 20.5 GO:1900239 phenotypic switching(GO:0036166) regulation of phenotypic switching(GO:1900239)
3.1 9.3 GO:0060620 regulation of cholesterol import(GO:0060620) negative regulation of cholesterol import(GO:0060621) regulation of sterol import(GO:2000909) negative regulation of sterol import(GO:2000910)
2.4 12.2 GO:1904637 response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637)
2.4 9.4 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
1.6 4.8 GO:0002071 glandular epithelial cell maturation(GO:0002071) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913) type B pancreatic cell maturation(GO:0072560)
1.6 7.9 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
1.3 3.8 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
1.2 23.0 GO:1904714 regulation of chaperone-mediated autophagy(GO:1904714)
1.0 39.3 GO:0060384 innervation(GO:0060384)
1.0 4.1 GO:0048631 regulation of skeletal muscle tissue growth(GO:0048631)
1.0 3.8 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.9 3.6 GO:0044467 glial cell-derived neurotrophic factor secretion(GO:0044467) regulation of glial cell-derived neurotrophic factor secretion(GO:1900166) positive regulation of glial cell-derived neurotrophic factor secretion(GO:1900168)
0.8 4.2 GO:0018101 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.8 8.8 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.7 2.2 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.7 2.9 GO:0032053 ciliary basal body organization(GO:0032053) positive regulation of protein localization to cilium(GO:1903566)
0.7 2.8 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
0.7 4.1 GO:0002725 negative regulation of T cell cytokine production(GO:0002725)
0.7 5.4 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.7 7.4 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.6 5.2 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.6 3.9 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.6 4.6 GO:0042048 olfactory behavior(GO:0042048)
0.4 3.5 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.4 6.4 GO:0048304 positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.4 2.3 GO:0051012 microtubule sliding(GO:0051012)
0.4 9.9 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.3 1.7 GO:1990034 calcium ion export from cell(GO:1990034)
0.3 1.7 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.3 2.4 GO:0050915 sensory perception of sour taste(GO:0050915)
0.3 15.9 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.3 6.7 GO:0030539 male genitalia development(GO:0030539)
0.3 1.8 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.3 3.5 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
0.3 4.4 GO:1902260 diaphragm development(GO:0060539) negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.3 2.5 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.2 1.0 GO:0042418 epinephrine biosynthetic process(GO:0042418)
0.2 1.5 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.2 3.3 GO:0051546 keratinocyte migration(GO:0051546)
0.2 2.6 GO:0007320 insemination(GO:0007320)
0.2 0.8 GO:0002155 regulation of thyroid hormone mediated signaling pathway(GO:0002155) kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353)
0.2 9.9 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.2 1.9 GO:2001197 regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.2 2.7 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.1 1.7 GO:0048484 enteric nervous system development(GO:0048484)
0.1 0.9 GO:0051601 exocyst localization(GO:0051601)
0.1 8.3 GO:0035418 protein localization to synapse(GO:0035418)
0.1 7.6 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.1 0.9 GO:0002710 negative regulation of T cell mediated immunity(GO:0002710)
0.1 0.7 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.1 3.9 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 2.7 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.1 3.0 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.1 0.8 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.1 2.5 GO:0043171 peptide catabolic process(GO:0043171)
0.0 2.0 GO:0035987 endodermal cell differentiation(GO:0035987)
0.0 0.1 GO:0042421 norepinephrine biosynthetic process(GO:0042421)
0.0 3.6 GO:0008584 male gonad development(GO:0008584) development of primary male sexual characteristics(GO:0046546)
0.0 0.9 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.1 GO:0070459 prolactin secretion(GO:0070459)
0.0 3.6 GO:0060326 cell chemotaxis(GO:0060326)
0.0 1.2 GO:0007062 sister chromatid cohesion(GO:0007062)
0.0 9.5 GO:0016567 protein ubiquitination(GO:0016567)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 23.4 GO:0097449 astrocyte projection(GO:0097449)
1.5 13.8 GO:0005955 calcineurin complex(GO:0005955)
1.4 39.3 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
1.2 9.3 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
1.0 15.9 GO:0031080 nuclear pore outer ring(GO:0031080)
0.6 4.4 GO:1990635 proximal dendrite(GO:1990635)
0.5 13.7 GO:0035145 exon-exon junction complex(GO:0035145)
0.5 2.8 GO:1990584 cardiac Troponin complex(GO:1990584)
0.4 9.4 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.3 2.9 GO:0035253 ciliary rootlet(GO:0035253)
0.3 2.5 GO:0034464 BBSome(GO:0034464)
0.3 12.0 GO:0099738 cell cortex region(GO:0099738)
0.3 4.6 GO:0005922 connexon complex(GO:0005922)
0.2 1.9 GO:0032593 insulin-responsive compartment(GO:0032593)
0.2 2.7 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.2 26.3 GO:0005882 intermediate filament(GO:0005882)
0.2 3.8 GO:0000242 pericentriolar material(GO:0000242)
0.2 5.4 GO:0030673 axolemma(GO:0030673)
0.2 3.5 GO:0030127 COPII vesicle coat(GO:0030127)
0.2 1.8 GO:0060077 inhibitory synapse(GO:0060077)
0.1 0.9 GO:0000145 exocyst(GO:0000145)
0.1 3.7 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 16.4 GO:0001650 fibrillar center(GO:0001650)
0.1 20.5 GO:0032993 protein-DNA complex(GO:0032993)
0.1 3.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 7.4 GO:0031225 anchored component of membrane(GO:0031225)
0.1 2.0 GO:0098644 complex of collagen trimers(GO:0098644)
0.0 3.6 GO:0016328 lateral plasma membrane(GO:0016328) ciliary membrane(GO:0060170)
0.0 9.1 GO:0030496 midbody(GO:0030496)
0.0 3.5 GO:0005776 autophagosome(GO:0005776)
0.0 2.3 GO:0072686 mitotic spindle(GO:0072686)
0.0 8.8 GO:0005819 spindle(GO:0005819)
0.0 0.1 GO:0042584 chromaffin granule membrane(GO:0042584)
0.0 2.1 GO:0005581 collagen trimer(GO:0005581)
0.0 0.8 GO:0032982 myosin filament(GO:0032982)
0.0 11.9 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 21.5 GO:0045202 synapse(GO:0045202)
0.0 0.8 GO:0045178 basal part of cell(GO:0045178)
0.0 31.7 GO:0005615 extracellular space(GO:0005615)
0.0 0.9 GO:0031526 brush border membrane(GO:0031526)
0.0 3.0 GO:0030133 transport vesicle(GO:0030133)
0.0 7.8 GO:0016607 nuclear speck(GO:0016607)
0.0 0.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.2 GO:0000775 chromosome, centromeric region(GO:0000775)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
7.5 37.6 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
4.0 11.9 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
3.4 13.8 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
2.3 9.3 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
1.9 39.3 GO:0050811 GABA receptor binding(GO:0050811)
1.8 23.4 GO:0046870 cadmium ion binding(GO:0046870)
1.4 4.2 GO:0034618 arginine binding(GO:0034618)
1.3 9.4 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
1.3 9.1 GO:0004035 alkaline phosphatase activity(GO:0004035)
1.2 3.5 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.9 3.6 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.9 12.2 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.9 20.5 GO:0071837 HMG box domain binding(GO:0071837)
0.8 8.8 GO:0035184 histone threonine kinase activity(GO:0035184)
0.8 5.4 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.6 5.2 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.6 15.4 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.6 9.9 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.5 3.6 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.5 2.4 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.4 15.9 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.4 4.1 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.4 1.8 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.3 2.8 GO:0030172 troponin C binding(GO:0030172)
0.3 1.0 GO:0004603 phenylethanolamine N-methyltransferase activity(GO:0004603)
0.3 6.5 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.3 7.9 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.2 5.2 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.2 4.4 GO:0070402 NADPH binding(GO:0070402)
0.2 2.2 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.1 5.4 GO:0043236 laminin binding(GO:0043236)
0.1 26.3 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 3.8 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 1.7 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 0.9 GO:0017049 GTP-Rho binding(GO:0017049)
0.1 2.9 GO:0019894 kinesin binding(GO:0019894)
0.1 8.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 0.7 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 0.8 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 8.4 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 5.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 12.0 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.9 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 4.3 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 1.1 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 1.5 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 4.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.8 GO:0051371 muscle alpha-actinin binding(GO:0051371) structural molecule activity conferring elasticity(GO:0097493)
0.0 3.9 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 3.0 GO:0030246 carbohydrate binding(GO:0030246)
0.0 5.6 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 1.8 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 7.2 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.0 0.9 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.1 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 16.5 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.4 20.5 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.4 7.9 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.3 4.1 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.1 11.0 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.1 3.6 ST G ALPHA I PATHWAY G alpha i Pathway
0.1 1.7 PID ALK2 PATHWAY ALK2 signaling events
0.1 3.9 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 3.6 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 2.0 NABA COLLAGENS Genes encoding collagen proteins
0.0 1.7 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 1.4 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 2.7 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 7.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 4.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 4.9 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.7 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 39.3 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.8 9.9 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.7 9.9 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.5 37.6 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.5 9.4 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.4 9.3 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.4 20.5 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.4 15.4 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.4 7.9 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.3 23.0 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.3 4.6 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.2 4.1 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.2 1.8 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.2 4.8 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.1 6.2 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 6.1 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 4.4 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 3.6 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 1.7 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.1 1.7 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 1.8 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 3.6 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 3.5 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 1.1 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 1.4 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 3.8 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.8 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 6.6 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.7 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 1.2 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis